CN1264563C - Gastropathy treating medicine and its preparation - Google Patents

Gastropathy treating medicine and its preparation Download PDF

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Publication number
CN1264563C
CN1264563C CN 200410022397 CN200410022397A CN1264563C CN 1264563 C CN1264563 C CN 1264563C CN 200410022397 CN200410022397 CN 200410022397 CN 200410022397 A CN200410022397 A CN 200410022397A CN 1264563 C CN1264563 C CN 1264563C
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medicament
medicine
stomach
ulcer
gastrointestinal tract
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CN 200410022397
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Chinese (zh)
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CN1569143A (en
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方明义
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Yunnan Yousheng Pharmaceutical Co ltd
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Individual
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Abstract

The present invention relates to a medicament for treating gastropathy, and a preparation method thereof. The medicament is prepared from the following raw materials, in weight, 40 to 50 of clovershrub, 40 to 50 of Chinese fevervine herb, 20 to 40 of shiny chinquefoil herb, 30 to 50 of wild buckwheat, 1 to 3 of coptis root, 3 to 5 of villous amomum fruit, 2 to 4 of corydalis tuber and 3 to 5 of aucklandia root. Pharmacodynamic experiments and clinical trials show that the medicament has an obvious function for resisting acute ulcer and chronic ulcer in a dose effect relationship, and the medicament also has good functions of analgesia, protection of gastrointestinal tract ulcer, spasmolysis for the intestinal unsmooth muscle and inflammation resistance. The medicament has obvious curative effects for treating gastrointestinal tract diseases, is praised by patients and is an effective medicament with good development perspectives for treating gastrointestinal tract diseases.

Description

A kind of medicine for the treatment of gastropathy
Technical field
The present invention relates to a kind of medicine for the treatment of gastropathy, specifically is the Chinese patent medicine of the preparation of raw material with the Chinese herbal medicine.
Background technology
Gastrointestinal disease is a kind of common and see disease more.The traditional Chinese medical science is thought " stomach receiving food and drink ", if functional activity of QI being not smooth is then easily sent out gastrointestinal dysfunction, easily violates stomach, duodenum digestive tract ulcer.The primary disease sickness rate is higher, and the lighter returns acid, belch, abdominal discomfort, weight person's stomachache, vomiting, and upper gastrointestinal hemorrhage can cause anemia, become thin, and the course of disease reaches several months, several years, even the danger of cancerating is arranged.The Chinese medicine worker has carried out the clinical research and the exploration that hinder greatly around this disease for a long time, facts have proved, this disease of Chinese medicine has the advantage that solves this difficult problem.Therefore, further the national folk medicine of gastric abscess diseases such as research and development adjustment gastrointestinal function, the treatment stagnation of QI and QI rising in reverse order still has huge DEVELOPMENT PROSPECT and value.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that digestive tract ulcer such as acute and chronic stomach, duodenum is had better curative effect.
Medicine of the present invention is the summary of experience according to the national folk medicine that uses for many years; the scientific composition that draws through clinical observation for many years; be that gastric mucosa injury and ulcer are had protective effect, have spasmolytic, antiinflammatory, analgesia simultaneously and the creeping effect medicine of small intestinal.It is the medicine of being made by the following weight proportion raw material:
Radix Campylotropis Hirtella (Herba Myrsines Africanae) 40~50 fevervines 40~50 Herba potentillae fulgentis 20~40 Rhizoma Fagopyri Dibotryiss 30~50
Rhizoma Coptidis 1~3 Fructus Amomi 3~5 Rhizoma Corydalis 2~4 Radix Aucklandiae 3~5.
The preparation method of the medicine of above-described treatment gastropathy is made according to the following steps:
1) get Rhizoma Coptidis, Fructus Amomi, Rhizoma Corydalis, the Radix Aucklandiae four flavors and be ground into the fine powder mixing, it is standby to sterilize;
2) Radix Campylotropis Hirtella (Herba Myrsines Africanae), fevervine, Herba potentillae fulgentis, Rhizoma Fagopyri Dibotryis four flavors are decocted with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter merging filtrate, be evaporated to the thick paste of relative density 1.28~1.35 (50 ℃), drying is ground into fine powder;
3) 1) fine powder of gained and 2) the fine powder mixing of gained is made capsule.
Medicine of the present invention also can be made tablet, powder and other dosage form.
Medicine of the present invention is through pharmacodynamic experiment and clinical trial certificate: have the acute and chronic ulcer function of significant antagonism, and be dose-effect relationship; Also have stronger analgesic activity, gastrointestinal ulceration is had the better protect effect, the not sliding flesh of intestinal tube is had tangible spasmolysis, show stronger town simultaneously and complete antiinflammatory action.
Below further show above-mentioned function and effect with the clinical observation situation.
1, clinical data
1.1 physical data:
1) doctor trained in Western medicine is diagnosed as gastroduodenal ulcer patient 100 examples through gastroscope, intestinal mirror.Wherein tcm diagnosis is syndrome of stagnation of QI person 74 examples, hot and suffocating card 26 examples, maximum 72 years old age, minimal ages 4 years old, 40.8 years old mean age.
2) the doctor trained in Western medicine gastroscope is diagnosed as chronic superficial gastritis patient 100 examples, wherein tcm diagnosis is syndrome of incoordination between liver and stomach 25 examples, weakness of the spleen and stomach 18 examples, deficiency of stomach-Yin is demonstrate,proved 12 examples, syndrome of dampness-heat of spleen and stomach 13 examples, incoordination between the liver and stomach and syndrome of dampness-heat of spleen and stomach 23 examples, incoordination between the liver and stomach and weakness of the spleen and stomach 8 examples, weakness of the spleen and stomach, deficiency of stomach-Yin are demonstrate,proved 1 example, maximum 76 years old age, minimal ages 14 years old, 43.3 years old mean age.
3) doctor trained in Western medicine is diagnosed as chronic non-particularity opposite sex ulcerative colitis 100 examples with the intestinal mirror, wherein tcm diagnosis is diarrhea (damp-heat in the large intestine) 41 examples, insufficiency of the spleen diarrhea 17 examples, deficiency of spleen-YANG and kidneyYANG 14 examples, Liver and kidney two empty 1 examples, irritability is taken advantage of spleen type 13 examples, renal deficiency type 7 examples, spleen-stomach deficiency-cold 3 examples, due to weakness of spleen and stomach 7 examples, maximum 76 years old age, minimal ages 18 years old, 43.1 years old mean age.
1.2 Therapeutic Method
Obey three general every day, obeys 0.6 gram~1.2 grams at every turn, warm water delivery service, and 30 days is a course of treatment.
2, therapeutic effect
2.1 criterion of cure
1) clinical recovery: clinical symptoms all disappears.
2) produce effects: only remaining indivedual symptoms, and symptom is lighter.
3) effective: most of remission.
4) invalid: symptom does not have change or increases the weight of.
2.2 clinical efficacy (seeing Table 1,2,3)
Table 1 treatment stomach, the various comparison of duodenal ulcer
The disease type Total example Clinical recovery Produce effects Effectively Invalid Effectively total
The example number The example number The example number The example number
Vapour stagnates and demonstrate,proves hot and suffocating card 74 26 63 23 85.1 88.4 4 2 5.4 7.6 6 1 8.1 4 1 1.4 98.6 100
The various comparison of table 2 treatment chronic superficial gastritis
The disease type Total example Clinical recovery Produce effects Effectively Invalid Effectively total
The example number The example number The example number The example number
Syndrome of incoordination between liver and stomach weakness of the spleen and stomach deficiency of stomach-Yin card syndrome of dampness-heat of spleen and stomach incoordination between the liver and stomach, the damp-heat in the spleen and stomach incoordination between the liver and stomach, the weakness of the spleen and stomach weakness of the spleen and stomach, deficiency of stomach-Yin 25 18 12 13 23 8 1 21 15 10 10 19 6 84 83.3 83.3 76.9 83 75 2 1 1 2 3 1 1 8 5.6 8.3 15.4 13 12.5 100 2 1 1 1 1 8 .5.6 7.7 4 12.5 1 5.5 100 94.5 100 100 100 100 100
The various comparison of table 3 treatment chronic non-specific ulcerative colitis
The disease type Total example Clinical recovery Produce effects Effectively Invalid Effectively total
The example number The example number The example number The example number
The damp-heat in the large intestine diarrhea is insufficiency of the spleen, and diarrhea deficiency of spleen-YANG and kidneyYANG irritability is taken advantage of the spleen weakness of the spleen and stomach 41 17 14 16 12 33 15 10 12 10 80.5 88.2 71.4 75 83.3 3 1 2 1 1 7.3 5.9 14.3 6.3 8.3 5 2 3 1 12.2 14.3 18.7 8 1 5.9 100 94.1 100 100 100
Annotate: it is standard with the clinical symptom disappearance situation all that above disease curative effect is judged.
3, model case
Case 1: gastroduodenal ulcer
Congratulate * *, the man, 42 years old, suffered from stomach, duodenal ulcer 2 years, distending pain is arranged during gastral cavilty, belch, light red tongue, yellow and thin fur during first visit, thready pulse is heavy, and dialectical is syndrome of stagnation of QI, takes medicine of the present invention continuously 8 days, and clinical condition of illness all disappears.
Case 2: chronic superficial gastritis
Soup * *, the woman, 26 years old, suffered from superficial gastritis 2 years, the time abdominal distention, diarrhoea arranged.Light red tongue, yellow and thin fur, thready pulse during first visit are dialectically taken advantage of spleen for irritability, take medicine of the present invention continuously 9 days, and clinical symptoms all disappears.
Use Drug therapy stomach of the present invention, duodenal ulcer 100 examples, day number of drug administration is the longest 30 days, and is the shortest 7 days, average 16.5 days, clinical recovery rate 85.3%, produce effects 5.8%, effective percentage 5.8%, total effective rate 96.9% is used this medicine treatment chronic superficial gastritis 100 examples, medication is the shortest 8 days, and is the longest 30 days, average 17.2 days, clinical recovery rate 86%, obvious effective rate 10%, effective percentage 2%, inefficiency 2%, total effective rate 98%, use this Drug therapy chronic non-specific ulcerative colitis 100 examples, it is the shortest 6 days to take medicine, the longest 30 days, average 18.2 days, clinical recovery rate 81%, obvious effective rate 7.5%, effective percentage 9.4%, total effective rate 98%, it is evident in efficacy that this medicine is used to treat gastroenteropathy, is subjected to patient's favorable comment deeply, is the gastroenteropathy good medicine with better DEVELOPMENT PROSPECT.
The specific embodiment
Embodiment 1:
Parts by weights takes by weighing following raw material (kilogram):
Radix Campylotropis Hirtella (Herba Myrsines Africanae) 40 fevervines 40 Herba potentillae fulgentis 20 Rhizoma Fagopyri Dibotryiss 30
Rhizoma Coptidis 1 Fructus Amomi 3 Rhizoma Corydalis 2 Radix Aucklandiae 3
Preparation as follows:
1) get Rhizoma Coptidis, Fructus Amomi, Rhizoma Corydalis, the Radix Aucklandiae four flavors and be ground into the fine powder mixing, it is standby to sterilize;
2) Radix Campylotropis Hirtella (Herba Myrsines Africanae), fevervine, Herba potentillae fulgentis, Rhizoma Fagopyri Dibotryis four flavors are decocted with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter merging filtrate, be evaporated to the thick paste of relative density 1.28~1.35 (50 ℃), drying is ground into fine powder;
3) 1) fine powder of gained and 2) the fine powder mixing of gained is made capsule.
Embodiment 2:
Parts by weights takes by weighing following raw material (kilogram):
Radix Campylotropis Hirtella (Herba Myrsines Africanae) 50 fevervines 50 Herba potentillae fulgentis 30 Rhizoma Fagopyri Dibotryiss 40
Rhizoma Coptidis 2 Fructus Amomis 4 Rhizoma Corydalis 3 Radix Aucklandiae 4
Press the method preparation of embodiment 1.

Claims (1)

1, a kind of medicine for the treatment of gastropathy is characterized in that it is the medicine of being made by the following weight proportion raw material:
Radix Campylotropis Hirtella (Herba Myrsines Africanae) 40 fevervines 40 Herba potentillae fulgentis 20 Rhizoma Fagopyri Dibotryiss 30
Rhizoma Coptidis 1 Fructus Amomi 3 Rhizoma Corydalis 2 Radix Aucklandiae 3.
CN 200410022397 2004-04-24 2004-04-24 Gastropathy treating medicine and its preparation Expired - Lifetime CN1264563C (en)

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CN1264563C true CN1264563C (en) 2006-07-19

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104117004A (en) * 2014-08-17 2014-10-29 黑龙江江恒医药科技有限公司 Stomach harmonizing and pain relieving capsule and preparation method thereof
CN106822679A (en) * 2017-03-29 2017-06-13 芜湖市中医医院 It is a kind of to treat compound Chinese medicinal preparation of rheumatic disease and preparation method thereof
CN108066389A (en) * 2018-01-10 2018-05-25 金培林 A kind of medicinal liquor for treating stomach trouble and preparation method and application

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Owner name: XU PEIWANG

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Free format text: CORRECT: ADDRESS; FROM: 650000 407, UNIT 2, NO.49, DONGSI STREET, KUNMING CITY, YUNNAN PROVINCE TO: 510800 ROOM 705, NO.19, XIANLIN LANE, YUEXIU DISTRICT, GUANGZHOU CITY, GUANGDONG PROVINCE

TR01 Transfer of patent right

Effective date of registration: 20100902

Address after: 510800, room 19, No. 705, Lane No. 2, Yuexiu District, Guangdong, Guangzhou

Patentee after: Xu Peiwang

Address before: Yunnan city of Kunming Province East Temple Street 650000 No. 49 2 unit 407

Patentee before: Fang Mingyi

TR01 Transfer of patent right
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Effective date of registration: 20230927

Address after: Room 705, No. 19 Xianlin Lane, Yuexiu District, Guangzhou City, Guangdong Province, 510800

Patentee after: Xu Peiwang

Patentee after: YUNNAN YOUSHENG PHARMACEUTICAL Co.,Ltd.

Address before: Room 705, No. 19 Xianlin Lane, Yuexiu District, Guangzhou City, Guangdong Province, 510800

Patentee before: Xu Peiwang

CI03 Correction of invention patent
CI03 Correction of invention patent

Correction item: Patentee|Address|Patentee

Correct: Xu Peiwang|Room 705, No. 19 Xianlin Lane, Yuexiu District, Guangzhou City, Guangdong Province, 510800

False: Xu Peiwang|Room 705, No. 19 Xianlin Lane, Yuexiu District, Guangzhou City, Guangdong Province, 510800|YUNNAN YOUSHENG PHARMACEUTICAL Co.,Ltd.

Number: 41-02

Volume: 39

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Address after: 653199 Xichong, Liujie Town, Yimen County, Yuxi City, Yunnan Province

Patentee after: YUNNAN YOUSHENG PHARMACEUTICAL Co.,Ltd.

Address before: Room 705, No. 19 Xianlin Lane, Yuexiu District, Guangzhou City, Guangdong Province, 510800

Patentee before: Xu Peiwang

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Granted publication date: 20060719