CN1424102A - Chinese medicine preparation for weight-off and reducing fat - Google Patents
Chinese medicine preparation for weight-off and reducing fat Download PDFInfo
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- CN1424102A CN1424102A CN 02159229 CN02159229A CN1424102A CN 1424102 A CN1424102 A CN 1424102A CN 02159229 CN02159229 CN 02159229 CN 02159229 A CN02159229 A CN 02159229A CN 1424102 A CN1424102 A CN 1424102A
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Abstract
A Chinese medicine in the form of capsule for treating hyperlipemia and fatty liver and lossing weight is prepared from 16 Chinese-medicinal materials including tetrandra root, alismatis rhizome, white mustard seed, peach kernel, etc. Its advantage is high curative effect.
Description
Technical field
The invention belongs to the prepared from traditional Chinese medicines technical field, a kind of Chinese medicine preparation that is used for the human body weight-losing blood fat reducing and preparation method thereof of more specifically saying so.
Background technology
As everyone knows; The fat worry of not only bringing self figure to people, and can cause diseases such as coronary heart disease, apoplexy because the extraordinary increase of body weight cause the cardiac function over loading.For this reason, the medical worker attempts to seek the way of various fat-reducing, but poor effect often, and the chemical drugs that has fat-reducing also has side effect.In recent years, some study the prepared from traditional Chinese medicines product and are used for the human body lowering blood-fat and reducing weight, and as " a kind of fat-reducing powder " that the CN1114574A patent application proposes, it is the electuary that is made by 20 pleasant impression Chinese herbal medicine such as Radix Stephaniae Tetrandrae, Radix Scutellariae, the Radix Astragali, Radix Et Rhizoma Rhei, Radix Glycyrrhizaes; The lowering blood-fat and reducing weight Chinese medicine that proposes of CN1329893A patent application and for example is by being the distinguish the flavor of medicaments of prepared from traditional Chinese medicines of the Radix Astragali, Semen Cuscutae, Hirudo, Radix Paeoniae Rubra, Semen Ginkgo, Fructus Lycii etc. 16.Different Chinese herbal medicine formulas, the effect of the slimming preparation that makes has marked difference.
Summary of the invention
The purpose of this invention is to provide a kind of triglyceride reducing and the tangible Chinese medicine preparation of fat-reducing effect and preparation method thereof.
Chinese medicine preparation of the present invention is by following materials based on weight system perfume (or spice):
Radix Stephaniae Tetrandrae 45-85 part Rhizoma Alismatis 80-120 part Semen Sinapis Albae 30-70 part
Semen Persicae 30-70 part Exocarpium Benincasae 80-120 part Folium Nelumbinis 80-120 part
Radix Ginseng 5-45 part Rhizoma Atractylodis 30-70 part Radix Et Rhizoma Rhei 7.5-47.5 part
Rhizoma Atractylodis Macrocephalae 30-70 part Radix Astragali 80-120 part Pericarpium Citri Reticulatae 20-60 part
Fructus Amomi Rotundus 10-50 part Rhizoma Polygonati Odorati 80-120 part Pollen Tyjphae 4.5-10.5 part
Fructus Gleditsia 90-130 part.
Chinese medicine preparation of the present invention fill a prescription preferably (in heavy umber) be
Radix Stephaniae Tetrandrae 55-75 part Rhizoma Alismatis 90-110 part Semen Sinapis Albae 40-60 part
Semen Persicae 40-60 part Exocarpium Benincasae 90-110 part Folium Nelumbinis 90-110 part
Radix Ginseng 15-35 part Rhizoma Atractylodis 40-60 part Radix Et Rhizoma Rhei 17.5-37.5 part
Rhizoma Atractylodis Macrocephalae 40-60 part Radix Astragali 90-110 part Pericarpium Citri Reticulatae 30-50 part
Fructus Amomi Rotundus 20-40 part Rhizoma Polygonati Odorati 90-110 part Pollen Tyjphae 5.5-9.5 part
Fructus Gleditsia 100-120 part.
Medicament optimum formula (in parts by weight) is in of the present invention
65 parts of Radixs Stephaniae Tetrandrae, 100 parts of Rhizoma Alismatis, 50 parts of Semen Sinapis Albaes, 50 parts in Semen Persicae, 100 parts of Exocarpium Benincasaes, 100 parts on Folium Nelumbinis, 25 parts of Radix Ginsengs, 50 parts of Rhizoma Atractylodis, 27.5 parts of Radix Et Rhizoma Rhei, 50 parts of the Rhizoma Atractylodis Macrocephalaes, 100 parts of the Radixs Astragali, 40 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Amomi Rotunduss, 100 parts of Rhizoma Polygonati Odorati, 7.5 parts of Pollen Tyjphae, 100 parts in Fructus Gleditsia.
The preparation method of Chinese medicine preparation of the present invention may further comprise the steps:
1. Radix Ginseng, Fructus Gleditsia were pulverized No. 6 sieve, Radix Et Rhizoma Rhei, Rhizoma Alismatis 2 flavor Chinese medicines are got 1/5 respectively and are ground into fine powder, and 4/5 is ground into coarse powder, and Radix Stephaniae Tetrandrae 1/3 is ground into fine powder, and 2/3 is ground into coarse powder, and described coarse powder is 24 orders, and fine powder is more than 80 orders;
2. get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Pollen Tyjphae, Fructus Amomi Rotundus, Rhizoma Atractylodis, peach kernel powder and be broken into coarse powder, mix with Chinese herbal medicine Radix Et Rhizoma Rhei, Rhizoma Alismatis, the Radix Stephaniae Tetrandrae coarse powder of step (1) then,, obtain percolate with 70% soak with ethanol 24-48 hour;
3. Semen Sinapis Albae, Exocarpium Benincasae, Folium Nelumbinis are decocted twice, filter rear filtrate and be concentrated into 1: 1, add 95% ethanol, make solution contain the alcohol amount and reach 70%, leave standstill, filter, with the percolate merging of its filtrate and step (2), reclaim ethanol, be concentrated into thick paste, powder is beaten in oven dry, is mixed and made into capsule with step (1) Radix Ginseng, Fructus Gleditsia, Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Stephaniae Tetrandrae Chinese herbal medicine fine powder.
Advantage of the present invention and effect:
Chinese medicine preparation of the present invention is with replenishing QI to invigorate the spleen, and the dampness removing that reduces phlegm is main, and assistant is applicable to simple obesity with the long-pending repercussive of row, comprises physical obesity and acquired obesity.Be conceived to fat pathogenetic key link, start with from the body constitution of adjusting adiposis patient, reach weight reduction, do not subtract muscle power, not appetite-suppressing, do not cause diarrhoea and the therapeutic effect of the fat-reducing of making light of one's life by commiting suicide.Remarkable blood fat reducing, abdomen fat, sebum are arranged and reduce the effect of abdomen circle, hip circumference, bluntness, Body Mass Index, and hyperlipemia, fatty liver are had significant curative effect.Product of the present invention shows without any side effects through the acute and long term toxicity test of animal.Clinical Practice proves that " light swallow slimming capsule " of the present invention has fat-reducing and antihyperglycemic significantly.
Below by the pharmacological testing method, observe of the influence of this medicine to indexs such as the weight of animals, body fat accumulation and blood fat, verify its curative effect, report content is as follows:
[test method]
1. experimental obese rat Preparation of model:
48 male and female half and half of above-mentioned SD rat, every day subcutaneous injection sodium glutamate 3g/kg, continuous 5 days, after three weeks, divide cage to feed rat, give high fat, high sugar, high protein feed (add 0.5kg Adeps Sus domestica, egg 5, milk powder 250g in the 10kg normal diet every day) drinking-water of freely ingesting, 24 rats (male and female half and half) subcutaneous injection equivalent normal saline is as normal control in addition, and every day, without stint gave normal diet and drinking-water.
2. animal divides into groups and administering mode:
Since the 4th week, above-mentioned normal rat and rat model are divided into 6 groups at random by sex: (1) normal control group (NC); (2) normal administration group (ND); Give light swallow appetrol by the 1g/kg/ daily dose; (3) model small dose group (ML); Give light swallow appetrol by the 1g/kg/ daily dose; (4) model heavy dose (MH); By giving light swallow appetrol 2g/kg/ day; (5) model fenfluramine group (MF): press 0.01g/kg/ day with fenfluramine filling stomach soluble in water; (6) model control group (MC).
During the administration, the model group rat continues quantity-unlimiting raising with high fat, high sugar, high protein feed, normal group is still given normal diet, through observing light swallow fat-reducing medicated powder free from extraneous odour, it is mixed in does not influence the rat food ration in the feedstuff, then this medicine is mixed compacting slivering in back with feedstuff, according to dosage regularly offers medicine once morning every day, to afternoon the pastille feedstuff all can be eaten up, throw no medicine feedstuff again, put to death the animal observation index after continuous 60 days.
3. observation procedure:
(1) measures body weight weekly once during the administration, calculate each treated animal body weight gain rate
(2) administration is put to death animal and is surveyed body long (nose is to anus length), the long C anus of tail to the tail point after 60 days), calculate Lee ' s index
(3) extract uterus and testis whole fat and liver on every side, weigh.
(4) adipose cell number and size are got genitals fat one fritter at same position on every side, and be liquid-solid fixed with 2.5% formaldehyde ethanol, and the paraffin wax section uses mircrometer gauge at microscopically counting 25 * 25 μ m
2Adipose cell number in the visual field, and measure the long-pending size in average cell plane, calculate fatty ester's number.
Fat index=adipose cell mean level of the sea amasss (μ m
2) * fat weight/(g/100g body weight)
(5) lipid determination: after 60 days, each organizes rat through fasting in 24 hours, and lumbar injection pentobarbital 0.8ml/kg anesthesia from the ventral aorta blood sampling, is measured serum triglycerides, cholesterol and hdl concentration.
More than every observed data all adopt the significance test of t-value method between organizing.
[experimental result]
One. light swallow slimming capsule medicine is to rat body weight, the influence of form and body fat accumulation.
Respectively organize the propagation process of rat body weight during the medication, (before the 4th week) each treated animal body weight gain speed basically identical before its body weight gain rate administration, model medication group growth rate begins to slow down and obvious poor Fig 1.b appears in model control group after the administration) and keep lower growth rate all the time, model control group rat body weight increasing value is significantly higher than matched group, its body is long on the form, the long normal group that all is shorter than of tail, Lee ' s index significantly raises, be fat figure, lipopexia amount maximum around the genitals can think that experimental fat Preparation of model is successful.
Light swallow slimming capsule medicine can suppress the body weight gain of this obesity rat model, and the growth long to body, that tail is long does not have obvious influence, thereby Lee ' s index is reduced, also reduce simultaneously the lipopexia amount, the above-mentioned effect of light swallow slimming capsule medicine presents certain dose dependent, the body weight gain after intact animal's administration and intact animal's matched group no significant difference.
Two. light swallow slimming capsule is to the influence of adipose cell number and size.
Table 3 is the result of the observed fat tissue cell of microscopically (amplifying 20 * 3.3 times), and the adipose cell of model control group animal is full full, (25 * 25 μ m in the unit visual field
2) in cell number obviously reduce, the cell plane is long-pending to increase, fat index is significantly higher than other each experimental grouies, light swallow fat-reducing is heavy dose of, and (2g/kg/ day 0 and fenfluramine (0.01g/kg/ day) all make Animal fat cell fullness degree diminish, the cell plane that unit visual field inner cell quantity increases is long-pending to be dwindled, fatty ester's number descends, and this result reduces consistent with the weight of the imitative tissue of the fat around the genitals.
Three. light swallow slimming capsule is to the influence of serum lipids;
Light swallow slimming capsule obviously reduces the content of triglyceride in the high fat diet animal blood, and the tendency that reduces serum cholesterol and high density lipoprotein increasing is arranged, but difference is given the check not statistically significant.
[experiment conclusion]
1. light swallow slimming capsule can suppress the body weight gain of sodium glutamate obese rat, improves the short fat mode of appearance of its body, reduces the body fat accumulation, reduces the fullness degree and size of adipose cell, and its effect is certain dose dependent.
2. light swallow slimming capsule can reduce the serum triglycerides content of high fat diet animal
The specific embodiment
Further specify characteristics of the present invention below by instantiation:
Example 1-3
The prescription of the Chinese medicine preparation of example 1-3 (in g) is to see the following form:
| Project | Example 1 | Example 2 | Example 3 |
| Radix Stephaniae Tetrandrae | ????65 | ????80 | ????48 |
| Rhizoma Alismatis | ????100 | ????90 | ????110 |
| Semen Sinapis Albae | ????50 | ????35 | ????65 |
| Semen Persicae | ????50 | ????65 | ????35 |
| Exocarpium Benincasae | ????100 | ????115 | ????75 |
| Folium Nelumbinis | ????100 | ????90 | ????110 |
| Radix Ginseng | ????25 | ????40 | ????8 |
| Rhizoma Atractylodis | ????50 | ????65 | ????40 |
| Radix Et Rhizoma Rhei | ????27.5 | ????8 | ????45 |
| The Rhizoma Atractylodis Macrocephalae | ????50 | ????65 | ????35 |
| The Radix Astragali | ????100 | ????85 | ????110 |
| Pericarpium Citri Reticulatae | ????40 | ????30 | ????45 |
| Fructus Amomi Rotundus | ????30 | ????45 | ????15 |
| Rhizoma Polygonati Odorati | ????100 | ????85 | ????110 |
| Pollen Tyjphae | ????7.5 | ????5.5 | ????9.5 |
| Fructus Gleditsia | ????110 | ????95 | ????120 |
Concrete preparation process:
Get Radix Ginseng, Fructus Gleditsia was pulverized sieve No. 6, got 1/5 of Radix Et Rhizoma Rhei, Radix Stephaniae Tetrandrae, Rhizoma Alismatis consumption respectively and was ground into fine powder, 1/3 Radix Stephaniae Tetrandrae is ground into fine powder, all the other are coarse powder; Above-mentioned Chinese medicine coarse powder is mixed with the coarse powder that the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Pollen Tyjphae, Fructus Amomi Rotundus, Rhizoma Atractylodis, peach kernel powder are broken into, with 70% soak with ethanol 48 hours, Semen Sinapis Albae, Exocarpium Benincasae, Folium Nelumbinis decocted secondary, are concentrated into 1: 1, add 95% ethanol, make solution contain the alcohol amount and reach 70%, leave standstill, filter, filtrate is mixed with aforesaid percolate, reclaim ethanol and be concentrated into thick paste, powder is beaten in oven dry, is mixed and made into capsule with above fine powder again.
Claims (5)
1. the Chinese medicine preparation of a Weight-reducing and lipid-lowering is characterized in that the medicament of being made by the following portions by weight raw material: Radix Stephaniae Tetrandrae 45-85 part, Rhizoma Alismatis 80-120 part, Semen Sinapis Albae 30-70 part, Semen Persicae 30-70 part, Exocarpium Benincasae 80-120 part, Folium Nelumbinis 80-120 part, Radix Ginseng 5-45 part, Rhizoma Atractylodis 30-70 part, Radix Et Rhizoma Rhei 7.5-47.5 part, Rhizoma Atractylodis Macrocephalae 30-70 part, Radix Astragali 80-120 part, Pericarpium Citri Reticulatae 20-60 part, Fructus Amomi Rotundus 10-50 part, Rhizoma Polygonati Odorati 80-120 part, Pollen Tyjphae 4.5-10.5 part, Fructus Gleditsia 90-130 part.
2. Chinese medicine preparation according to claim 1 is characterized in that the medicament of being made by following materials based on weight: Radix Stephaniae Tetrandrae 55-75 part, Rhizoma Alismatis 90-110 part, Semen Sinapis Albae 40-60 part, Semen Persicae 40-60 part, Exocarpium Benincasae 90-110 part, Folium Nelumbinis 90-110 part, Radix Ginseng 15-35 part, Rhizoma Atractylodis 40-60 part, Radix Et Rhizoma Rhei 17.5-37.5 part, Rhizoma Atractylodis Macrocephalae 40-60 part, Radix Astragali 90-110 part, Pericarpium Citri Reticulatae 30-50 part, Fructus Amomi Rotundus 20-40 part, Rhizoma Polygonati Odorati 90-110 part, Pollen Tyjphae 5.5-9.5 part, Fructus Gleditsia 100-120 part.
3. Chinese medicine preparation according to claim 1 is characterized in that: the medicament of being made by following materials based on weight:
65 parts of Radixs Stephaniae Tetrandrae, 100 parts of Rhizoma Alismatis, 50 parts of Semen Sinapis Albaes, 50 parts in Semen Persicae, 100 parts of Exocarpium Benincasaes, 100 parts on Folium Nelumbinis, 25 parts of Radix Ginsengs, 50 parts of Rhizoma Atractylodis, 27.5 parts of Radix Et Rhizoma Rhei, 50 parts of the Rhizoma Atractylodis Macrocephalaes, 100 parts of the Radixs Astragali, 40 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Amomi Rotunduss, 100 parts of Rhizoma Polygonati Odorati, 7.5 parts of Pollen Tyjphae, 100 parts in Fructus Gleditsia.
4. according to the described Chinese medicine preparation of claim 1,2 or 3, it is characterized in that described medicament is a capsule.
5. Chinese medicine preparation according to claim 4 is characterized in that described capsule preparation process may further comprise the steps:
(1) Radix Ginseng, Fructus Gleditsia were pulverized No. 6 sieve, Radix Et Rhizoma Rhei, Rhizoma Alismatis 2 flavor Chinese medicines are got 1/5 respectively and are ground into fine powder, and 4/5 is ground into coarse powder, and Radix Stephaniae Tetrandrae 1/3 is ground into fine powder, and 2/3 is ground into coarse powder, and described coarse powder is 24 orders, and fine powder is more than 80 orders;
(2) get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Pollen Tyjphae, Fructus Amomi Rotundus, Rhizoma Atractylodis, peach kernel powder and be broken into coarse powder, mix with Chinese herbal medicine Radix Et Rhizoma Rhei, Rhizoma Alismatis, the Radix Stephaniae Tetrandrae coarse powder of step (1) then,, obtain percolate with 70% soak with ethanol 24-48 hour;
(3) Semen Sinapis Albae, Exocarpium Benincasae, Folium Nelumbinis are decocted twice, filter rear filtrate and be concentrated into 1: 1, add 95% ethanol, make solution contain the alcohol amount and reach 70%, leave standstill, filter, with the percolate merging of its filtrate and step (2), reclaim ethanol, be concentrated into thick paste, powder is beaten in oven dry, is mixed and made into capsule with step (1) Radix Ginseng, Glcditsia Sinensis, Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Stephaniae Tetrandrae Chinese herbal medicine fine powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02159229 CN1209141C (en) | 2002-12-27 | 2002-12-27 | Chinese medicine preparation for weight-off and reducing fat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02159229 CN1209141C (en) | 2002-12-27 | 2002-12-27 | Chinese medicine preparation for weight-off and reducing fat |
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| Publication Number | Publication Date |
|---|---|
| CN1424102A true CN1424102A (en) | 2003-06-18 |
| CN1209141C CN1209141C (en) | 2005-07-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02159229 Expired - Fee Related CN1209141C (en) | 2002-12-27 | 2002-12-27 | Chinese medicine preparation for weight-off and reducing fat |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444614B (en) * | 2008-12-31 | 2011-04-20 | 宫守汪 | Pharmaceutical composition with fat burning and firming effect and preparation method thereof |
| CN101607051B (en) * | 2009-07-23 | 2011-06-29 | 薛伟 | Traditional Chinese medicine composition for losing weight and preparation method thereof |
| CN105327280A (en) * | 2015-11-28 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating pure obesity and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361701C (en) * | 2006-03-15 | 2008-01-16 | 刘晓平 | Green type medicine bag for reducing weight |
-
2002
- 2002-12-27 CN CN 02159229 patent/CN1209141C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444614B (en) * | 2008-12-31 | 2011-04-20 | 宫守汪 | Pharmaceutical composition with fat burning and firming effect and preparation method thereof |
| CN101607051B (en) * | 2009-07-23 | 2011-06-29 | 薛伟 | Traditional Chinese medicine composition for losing weight and preparation method thereof |
| CN105327280A (en) * | 2015-11-28 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating pure obesity and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1209141C (en) | 2005-07-06 |
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