CN1480179A - Preparation of houttuynia for treating peptic ulcer as well as acute and chronic gastritis - Google Patents
Preparation of houttuynia for treating peptic ulcer as well as acute and chronic gastritis Download PDFInfo
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- CN1480179A CN1480179A CNA031283543A CN03128354A CN1480179A CN 1480179 A CN1480179 A CN 1480179A CN A031283543 A CNA031283543 A CN A031283543A CN 03128354 A CN03128354 A CN 03128354A CN 1480179 A CN1480179 A CN 1480179A
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Abstract
A Chinese medicine in the form of oral liquid, syrup, powder, pill, particle, table, injection, or capsule for treating peptide ulcer and acute or chronic gastritis is prepared from houttuynia and assistant through extracting, fractionating, and mixing. Its advantage is high curative effect.
Description
Technical field the present invention relates to a kind of Herba Houttuyniae preparation for the treatment of peptic ulcer and acute and chronic gastritis.
Background technology PU mainly refers to occur in stomach and duodenal chronic ulcer, antacid maintenance therapy commonly used in the past, relapse rate was at 20%-57% in 1 year, after one principal element-HP theory of nineteen eighty-two proposition PU, use and eradicate the HP therapy, promptly bismuth triple therapy and proton pump inhibitor three are treated PU, and healing and the relapse rate of PU significantly reduce, but the triple therapy price is expensive, and side effect is many.
At present single preparation of being made by Herba Houttuyniae has Herba Houttuyniae injectio, cordate houttuynia tea, houttuynia beverage, Herba Houttuyniae nutritional solution (as the patent No. 93103769,94118267 etc.), Herba Houttuyniae packed food etc.The medicine that is used for the treatment of disease is a Herba Houttuyniae injectio, and as " a kind of Herba Houttuyniae injectio and preparation method thereof " (patent No. 96117459,99114767), the former has the obvious suppression effect to multiple coccus and bacillus.Function with heat clearing away, detoxifcation, dampness removing can be used for treating lung abscess, phlegm-heat cough, leucorrhea, urinary tract infection, carbuncle furuncle etc., and the effective percentage for the treatment of respiratory system and diseases of urinary system is reached 98% and 99% respectively.Clinical acute upper respiratory tract infection, chronic bronchitis, bronchiectasis, infantile pneumonia, rhinitis, keratitis, pyelonephritis, colitis, viral myocarditis, functional diarrhea, enteritis, the oral ulcer etc. of being used for of the preparation that Herba Houttuyniae is made.
The Chinese patent medicine that Herba Houttuyniae is used for the treatment of gastritis, peptic ulcer is compound preparation, is not main component with the Herba Houttuyniae during its prescription is formed.As " a kind of Chinese medicine for the treatment of gastropathy " (patent No. 98112529), to form by 6 flavor medicines such as Herba Houttuyniae, Herba Houttuyniae only contains 10～15%.The effect that this medical instrument has pain relieving, stops blooding, cools down has specially good effect to gastritis, gastric ulcer, duodenal ulcer." a kind of Chinese medicine composition for the treatment of digestive tract tumor " (patent No. 97105657), it forms by 20 Herba indigoferae Pseudotinctoriae such as Herba Houttuyniae are refining, digestive tract tumor such as esophagus, cardia, large intestine are had significant curative effect, have no side effect, can significantly improve the human body anti-cancer ability.
Also there is not to treat with Herba Houttuyniae separately the document of peptic ulcer.
Summary of the invention the objective of the invention is at above-mentioned present situation, aims to provide a kind of treatment peptic ulcer that is mixed with Herba Houttuyniae and shaping assistant and the Herba Houttuyniae preparation of acute and chronic gastritis.
The implementation of this utility model purpose is that the Herba Houttuyniae preparation of treatment peptic ulcer and acute and chronic gastritis includes oral liquid, syrup, powder, water pill agent, granule, tablet, injection and capsule.Oral liquid, syrup are formulated by Herba Houttuyniae distillate, decoction liquor and sucrose, medicinal water.Powder is the Herba Houttuyniae fine powder.Water pill is Herba Houttuyniae fine powder general weary, the exsiccant preparation of distilled water.Granule is the granule that thick paste, volatile oil and the Icing Sugar of the two lifting manipulation extracts of Herba Houttuyniae makes.Tablet, capsule be for to mix the tablet that is pressed into by Herba Houttuyniae distillate, decoction liquor with volatile oil, starch, or incapsulate the preparation that become.。Injection is for being added the supernatant behind the ethanol precipitation by Herba Houttuyniae distillate, decoction liquor.
The present invention is principal agent with the Herba Houttuyniae, and the pharmaceutical component of Herba Houttuyniae is mainly decanoylacetaldehyde.Herba Houttuyniae can strengthen leukocytic phagocytic activity, enhancing body nonspecific immunity ability can significantly improve the ratio of periphery blood T lymphocyte, strengthens the phagocytic activity of macrophage, promote the generation of the IgM due to the sheep red blood cell (SRBC) immunity, thereby can improve the specific immunity ability of body; Can promote phagocyte to the killing of HP, by to the killing of HP, alleviate the congestion and edema around the ulcer, promote the formation of ulcer surface granulation tissue, promote the healing of ulcer surface, reduce the recurrence of ulcer; Reduce the field planting of HP in stomach, duodenal mucosa; The multiple Cao Lanshi positive, negative bacterium all there is stronger inhibitory action; Inflammatory pain also there is stronger inhibitory action.
The present invention cooperates with the dosage form auxiliary agent with Herba Houttuyniae extract, distillation or powder and is made into oral liquid, syrup, powder, water pill agent, granule, tablet, injection and capsule.Can also Herba Houttuyniae extract be principal agent, add that other medicine is made into the medicament of treatment peptic ulcer and acute and chronic gastritis.This preparation can improve the specific immunity ability of body, and the promotion phagocyte is killed HP's, reduces HP in stomach, duodenal mucosa field planting, promotes the ulcer surface healing, reduces ulcer recurrence; Energy suppresses or kills helicobacter pylori, improves peptic ulcer patient's pain symptom.
The specific embodiment
This preparation is equipped with the shaping assistant of various dosage forms based on Herba Houttuyniae, is mixed with the medicament of various dosage forms, and its preparation method and dosage are specific as follows:
1, system oral liquid
1000g Herba Houttuyniae vapor distillation, it is standby to collect distillate 300ml, and medicinal residues decoct with water (2 hours, 2 hours, 1 hour) three times, merge decoction liquor, filter, filtrate is concentrated in right amount, adds ethanol to 50%, staticly settle, get supernatant, reclaim ethanol, add the water mixing, filter, filtrate concentrates standby.Other gets sucrose 100g, makes syrup and above-mentioned medicinal liquid and distillate and merges, and adds antiseptic, is diluted with water to 1000ml, and mixing filters, fill, and sterilization, promptly.
Usage and consumption: oral, three times on the one, each 15-30ml.
2, sugaring slurry formulation
With example 1, different is, filtrate concentrates, and other gets sucrose 600g, makes syrup and above-mentioned medicinal liquid and distillate and merges, and adds antiseptic, is diluted with water to 1000ml, and mixing filters, and fill is sterilized, promptly.
Usage and consumption: oral, three times on the one, each 15-30ml.
3, system powder
Method for making: get the 1000g Herba Houttuyniae and pulverized through Highefficientpulverizer and sieve fine powder for No. seven, make 1000g powder, packing, promptly.
Usage and consumption: oral, three times on the one, each 15-30g.
4, system water pill,
Get the 1000g Herba Houttuyniae through crushing screening, mixing, get even fine powder,,, make 1000g powder dry below 60 ℃ with the distillation water pill.
Usage and consumption: oral, three times on the one, each 15-30g.
5, system granule
Get the 1000g Herba Houttuyniae and extract medicine thick paste and volatile oil with " two lifting manipulation ", with Icing Sugar 200g mixing system 500g granule, drying, promptly.
Usage and consumption: oral, three times on the one, each 7.5-15g.
6, film-making agent
With example 1, different is that supernatant reclaims ethanol, continues to be condensed into thick paste, adds volatile oil, starch mixing, granulates, and dry below 60 ℃, is pressed into 500.
Usage and consumption: oral, three times on the one, each 8-15 sheet.
7, system injection
Get the 1000g Herba Houttuyniae and carry out vapor distillation, collect distillate 1000ml just, carry out redistillation again, collect re-distilled liquid 400ml, redistillation is standby to the 100ml distillate again.Medicinal residues decoct with water three times, merge decoction liquor, filter, and filtrate is concentrated in right amount, adds ethanol to 50%, staticly settles, and gets supernatant, get injection.
8, glue capsule
It is standby to get 1000g Herba Houttuyniae extraction volatile oil.Medicinal residues decoct with water three times, merge decoction liquor, filter, and filtrate is concentrated in right amount, adds ethanol to 50%, staticly settles, and gets supernatant, reclaim ethanol, continue to be condensed into silk fabric cream, add volatile oil, starch mixing, dry below 60 ℃, pulverize 200 capsules of packing into.
Usage and consumption: oral, three times on the one, each 3-6 grain.
The Hubei Prov. Medicine Industry Inst with Herba Houttuyniae crude drug content be respectively 2,4 and the oral liquid of 8g/kg stress in rats type and pyloric ligation ulcers gastric ulcer have been done the test of therapeutical effect,
One, to the therapeutical effect of stress in rats type gastric ulcer
49 of rats are divided into 5 groups at random, and divide and irritate different medicaments, administration in continuous 5 days, concrete outcome sees Table 1:
| Group | Number of elements | Ulcer index (X ± SD) | Ulcer inhibition rate (%) |
| Distilled water group group ranitidine hydrochloride 30mg/kg organizes this oral liquid 8g/kg and organizes this oral liquid 4g/kg and organize this oral liquid 2g/kg group | ?9 ?10 ?10 ?10 ?10 | ????30±10 ????17±8 ????16±7 ????18±5 ????25±6 | ??37 ??42 ??34 ??10 |
* P＜0.005 * * P＜0.001 (all with the comparison of distilled water group)
Two, to the therapeutical effect of rat pyloric ligation ulcers gastric ulcer:
50 of rats, random packet, medication 5 days the results are shown in Table 2
| Group | Number of elements | Ulcer area (mm 2· X±SD) | Ulcer index (X ± SD) | Ulcer inhibition rate (%) |
| Distilled water group group ranitidine hydrochloride 30mg/kg organizes this oral liquid 8g/kg and organizes this oral liquid 4g/kg and organize this oral liquid 2g/kg group | 9 9 9 9 9 | ????30±10 ????17±8 ????16±7 ????18±5 ????25±6 | 2.56±1.88 1.33±1.41 0.94±1.37 1.50±1.37 2.50±1.94 | ????60 ????65 ????59 ????9 |
* P＜0.005 * * P＜0.01 (all with the comparison of distilled water group)
Conclusion is: houttuynia oral administration liquid can alleviate the gastric mucosa extent of damage, dwindles the ulcer area, improves ulcer inhibition rate, and the therapeutical effect of gastric ulcer is better than ranitidine hydrochloride.
The Wuhan City, Hubei Province Jiangxia District hospital of traditional Chinese hospital has made the clinical observation experiment of treatment peptic ulcer with houttuynia oral administration liquid, and concrete condition is as follows:
Select 100 routine PU patients to be divided into two groups at random, make the treatment group, compare group with ranitidine hydrochloride capsules 30 examples with houttuynia oral administration liquid 70 examples.The result is:
The total effects ratio sees Table 1
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Total effective rate % |
| The treatment group | 70 | 30 | 18 | 14 | 8 | 88.6 |
| Matched group | 30 | 3 | 5 | 13 | 9 | 70.0 |
Compare P＜0.01 with matched group
Ulcer healing rate, anti-HP curative effect under two groups of gastroscopes, ulcer recurrence situation relatively reach doing well,improving situation before and after the treatment, see Table 2 respectively, table 3, table 4, table 5.
Table 2
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate % |
| The treatment group | 70 | 24 | 19 | 17 | 10 | 61.4 |
| Matched group | 30 | 2 | 7 | 15 | 6 | 30.0 |
Table 3
| Group | The example number | Eradicate | Reduce | Invalid | Effective percentage % |
| The treatment group | 62 | 38 | 13 | 11 | 82.3 |
| Matched group | 26 | 4 | 6 | 16 | 38.5 |
Table 4
| Group | Follow up a case by regular visits to half a year | Followed up a case by regular visits to 1 year | ||||
| The example number | Recurrence | Relapse rate | The example number | Recurrence | Relapse rate | |
| The treatment group | ????56 | 9 | 11.1％ | 45 | 15 | ????53.3％ |
| Matched group | ????25 | 10 | 40.0％ | 18 | 11 | ????61.1％ |
Table 5
| Symptom | Pain | Gastral cavity is vexed | Nausea | Belch | Lack of appetite | It is uncomfortable to defecate |
| Before the treatment | 68 | ??42 | 40 | 38 | 62 | 31 |
| After the treatment | 60 | ??34 | 31 | 30 | 54 | 22 |
| Effective percentage % | 88.2 | ??81.0 | 77.5 | 78.9 | 87.1 | 71.0 |
Conclusion is: ulcer healing obvious effective rate under clinical total effective rate, the gastroscope is organized in treatment, anti-helicobacter pylori (HP) effective percentage is better than matched group (P＜0.01), and relapse rate is lower than matched group (P＜0.05) after half a year and 1 year.
Model case with this pharmaceutical treatment:
The king * * gastral cavilty portion distending pain discomfort, happiness belch, general acid regurgitation water, lack of appetite uncomfortable in chest, bitter taste, yellow urine are obeyed poor effect such as ranitidine, motilium certainly.Gastroscope shows: duodenal bulbar ulcer (A
1Phase), check HP, the urease methods positive, smear staining microscopy (++).
Take this medicine every day 3 times, a 20ml (being equivalent to crude drug 15g), the 5 days symptoms of taking medicine are clearly better, and 2 all symptoms all disappear, and the no any discomforts in 3 week backs are reacted.Gastroscopy: the ulcer complete obiteration, survey HP, urease methods and smear staining microscopy are (-).Follow up a case by regular visits to after half a year and 1 year and do not have recurrence.
Claims (1)
1, treatment peptic ulcer and urgency, the Herba Houttuyniae preparation of chronic gastritis, it is characterized in that including oral liquid, syrup, powder, the water pill agent, granule, tablet, injection and capsule, oral liquid, syrup is by the Herba Houttuyniae distillate, decoction liquor and sucrose, medicinal water is formulated, powder is the Herba Houttuyniae fine powder, water pill is general weary with distilled water for the Herba Houttuyniae fine powder, exsiccant preparation, granule is the thick paste of the two lifting manipulation extracts of Herba Houttuyniae, the granule that volatile oil and Icing Sugar make, tablet, capsule is by the Herba Houttuyniae distillate, decoction liquor and volatile oil, starch mixes the tablet that is pressed into, or incapsulating the preparation that become, injection is by the Herba Houttuyniae distillate, decoction liquor adds the supernatant behind the ethanol precipitation.
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| CNA031283543A CN1480179A (en) | 2003-07-21 | 2003-07-21 | Preparation of houttuynia for treating peptic ulcer as well as acute and chronic gastritis |
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| CNA031283543A CN1480179A (en) | 2003-07-21 | 2003-07-21 | Preparation of houttuynia for treating peptic ulcer as well as acute and chronic gastritis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085096B (en) * | 2007-06-04 | 2011-04-13 | 莫少凡 | Method for extracting cordate houttuynia |
| CN106421082A (en) * | 2016-12-27 | 2017-02-22 | 郑州莉迪亚医药科技有限公司 | Medicine composition for treating gastric ulcer |
| CN110327397A (en) * | 2019-08-13 | 2019-10-15 | 贵州医科大学 | A kind of cordate houttuynia dew and the preparation method and application thereof |
-
2003
- 2003-07-21 CN CNA031283543A patent/CN1480179A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085096B (en) * | 2007-06-04 | 2011-04-13 | 莫少凡 | Method for extracting cordate houttuynia |
| CN106421082A (en) * | 2016-12-27 | 2017-02-22 | 郑州莉迪亚医药科技有限公司 | Medicine composition for treating gastric ulcer |
| CN110327397A (en) * | 2019-08-13 | 2019-10-15 | 贵州医科大学 | A kind of cordate houttuynia dew and the preparation method and application thereof |
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