CN101590189B - Traditional Chinese medicine composition containing radix aconiti carmichaeli for treating myasthenia gravis and preparation thereof - Google Patents
Traditional Chinese medicine composition containing radix aconiti carmichaeli for treating myasthenia gravis and preparation thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition containing radix aconiti carmichaeli for treating myasthenia gravis and a preparation thereof. The traditional Chinese medicine composition contains traditional Chinese medicines such as fructus evodiae, the radix aconiti carmichaeli, and the like, carries out syndrome differentiation treatment, lowers the adverse flow of qi, stops vomit, nourishes fire and helps yang aiming at the liver yang deficiency of the myasthenia gravis. Shown by clinical researches, the traditional Chinese medicine composition can effectively treat the myasthenia gravis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation thereof that contains the treatment myasthenia gravis of Radix Aconiti Lateralis Preparata, belong to the Chinese herbal and crude drugs preparations technical field.
Background technology
Myasthenia gravis is mainly to add up second phthalein cholinoceptor on the neuromuscular junction place postsynaptic membrane, mainly by acetylcholine receptor antibodies mediation, cellular immunization relies on, complement is participated in autoimmune disease.Its clinical manifestation mainly is the fatigability and the myasthenia of skeletal muscle.Outstanding clinical manifestation is the activity postemphasis, alleviates behind the rest, and be that morning, gently dusk, skeletal muscle heavily was unable to ordinary person.
Myasthenia gravis, tcm clinical practice belong to " myopathy " category more and carry out diagnosis and treatment.At present from traditional Chinese medical science angle to the amyasthenic discussion of serious symptom, present the general layout of " three minutes all over the world ", promptly control, control, control from the eight extra-channel opinion from the liver opinion from Treatise on the spleen and stomach.
Control myasthenia gravis from liver opinion: the symptom feature of (1) myasthenia gravis conform to the characteristics of " hepatopathy " the TCM Document " during Suo Wenzang gas method opinion piece " say: " the liver patient, dawn is intelligent, following dried meat very, midnight is quiet." and myasthenia gravis, light dusk in morning is heavy " characteristics be consistent.(2) crisis that lapses to myasthenia gravis of the prognosis of " hepatopathy " is harmonious, and the myasthenia gravis crisis is meant that the state of an illness of myasthenia gravis patient own increases the weight of or malpractice causes the severe dyspnea state of respiratory muscle due to unable.Crisis is in case take place, and dyspnea and even depletion are patient's causes of death, and the traditional Chinese medical science is thought lung governing qi, and department breathes; So " the severe dyspnea state " that occur during crisis is the performance of traditional Chinese medical science lung, this must pass earlier and walk to its restraining with " rope ask beautiful machine really hide an opinion piece of writing) " contained disease and dead; Sick and dead, this says driving in the wrong direction also of gas, so dead ... Irritability receives in the heart; Biography in spleen, Qishe is in kidney, to lung and dead." be harmonious, this meet the traditional Chinese medical science " must lie prostrate its lead, and earlier its because of " principle.(3) myasthenia gravis patient's depression and anxiety symptom can be controlled from the liver opinion.The traditional Chinese medical science is thought liver being bold and firm viscera, and the happiness bar reaches and dislikes depression, and stagnation of liver-QI can fire-transformation, so depressed and anxiety neurosis can be from liver by controlling.(4) control myasthenia gravis from the liver opinion a few days ago obtained certain curative effect
The clinical treatment thinking of myasthenia gravis: the pathogenesis that links closely, dialectical executing controlled, and liver is general's official; Body is cloudy and with positive; The main liter, initiatively, " imbalance of the yang blood and qi of liver ... liver-yin, liver blood are often not enough ... the imbalance of irritability, liver-yang; with the high Sheng of irritability, liver-yang for seeing more, and the rarely deficiency of vital energy and the yang deficiency of liver ".So clinically thinks that hepatopathy is how real, should dredge, should let out, should profit.So deficiency of the liver card has and belongs to anemia and body does not fill, the weakness of QI of belonging to is also arranged and strong with not, should comprise negative and positive of qi and blood, promptly deficiency of liver-blood, deficiency of liver-QI, deficiency of liver-YIN, dificiency of liver-YANG are four kinds.So normal irritability and liver-yang are liver to be risen send out and transfer smooth a kind of ability, be called usefulness ... or it is warm etc. to show as slack, melancholy, timid, the numbness of having a headache, extremity, is the disease of deficiency of liver-QI and dificiency of liver-YANG.So clinical should serve as main the treatment with tonifying liver gas, warming the liver sun.
The clinical manifestation of dificiency of liver-YANG type myasthenia gravis: 1. the pale tongue or the stasis of blood are dark, and tongue is white, and arteries and veins sinks thin and string more; 2. general weakness, easy fatigue, fear of cold happiness heat, skin is owed temperature, top, mountain peak cold type of pain, blurring of vision, or being unable to see for a long time, dim and greenish complexion or local skin are pale; 3. numb limbs and tense tendons, muscle arteries and veins contraction is anxious, and joint motion is ineffective or unable, lustrelessness of the nails or purple dark; Be anxious and uneasy without joy emaciated physique, spirit decay, timid few scheme; 4. fullness in the chest and hypochondrium is vexed, abdominal distension and anorexia, and the enlargement of liver body, the then pain of touching, belch is heaved a deep sigh, ten vomiting saliva, diarrhea with loose stool; 5. cramp and pain in the lower abdomen or YIN-cold colic, the cold Jinsuo of impotence in male or capsule; The woman is leaked down or menoxenia, and is dark and damp; Old man's body jolts, brothers' vibration.
At present the amyasthenic Therapeutic Method of serious symptom is mainly comprised: (1) Drug therapy: mainly contain hormones, immunosuppressant class and immunoglobulin etc.; (2) plasmapheresis: be one of effective, safe Therapeutic Method commonly used in the autoimmune disease; (3) operative treatment etc.(Yu Fengchun; Yu Huafeng. the Therapy for Myasthemia Gravis present situation. Chinese prescription drugs .2004 02 month) in recent years; Chinese medicine is being obtained certain achievement aspect the treatment myasthenia gravis, and drug main of the present invention will be made up of Fructus Evodiae, Radix Aconiti Lateralis Preparata etc., stopping nausea and vomiting by lowering the adverse flow of QI; It is supporing yang to mend fire, has significant curative effect for treatment dificiency of liver-YANG type myasthenia gravis.
Summary of the invention
The invention provides a kind of Chinese medicine composition and preparation thereof that contains the treatment myasthenia gravis of Radix Aconiti Lateralis Preparata.
Chinese medicine composition of the present invention is selected Fructus Evodiae, Radix Aconiti Lateralis Preparata stopping nausea and vomiting by lowering the adverse flow of QI for use, and it is supporing yang to mend fire; Radix Astragali benefiting QI for strengthening the superficies; Fructus Lycii, Herba Taxilli, Radix Dipsaci invigorating the liver and kidney, bone and muscle strengthening; The Fructus Hordei Germinatus promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite.
The present invention provides a kind of Chinese medicine composition that contains the treatment myasthenia gravis of Radix Aconiti Lateralis Preparata, it is characterized in that being being processed by the crude drug of following weight portion ratio:
Fructus Evodiae 2-7 Radix Aconiti Lateralis Preparata 5-20 Radix Astragali 6-28 Fructus Lycii 5-15
Herba Taxilli 10-20 Radix Dipsaci 11-22 Fructus Hordei Germinatus 7-15
Preferably, Chinese medicine composition of the present invention is to be processed by the crude drug of following weight portion ratio:
Fructus Evodiae 2 Radix Aconiti Lateralis Preparatas 20 Radixs Astragali 6 Fructus Lycii 15
Herba Taxilli 10 Radix Dipsacis 22 Fructus Hordei Germinatus 7
Or
Fructus Evodiae 7 Radix Aconiti Lateralis Preparatas 5 Radixs Astragali 28 Fructus Lycii 5
Herba Taxilli 20 Radix Dipsacis 11 Fructus Hordei Germinatus 15
Or
Fructus Evodiae 2 Radix Aconiti Lateralis Preparatas 12 Radixs Astragali 17 Fructus Lycii 10
Herba Taxilli 15 Radix Dipsacis 17 Fructus Hordei Germinatus 15
Or
Fructus Evodiae 3 Radix Aconiti Lateralis Preparatas 7 Radixs Astragali 8 Fructus Lycii 7
Herba Taxilli 19 Radix Dipsacis 21 Fructus Hordei Germinatus 14
Or
Fructus Evodiae 6.5 Radix Aconiti Lateralis Preparatas 18 Radixs Astragali 27 Fructus Lycii 13.5
Herba Taxilli 11 Radix Dipsacis 12 Fructus Hordei Germinatus 8.5
The preparation formulation of Chinese medicine composition of the present invention is decoction, powder, capsule, tablet, pill or oral liquid.
The dosage form of Chinese medicine composition of the present invention adopts conventional method for preparing preparation, and for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record processes the acceptable regular dosage form of pharmaceutics.
In the application of the present invention; Said Chinese medicine composition is a kind of in decoction, powder, capsule, tablet, pill, the oral liquid formulations; For above-mentioned dosage form can be realized; Need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Preferably, the myasthenia gravis of traditional Chinese medicine composition for treating of the present invention is a dificiency of liver-YANG type myasthenia gravis.We are because of stopping nausea and vomiting by lowering the adverse flow of QI, and it is supporing yang to mend fire, so treatment dificiency of liver-YANG type myasthenia gravis has better effect.
Different according to pattern of syndrome clinically, can also add any one or any several kinds of Chinese medicines in Folium Eriobotryae, Radix Platycodonis, Semen Armeniacae Amarum, Rhizoma Cyperi and the Fructus Citri Sarcodactylis, also belong to the present invention's design.
Be confirmation clinical drug curative effect of the present invention, the decoction that use prepares according to embodiment 1 described method (to call in the following text: medicine of the present invention) carried out following clinical observation:
One, clinical diagnosis standard
1, Western medicine diagnose standard:
1. be diagnosed as myasthenia gravis according to medical history, sign, fatigue test, neostigmine test and electromyogram inspection: the patient all has typical myasthenia gravis performance, and the neostigmine test is all positive; The muscle fatigue test is positive; SFEMG is supported myasthenia gravis.
2. do not use any rabbit epidemic disease inhibitor and cholinesterase inhibitor before treating.
3. CT, MRI or X ray examination are not found thymus abnormalities.
4. thyroid function is checked no abnormality seen.
5. no myasthenic crisis and amyotrophy before treating.
2, traditional Chinese medical science disease diagnostic criteria
The dificiency of liver-YANG type
1. the pale tongue or the stasis of blood are dark, and tongue is white, and arteries and veins sinks thin and string more.
2. general weakness, easy fatigue, fear of cold happiness heat, skin is owed temperature, top, mountain peak cold type of pain, blurring of vision, or being unable to see for a long time, dim and greenish complexion or local skin are pale;
3. numb limbs and tense tendons, muscle arteries and veins contraction is anxious, and joint motion is ineffective or unable, lustrelessness of the nails or purple dark; Be anxious and uneasy without joy emaciated physique, spirit decay, timid few scheme;
4. fullness in the chest and hypochondrium is vexed, abdominal distension and anorexia, and the enlargement of liver body, the then pain of touching, belch is heaved a deep sigh, ten vomiting saliva, diarrhea with loose stool;
5. cramp and pain in the lower abdomen or YIN-cold colic, the cold Jinsuo of impotence in male or capsule; The woman is leaked down or menoxenia, and is dark and damp; Old man's body jolts, brothers' vibration.
Two, data and method
1, physical data:
This research is carried out with mountain range hospital in that Hebei Medical University is attached, and all cases meet above-mentioned Western medicine diagnose standard.The patient is totally 131 examples, is divided into 2 groups at random, and matched group is totally 62 examples, male 28 examples, women 34 examples, age 19-55 year.Wherein 40 examples meet the diagnostic criteria of dificiency of liver-YANG type, are the S1 group; Drug group of the present invention is totally 69 examples, male 31 examples, women 38 examples, age 17-57 year.Wherein 43 examples meet the diagnostic criteria of deficiency of liver-QI type, are the S2 group.Treat preceding two groups of patients at aspect difference not statistically significants such as sex, age, the course of disease, degree of being in a bad way.
2, Therapeutic Method:
Matched group: take prednisone 60mg decoction being taken at a draught in morning, subtracted 5-10mg in every month after the stable disease, 10-20mg keeps (the decrement speed varies with each individual) until every day.Take pyridostigmine bromide 60mg simultaneously, 3 times/day.
The treatment group: on the basis of matched group, add medicine of the present invention (producing) treatment by Shijiazhuang Yiling Pharmaceutical Co., Ltd, sooner or later respectively once, each 38g crude drug amount.
3, observed content:
Observe the Chinese medicine symptom: 1. myasthenia gravis self doing well,improving situation, mainly observe skeletal muscle unable from begin treatment to the used time of basic alleviation.2. the untoward reaction traditional Chinese medical science reveal any symptoms that produces because of the use hormone, symptoms such as the deficiency of YIN that is showed when promptly hormone is used early stage and decrement, the deficiency of vital energy, yang deficiency, adverse rising of stomach-QI.
4, curative effect determinate standard:
Use " clinical relative scoring method " evaluation.Clinically keep the score relatively=preceding clinical of (clinical before the treatment after definitely keeping the score-treat clinical definitely keep the score)/treatment definitely keep the score.1. clinical recovery: clinically keep the score relatively >=95%, clinical symptoms and sign disappear, can orthobiosis, study and work, and the medicine of all treatment myasthenia graviss of stopping using; 2. basic scabies is more: the clinical 80-95% that keeps the score relatively, and clinical symptoms disappears with sign, can orthobiosis, study and work, the medicine of all treatment myasthenia graviss of stopping using or dose minimizing are more than 3/4.3. produce effects: clinical 50-80% clinical symptoms and the sign of keeping the score relatively is clearly better, and life can be taken care of oneself, can be engaged in light work, and the dose minimizing of treating the myasthenia gravis medicine is more than 1/2.4. take a turn for the better: the clinical 25-50% bed sings and symptoms of keeping the score relatively take a favorable turn, and self care ability improves, and the dose of treatment myasthenia gravis medicine reduces more than 1/4.
5. invalid: clinically keep the score relatively<25%, clinical symptoms and sign do not have improvement, even worsen.
5, statistical method
Two groups of curative effects relatively adopt rank test.Adopt the SPSS10.0 statistical software, there is statistical significance P<0.05 for difference; Two inferior group curative effects more also adopt rank test, and there is statistical significance P<0.05 for difference;
Three, result
1, tcm symptom is learned observed result:
1. begin to the unable basic remission time of skeletal muscle from treatment, in 26 weeks of treatment group average out to, matched group was 34 weeks.
It is 5 examples that deficiency of YIN symptom appears in 2. treatment group, the deficiency of vital energy or yang deficiency symptom 6 examples, and adverse rising of stomach-QI person 2 examples add up to 13 examples, and the tcm symptom adverse reaction rate is 18.8%.Deficiency of YIN symptom 18 examples appear in matched group, the deficiency of vital energy or yang deficiency symptom 14 examples, and adverse rising of stomach-QI person 15 examples add up to 40 examples, and the tcm symptom adverse reaction rate is that 75.8%, two group of adverse reaction rate has significant differences (P<0.01).
2, medication therapy groups of the present invention and matched group curative effect are relatively
Table 1 liang group clinical curative effect analysis (routine number, %)
Divide into groups | The example number | Recovery from illness | Produce effects | Take a turn for the better | Invalid | Total effective rate (%) |
Matched group | 62 | 20(32.3) | 31(50.0) | 8(12.9) | 3(4.8) | 51(82.3) |
Drug group of the present invention | 69 | 51(73.9) * | 12(17.4) | 4(5.8) | 2(2.9) | 63(91.3) |
Annotate:
*Compare P<0.05 with matched group
Drug group of the present invention compares with matched group on the routine number of recovery from illness, and there is the significance difference P<0.05, so the matched group that is superior to evident in efficacy of medicine of the present invention;
3, different TCM Syndrome Type curative effects relatively
The different TCM Syndrome Type efficacy analysis of table 2 (routine number, %)
Divide into groups | The example number | Recovery from illness | Produce effects | Take a turn for the better | Invalid | Total effective rate (%) |
The S1 group | 40 | 13(32.5) | 23(57.5) | 3(5.9) | 1(2.9) | 36(90.0) |
The S2 group | 43 | 33(76.7) * | 8(18.6) | 2(4.7) | 0 | 41(95.3) |
Annotate:
*Compare P<0.05 with the S1 group
S2 group on the routine number of recovery from illness with the S1 group relatively, there is the significance difference P<0.05, medicine of the present invention is superior to non-dificiency of liver-YANG type myasthenia gravis for dificiency of liver-YANG type myasthenia gravis evident in efficacy.
Four, conclusion
Chinese medicine composition of the present invention can effectively be treated myasthenia gravis, and can effectively reduce the untoward reaction rate, and treatment dificiency of liver-YANG type myasthenia gravis has better effect.
The specific embodiment
Below in conjunction with the instance of the preparation of medicine decoction of the present invention, powder, capsule, tablet, pill, oral liquid, the specific embodiment of the present invention is described.
Embodiment 1:
The Fructus Evodiae 2 gram Radix Aconiti Lateralis Preparatas 20 gram Radixs Astragali 6 gram Fructus Lycii 15 grams
Herba Taxilli 10 gram Radix Dipsacis 22 gram Fructus Hordei Germinatus 7 grams
Method for preparing: process decoction by the conventional formulation method.
Embodiment 2:
The Fructus Evodiae 7 gram Radix Aconiti Lateralis Preparatas 5 gram Radixs Astragali 28 gram Fructus Lycii 5 grams
Herba Taxilli 20 gram Radix Dipsacis 11 gram Fructus Hordei Germinatus 15 grams
Method for preparing: press conventional formulation method porphyrize foam altogether, process powder.
Embodiment 3:
The Fructus Evodiae 2 gram Radix Aconiti Lateralis Preparatas 12 gram Radixs Astragali 17 gram Fructus Lycii 10 grams
Herba Taxilli 15 gram Radix Dipsacis 17 gram Fructus Hordei Germinatus 15 grams
Method for preparing: process capsule by the conventional formulation method.
Embodiment 4:
The Fructus Evodiae 3 gram Radix Aconiti Lateralis Preparatas 7 gram Radixs Astragali 8 gram Fructus Lycii 7 grams
Herba Taxilli 19 gram Radix Dipsacis 21 gram Fructus Hordei Germinatus 14 grams
Method for preparing: process tablet by the conventional formulation method.
Embodiment 5:
The Fructus Evodiae 6.5 gram Radix Aconiti Lateralis Preparatas 18 gram Radixs Astragali 27 gram Fructus Lycii 13.5 grams
Herba Taxilli 11 gram Radix Dipsacis 12 gram Fructus Hordei Germinatus 8.5 grams
Method for preparing: process pill by the conventional formulation method.
Embodiment 6:
The Fructus Evodiae 5 gram Radix Aconiti Lateralis Preparatas 15 gram Radixs Astragali 21 gram Fructus Lycii 13 grams
Herba Taxilli 14 gram Radix Dipsacis 14 gram Fructus Hordei Germinatus 10 grams
Method for preparing: process oral liquid by the conventional formulation method.
Claims (9)
1. Chinese medicine composition that contains the treatment myasthenia gravis of Radix Aconiti Lateralis Preparata is characterized in that it is to be processed by the crude drug of following weight portion ratio:
Fructus Evodiae 2-7 Radix Aconiti Lateralis Preparata 5-20 Radix Astragali 6-28 Fructus Lycii 5-15
Herba Taxilli 10-20 Radix Dipsaci 11-22 Fructus Hordei Germinatus 7-15.
2. Chinese medicine composition according to claim 1 is characterized in that being being processed by the crude drug of following weight portion ratio:
Fructus Evodiae 2 Radix Aconiti Lateralis Preparatas 20 Radixs Astragali 6 Fructus Lycii 15
Herba Taxilli 10 Radix Dipsacis 22 Fructus Hordei Germinatus 7.
3. Chinese medicine composition according to claim 1 is characterized in that being being processed by the crude drug of following weight portion ratio:
Fructus Evodiae 7 Radix Aconiti Lateralis Preparatas 5 Radixs Astragali 28 Fructus Lycii 5
Herba Taxilli 20 Radix Dipsacis 11 Fructus Hordei Germinatus 15.
4. Chinese medicine composition according to claim 1 is characterized in that being being processed by the crude drug of following weight portion ratio:
Fructus Evodiae 2 Radix Aconiti Lateralis Preparatas 12 Radixs Astragali 17 Fructus Lycii 10
Herba Taxilli 15 Radix Dipsacis 17 Fructus Hordei Germinatus 15.
5. Chinese medicine composition according to claim 1 is characterized in that being being processed by the crude drug of following weight portion ratio:
Fructus Evodiae 3 Radix Aconiti Lateralis Preparatas 7 Radixs Astragali 8 Fructus Lycii 7
Herba Taxilli 19 Radix Dipsacis 21 Fructus Hordei Germinatus 14.
6. Chinese medicine composition according to claim 1 is characterized in that being being processed by the crude drug of following weight portion ratio:
Fructus Evodiae 6.5 Radix Aconiti Lateralis Preparatas 18 Radixs Astragali 27 Fructus Lycii 13.5
Herba Taxilli 11 Radix Dipsacis 12 Fructus Hordei Germinatus 8.5.
7. according to the arbitrary described Chinese medicine composition of claim 1-6, the preparation formulation that it is characterized in that this Chinese medicine composition is decoction, powder, capsule, tablet, pill or oral liquid.
8. Chinese medicine composition as claimed in claim 7 is characterized in that containing one or more pharmaceutically acceptable excipient in the preparation of this Chinese medicine composition.
9. according to each described Chinese medicine composition of claim 1-6, it is characterized in that said myasthenia gravis is a dificiency of liver-YANG type myasthenia gravis.
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1199656C (en) * | 2000-09-08 | 2005-05-04 | 姜东海 | Medicine for treating myashthenia gravis |
CN100344316C (en) * | 2005-01-12 | 2007-10-24 | 王振球 | Chinese medicine for treating myasthenia gravis |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1199656C (en) * | 2000-09-08 | 2005-05-04 | 姜东海 | Medicine for treating myashthenia gravis |
CN100344316C (en) * | 2005-01-12 | 2007-10-24 | 王振球 | Chinese medicine for treating myasthenia gravis |
Non-Patent Citations (2)
Title |
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张志慧等.重症肌无力的中医药治疗进展.《河北中医》.2003,第25卷(第3期),第231-233页. * |
苏卫东等.浅论肝气(阳)虚证.《安徽中医学院学报》.2005,第24卷(第5期),第1-3页. * |
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