CN104324209A - Traditional Chinese medicine composition for treating mycoplasma pneumoniae of swine and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating mycoplasma pneumoniae of swine and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating mycoplasma pneumoniae of swine and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal raw materials: ephedra, semen armeniacae amarae, scutellaria baicalensis, tangerine, platycodon grandiflorum, bulbus fritillariae ussuriensis, rhizoma anemarrhenae, cortex mori radicis, gypsum and licorice root. The traditional Chinese medicine composition has the advantages of safety, convenience and economy, and has an ideal treatment effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to snorting Chinese medicine composition for the treatment of pig and preparation method thereof.
Background technology
Swine enzootic pneumonia or mycoplasma pneumoniae of swine, also known as mycoplasma hyopneumoniae, are a kind of chronic respiratory infectious disease of pig.The main clinic symptoms of primary disease is cough and asthma, and pathological change position is mainly positioned at thoracic cavity.Lungs are major organs of pathological changes.Acute case is based on pulmonary edema and emphysema; Subacute and chronic cases is shown in pulmonary's " Macrobrachium nipponensis " sample consolidation.The speed of growth of morbidity pig is slow, and efficiency of feed utilization is low, and the feeding for fattening phase extends.
This disease is also called mycoplasmal pneumonia of swine and epidemic swine pneumonia.All pig-raising countries all have this disease popular, and primary disease is caused by mycoplasma hyopneumoniae.The infection of piglets is mostly suffered from by contact caused by the sow of primary disease.Infected piglets relays other pigs again when weaning.Dense husbandry can promote that it is propagated.The incubation period of primary disease is longer, therefore has more swinery infected under not realized, causes primary disease often to be deposited in what swinery.The infection rate of primary disease is high, and mortality rate is low, but can cause retardation of growth and reduce meat change rate.In other words, the feeding period of pig listing will be extended.
Hyopneumoniae gas substance is one of 3 kinds of main pathogens causing porcine respiratory disease, suffers from recall rate in the case of respiratory tract disease be about 19% pig.Mycoplasma hyopneumoniae is mainly present in the respiratory tract of infected pigs, lung tissue, hilar lymph node and vertical phrenic lymph nodes, and sick pig and the pig that carries disease germs are its major source of infection.Its route of transmission mainly contains: respiratory infectious, direct contact infection and droplet transmission, source of disease Jun Zhi infected pigs; Initial infection mycoplasma hyopneumoniae is present in trachea and bronchus surface, and damages mucosa-cilium barrier, makes bronchus and blood vessel peripheral lymphoid like cell hypertrophy (immunoreation obviously participates in pathological development and causes lungs generation consolidation); Infected pigs mainly betides the later stage (after infecting 15 ~ 20 weeks) of disease to the immunne response of mycoplasma hyopneumoniae, and this infection has certain immunosuppressive action as can be seen here.
Primary disease clinical symptoms and dissection pathological changes, can for the reference in diagnosis.When large numbers of pig battle array dry cough, breathe, retarded growth or delay but very low mortality rate etc. and can suspect it is primary disease.Dissecting pathological changes is demarcate clear between the focus of lung and normal lung tissue, and lateral symmetry and diseased region mostly limit what point leaf, lobus cardiacus, middle leaf and every leaf front lower portion.There is the sensation that pancreas sample is solid.
When natural infection, easy secondary pasteurellosis bacillus, streptococcus pneumoniae, Actinobacillus pleuropneumoniae, Salmonella and various suppurative bacterium, mycoplasma hyorhinis and granular chlamydia etc., thus cause patient's condition to aggravate and mortality rate rising.
General antibacterial is as sulfanilamide, and penicillin, streptomycin and erythromycin etc. are all without therapeutical effect.A new generation's quinolones is the curative to primary disease optimum.The weak plain freeze-dried vaccine of mycoplasma pneumoniae of swine of domestic production can be used for 20-25 age in days sodium selenite, immunization rate can reach more than 80%.Kind of a swinery must be bred voluntarily in pig farm, and strict this encephalapthy agent of prevention invades.
Immunologic escape is caused because mycoplasma hyopneumoniae can change surface antigen, immunity is caused to weaken, therefore pig farm need coordinate medical treatment, general 3 ~ 5 days an of course for the treatment of, particularly farrowing sow spice purification, its pig that farrows is raised separately, use of not reserving seed for planting, segregated early weaning is carried out on the pig farm that condition possesses, and reduces the time of contact of sow and piglet as far as possible.
Summary of the invention
The object of this invention is to provide one and treat the snorting Chinese medicine composition of pig;
Another object of the present invention is to provide a kind of preparation method for the treatment of the snorting Chinese medicine composition of pig.
The object of the invention is by following technical scheme realize:
The snorting Chinese medicine composition for the treatment of pig of the present invention, it is prepared from by the raw material of following weight portion:
Herba Ephedrae 40-60 part, Semen Armeniacae Amarum 25-35 part, Radix Scutellariae 20-30 part, Fructus Citri tangerinae 25-35 part, Radix Platycodonis 25-35 part, Bulbus Fritillariae Ussuriensis 25-35 part, Rhizoma Anemarrhenae 25-35 part, Cortex Mori 25-35 part, Gypsum Fibrosum 80-120 part, Radix Glycyrrhizae 15-25 part.
Preferably, be prepared from by the raw material of following weight portion:
50 parts, Herba Ephedrae, Semen Armeniacae Amarum 30 parts, Radix Scutellariae 25 parts, Fructus Citri tangerinae 30 parts, Radix Platycodonis 30 parts, Bulbus Fritillariae Ussuriensis 30 parts, the Rhizoma Anemarrhenae 30 parts, Cortex Mori 30 parts, 100 parts, Gypsum Fibrosum, 20 parts, Radix Glycyrrhizae.
Below Chinese crude drug source and the primary efficacy that the present invention treats the snorting Chinese medicine composition of pig:
Herba Ephedrae: be the dry herb stem of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, epheday intermedia Ephedra intermedia Schrenk et C.A.Mey. or ephedra equisetina Ephedra equisetina Bge..Autumn Mo taps green herb stem, dries.[nature and flavor with return through] pungent, micro-hardship, temperature.Return lung, urinary bladder channel.[function with cure mainly] diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema.Herba ephedrae nourishing the lung to arrest cough.Be used for exterior syndrome to separate, asthma and cough.
Semen Armeniacae Amarum: be the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. Prunus armeniaca L.var.ansu Maxim., Siberia Fructus Pruni Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..To gather summer mature fruit, in removing fruit and nucleocapsid, take out seed, dry.[nature and flavor write return through] are bitter, tepor; Slightly poisonous.Return lung, large intestine channel.[function with cure mainly] sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, dryness of the intestine constipation.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and removing fibrous root and silt, hit rough bark after solarization, dry.[nature and flavor with return through] are bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.[function with cure mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst. heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Fructus Citri tangerinae: be Rutaceae Rutaceae Citrus Citrus plant Fructus Citri tangerinae Citrus reticulata.[nature and flavor with return through] sweet acid, warm in nature, enter lung, stomach warp.[function with cure mainly] has appetizing and regulates the flow of vital energy, the effect of lung moistening of quenching the thirst, and cures mainly septum pectorale stagnation of QI, vomiting is eaten less, very thirsty in deficiency of stomach-Yin, mouth, cough due to lung-heat and insobriety.
Radix Platycodonis: be the dry root of Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.Dc..Spring, Qiu Erji excavate, and clean, and removing fibrous root, takes advantage of and freshly peel off crust or do not remove crust, dry.[nature and flavor with return through] are bitter, pungent, flat.Return lung meridian.[function with cure mainly] lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus.
Bulbus Fritillariae Ussuriensis: be the dry bulb of liliaceous plant Bulbus Fritillariae Ussuriensis Fritillaria ussuriensis Maxim..Spring excavates, removing crust, fibrous root and silt, dry or low temperature in dry.[nature and flavor with return through] are bitter, sweet, are slightly cold.Return lung, heart channel.[function with cure mainly] clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, cough with blood-flecked phlegm.[usage and consumption] 3 ~ 9g, levigation is taken after mixing it with water, a 1 ~ 2g.[attention] should not with Radix Aconiti, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata with using.
The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge..Spring, Qiu Erji excavate, and removing fibrous root and silt, dry, and practise and claim " RHIZOMA ANEMARRHENAE with peet "; Or removing crust, dry.Nature and flavor with return through] bitter, sweet, cold.Return lung, stomach, kidney channel.[function with cure mainly] clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Cortex Mori: be the dry root bark of moraceae plants Mulberry Morus alba L..Fall last years of a century in autumn and excavate root before secondary spring germinates, scrape off yellowish-brown rough bark, longitudinally cut open, strip root bark, dry.[nature and flavor with return through] are sweet, cold.Return lung meridian.[function with cure mainly] eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Gypsum Fibrosum: be Sulfates mineral anhydrite race Gypsum Fibrosum, main containing hydrous calcium sulfate (CaS042H2O), after excavating, except roguing stone and silt.[nature and flavor with return through] are sweet, pungent, Great Cold.Attach to the lung and stomach meridians.[function with cure mainly] clearing away heat-fire, relieving restlessness is quenched the thirst.For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
Radix Glycyrrhizae: be the dry root welding technology of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflate Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..In the spring, Qiu Erji excavates, and removing fibrous root, dries.[nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.[function with cure mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains active component.
Scheme two: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
Scheme three: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The snorting Chinese medicine composition for the treatment of pig of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Herba Ephedrae depressed lung-energy dispersing of the present invention, Semen Armeniacae Amarum sending down the abnormal ascending QI relieving cough and asthma; Radix Scutellariae heat clearing and damp drying; Fructus Citri tangerinae quenches the thirst lung moistening; Radix Platycodonis lung qi dispersing sore-throat relieving eliminates the phlegm; Bulbus Fritillariae Ussuriensis; Rhizoma Anemarrhenae clearing away heat-fire is nourshing Yin and drynsessmoistening prescription; Cortex Mori eliminating pathogen from the lung for relieving asthma; Gypsum Fibrosum clearing away heat-fire, relieving restlessness is quenched the thirst; Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing.The present invention just arranges in pairs or groups scientific and reasonable entirely, can clear interior-heat, rushes down pathogenic fire, a surname opens lung qi, relieving asthma, invigorating the spleen and replenishing QI, and Yin Wenre is violated pig that lung causes various symptom of breathing rapidly disappears.
One provided by the invention is treated the snorting Chinese medicine composition of pig and is had the following advantages:
1, Chinese medicine composition provided by the invention can clear interior-heat, rushes down pathogenic fire, a surname opens lung qi, relieving asthma, invigorating the spleen and replenishing QI, and Yin Wenre is violated pig that lung causes various symptom of breathing rapidly disappears.Result in clinical application shows: the present invention can effectively alleviate or eliminate cough and the asthma symptom of disease pig, is simple and easy to do, Therapeutic Method safely and effectively.The total effective rate of the high, medium and low dosage group of the embodiment of the present invention to mycoplasma pneumoniae of swine is respectively 95%, 90%, 70%, proves that therapeutic effect of the present invention is extremely remarkable.
2, the present invention is by taking treatment by Chinese herbs, allows cough and asthma symptom rapidly disappear, and has safety, thorough, convenient, economic advantage.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1:
Get Herba Ephedrae 50g, Semen Armeniacae Amarum 30g, Radix Scutellariae 25g, Fructus Citri tangerinae 30g, Radix Platycodonis 30g, Bulbus Fritillariae Ussuriensis 30g, Rhizoma Anemarrhenae 30g, Cortex Mori 30g, Gypsum Fibrosum 100g, Radix Glycyrrhizae 20g, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, 1 times of filtrate simmer down to medical material total amount, obtains decoction.
Embodiment 2:
Get Herba Ephedrae 40g, Semen Armeniacae Amarum 25g, Radix Scutellariae 20g, Fructus Citri tangerinae 25g, Radix Platycodonis 25g, Bulbus Fritillariae Ussuriensis 25g, Rhizoma Anemarrhenae 25g, Cortex Mori 25g, Gypsum Fibrosum 80g, Radix Glycyrrhizae 15g, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filters, when filtrate is concentrated into 60 DEG C, relative density is the extractum of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3:
Get Herba Ephedrae 60g, Semen Armeniacae Amarum 35g, Radix Scutellariae 30g, Fructus Citri tangerinae 35g, Radix Platycodonis 35g, Bulbus Fritillariae Ussuriensis 35g, Rhizoma Anemarrhenae 35g, Cortex Mori 35g, Gypsum Fibrosum 120g, Radix Glycyrrhizae 25g, extracting in water 3 times, three amount of water are equivalent to 12 times of medical material gross weight respectively, 8 times, 6 times, 3 hours respectively each extraction time, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, add ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.10, add 3 times that purified water ad pond om is medical material gross weight, fill, obtain mixture of the present invention.
Embodiment 4:
Get Herba Ephedrae 50g, Semen Armeniacae Amarum 25g, Radix Scutellariae 30g, Fructus Citri tangerinae 30g, Radix Platycodonis 25g, Bulbus Fritillariae Ussuriensis 35g, Rhizoma Anemarrhenae 30g, Cortex Mori 25g, Gypsum Fibrosum 120g, Radix Glycyrrhizae 20g, with alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, and each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filters, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 5:
Get Herba Ephedrae 40g, Semen Armeniacae Amarum 35g, Radix Scutellariae 25g, Fructus Citri tangerinae 25g, Radix Platycodonis 35g, Bulbus Fritillariae Ussuriensis 30g, Rhizoma Anemarrhenae 25g, Cortex Mori 35g, Gypsum Fibrosum 100g, Radix Glycyrrhizae 15g, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulates shell, obtained capsule.
Embodiment 6:
Get Herba Ephedrae 60g, Semen Armeniacae Amarum 25g, Radix Scutellariae 25g, Fructus Citri tangerinae 35g, Radix Platycodonis 25g, Bulbus Fritillariae Ussuriensis 30g, Rhizoma Anemarrhenae 35g, Cortex Mori 25g, Gypsum Fibrosum 80g, Radix Glycyrrhizae 25g, extracting in water 2 times, each amount of water is equivalent to 12 times of medical material gross weight respectively, 10 times, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, add ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.
Embodiment 7:
Take Herba Ephedrae 50g, Semen Armeniacae Amarum 25g, Radix Scutellariae 25g, Fructus Citri tangerinae 35g, Radix Platycodonis 30g, Bulbus Fritillariae Ussuriensis 25g, Rhizoma Anemarrhenae 30g, Cortex Mori 35g, Gypsum Fibrosum 100g, Radix Glycyrrhizae 15g, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 8:
Take Herba Ephedrae 50g, Semen Armeniacae Amarum 30g, Radix Scutellariae 25g, Fructus Citri tangerinae 30g, Radix Platycodonis 30g, Bulbus Fritillariae Ussuriensis 30g, Rhizoma Anemarrhenae 30g, Cortex Mori 30g, Gypsum Fibrosum 100g, Radix Glycyrrhizae 20g, cleans, and pulverizes, obtains powder of the present invention.
Clinical treatment is summed up
1 materials and methods
1.1 test material
1.1.1 the test drug embodiment of the present invention 1 decoction
1.1.2 experimental animal collects 5 batches of pigs at Guangxi large―scale hoggery
Have the natural cases pig of the doubtful mycoplasma pneumoniae of swine disease of obvious clinical symptoms to amount to 90, its symptom is: sneeze, cough, asthma, shortly to cough, seriality is long coughs and dry cough; Breathing shows as ventral breathing, or sick pig presents " dog is horizontal " posture; Spirit is depressed, slow-witted vertical; Appetite declines.The age in days of pig is 40-45 days, after clinical definite, selects positive sick pig 80 to be test pig by test requirements document and " is divided into 4 groups, often organizes 20.
1.2 test method
1.2.1 the making a definite diagnosis of doubtful mycoplasma pneumoniae of swine
1.2.1.1 clinical observation and inspection.Sick temperature of pig body reaches more than 40 DEG C, lassitude, sends overcast dry cough, and be that dog sits shape during breathing, in continuous print spasmodic cough in feed way, dyspnea, frequency of respiration reaches 90-100 time/min, mouth breathing time serious.
1.2.1.2 serodiagnosis.Whole pig blood sampling separation of serum, go out can after carry out microparticle agglutination reaction, method and criterion are with reference to " examining under a microscope microparticle agglutination reaction to the diagnosis of porcine enzootic pneumonia and the research of firm Mycoplasma hyopneumoniae " method.
1.2.1.3X photodynamic diagnosis.Whole pig carries out x-ray fluoroscopy film making, and uprightly to carry on the back breast position, position, side is auxiliary, and perspective criterion specifies by the meeting of national mycoplasmal pneumonia Harbin: "-" cardiopulmonary are without visible shadow; There is partial phantom at "+" septum cordis angle; " ++ " shaded region is comparatively large, but heart circle is still visible; " +++ " heart circle is unclear.
1.2.1.4 pathology cuts open inspection.Cut open inspection sick dead pig at random, can find that lung has edema in various degree and edema due to disorder of QI, it is pale red that diseased region occurs, boundary is obvious, and apex pulmonis leaf is typical " meat sample " consolidation, hilus pulumonis and the remarkable enlargement of vertical phrenic lymph nodes, there is inflammatory exudate, and tissue and lymphocytosis.
1.2.1.5 laboratory diagnosis.Plate coating checking: the tangent plane getting disease pig pulmonary lesions and healthy lung tissue intersection, smear is made with the microscope slide of clean dry, after natural drying number minute, 3min is fixed with methanol, the Ji's nurse Sa Albert'stain Albert liquid dyeing 3h diluting 20 times with the phosphate buffer of pH7.2 rinses, embathe 1 time, microscopy with acetone soln immediately after drying, have purple ring-type, colyliform, the polymorphic microorganism such as spherical as seen.
1.2.1.6 making a definite diagnosis of mycoplasma pneumoniae of swine.According to Epidemiological study, there is Mycoplasmal pneumonia morbidity history in sick pig farm, therefore the pig that this time falls ill is that the probability of mycoplasmal pneumonia is very large: the sick pig of all collections, clinical onset symptom is obvious, and Major respiratory symptom is cough and asthma, and feeding is particularly evident sooner or later, cough seasonal disease pig is stood, rear arch rises, and neck stretches, sagging.Analyse pathological change result to show as typical lung (comprising hilar lymph node) trachea and bronchus pathological changes (test in laboratory microparticle agglutination reaction result is more than " ++ "; X-ray fluoroscopy film making result is more than " ++ "; According to above result, make a definite diagnosis disease pig and infect disease of breathing.
1.2.2 therapeutic trial.After making a definite diagnosis, select the sick pig totally 80 of mycoplasma pneumoniae of swine (all performance has classical symptom) to be divided into 4 groups at random immediately, often organizing 20, giving medicine, the medication when there is disease symptom, administration every day 3 times by grouping, continuous was a course for the treatment of with 7 days.Treat the clinical symptoms change of observing pig in 1 week.
Experimental group 1: give embodiment 1 decoction, by crude drug gauge, 200g/kg.
Experimental group 2: give embodiment 2 decoction, by crude drug gauge, 100g/kg.
Experimental group 3: give embodiment 3 decoction, by crude drug gauge, 50g/kg.
Blank group: not administration, observes.
1.2.3 index of assessment of curative effect
(1) inefficiency.At duration of test, occur that the classical symptom of mycoplasma pneumoniae of swine is also dead, necropsy has characteristic pathological changes to be defined as death.After drug treatment the clinical symptoms of pig have no obvious improver be defined as invalid.Quantity according to dead pig and invalid pig calculates inefficiency.
(2) cure rate.At test drug treatment and viewing duration, after pig medication, essence, appetite all recover normal, and the classical symptom disappearance person of mycoplasma pneumoniae of swine is defined as curing, and the quantity according to curing calculates cure rate.
(3) effective percentage.At test drug treatment and viewing duration, after curing pig and administration, symptom has obvious alleviator, is all judged to be effectively.Calculate effective percentage accordingly.
2 results and discussion
The cure rate of each test group, effective percentage, inefficiency are in table 1.By table 1
Known, take effective percentage as evaluation index, the present invention's high, medium and low dosage group is extremely remarkable with the therapeutic effect difference of not administration matched group to mycoplasma pneumoniae of swine of falling ill.The effective percentage of the high, medium and low dosage group of the embodiment of the present invention to mycoplasma pneumoniae of swine is respectively 95%, 90%, 70%.High dose group therapeutic effect of the present invention is especially remarkable.
Table 1 test group efficacy result of the present invention
| Cure rate (%) | Effective percentage (%) | Inefficiency (%) | |
| Blank group | 0 | 0 | 100 |
| Test 1 group | 85* | 95* | 5 |
| Test 2 groups | 80* | 90* | 10 |
| Test 3 groups | 60* | 70* | 30 |
Note: compared with blank group, * P < 0.01.
To the snorting emergent treatment of pig, if adopt Western medicine antibiotic therapy, once form indication in swinery, when antibiotic therapy is invalid, swinery there will be the situation of large quantities of death.Adopt treatment by Chinese herbs then can not occur Drug resistance status easily.Advocate so all try one's best when can avoid not adopt antibiotics.By taking treatment by Chinese herbs, there is safety, thorough, convenient, economic advantage.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. the snorting Chinese medicine composition for the treatment of pig, it is characterized in that it is prepared from by the raw material of following weight portion: Herba Ephedrae 40-60 part, Semen Armeniacae Amarum 25-35 part, Radix Scutellariae 20-30 part, Fructus Citri tangerinae 25-35 part, Radix Platycodonis 25-35 part, Bulbus Fritillariae Ussuriensis 25-35 part, Rhizoma Anemarrhenae 25-35 part, Cortex Mori 25-35 part, Gypsum Fibrosum 80-120 part, Radix Glycyrrhizae 15-25 part.
2. Chinese medicine composition according to claim 1, is characterized in that it is prepared from by the raw material of following weight portion: 50 parts, Herba Ephedrae, Semen Armeniacae Amarum 30 parts, Radix Scutellariae 25 parts, Fructus Citri tangerinae 30 parts, Radix Platycodonis 30 parts, Bulbus Fritillariae Ussuriensis 30 parts, the Rhizoma Anemarrhenae 30 parts, Cortex Mori 30 parts, 100 parts, Gypsum Fibrosum, 20 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition as described in claim 1 or 2 any one, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
4. Chinese medicine composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains described active component.
5. Chinese medicine composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, adds ethanol, makes alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
6. Chinese medicine composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
7. treat a pig snorting Chinese medicine composition, prepare by treating acceptable carrier in the snorting Chinese medicine composition of pig and pharmaceuticals industry described in claim 1 or 2 and obtain.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984174A (en) * | 2015-07-24 | 2015-10-21 | 黑龙江省动物疫病预防与控制中心 | Traditional Chinese medicine veterinary drug for treating pig respiratory disease, preparation method and applications thereof |
| CN104984174B (en) * | 2015-07-24 | 2018-06-01 | 黑龙江省动物疫病预防与控制中心 | Prevent herbal medicine of porcine respiratory disease and its preparation method and application |
| CN111773309A (en) * | 2020-08-05 | 2020-10-16 | 辽宁华飞药业有限公司 | Lung-clearing cough-relieving powder electuary |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658660A (en) * | 2009-09-18 | 2010-03-03 | 天津诺康动物药业有限公司 | Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine and preparation method thereof |
| CN102188597A (en) * | 2011-05-03 | 2011-09-21 | 赵志敏 | Medicament of pure traditional Chinese medicine for treating swine enzootic pneumonia |
| CN102247565A (en) * | 2010-12-16 | 2011-11-23 | 桑立功 | Prescription for cough relieving and lung-heat clearing |
| CN102512540A (en) * | 2011-12-23 | 2012-06-27 | 荣成市崖头美全口腔诊所 | Chinese medicine composition for treating asthma |
| CN102552653A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition with phlegm reducing and cough relieving functions and preparation method thereof |
| CN103156983A (en) * | 2013-03-12 | 2013-06-19 | 山东春雪药业有限公司 | Feed traditional Chinese medicine additive for preventing broiler chicken respiratory diseases and production method thereof |
| CN103272030A (en) * | 2013-05-31 | 2013-09-04 | 武伟 | Pneumonic treatment medicine and preparation method thereof |
| CN103432374A (en) * | 2013-09-10 | 2013-12-11 | 周冠旻 | Medicine for treating pneumonia of pig |
-
2014
- 2014-10-21 CN CN201410561505.5A patent/CN104324209B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658660A (en) * | 2009-09-18 | 2010-03-03 | 天津诺康动物药业有限公司 | Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine and preparation method thereof |
| CN102552653A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition with phlegm reducing and cough relieving functions and preparation method thereof |
| CN102247565A (en) * | 2010-12-16 | 2011-11-23 | 桑立功 | Prescription for cough relieving and lung-heat clearing |
| CN102188597A (en) * | 2011-05-03 | 2011-09-21 | 赵志敏 | Medicament of pure traditional Chinese medicine for treating swine enzootic pneumonia |
| CN102512540A (en) * | 2011-12-23 | 2012-06-27 | 荣成市崖头美全口腔诊所 | Chinese medicine composition for treating asthma |
| CN103156983A (en) * | 2013-03-12 | 2013-06-19 | 山东春雪药业有限公司 | Feed traditional Chinese medicine additive for preventing broiler chicken respiratory diseases and production method thereof |
| CN103272030A (en) * | 2013-05-31 | 2013-09-04 | 武伟 | Pneumonic treatment medicine and preparation method thereof |
| CN103432374A (en) * | 2013-09-10 | 2013-12-11 | 周冠旻 | Medicine for treating pneumonia of pig |
Non-Patent Citations (4)
| Title |
|---|
| 光若静等: "止咳类药材的功效及性味归经规律的探讨", 《时珍国医国药》 * |
| 曹昌霞等: "中西医结合治疗慢性肺源性心脏病急性加重期的临床观察", 《青海医学院学报》 * |
| 胡功政等: "《"兽药合理配伍使用》", 31 October 2009 * |
| 韩静枫: "咳喘Ⅱ号配合西药治疗婴幼儿哮喘及护理体会", 《陕西中医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984174A (en) * | 2015-07-24 | 2015-10-21 | 黑龙江省动物疫病预防与控制中心 | Traditional Chinese medicine veterinary drug for treating pig respiratory disease, preparation method and applications thereof |
| CN104984174B (en) * | 2015-07-24 | 2018-06-01 | 黑龙江省动物疫病预防与控制中心 | Prevent herbal medicine of porcine respiratory disease and its preparation method and application |
| CN111773309A (en) * | 2020-08-05 | 2020-10-16 | 辽宁华飞药业有限公司 | Lung-clearing cough-relieving powder electuary |
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