CN103933121B - A kind of Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors and preparation method thereof - Google Patents
A kind of Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors and preparation method thereof, its bulk drug includes Scullcap stem and leaf and caulis lonicerae, by quality ratio, Scullcap stem and leaf：Caulis lonicerae=60~100：50~80；Its active ingredient is the water extract of bulk drug.The Chinese medicine composition uses new prescription, and the effect with clearing heat and detoxicating, antibacterial, anti-inflammatory can be applied to the treatment of livestock and poultry affection of exogenous wind-heat.Overcome the defect of antibiotic or chemical antibacterial drug therapy.
Description
Technical field
The invention belongs to livestock and poultry practical technique field, it is related to a kind of Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors and its preparation
Method.
Background technology
External wind heat syndrome, such as infective bronchitis, infectious laryngotracheitis, infective rhinitis, mycoplasma gallisepticum infection
It is the disease for having a strong impact on poultry farming benefit etc. infectious disease.The infectious diseases caused by external factors card of current gal virus, using vaccine prevention as
It is main, but immuning failure normalization：1. virus stain variation is fast, serotype is more, vaccine failure, immuning failure；2. scale, intensive
Change under breeding environment, animal feeding density is high, body is chronically at sub-health state, and immunologic hypofunction causes vaccine immunity
Failure；3. disease is complicated, and multiple infection is simultaneously deposited, vaccine immunity failure.Secondly, the antiviral drugs such as amantadine, Ribavirin
Forbid using in cultivating link.Once diseases caused by external factors card morbidity, the alternative medicine of raiser is seldom, general to be suited the medicine to the illness using diaphoretic medicine
Treatment joint antibiotic prevents scabies secondary infection, it is impossible to effectively kill and to viral diseases source.
The content of the invention
Present invention solves the problem in that a kind of Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors and preparation method thereof is provided, should
Chinese medicine composition uses new prescription, and the effect with clearing heat and detoxicating, antibacterial, anti-inflammatory can be applied to controlling for livestock and poultry affection of exogenous wind-heat
Treat.
The present invention is to be achieved through the following technical solutions：
A kind of Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors, its bulk drug includes Scullcap stem and leaf and caulis lonicerae, with mass ratio
Meter, Scullcap stem and leaf：Caulis lonicerae=60~100：50~80；Its active ingredient is the water extract of bulk drug.
Further, by quality ratio, Scullcap stem and leaf：Caulis lonicerae=60~80：60~80.
The water extract of described bulk drug is to add water to cook bulk drug repeatedly, and collecting decoction simultaneously filters, concentrates and obtain
Medicinal extract.
Active ingredient and auxiliary material are also mixed and made into Chinese medicine preparation, by quality ratio, Scullcap stem and leaf：Chinese medicine preparation=3：0.8
~1.
Scullcap stem and leaf must not be less than 12 milligrams in every gram of Chinese medicine preparation in terms of scutellarin containing scutellarin.
A kind of preparation method for the Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors, including following operation：
1）Using Scullcap stem and leaf and caulis lonicerae as bulk drug, by Scullcap stem and leaf：Caulis lonicerae=60~80：60~80 quality
Than shredding and being sufficiently mixed bulk drug, add water to cook repeatedly, every time 0.5~1.5h, amount of water successively decreases successively, collecting decoction,
Filtration, filtrate is concentrated into the medicinal extract that relative density is 1.10~1.20；
2）After medicinal extract is mixed with auxiliary material, it is dried under reduced pressure or is spray-dried, Chinese medicine preparation is made.
Bulk drug is added water to cook twice, 1 hour every time, added water for the first time as 12 times of bulk drug quality, added for the second time
Water is 10 times of bulk drug quality.
Described Chinese medicine preparation is granule, by quality ratio, bulk drug：Chinese medicine preparation=6：0.8~1.
Described is used for Chinese medicine composition the answering in the medicine for preparing preventing and treating livestock and poultry external wind heat syndrome that livestock and poultry diseases caused by external factors are demonstrate,proved
With.
Described is used for Chinese medicine composition the answering in clearing heat and detoxicating, antibacterial, the medicine of anti-inflammatory is prepared that livestock and poultry diseases caused by external factors are demonstrate,proved
With.
Compared with prior art, the present invention has following beneficial technique effect：
Chinese medicine composition demonstrate,proved provided by the present invention for livestock and poultry diseases caused by external factors and preparation method thereof, is a kind of determined curative effect, makes
With convenient, cheap new herbal medicine, it is by Scullcap stem and leaf and the taste prescription of caulis lonicerae two, extracted, concentration, refined institute
, with clearing heat and detoxicating, the effect of expelling wind to resolve the exterior, for the preventing and treating of poultry affection of exogenous wind-heat disease, its prescription is simple, and effect is clear, also
There is antibacterial, anti-inflammatory.The Chinese medicine composition demonstrate,proved provided by the present invention for livestock and poultry diseases caused by external factors is empty supplemented with antiviral veterinary drug
Lack, enrich clinical application selection, overcome the defect that vaccine prevention, antiviral combination drug treat external wind heat syndrome.
Chinese medicine composition demonstrate,proved provided by the present invention for livestock and poultry diseases caused by external factors and preparation method thereof, original is used as using Scullcap stem and leaf
Expect medicine, it is its wide material sources, cheap, Scullcap stem and leaf as radix scutellariae root auxiliary product, for controlling for livestock and poultry affection of exogenous wind-heat
Treat, it is only necessary to which simple extract can just complete, and expand it and use scope, its simple process is just completed medicinal.This
Invention not only improves livestock and poultry cultivation family, is also beneficial to radix scutellariae plantation medicinal herb grower：In traditional Chinese medicine theory, radix scutellariae is used as medicine with rhizome,
Radix scutellariae aerial part（Scullcap stem and leaf）Do not make medicinal.Medicinal herb grower is typically considered as firewood and used, or chopping and returning.The present invention is provided
Be used for the Chinese medicine composition that livestock and poultry diseases caused by external factors are demonstrate,proved, develop the new medicinal part of antiviral radix scutellariae, also determine Scullcap stem and leaf
The property of medicine, major function and the application in veterinary clinic.
Embodiment
With reference to specific embodiment, the present invention is described in further detail, it is described be explanation of the invention and
It is not to limit.
The present invention provide by Scullcap stem and leaf and the taste prescription of caulis lonicerae two, extracted, concentration, refined gained, with heat-clearing
Removing toxic substances, the effect of expelling wind to resolve the exterior, the preventing and treating for poultry affection of exogenous wind-heat disease；Also determine the property of medicine of Scullcap stem and leaf, major function with
And in the application of veterinary clinic.
Embodiment 1
Bulk drug：Scullcap stem and leaf 3000g, caulis lonicerae 3000g
Preparation method：The taste bulk drug of the above two, adds water to cook secondary, 1 hour every time, 12 times of amounts of first time, second 10
Measure again, collecting decoction, filtration, filtrate is concentrated into the clear cream that relative density is 1.10~1.20；
Clear cream adds appropriate amount of auxiliary materials, is dried under reduced pressure；Or spray drying, 1000g granule is made.
Differentiate：
（1）This product 0.5g, plus 60% ethanol 10ml, ultrasonically treated 10min are taken, is stood, supernatant is used as need testing solution.
Separately take scutellarin reference substance, plus methanol that solution of every 1ml containing 0.5mg is made, be used as reference substance solution.According to thin-layered chromatography
（Annex page 32）Experiment, draws each 2 μ l of above two solution, puts respectively on same polyamide film, with n-butanol-ice vinegar
Acid-water（6：1.5：2.5）For solvent, deploy, take out, dry, put ultraviolet lamp（365nm）Under inspect.In test sample chromatogram,
On position corresponding with reference substance chromatogram, as a result show the fluorescence spot of same color, show containing scutelloside.
（2）This product 1g, plus 60% ethanol 10ml, ultrasonically treated 10min are taken, is filtered, filtrate is evaporated, and residue adds methanol 1mL to make
Dissolving, is used as need testing solution.Separately take chlorogenic acid reference substance, plus methanol that solution of every 1ml containing 1mg is made, it is molten as reference substance
Liquid.According to thin-layered chromatography（Annex page 32）Experiment, draws each 4 μ l of above two solution, puts respectively in same high-efficient silica gel G thin layers
On plate, with ethyl acetate-acetone-formic acid-water（5:1:1:1）For solvent, deploy, take out, dry, put ultraviolet lamp
（365nm）Under inspect.In test sample chromatogram, on position corresponding with reference substance chromatogram, as a result show the fluorescent spot of same color
Point, shows containing chlorogenic acid.
Assay：
Scutellarin shines high effective liquid chromatography for measuring.
Chromatographic condition and system suitability：Using octadecylsilane chemically bonded silica as filler；With methanol-water-phosphorus
Acid（38：62：0.05）For mobile phase, Detection wavelength is 335nm.Number of theoretical plate is calculated by scutellarin peak should be not less than 2000.
The preparation of reference substance solution：Take scutellarin reference substance appropriate, it is accurately weighed, plus 50% methanol is made in every 1ml and contains
50 μ g solution, is produced.
The preparation of need testing solution：Granule 0.2g is taken, it is accurately weighed, put in 25ml measuring bottles, plus appropriate methanol, at ultrasound
Reason 30 minutes, lets cool, plus methanol is to scale, shakes up, filtration, takes subsequent filtrate, produces.
Determination method：It is accurate respectively to draw reference substance solution and each 10 μ l of need testing solution, liquid chromatograph is injected, is determined,
Produce.
As a result show：Granule is per g containing Scullcap stem and leaf with scutellarin（C21H18O12）Meter is no less than 12mg.
Character：
Granule is the particle of brown color；Bitter, the easy moisture absorption.
Dissolubility：
Test sample 0.1g is taken, is put in nessler colorimetric tube, is added water（25±2℃）To 50ml, spin upside down 10 times, test sample should
All dissolvings, stand 30 minutes, do not there is muddy or precipitation generation.
Embodiment 2
Bulk drug：Scullcap stem and leaf 3000g, caulis lonicerae 2500g
Preparation method：The taste bulk drug of the above two, adds water to cook secondary, 1.5 hours every time, 15 times of amounts of first time, second
10 times of amounts, collecting decoction, filtration, filtrate is concentrated into the clear cream that relative density is 1.10~1.20；
Clear cream adds appropriate amount of auxiliary materials, is dried under reduced pressure；Or spray drying, 1000g granule is made.
Embodiment 3
Bulk drug：Scullcap stem and leaf 3000g, caulis lonicerae 1500g
Preparation method：The taste bulk drug of the above two, adds water to cook secondary, 1.2 hours every time, 10 times of amounts of first time, second 8
Measure again, collecting decoction, filtration, filtrate is concentrated into the clear cream that relative density is 1.10~1.20；
Clear cream adds appropriate amount of auxiliary materials, is dried under reduced pressure；Or spray drying, 1000g granule is made.
Embodiment 4
Bulk drug：Scullcap stem and leaf 3000g, caulis lonicerae 2400g
Preparation method：The taste bulk drug of the above two, adds water to cook secondary, 1 hour every time, 12 times of amounts of first time, second 10
Measure again, collecting decoction, filtration, filtrate is concentrated into the clear cream that relative density is 1.10~1.20；
Clear cream adds appropriate amount of auxiliary materials, is dried under reduced pressure；Or spray drying, 1000g granule is made.
Embodiment 5
Bulk drug：Scullcap stem and leaf 3000g, caulis lonicerae 4000g
Preparation method：The taste bulk drug of the above two, adds water to cook secondary, 1 hour every time, 12 times of amounts of first time, second 10
Measure again, collecting decoction, filtration, filtrate is concentrated into the clear cream that relative density is 1.10~1.20；
Clear cream adds appropriate amount of auxiliary materials, is dried under reduced pressure；Or spray drying, 1000g granule is made.
Embodiment 6
Bulk drug：Scullcap stem and leaf 3000g, caulis lonicerae 3500g
Preparation method：The taste bulk drug of the above two, adds water to cook secondary, 1 hour every time, 12 times of amounts of first time, second 10
Measure again, collecting decoction, filtration, filtrate is concentrated into the clear cream that relative density is 1.10~1.20；
Clear cream adds appropriate amount of auxiliary materials, is dried under reduced pressure；Or spray drying, 1000g granule is made.
Pharmacodynamics test research has been carried out to the prepared medicine for being used for poultry diseases caused by external factors card below, has as a result shown that its has
There are antibacterial, antipyretic, anti-inflammatory.
1st, extracorporeal bacteria inhibitor test
The extracorporeal bacteria inhibitor test effect of prepared Chinese medicine preparation is evaluated using Plating.As a result Chinese medicine group of the present invention is shown
Compound（Detected with embodiment 1）To staphylococcus aureus ATCC25923, Escherichia coli ATCC25922, Pseudomonas aeruginosa
ATCC27853 minimum inhibitory concentration MIC be 1.25,6.25,12.5mg/mL.
2nd, refrigeration function
SD male rats are randomly divided into 2 groups, every group 10, administration group gavage medicine 0.1g/kg of the present invention（1mL/100g）,
Control group gavages same dosage physiological saline.After administration 1 hour in dorsal sc injection 2,4- dinitrophenol 1mL/100g
（15mg/kg）, survey body temperature 1 time within every 60 minutes, METHOD FOR CONTINUOUS DETERMINATION 4 hours.Pudilan antiphlogistic granules cause to 2,4-DNP
Rat temperature rise have good refrigeration function, being compared with physiological saline group has significant difference（P<0.05）（It is shown in Table 1）.
Table 1 to rat temperature influence (n=10)
As a result show, attacking blank group after poison, administration group has temperature change, but compared with blank group, administration group is small from 1
When from can preferably control the change of body temperature, keep body temperature to have a certain degree of alleviation, cooling is more especially from after 2 hours
To be obvious, with statistics effect.
3rd, antiinflammatory action
Wister mouse are randomly divided into 2 groups, and every group 10, administration group gavage medicine 0.1g/kg of the present invention, control group is gavaged
Corresponding dosage physiological saline.After successive administration 3 days, each mouse is injected intravenously 0.5% evans blue normal saline solution（0.1ml/
10kg）, 0.6% acetic acid is injected intraperitoneally immediately（0.2ml/ is only）, cervical vertebra is taken off after 20 minutes and is put to death, abdominal cavity is opened, uses 6ml physiology salts
Moisture washs abdominal cavity for several times, collects cleaning solution, adds physiological saline to be centrifuged 15 minutes to 10ml, 3000r/min after merging, takes supernatant
Liquid determines absorbance in 590nm（It the results are shown in Table 2）.
Influence that table 2 increases to HAC induced mices abdominal cavity capillary permeability (n=10)
The result of table 2 shows that it is penetrating that Chinese medicine preparation of the present invention can suppress intraperitoneal injection acetic acid induced mice abdominal cavity capillary
Property increase, display this product there is antiinflammatory action.
4th, clinical verification
Animal packet and processing：The rich Salted chicken of 180 1 ages in days, male is raised to 15 ages in days, is randomly divided into 6 groups, every group 30
Only.Wherein the 1st~3 group is high, medium and low three groups of dosage；4th group is Shuanghuanglian oral liquid control group；5th group is infection control
Group；6th group is blank control group.1st~5 group of every chicken is with 100 × EID50The 3rd generations of IBV chick embryo allantoic liquid collunarium eye droppings is contaminated,
0.2mL/ is only.6th group is blank control group, without any processing（Referring to table 3）.
Attack after poison 48 hours, test chicken is fallen ill successively, spiritual depressed, loss of appetite, loose random occur, generate heat, dehisce
The clinical manifestation of the diseases caused by external factors cards such as breathing, asthma, rale, oral cavity stream mucus, amount of drinking water increase；Usage and dosage as listed by table 1 is given
Medicine.Observation is tracked to the clinical manifestation of animal after drug withdrawal, observing time continues to after drug withdrawal the 7th day.In infection before and see
Test chicken is weighed after examining end.
The experimental animal of table 3 is grouped and handled
Therapeutic effect
The incidence of disease for respectively attacking poison group is 100%.Compared after medicine 3 days by giving various dose with infection control group,
The state of an illness mitigates, and spirit and appetite take a turn for the better, and night observation cough and rale are reduced, wherein optimal with medicine high dose group.Medication
First day after end, the state of mind for observing each medication group test chicken is clearly better, and clinical symptoms substantially mitigate.Night observation is only
There is fragmentary cough, rale has disappeared.Observe within the 6th day after administration, the state of mind of each medication group test chicken is returned to normal,
What different frequency occurred in only fraction of chicken gets rid of a phenomenon.
Table 4 is to the sick therapeutic effect of artificial challenge's infectious bronchitis of chicken
Note：Compared with infection control group, * P ＜ 0.05 are significant difference.“#" represent self-healing.Similarly hereinafter.
To chicken growth and the influence of Immune Organs Index
Every group of test chicken is weighed respectively in the 7th day after administration.The body weight increase rate and Immune Organs Index of each test group
Refer to table 5.The body weight increase rate highest of medicine middle dose group.Medicine low dose group index and spleen index, bursal index and blank pair
There is pole significant difference according to group（P<0.01）；Drug control group bursal index has pole significant difference with blank control group（P<
0.01）.
The body weight increase rate and each Immune Organs Index of each test group chicken of table 5
| Group | It is relative to increase | The bursa of farbricius | Thymus gland refers to | Spleen refers to |
| 1 group（High agent | 90.87 | 5.30±0. | 5.03±1.4 | 1.50±0.5 |
| 2 groups（Middle dose | 96.52 | 4.61±1. | 5.70±1.8 | 1.57±0.4 |
| 3 groups（Low dose | 91.55 | 3.38±1. | 6.05±1.8 | 2.17±0.5 |
| 4 groups（Medicine | 87.34 | 5.70±0. | 6.61±2.2 | 1.73±0.3 |
| 5 groups（Infection | 90.77 | 5.10±0. | 5.57±1.3 | 1.57±0.3 |
| 6 groups（Blank | 100 | 4.80±1. | 5.62±1.5 | 1.47±0.4 |
As a result show, the Chinese medicine composition that the present invention is provided has clearing heat and detoxicating, the effect of expelling wind to resolve the exterior, also have,
Antibacterial, the effect of anti-inflammatory, can be used in the preventing and treating of livestock and poultry external wind heat syndrome.
Described livestock and poultry affection of exogenous wind-heat, card is shown in that body temperature is raised, ear nose warm, and spiritual depressed, conjunctiva flush is shed tears, appetite
Decline, or have cough, expiratory air heat, abscess of throat, thirst with desire to drink, thin lingual fur is yellow, superficial and rapid pulse.Such as infective bronchitis, biography
The infectious diseases such as metachromia laryngotracheitis, infective rhinitis, mycoplasma gallisepticum infection.
Claims (4)
1. a kind of Chinese medicine composition demonstrate,proved for livestock and poultry diseases caused by external factors, it is characterised in that its bulk drug is by Scullcap stem and leaf and caulis lonicerae group
Into, by quality ratio, Scullcap stem and leaf：Caulis lonicerae=1：1；Its active ingredient is the water extract of bulk drug, described bulk drug
Water extract is to add water to cook bulk drug repeatedly, collecting decoction and filter, concentrate obtained from medicinal extract；Also by active ingredient with it is auxiliary
Material is mixed and made into Chinese medicine preparation, by quality ratio, Scullcap stem and leaf：Chinese medicine preparation=3：0.8~1, Scullcap stem and leaf is with scutellarin
In meter, every gram of Chinese medicine preparation 12 milligrams must not be less than containing scutellarin.
2. it is used for the preparation method for the Chinese medicine composition that livestock and poultry diseases caused by external factors are demonstrate,proved described in claim 1, it is characterised in that according to following
It is prepared by step：
1) using Scullcap stem and leaf and caulis lonicerae as bulk drug, by Scullcap stem and leaf：Caulis lonicerae=1：1 mass ratio shreds bulk drug
And be sufficiently mixed, add water to cook twice, 1 hour every time, add water as 12 times of bulk drug quality, added water for the second time as original for the first time
Expect medicine quality 10 times, collecting decoction, filtration, filtrate is concentrated into the medicinal extract that relative density is 1.10~1.20；
2) after medicinal extract is mixed with auxiliary material, it is dried under reduced pressure or is spray-dried, Chinese medicine preparation is made, described Chinese medicine preparation is particle
Agent, by quality ratio, bulk drug：Chinese medicine preparation=6：0.8~1.
3. the Chinese medicine composition for being used for livestock and poultry diseases caused by external factors card described in claim 1 is preparing the medicine of preventing and treating livestock and poultry external wind heat syndrome
In application.
4. described in claim 1 be used for livestock and poultry diseases caused by external factors demonstrate,prove Chinese medicine composition prepare clearing heat and detoxicating, antibacterial, anti-inflammatory medicine
In application.
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Inventor after: Xing Yujuan Inventor after: Yang Yanping Inventor after: Lei Xiaoli Inventor after: Gao Lei Inventor after: Zhang Min Inventor before: Yang Yanping Inventor before: Lei Xiaoli Inventor before: Gao Lei Inventor before: Zhang Min |
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