CN1454099A - 医用树枝状分子-光敏剂络合物 - Google Patents
医用树枝状分子-光敏剂络合物 Download PDFInfo
- Publication number
- CN1454099A CN1454099A CN00819683A CN00819683A CN1454099A CN 1454099 A CN1454099 A CN 1454099A CN 00819683 A CN00819683 A CN 00819683A CN 00819683 A CN00819683 A CN 00819683A CN 1454099 A CN1454099 A CN 1454099A
- Authority
- CN
- China
- Prior art keywords
- dendrimer
- photosensitizer
- complexes
- tetrapyrrole
- photosensitizers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Radiation-Therapy Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
样品 | τFL[ns] | ΦΔ | |
脱镁叶绿甲酯一酸a | 5.7±0.2 | 0.52 | |
Pheo-丁二酰亚胺酯 | 6.1±0.3 | 0.55 | |
Pheo与树枝状分子的混合物 | 5.9±0.3 | 0.48 | |
Pheo-16-树枝状分子络合物 | 4.9±0.3 | 0.5±0.3 | 0.05 |
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19936997A DE19936997B4 (de) | 1999-08-02 | 1999-08-02 | Verfahren zur Applikation von Photosensibilisatoren (PS) mittels Multiplikatoren in der photodymamischen Therapie |
DE19936997.6 | 1999-08-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1454099A true CN1454099A (zh) | 2003-11-05 |
CN100372569C CN100372569C (zh) | 2008-03-05 |
Family
ID=7917344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008196834A Expired - Fee Related CN100372569C (zh) | 1999-08-02 | 2000-07-28 | 医用树枝状分子-光敏剂络合物 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060292112A1 (zh) |
EP (1) | EP1246648A2 (zh) |
JP (1) | JP4722355B2 (zh) |
CN (1) | CN100372569C (zh) |
BR (1) | BR0013304A (zh) |
CA (1) | CA2381143C (zh) |
DE (1) | DE19936997B4 (zh) |
WO (1) | WO2001008704A2 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102977110A (zh) * | 2012-12-06 | 2013-03-20 | 济南大学 | 不对称的树枝状金属卟啉及其制备方法和应用 |
CN103073553A (zh) * | 2013-01-25 | 2013-05-01 | 山东大学 | 水溶性萘菁基化合物、制备方法及作为光敏剂的应用 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10104389A1 (de) * | 2001-01-19 | 2002-08-01 | Schering Ag | Multimere Photosensibilisatoren sowie deren Konjugate für die PDT |
US8153111B2 (en) * | 2004-06-18 | 2012-04-10 | Ceramoptec Industries, Inc. | Photo-triggered release of active substances from dendrimer-photosensitizer complexes |
GB0520436D0 (en) | 2005-10-07 | 2005-11-16 | Photobiotics Ltd | Biological materials and uses thereof |
EP1834955A1 (en) | 2006-03-10 | 2007-09-19 | Humboldt Universität zu Berlin | Porphyrin derivates and their use as photosensitizers in photodynamic therapy |
GB2464958A (en) * | 2008-10-31 | 2010-05-05 | Univ Muenster Wilhelms | A method for the manufacture of a photosensitising nano-material |
GB0904825D0 (en) | 2009-03-20 | 2009-05-06 | Photobiotics Ltd | Biological materials and uses thereof |
WO2015026963A2 (en) * | 2013-08-21 | 2015-02-26 | Oregon State University | Phthalocy anine-dendrimer compositions and a method of using |
CN112007153B (zh) * | 2020-07-22 | 2021-07-20 | 东华大学 | 一种叶绿素铜修饰的树状大分子铜络合物纳米诊疗材料的制备方法 |
CN112316139B (zh) * | 2020-11-04 | 2021-11-16 | 燕山大学 | 一种吲哚菁绿纳米药物及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
GB9203037D0 (en) * | 1992-02-11 | 1992-03-25 | Salutar Inc | Contrast agents |
DE699079T1 (de) * | 1994-03-07 | 1997-09-25 | Dendritech Inc | Bioaktive und/oder gezielte dendrimere-konjugate |
NL9401886A (nl) * | 1994-05-27 | 1996-01-02 | Dsm Nv | Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof. |
WO1997006833A1 (en) * | 1995-08-11 | 1997-02-27 | Dendritech, Inc. | Hyper comb-branched polymer conjugates |
DK1154991T3 (da) * | 1999-02-18 | 2004-11-22 | Univ California | Salicylamid-lanthanidkomplekser til anvendelse som luminescerende markörer |
AU768957B2 (en) * | 1999-02-18 | 2004-01-08 | Regents Of The University Of California, The | Phthalamide-lanthanide complexes for use as luminescent markers |
DE29916518U1 (de) * | 1999-09-15 | 2000-06-29 | Rueckmann Ilja | Vorrichtung zur kontinuierlichen licht-induzierten Keimreduzierung mittels fester, unlöslicher und schichtförmig aufgetragener Photosensibilisatorstrukturen für Anwendungen in Konservierungs- und Vorratsbehältern, Umwälz- und Durchflußanlagen |
-
1999
- 1999-08-02 DE DE19936997A patent/DE19936997B4/de not_active Expired - Fee Related
-
2000
- 2000-07-28 JP JP2001513434A patent/JP4722355B2/ja not_active Expired - Fee Related
- 2000-07-28 WO PCT/IB2000/001165 patent/WO2001008704A2/en active Search and Examination
- 2000-07-28 EP EP00951787A patent/EP1246648A2/en not_active Withdrawn
- 2000-07-28 CN CNB008196834A patent/CN100372569C/zh not_active Expired - Fee Related
- 2000-07-28 CA CA2381143A patent/CA2381143C/en not_active Expired - Fee Related
- 2000-07-28 BR BR0013304-3A patent/BR0013304A/pt not_active Application Discontinuation
-
2006
- 2006-09-01 US US11/514,662 patent/US20060292112A1/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102977110A (zh) * | 2012-12-06 | 2013-03-20 | 济南大学 | 不对称的树枝状金属卟啉及其制备方法和应用 |
CN102977110B (zh) * | 2012-12-06 | 2015-02-18 | 济南大学 | 不对称的树枝状金属卟啉及其制备方法和应用 |
CN103073553A (zh) * | 2013-01-25 | 2013-05-01 | 山东大学 | 水溶性萘菁基化合物、制备方法及作为光敏剂的应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2001008704A2 (en) | 2001-02-08 |
JP4722355B2 (ja) | 2011-07-13 |
US20060292112A1 (en) | 2006-12-28 |
EP1246648A2 (en) | 2002-10-09 |
BR0013304A (pt) | 2003-01-07 |
CA2381143C (en) | 2011-12-20 |
CA2381143A1 (en) | 2001-02-08 |
DE19936997A1 (de) | 2001-02-15 |
WO2001008704A3 (en) | 2001-08-23 |
CN100372569C (zh) | 2008-03-05 |
DE19936997B4 (de) | 2007-06-14 |
JP2003526405A (ja) | 2003-09-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20060292112A1 (en) | Dendrimer-photosensitizer complexes for medical applications | |
Tedesco et al. | Synthesis, photophysical and photochemical aspects of phthalocyanines for photodynamic therapy | |
Phillips | The photochemistry of sensitisers for photodynamic therapy | |
Samaroo et al. | meso-Tetra (pentafluorophenyl) porphyrin as an efficient platform for combinatorial synthesis and the selection of new photodynamic therapeutics using a cancer cell line | |
CN1222309C (zh) | 将分子导入细胞溶质 | |
CN1894344A (zh) | 用于二联光学诊断和治疗的化合物 | |
Villanueva et al. | Pharmacokinetic and tumour-photosensitizing properties of the cationic porphyrin meso-tetra (4N-methylpyridyl) porphine | |
König et al. | Variation in the fluorescence decay properties of haematoporphyrin derivative during its conversion to photoproducts | |
US8180444B2 (en) | Enhanced PhotoDynamic Therapy with immune system assist | |
EP1066293A2 (de) | Porphyrine und ihre verwendung als photosensitizer | |
Villanueva et al. | Photodynamic induction of DNA–protein cross‐linking in solution by several sensitizers and visible light | |
Croce et al. | Distribution and retention of rose bengal and disulphonated aluminium phthalocyanine: a comparative study in unicellular eukaryote | |
Jori | The molecular biology of photodynamic action | |
US7390510B2 (en) | Preparation of hypericin bonded with poly-N-vinylamides | |
Kulsi et al. | Sub cellular organelles-targeting photo dynamic therapy (PDT) | |
Lassalle et al. | Photodegradation and phototransformation of 5, 10, 15, 20-tetrakis (m-hydroxyphenyl) bacteriochlorin (m-THPBC) in solution | |
CN1100750C (zh) | 15-脱乙酰基-13-氨基酸取代的竹红菌素及其制法 | |
Boodram et al. | The use of inorganic compounds in photodynamic therapy: improvements in methods and photosensitizer design | |
Drain et al. | New porphyrin glyco-conjugates | |
JP2005104905A (ja) | ポリリジン結合型光線力学治療剤 | |
Luo | Femtosecond time-resolved studies on the reaction pathways for the generation of reactive oxygen species in photodynamic therapy by indocyanine green | |
Chekulayev et al. | Influence of metronidazole and some electron acceptors on the chlorin e6 photosensitized killing of Ehrlich carcinoma cells | |
Kreimer-Birnbaum et al. | Silicon naphthalocyanines derivatives: delivery systems as modulators of pharmacokinetics and photodynamic therapy (PDT) outcomes | |
Tjahjono | Porphyrin structure-based molecules for photodynamic therapy of cancer | |
CN1660863A (zh) | 竹红菌素联吡啶类钌配合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BIOLITEC PHARMA MARKETING LTD. Free format text: FORMER OWNER: BIOLITEC AG Effective date: 20120424 Free format text: FORMER OWNER: BIOLITEC AG Effective date: 20120424 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20120424 Address after: Malaysia, Bazhou, Labuan Patentee after: Biolitec Pharma Marketing Ltd. Address before: Analytik Jena Co-patentee before: Beille Tektronix Inc Patentee before: Biolitec Ag |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080305 Termination date: 20140728 |
|
EXPY | Termination of patent right or utility model |