CN110327397A - A kind of cordate houttuynia dew and the preparation method and application thereof - Google Patents
A kind of cordate houttuynia dew and the preparation method and application thereof Download PDFInfo
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- CN110327397A CN110327397A CN201910743070.9A CN201910743070A CN110327397A CN 110327397 A CN110327397 A CN 110327397A CN 201910743070 A CN201910743070 A CN 201910743070A CN 110327397 A CN110327397 A CN 110327397A
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- cordate houttuynia
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- 235000013717 Houttuynia Nutrition 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 240000000691 Houttuynia cordata Species 0.000 title description 41
- 238000001256 steam distillation Methods 0.000 claims abstract description 13
- 239000003443 antiviral agent Substances 0.000 claims abstract description 4
- 241000758769 Houttuynia Species 0.000 claims abstract 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 239000012153 distilled water Substances 0.000 claims description 9
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 7
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 239000005711 Benzoic acid Substances 0.000 claims description 4
- 241000711920 Human orthopneumovirus Species 0.000 claims description 4
- 235000010233 benzoic acid Nutrition 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- KCQRUBFGEILVKV-UHFFFAOYSA-L C(CC)(=O)[O-].[Ca+2].C(C=CC=CC)(=O)[O-].[K+] Chemical compound C(CC)(=O)[O-].[Ca+2].C(C=CC=CC)(=O)[O-].[K+] KCQRUBFGEILVKV-UHFFFAOYSA-L 0.000 claims description 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 abstract description 5
- 235000009508 confectionery Nutrition 0.000 abstract description 4
- CHTUTNRSUGMGBL-UHFFFAOYSA-N C(CCCCCCCCC)(=O)CC=O.C(C)=O Chemical compound C(CCCCCCCCC)(=O)CC=O.C(C)=O CHTUTNRSUGMGBL-UHFFFAOYSA-N 0.000 abstract description 3
- 125000003118 aryl group Chemical group 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 239000003643 water by type Substances 0.000 abstract description 3
- 244000269722 Thea sinensis Species 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 4
- 235000010199 sorbic acid Nutrition 0.000 description 4
- 239000004334 sorbic acid Substances 0.000 description 4
- 229940075582 sorbic acid Drugs 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 240000004307 Citrus medica Species 0.000 description 2
- 235000013719 Houttuynia cordata Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- XLYLQUQHYUOPIW-UHFFFAOYSA-N 3-oxo-Tetradecanal Chemical compound CCCCCCCCCCCC(=O)CC=O XLYLQUQHYUOPIW-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- QBDCOUHKEVYWLO-UHFFFAOYSA-N Decanoylacetaldehyde Natural products CCCCCCCCCC(=O)CC=O QBDCOUHKEVYWLO-UHFFFAOYSA-N 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000192041 Micrococcus Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000758742 Saururaceae Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241001530209 Swertia Species 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000013010 irrigating solution Substances 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of cordate houttuynia dew extremely preparation method and application.Cordate houttuynia dew provided by the invention obtains the aromatic waters containing volatile active-decanoy acetaldehyde (decanoyl acetaldehyde) etc. by steam distillation, it is colourless to flaxen transparency liquid, by adding corrigent, the stink smell itself having, slightly sweet or sweet tea can be covered, improve the adaptability of user, it can directly take orally, cordate houttuynia dew provided by the invention has antiviral curative effect, it can be used as the use of antiviral drugs preparation, be with a wide range of applications.
Description
Technical field
Reveal the present invention relates to microorganisms technical field more particularly to a kind of cordate houttuynia and the preparation method and application thereof.
Background technique
Cordate houttuynia (Classification system: Houttuynia cordata Thunb.) is the herbal medicine that Chinese Pharmacopoeia is included, and herbal medicine comes
Source is the fresh herb or dry aerial parts of saururaceae plant houttuynia cordata.Fresh goods whole year can tap；Dry product summer cauline leaf cyclopentadienyl
Full blossom fringe is tapped when more, is removed impurity, is dried.Herbal medicine character: stem is in oblate cylindricality, is distorted, long 20~35cm, and diameter 0.2~
0.3cm；Surface brown color, tool vertical rib several, section is obvious, has remaining fibrous root on the section of lower part；Matter is crisp, frangibility.Leaf alternate, blade
Convolution shrinkage, in heart, long 3~5cm, wide 3~4.5cm after flattening；Apex is tapering, full edge；Upper surface darker yellow green is to dark palm fibre
Color, lower surface celadon or taupe brown；Petiole is elongated, and base portion and stipule symphysis are at sheath shape.Spike basidixed, yellowish-brown.It rubs with the hands
The broken taste that bears the odor of fish.Cordate houttuynia acrid flavour, cold nature is distributed in lung channel, has clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.For pulmonary abscess
The effect of pyemesis, phlegm heat panting cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
Modern research shows that cordate houttuynia characteristic odor is mainly derived from one of Herba Houttuyniae volatile oil effective component ---
Decanoy acetaldehyde (decanoyl acetaldehyde).Elongated swertia herb element is the main antimicrobial component of cordate houttuynia, to micrococcus catarrhalis, Bacillus influenzae, pneumonia ball
Bacterium, staphylococcus aureus etc. have obvious inhibiting effect.The preparation that cordate houttuynia is embodied in pharmacopeia at present have cordate houttuynia eye drops and
FUFANG YUXINGCAO PIAN, preparation and application range are extremely limited.
Summary of the invention
The present invention in view of the above technical problems, provides a kind of cordate houttuynia dew and the preparation method and application thereof.Distillate medicinal water, which is meant, to be contained
Aromatic waters made of the medicinal material steam distillation of volatile component.The present invention is directed to cordate houttuynia main active ---
The volatility of decanoy acetaldehyde (decanoyl acetaldehyde), develop and prepare cordate houttuynia dew, while to cordate houttuynia dew Anti-viral Treatment into
Row is investigated.
To achieve the goals above, the invention provides the following technical scheme:
A kind of cordate houttuynia dew provided by the invention, the aqua aromatica for using extraction by steam distillation to obtain for cordate houttuynia.
Wherein, the cordate houttuynia is fresh herb or fresh aerial part or fresh under ground portion, or dry herb or
Dry aerial parts, or dry under ground portion.
Above-mentioned cordate houttuynia dew, every 100mL aqua aromatica add 1-40g corrigent.
The corrigent is one of sucrose, mannose, honey, rock sugar or a variety of.
Above-mentioned cordate houttuynia dew, every 100mL aqua aromatica add 0.1-5g preservative.
The preservative is one of benzoic acid, sodium benzoate, sorbic acid and potassium sorbate calcium propionate or a variety of.
The present invention also provides the preparation methods of above-mentioned cordate houttuynia dew, comprising the following steps:
S1, cordate houttuynia is taken, measures distilled water with 6-16 times, impregnate 0-2h, carries out steam distillation, vapo(u)rizing temperature 85-100
DEG C, time 6-10h collects distillate, and adjusting pH value is to 4.5-8, obtained aqua aromatica；
S2, every 100mL aqua aromatica add 1-40g corrigent, filtration；
S3, every 100mL aqua aromatica add 0.1-5g preservative, filtration；
S4, encapsulating, sterilizing；Or sterilizing, encapsulating；Up to cordate houttuynia dew.
The present invention also provides the applications that above-mentioned cordate houttuynia is exposed at preparation antiviral drugs.
In above-mentioned application, the virus is human respiratory syncytial virus.
Compared with prior art, the invention has the benefit that
Cordate houttuynia dew provided by the invention is obtained by steam distillation containing volatile active-decanoy acetaldehyde
The aromatic waters of (decanoyl acetaldehyde) etc. is colourless to flaxen transparency liquid, by addition corrigent, can cover it
The stink smell that body has, slightly sweet or sweet tea improve the adaptability of user, can directly take orally, and have antiviral curative effect, can be used as
Antiviral drugs preparation, is with a wide range of applications.
Detailed description of the invention
In order to illustrate the technical solutions in the embodiments of the present application or in the prior art more clearly, below will be to institute in embodiment
Attached drawing to be used is needed to be briefly described, it should be apparent that, the accompanying drawings in the following description is only one recorded in the present invention
A little embodiments are also possible to obtain other drawings based on these drawings for those of ordinary skill in the art.
Fig. 1 is the experimental result of embodiment 7 provided by the invention.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, below in conjunction with embodiment to this
Invention is further detailed.Without specified otherwise, raw material of the present invention is commercial product.
The preparation of 1 cordate houttuynia of embodiment dew
Cordate houttuynia 100g is taken, with 16 times of amount distilled water, carries out steam distillation, vapo(u)rizing temperature is 100 DEG C, time 6h,
Distillate about 1600ml, every 100mL addition 40g sucrose and sodium benzoate 5g are collected, is mixed, adds the appropriate citron acid for adjusting pH value to be
4.5, filtration, encapsulating, sterilizing to get.
The preparation of 2 cordate houttuynia of embodiment dew
Cordate houttuynia 100g is taken, with 12 times of amount distilled water, impregnates 0.5h, carries out steam distillation, vapo(u)rizing temperature is 95 DEG C, when
Between be 7h, collect distillate about 1200ml, every 100mL addition 30g mannose and sodium benzoate 4g, mix, add appropriate citric acid
Adjust pH value be 5.5, filtration, encapsulating, sterilizing to get.
The preparation of 3 cordate houttuynia of embodiment dew
Cordate houttuynia 100g is taken, with 10 times of amount distilled water, impregnates 1h, carries out steam distillation, vapo(u)rizing temperature is 90 DEG C, the time
For 8h, distillate about 1000ml, every 100mL addition 20g sucrose and benzoic acid 4g are collected, mixes, adds appropriate citron acid for adjusting pH
Value be 6.5, filtration, encapsulating, sterilizing to get.
The preparation of 4 cordate houttuynia of embodiment dew
Cordate houttuynia 100g is taken, with 8 times of amount distilled water, impregnates 1.5h, carries out steam distillation, vapo(u)rizing temperature is 90 DEG C, when
Between be 9h, collect distillate about 800ml, every 100mL addition 10g honey and rock sugar 10g and sorbic acid 2g, mix, add appropriate small
Soda adjust pH value be 7.0, filtration, encapsulating, sterilizing to get.
The preparation of 5 cordate houttuynia of embodiment dew
Cordate houttuynia 100g is taken, with 7 times of amount distilled water, impregnates 2h, carries out steam distillation, vapo(u)rizing temperature is 85 DEG C, the time
For 10h, distillate about 700ml, every 100mL addition 5g sucrose and sorbic acid 0.05g and potassium sorbate calcium propionate 0.1g are collected, is mixed
Even, adding appropriate sodium bicarbonate to adjust pH value is 7.5, is filtered, sterilizing, encapsulating to get.
The preparation of 6 cordate houttuynia of embodiment dew
Cordate houttuynia 100g is taken, with 6 times of amount distilled water, impregnates 2h, carries out steam distillation, vapo(u)rizing temperature is 85 DEG C, the time
For 10h, distillate about 600ml, every 100mL addition 1g sucrose and sorbic acid 0.05g and benzoic acid 0.05g are collected, mixes, adds suitable
Measure sodium bicarbonate adjust pH value be 8.0, filter, sterilizing, encapsulating to get.
Embodiment 7
Healthy Kunming mouse, 30 ± 2g of weight, 40, half male and half female adaptive feeding 7 days, is randomly divided into 4 groups, point
Not Wei Normal group (group 1), virus control group (group 2), administration group (group 3) and administration group (organizing 4), every group 10.
Wherein, the mouse of virus control group and administration group, after anesthesia, lung lavage gives human respiratory syncytial virus (human
Respiratory Syncytial Virus, is clinically separated from Guangzhou children's hospital, passes in laboratory animal body for 2008
50 generations), guarantee irrigating solution can substantially arrive at each part of the lobe of the lung as far as possible.Administration group is freely given daily drinks cordate houttuynia dew,
The cordate houttuynia dew 5ml/20g weight of the preparation of embodiment 1 is given once daily in group 3, and the cordate houttuynia dew of the preparation of embodiment 6 is given once daily in group 4
5ml/20g weight；Virus control group gives physiological saline daily, freely drinks；Distilled water is given once daily in Normal group, freely
It drinks.
Claim mouse weight variation and record death condition, the antiviral effect of comparative drug daily.The four groups of death rate such as Fig. 1
It is shown.The experimental results showed that the Normal group death rate is 0, the state of mind and diet are normal, and Normal-weight increases；Virus is right
Bad according to group mouse diet, hair is established, weight loss, listless, the death rate 100%；The administration group death rate is 0-
20%, mouse initial stage diet is not good enough, and hair is established, and latter portions mouse restores normal, and weight recovery normally increases.Experiments have shown that
Cordate houttuynia dew of the invention has better Anti-viral Treatment.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Example documented by technical solution modify perhaps equivalent replacement of some of the technical features but these modification or
Replacement, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.It is described above
Only presently preferred embodiments of the present invention is not intended to limit the invention, and all within the spirits and principles of the present invention, that is done appoints
What modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of cordate houttuynia dew, which is characterized in that its aqua aromatica for using extraction by steam distillation to obtain for cordate houttuynia.
2. cordate houttuynia according to claim 1 dew, which is characterized in that cordate houttuynia is fresh herb or fresh aerial part,
Or fresh under ground portion, or dry herb or dry aerial parts, or dry under ground portion.
3. cordate houttuynia dew according to claim 1, which is characterized in that every 100mL aqua aromatica adds 1-40g corrigent.
4. cordate houttuynia dew according to claim 3, which is characterized in that the corrigent is sucrose, mannose, honey, ice
One of sugar is a variety of.
5. cordate houttuynia dew according to claim 1, which is characterized in that every 100mL aqua aromatica adds 0.1-5g preservative.
6. cordate houttuynia dew according to claim 5, which is characterized in that the preservative is benzoic acid, sodium benzoate, sorb
One of acid and potassium sorbate calcium propionate are a variety of.
7. the preparation method of cordate houttuynia dew according to claim 1-6, which comprises the following steps:
S1, cordate houttuynia being taken, measures distilled water with 6-16 times, impregnates 0-2h, carry out steam distillation, vapo(u)rizing temperature is 85-100 DEG C,
Time is 6-10h, collects distillate, adjusting pH value is to 4.5-8, obtained aqua aromatica；
S2, every 100mL aqua aromatica add 1-40g corrigent, filtration；
S3, every 100mL aqua aromatica add 0.1-5g preservative, filtration；
S4, encapsulating, sterilizing；Or sterilizing, encapsulating；Up to cordate houttuynia dew.
8. the application that cordate houttuynia according to claim 1 is exposed at preparation antiviral drugs.
9. application according to claim 8, which is characterized in that the virus is human respiratory syncytial virus.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910743070.9A CN110327397A (en) | 2019-08-13 | 2019-08-13 | A kind of cordate houttuynia dew and the preparation method and application thereof |
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| CN201910743070.9A CN110327397A (en) | 2019-08-13 | 2019-08-13 | A kind of cordate houttuynia dew and the preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480179A (en) * | 2003-07-21 | 2004-03-10 | 洪彰福 | Preparation of houttuynia for treating peptic ulcer as well as acute and chronic gastritis |
| CN1583047A (en) * | 2004-06-11 | 2005-02-23 | 成都厚发科技开发有限公司 | Anti-virus houttuynia cordate medicine and its preparation |
| CN101766725A (en) * | 2010-03-09 | 2010-07-07 | 四川省中医药科学院 | Anti-inflammatory and antiviral medicine |
-
2019
- 2019-08-13 CN CN201910743070.9A patent/CN110327397A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480179A (en) * | 2003-07-21 | 2004-03-10 | 洪彰福 | Preparation of houttuynia for treating peptic ulcer as well as acute and chronic gastritis |
| CN1583047A (en) * | 2004-06-11 | 2005-02-23 | 成都厚发科技开发有限公司 | Anti-virus houttuynia cordate medicine and its preparation |
| CN101766725A (en) * | 2010-03-09 | 2010-07-07 | 四川省中医药科学院 | Anti-inflammatory and antiviral medicine |
Non-Patent Citations (1)
| Title |
|---|
| 余栋华: "鱼腥草注射液治疗小儿合胞病毒性肺炎41例", 《现代中西医结合杂志》 * |
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