CN100345575C - Chinese-medicinal preparation for treating gastropathy and its making method - Google Patents
Chinese-medicinal preparation for treating gastropathy and its making method Download PDFInfo
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Abstract
A Chinese medicine for treating gastrosis is prepared from 6 Chinese medicinal materials including hedgehog hydnum, white peony root, cyperus tuber, liquorice, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation for the treatment of gastropathy and preparation method thereof.
Background technology
Peptic ulcer is a global frequently-occurring disease.The sickness rate of peptic ulcer accounts for whole crowd's 10%-20% according to estimates, and men and women's ratio is about 2.6-6.5 than 1.Chronic gastritis is also very common, accounts for the 80%-90% that accepts the gastroscopy patient,, the male increases the merchant more than the women gradually with the age growth sickness rate.In medical chronic gastritis curative effect rather good, effective percentage can reach 40%-73%.Chinese medicine thinks that chronic gastritis belongs to " stomach painful abdominal mass disease " category, and " interior warp " is referred to as " painful abdominal mass " " feeling of fullness " " painful abdominal mass plug " etc. with stomach painful abdominal mass disease.Say as " element asks 5 constant virtues political affairs big opinion ": " turning to discipline fully ... its sick painful abdominal mass ", " discipline of inferior prison ... its disease is stayed full painful abdominal mass plug ".The treatise on Febrile Diseases that Zhang Zhongjing is shown claims then that the stomach painful abdominal mass is sick and is " epigastric oppression ", and this sick principle-method-recipe-medicines has been carried out detailed argumentation, says: " but feeling fullness but no pain person, draw be painful abdominal mass ", " diseases occurring in YIN meridians or ZANG FU-organs and anti-purgation, because of making painful abdominal mass also ".Next position that spells out the painful abdominal mass location is gastral cavilty portion under the heart, and its primary symptom has the sense of blocking up vexed painful abdominal mass plug, the softness of pressing for gastral cavilty portion.Stomach is a reservoir of food and drink, leads and is received, lead to and fall diet water paddy, and be energy and blood of human body the source of vital function spring, the vital organs of the human body all are bullied in stomach, so stomach is bases of the vital organs of the human body.Gastropathy then influences human body to be received, digestion diet water paddy, and QI and bloodization is given birth to not enough and is become living all diseases.Symptom difference to some extent between the atrophic gastritis individuality, not outer fullness and oppression in the stomach distending pain, indigestion and loss of appetite lack of appetite, heating installation noisy, weak digestive system and General Symptoms such as tired.
Treat chronic gastritis at present, the medicine of gastric and duodenal ulcers is various.Doctor trained in Western medicine at present because the cause of disease of primary disease and essence thereof are not still had thoroughly clear, does not particularly have efficacy assessment standard really up to the mark, so there not be the generally acknowledged specific short that can effect a radical cure.The treatment measure of Western medicine mainly contains antacid, gastric mucosa protectant, suppresses the medicine of helicobacter pylori etc., and these medicines all can not effectively be eradicated disease, can only relief of symptoms.
Summary of the invention
Purpose of the present invention overcomes the deficiencies in the prior art exactly, and a kind of active ingredient height is provided, and the Chinese medicine preparation of treatment gastropathy evident in efficacy makes it to be fit to clinical practice.
An object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of gastropathy.
Another object of the present invention provides the preparation method of the Chinese medicine preparation of described treatment gastropathy.
The objective of the invention is to be achieved through the following technical solutions:
A kind of Chinese medicine preparation for the treatment of gastropathy is by comprising that following parts by weight of traditional Chinese medicines feedstock production forms;
Hericium erinaceus culture extractum 90-120 Endoconcha Sepiae 70-90
Rhizoma Corydalis 30-45 Radix Paeoniae Alba 35-50
Rhizoma Cyperi 30-50 Radix Glycyrrhizae 30-50
Preferably, a kind of Chinese medicine preparation for the treatment of gastropathy, by comprising that following parts by weight of traditional Chinese medicines feedstock production forms:
Hericium erinaceus culture extractum 100 Endoconcha Sepiaes 80
Rhizoma Corydalis 40 Radix Paeoniae Albas 40
Rhizoma Cyperi 40 Radix Glycyrrhizaes 40
A kind of preparation method for the treatment of the Chinese medicine preparation of gastropathy of the present invention, it may further comprise the steps;
One, the preparation of Hericium erinaceus culture extractum
1, take by weighing wheat bran 20 weight portions respectively, bran coat 1 weight portion, corn 4 weight portions, Gypsum Fibrosum 0.25 weight portion adds water 25 weight portions and is mixed and made into culture medium after the mixing.
2, culture medium is sub-packed in the container.Send into 115 ℃-125 ℃ sterilizations of disinfection cabinet flowing steam 90-160 minute.
3, the Hericium erinaceus (Bull. Ex Fr.) Pers. strain is linked into the culture medium of having sterilized, puts culturing room at relative humidity 45%-65%, 22 ℃-28 ℃ of temperature were cultivated 40-50 days.
4, cultured Hericium erinaceus (Bull. Ex Fr.) Pers. is drawn out from container, vacuum drying, oven dry promptly get Hericium erinaceus culture.
5, get Hericium erinaceus culture, will be wherein 15-25% to be ground into fine powder A standby, get remainder again and place the hot reflux extraction pot, add 8-12 times of water gaging, extracted 2-6 hour, collect medicinal liquid, being concentrated into relative density is 0.8-1.1 (70 ℃), pumps in the scraper plate concentration tank again, and being concentrated into relative density is the clear paste of 1.2-1.3 (70 ℃), add Hericium erinaceus culture fine powder A, mixing is drying to obtain Hericium erinaceus culture extractum;
Two, Endoconcha Sepiae, the Radix Paeoniae Alba, Rhizoma Corydalis, Rhizoma Cyperi, the Radix Glycyrrhizae of formula ratio are concocted into the prepared slices of Chinese crude drugs respectively by 2005 editions requirements of Chinese Pharmacopoeia, after formula ratio Hericium erinaceus culture extractum mixes, pulverize the 60-120 mesh sieve, made the Chinese medicine preparation that the present invention treats gastropathy.
The present invention treats the Chinese medicine preparation of gastropathy, and it is made into various dosage forms, comprises capsule, powder, tablet, granule, chewable tablet, oral liquid etc.
The Chinese medicine preparation of treatment gastropathy of the present invention, dosage form: capsule, usage: oral, every day three times, each 4-6 grain, 30 days is a course of treatment.
The Chinese medicine preparation of treatment gastropathy of the present invention, it is made by Six-element medicines such as Hericium erinaceus culture, Endoconcha Sepiae, the Radix Paeoniae Alba, Rhizoma Corydalis, Rhizoma Cyperi, Radix Glycyrrhizaes, the strain (this strain is for existing) that wild hedgehog hydnum domestication in the fungus hedgehog hydnum fungus strain virgin forest that adopts in the side forms, it is except that containing the polysaccharide polypeptide, also contain five kinds of cancer-resisting substances, it and depressed liver-energy dispersing and QI regulating such as 18 seed amino acids, multivitamin, organic acid, alkaloid, trace element, antacid convergence, the new way for the treatment of gastropathy has been opened up in drug matchings such as the Rhizoma Corydalis of anti-inflammatory analgetic, the Radix Paeoniae Alba, Endoconcha Sepiae.This product has dispersing the stagnated liver-QI for regulating the stomach, and the effect of regulating QI to relieve pain is used for incoordination between the liver and stomach, gastral cavilty distending pain over the hypochondrium, vomiting acid regurgitation; Chronic gastritis, gastric and duodenal ulcers are seen above-mentioned sign person.Can be effectively press down and kill stomach Helicobacter pylori, eliminate the gastrointestinal symptoms of drinking and causing, take for a long time that canceration has preventive effect to digestive tract, can relief of symptoms to early metaphase gastric cancer, have no side effect.
Hericium erinaceus culture is a monarch drug in the side, has the soothing liver-QI stomach function regulating, the effect of regulating QI to relieve pain; Rhizoma Cyperi is a ministerial drug, has promoting QI circulation for relieving depression analgesic effect; Rhizoma Corydalis, the Radix Paeoniae Alba, Endoconcha Sepiae are adjuvant drug altogether, and wherein Endoconcha Sepiae has astringing to arrest bleeding, holds back the effect of skin ulcer; The Radix Paeoniae Alba has the analgesic of nourishing blood effect; Rhizoma Corydalis have invigorate blood circulation, promoting the circulation of QI, analgesic effect; Radix Glycyrrhizae is a messenger drug, has the effect of spleen reinforcing stomach function regulating, Yiqi and vein recovery, has coordinating the actions of various ingredients in a prescription concurrently.Six the medicine compatibilities in full side use, and reach treating both the principal and secondary aspects of a disease, soothing liver-QI stomach function regulating, the effect of regulating QI to relieve pain.
The specific embodiment
Following examples are in order further to describe the present invention for example, rather than limit the present invention by any way.
Embodiment 1
Hericium erinaceus culture extractum 100kg Endoconcha Sepiae 80kg
Rhizoma Corydalis 40kg Radix Paeoniae Alba 40kg
Rhizoma Cyperi 40kg Radix Glycyrrhizae 40kg
Its preparation method is as follows:
One, the preparation of Hericium erinaceus culture extractum
1, take by weighing wheat bran 480kg respectively, bran coat 24kg, corn 96kg, Gypsum Fibrosum 6kg adds water 480kg and is mixed and made into culture medium after the mixing.
2, culture medium is sub-packed in the bottle, and every bottle of 1kg sends into 115 ℃-125 ℃ sterilizations of disinfection cabinet flowing steam 100 minutes.
3, Hericium erinaceus (Bull. Ex Fr.) Pers. strain (by every bottle of 10g) is linked into the culture medium of having sterilized, puts culturing room, temperature 25-27 ℃, cultivated 45 days at relative humidity 55%-65%.
4, cultured Hericium erinaceus (Bull. Ex Fr.) Pers. is drawn out from bottle, vacuum drying, oven dry promptly get Hericium erinaceus culture 300kg.
5, get Hericium erinaceus culture, it is standby that first wherein 50kg is ground into fine powder A, get residue 250kg again and place the hot reflux extraction pot, add 10 times of water gagings, extracted 3 hours, collect medicinal liquid, being concentrated into relative density is 1.04 (70 ℃), pumps in the scraper plate concentration tank again, and being concentrated into relative density is the clear paste 100kg of 1.3 (70 ℃), add Hericium erinaceus culture fine powder A, mixing is drying to obtain Hericium erinaceus culture extractum 100kg;
Two, Endoconcha Sepiae, the Radix Paeoniae Alba, Rhizoma Corydalis, Rhizoma Cyperi, the Radix Glycyrrhizae of formula ratio are concocted into the prepared slices of Chinese crude drugs respectively by 2005 editions requirements of Chinese Pharmacopoeia, after formula ratio Hericium erinaceus culture extractum mixes, pulverized 80 mesh sieves, promptly get the former powder of medicine, again according to 2005 editions two-shift system agent capsules of Chinese Pharmacopoeia agent standard, do not add adjuvant, make capsule.
Embodiment 2
Hericium erinaceus culture 110kg Endoconcha Sepiae 88kg
Rhizoma Corydalis 45kg Radix Paeoniae Alba 40kg
Rhizoma Cyperi 38kg Radix Glycyrrhizae 45kg
Its preparation method is as follows:
One, the preparation of Hericium erinaceus culture extractum
1, take by weighing wheat bran 480kg respectively, bran coat 24kg, corn 96kg, Gypsum Fibrosum 6kg adds water 400kg and is mixed and made into culture medium after the mixing.
2, culture medium is sub-packed in the bottle, and every bottle of 1kg sends into 115 ℃-125 ℃ sterilizations of disinfection cabinet flowing steam 150 minutes.
3, Hericium erinaceus (Bull. Ex Fr.) Pers. strain (by every bottle of 5g) is linked into the culture medium of having sterilized, puts culturing room, temperature 25-27 ℃, cultivated 45 days at relative humidity 55%-65%.
4, cultured Hericium erinaceus (Bull. Ex Fr.) Pers. is drawn out from bottle, vacuum drying, oven dry promptly get Hericium erinaceus culture 350kg.
5, get Hericium erinaceus culture, it is standby that first wherein 55kg is ground into fine powder A, gets residue 295kg again and place the hot reflux extraction pot, adds 12 times of water gagings, extracted 4 hours, collect medicinal liquid, being concentrated into relative density is 1.04 (70 ℃), pumps in the scraper plate concentration tank again, being concentrated into relative density is 1.3 (70 ℃), get clear paste 105kg, add Hericium erinaceus culture fine powder A, mixing is drying to obtain Hericium erinaceus culture extractum 110kg;
Two, Endoconcha Sepiae, the Radix Paeoniae Alba, Rhizoma Corydalis, Rhizoma Cyperi, the Radix Glycyrrhizae of formula ratio are concocted into the prepared slices of Chinese crude drugs respectively by 2005 editions requirements of Chinese Pharmacopoeia, after formula ratio Hericium erinaceus culture extractum mixes, pulverized 80 mesh sieves, promptly get the former powder of medicine, again according to 2005 editions two-shift system agent of Chinese Pharmacopoeia tablet standard, make tablet.
It below is the clinical effectiveness test of the embodiment of the invention 1;
53 routine chronic gastritis patients are organized as treatment, the different symptoms of digestive tract of degree such as most of case has stomachache, abdominal distention, heartburn, acid regurgitation, feels sick, vomiting, inappetence, meet the chronic gastritis diagnosis through gastroscopy and pathological biopsy, do matched group with diagnosis with inpatient 21 examples same period of chronic gastritis in addition.
The treatment group is taken the capsule of the embodiment of the invention 1, and every day three times, each six, ante cibum, half an hour, boiled water took.The a small amount of Chinese medicine of clothes short-term becomes the pill except that between individual patient, withdraws any Pharmaceuticals during the general treatment.Matched group is given Hericium Evimaccus slice (commercially available), and every day three times, each four add Chinese medicine placebo Pericarpium Citri Reticulatae Massa Medicata Fermentata water or Chinese medicine (pressing the dialectical prescription of Chinese medicine), and every day, potion divided the secondary clothes.Treatment group and matched group were a course of treatment with 30 days, and the individual patients symptom does not subtract and can carry out for second course of treatment.During the treatment of all cases by being responsible for doctor's routine observation and writing down change of illness state, finish the course of treatment to carry out in back 5 days the gastroscope check and (or) get disease inspection tissue at former position roughly, specimen is sent Pathology Deparment's inspection.Treatment group 15-62 days, average 34 days, matched group 20-120 days, average 46 days.
Therapeutic outcome is:
1, clinical efficacy: criterion of therapeutical effect is produce effects, improvement, invalid three.(1) produce effects, clinical symptoms and sign disappear substantially or significantly alleviate, and it is normal that food recovers.(2) take a turn for the better: clinical symptoms and sign major part disappear or alleviate, and diet obviously increases.(3) invalid: clinical symptoms or the sign treatment any improvement in back, even increase the weight of.
According to above standard determination, treatment group: produce effects 33 examples (62.3%), 18 examples that take a turn for the better (34%), invalid 2 examples (3.7%), total effective rate (96.3%); Matched group: produce effects 8 examples (38.1%), 9 examples that take a turn for the better (42.9%), invalid 4 examples (19%), total effective rate (81%).There were significant differences (P＜0.05) in processing by statistics.
2, gastroscope picture and gastric mucosa biopsy change: after finishing the course of treatment, treatment is organized 53 examples and has all been done the check of the sick inspection of gastroscope tissue slice.Matched group 21 examples have all been done the gastroscope check, and its 11 example has been done sick inspection check simultaneously, its criterion of therapeutical effect branch produce effects, improvement, no change, increase the weight of level Four.(1) produce effects: the gastroscope picture has clear improvement before the treatment, and the most index of biopsy gastric mucosa is improvement person in various degree.(2) take a turn for the better: the gastroscope picture has improvement in various degree, the biopsy gastric mucosa part index number person of taking a favorable turn before the treatment.(3) invalid: gastroscope picture and the every index of sick inspection be the preceding no any progressive person of treatment.(4) increase the weight of: increasing the weight of tendency person appears in gastroscope picture and biopsy gastric mucosa.Review result, treatment group produce effects 25 examples (47.2%), invalid 14 examples (20.7%) increase the weight of 1 example (1.9%).Matched group produce effects 6 examples (28.6%), invalid 5 examples of 4 examples that take a turn for the better (19.1%) (23.8%) increase the weight of 6 examples (28.5%).There were significant differences (P0.01) to learn processing by statistics.
3, the improvement that mainly digests symptom sees the following form:
The Chinese medicine preparation treatment chronic gastritis 53 routine observation of curative effect of table 3.1 embodiment of the invention 1;
| The treatment group | The example number | Produce effects | (％) | Take a turn for the better | (％) | Invalid | (％) |
| Gastric abscess | 50 | 34 | (68) | 14 | (28) | 2 | (4) |
| The abdominal distension heartburn sour regurgitation belch n and V stool of losing the appetite is uncomfortable | 37 39 24 23 24 25 14 21 | 19 30 18 17 18 19 9 13 | (51.4) (76.9) (75) (73.9) (75) (76) (64.3) (61.9) | 18 7 5 6 6 3 3 6 | (48.6) (18) (20.8) (26.1) (26.1) (12) (21.4) (28.6) | 0 2 1 0 0 3 2 2 | (5.1) (4.2) (12) (14.3) (9.5) |
Table 3.2 Hericium Evimaccus slice (commercially available) treatment chronic gastritis 21 routine observation of curative effect
| Matched group | The example number | Produce effects | (％) | Take a turn for the better | (％) | Invalid | (％) |
| The epigastric pain abdominal distension heartburn sour regurgitation belch n and V stool of losing the appetite is uncomfortable | 21 12 12 5 6 9 6 5 14 | 4 3 4 2 2 2 2 2 4 | (19.1) (25) (33.3) (40) (33.3) (22.2) (16.7) (40) (28.6) | 10 5 6 3 4 5 3 3 3 | (47.6) (41.7) (50) (60) (66.7) (55.6) (50) (60) (21.4) | 7 4 2 0 0 2 1 0 7 | (33.3) (33.3) (16.7) (22.2) (33.3) (50) |
Show according to The above results, the Chinese medicine preparation of the embodiment of the invention 1 has tangible invigorating the spleen and regulating the stomach, relieving spasm to stop pain, eliminate distension, effects such as appetite strengthening are according to our clinical experience, the gastric abscess patient of different pattern of syndrome all there is in various degree curative effect, belong to weakness of the spleen and stomach for disease, incoordination between the liver and stomach person, curative effect is particularly satisfied.
Claims (1)
1. a preparation method for the treatment of the Chinese medicine preparation of gastropathy may further comprise the steps;
One, the preparation of Hericium erinaceus culture extractum
1, take by weighing wheat bran 20 weight portions respectively, bran coat 1 weight portion, corn 4 weight portions, Gypsum Fibrosum 0.25 weight portion adds water 25 weight portions and is mixed and made into culture medium after the mixing;
2, culture medium is sub-packed in the container, sends into 115 ℃-125 ℃ sterilizations of disinfection cabinet flowing steam 90-160 minute;
3, the Hericium erinaceus (Bull. Ex Fr.) Pers. strain is linked into the culture medium of having sterilized, puts culturing room at relative humidity 45%-65%, 22 ℃-28 ℃ of temperature were cultivated 40-50 days;
4, cultured Hericium erinaceus (Bull. Ex Fr.) Pers. is drawn out from container, vacuum drying, oven dry promptly get Hericium erinaceus culture;
5, get Hericium erinaceus culture, will be wherein 15-25% to be ground into fine powder A standby, get remainder again and place the hot reflux extraction pot, add 8-12 times of water gaging, extracted 2-6 hour, collect medicinal liquid, the relative density that is concentrated into when measuring 70 ℃ of temperature is 0.8-1.1, pumps in the scraper plate concentration tank again, and the relative density that is concentrated into when measuring 70 ℃ of temperature is the clear paste of 1.2-1.3, add Hericium erinaceus culture fine powder A again, mixing is drying to obtain Hericium erinaceus culture extractum;
Two, get Endoconcha Sepiae 80 weight portions, the Radix Paeoniae Alba 40 weight portions, Rhizoma Corydalis 40 weight portions, Rhizoma Cyperi 40 weight portions, Radix Glycyrrhizae 40 weight portions and concoct into the prepared slices of Chinese crude drugs respectively by 2005 editions requirements of Chinese Pharmacopoeia, again with after the Hericium erinaceus culture extractum of 100 weight portions mixes, pulverize the 60-120 mesh sieve, made the Chinese medicine preparation of treatment gastropathy.
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| CN1736454A (en) * | 2004-08-19 | 2006-02-22 | 湖南新汇制药有限公司 | Process for preparing concentration type stomach-invigorating medicine of hericium erinaceus |
| CN1895495A (en) * | 2006-06-29 | 2007-01-17 | 王建辉 | Hericiaceae contained Jianweiling capsules for stomach disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1736454A (en) * | 2004-08-19 | 2006-02-22 | 湖南新汇制药有限公司 | Process for preparing concentration type stomach-invigorating medicine of hericium erinaceus |
| CN1895495A (en) * | 2006-06-29 | 2007-01-17 | 王建辉 | Hericiaceae contained Jianweiling capsules for stomach disease |
Non-Patent Citations (2)
| Title |
|---|
| 不同培养料栽培猴头实验 浦训等，甘肃科学学报，第9卷第3期 1997 * |
| 中华人民共和国药典 药典委员会，609.610，化学工业出版社 2000 * |
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