CN1450995A - 用于治疗青光眼的5－羟基吲唑衍生物 - Google Patents

用于治疗青光眼的5－羟基吲唑衍生物 Download PDF

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Publication number
CN1450995A
CN1450995A CN00819348A CN00819348A CN1450995A CN 1450995 A CN1450995 A CN 1450995A CN 00819348 A CN00819348 A CN 00819348A CN 00819348 A CN00819348 A CN 00819348A CN 1450995 A CN1450995 A CN 1450995A
Authority
CN
China
Prior art keywords
alkyl
hydrogen
indazole
aminopropyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00819348A
Other languages
English (en)
Chinese (zh)
Inventor
J·A·梅
冯子侠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Alcon Universal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Universal Ltd filed Critical Alcon Universal Ltd
Publication of CN1450995A publication Critical patent/CN1450995A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN00819348A 2000-03-17 2000-11-14 用于治疗青光眼的5－羟基吲唑衍生物 Pending CN1450995A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19028300P 2000-03-17 2000-03-17
US60/190,283 2000-03-17

Publications (1)

Publication Number Publication Date
CN1450995A true CN1450995A (zh) 2003-10-22

Family

ID=22700701

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00819348A Pending CN1450995A (zh) 2000-03-17 2000-11-14 用于治疗青光眼的5－羟基吲唑衍生物

Country Status (12)

Country Link
EP (1) EP1268439A1 (xx)
JP (1) JP2003535821A (xx)
KR (1) KR20030095183A (xx)
CN (1) CN1450995A (xx)
AR (1) AR026708A1 (xx)
AU (2) AU1918001A (xx)
BR (1) BR0017163A (xx)
CA (1) CA2401959A1 (xx)
MX (1) MXPA02008825A (xx)
PL (1) PL365422A1 (xx)
WO (1) WO2001070701A1 (xx)
ZA (1) ZA200206853B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
PT1392292E (pt) 2001-06-01 2006-05-31 Alcon Inc Piranoindazoles e sua utilizacao para o tratamento de glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
CN100384827C (zh) * 2002-11-08 2008-04-30 默克公司 用于治疗高眼压症的眼用组合物
WO2004043354A2 (en) * 2002-11-08 2004-05-27 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
CA2506204A1 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
JP2004262812A (ja) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd 眼圧低下剤
CN1842335A (zh) * 2003-09-04 2006-10-04 默克公司 用于治疗高眼压的眼用组合物
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (en) 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
WO2006056873A2 (en) 2004-11-29 2006-06-01 Warner-Lambert Company Llc Therapeutic pyrazolo[3,4-b] pyridines and indazoles
WO2006062839A1 (en) 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
KR100972921B1 (ko) * 2009-12-02 2010-07-28 제이케이이앤씨 주식회사 회전 격판식 선회류 세정 및 탈취장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
JP2002515408A (ja) * 1998-05-19 2002-05-28 アルコン ラボラトリーズ， インコーポレーテッド 眼および中枢神経系疾患治療用セロトニン作動性５ｈｔ７受容体化合物
GB9819020D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds III
CN1269484C (zh) * 1998-09-18 2006-08-16 艾尔科实验室公司 用于治疗青光眼的5－羟色胺激活性激动剂

Also Published As

Publication number Publication date
JP2003535821A (ja) 2003-12-02
KR20030095183A (ko) 2003-12-18
ZA200206853B (en) 2004-11-02
EP1268439A1 (en) 2003-01-02
AU1918001A (en) 2001-10-03
AU2001219180B2 (en) 2005-04-07
MXPA02008825A (es) 2004-10-15
WO2001070701A1 (en) 2001-09-27
BR0017163A (pt) 2003-01-14
AR026708A1 (es) 2003-02-26
CA2401959A1 (en) 2001-09-27
PL365422A1 (en) 2005-01-10

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