CN105327280A - Traditional Chinese medicine composition for treating pure obesity and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating pure obesity and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese medicine composition for treating pure obesity and a preparation method thereof. The existing medicine for treating the pure obesity is poor in treatment effect, and therefore the invention provides the traditional Chinese medicine composition for treating the pure obesity. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine ingredients in parts by weight: 45-60 parts of figwort flower picrorhiza rhizome, 5.5-7 parts of weeping forsythia capsule, 30-40 parts of rhubarb, 25-30 parts of turmeric, 30-35 parts of oriental waterplantain rhizome, 85-90 parts of rhizoma corydalis, 15-20 parts of cattail pollen, 12-15 parts of light yellow sophora root, 5-10 parts of common cephalanoplos herb, 9-15 parts of purpleflower crotalarla herb, 10-15 parts of root of woodland beakchervil, 6-9 parts of dwarf lilyturf tuber and 10-15 parts of areca seed. The traditional Chinese medicine composition can modify the clinical symptoms of a pure obesity suffer, corrects the hormone level of the pure obesity suffer so as to be suitable for popularizing and using clinically.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition being used for the treatment of simple obesity and preparation method thereof.
Background technology
Obesity (obesity) is a kind of chronic disease.According to World Health Organization (WHO) estimate it be the mankind face at present the most out in the cold, but a kind of disease that sickness rate is sharply rising.Except the mankind, many house pets also can suffer from obesity.Mammal (comprising people) storage hyperliposis, to such an extent as to health is affected.Obesity (obesity) is one group of common, ancient metabolism disease group.When human body feed heat is more than consumption of calorie, waste heat is with storage as fat in body, and its amount exceedes normal physiological requirement, and then develops into obesity when reaching certain value.Normal Male Adults adipose tissue mass is about 15% ~ 18% of percentage of liveweight, and women accounts for 20% ~ 25%.Increase with the age, the corresponding increase of body fat proportion.Because the increase of body fat makes be above standard body weight 20% or Body Mass Index [BMI=body weight (Kg)/(height) 2 (m2)] of body weight be greater than 24 and be called obesity.As can be the person of seeking claimed simple obesity without the obvious cause of disease; There is clear and definite cause of disease person and be called secondary obesity.
Of long standing and well established in China by the history of traditional Chinese medicine capable of reducing weight, when three states with regard to the story of Huatuo on the books by Chinese medicine obesity.Ancients' treatment by Chinese herbs obesity has much different methods of weight-reducing, such as; The understanding of motherland's medical science to obesity is sporadically appeared in the successive dynasties and in work." Plain Questions is logical comments deficiency and excess opinion " cloud: " fertile high official, then the disease of fat meat and fine grain also." " the strange sick opinion of Plain Questions " meaning: " this person must count the sweet and refreshing and many fertilizer of food also, overeating greasy food bringing about internal heat, over-eating the food with sweet flavor bringing about abdominal distension." but the dialectical Therapeutic Method of theory of Chinese medical science is its topic constant.That is exactly will be particular about " controlling because of body " according to the various different origins of disease: be exactly the various different origins according to obesity disease, open different prescriptions according to dissimilar system.Here it is why traditional Chinese medicine capable of reducing weight have the reason of so magical curative effect why.Traditional Chinese medicine capable of reducing weight treats according to the body constitution that slimmer is different is dialectical according to Chinese medical discrimination theory, suits the remedy to the case, fundamentally solve problem of obesity.Compare Western medicine because of traditional Chinese medicine capable of reducing weight in addition safer, be free from side effects, and Western medicine is gradually subject to the repulsion of fat-reducing personage comparatively speaking containing various chemical analysis.
In Simple Obesity, the research such as Wu Ping finds that single Fructus Lycii 30g every day makes tea and takes after mixing it with water, and continue long-term taking, treatment Simple Obesity Patient 40 example, result cures 20 examples, and effective 12 examples, total effective rate is 80%.Majority weight after taking medicine 3 months has obvious decline, and part is down to normal range after taking medicine 6 months, is showed no untoward reaction.This shows; medicine therapeutic effect at present clinically for simple obesity is unsatisfactory; and chemicals often can cause serious side effect in medication process, therefore, a kind of effective treatment simple obesity is found and the little medicine of side effect becomes and is badly in need of in the industry.
Summary of the invention
Not good enough and side effect is large to simple obesity therapeutic effect for chemicals of the prior art, and the therapeutic effect of Chinese medicine imprecise.For this reason, the invention provides a kind of Chinese medicine composition being used for the treatment of simple obesity, this Chinese medicine composition can alleviate rapidly the symptom of simple obesity patient, and the low therapeutic effect of relapse rate is better than existing medicine, is therefore suitable for promoting the use of in clinical.
The present invention is solved the problems of the technologies described above by following technical proposals:
The invention provides a kind of Chinese medicine composition being used for the treatment of simple obesity, it is prepared by the Chinese medicinal components of following weight portion: Rhizoma Picrorhizae 45 ~ 60 parts, Fructus Forsythiae 5.5 ~ 7 parts, Radix Et Rhizoma Rhei 30 ~ 40 parts, 25 ~ 30 parts, Rhizoma Curcumae Longae, Rhizoma Alismatis 30 ~ 35 parts, Rhizoma Corydalis 85 ~ 90 parts, Pollen Typhae 15 ~ 20 parts, Radix Sophorae Flavescentis 12 ~ 15 parts, Herba Cirsii 5 ~ 10 parts, Bulbus Lilii 9 ~ 15 parts, 10 ~ 15 parts, Radix Notoginseng, Radix Ophiopogonis 6 ~ 9 parts, Semen Arecae 10 ~ 15 parts.
In Chinese medicine composition described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, and the dosage of drug used is reasonable, and can alleviate rapidly the symptom of simple obesity patient after all medicines share, relapse rate is low.Improve effect to strengthen it further, described Chinese medicine granules also comprises 15 ~ 18 parts of Radix Polygoni Multiflori Preparatas and 10 ~ 14 portions of Herba Plantaginiss.
As a kind of embodiment preferred for this invention, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Rhizoma Picrorhizae 52.5 parts, Fructus Forsythiae 6.5 parts, Radix Et Rhizoma Rhei 35 parts, 27.5 parts, Rhizoma Curcumae Longae, Rhizoma Alismatis 32.5 parts, Rhizoma Corydalis 87.5 parts, Pollen Typhae 17.5 parts, Radix Sophorae Flavescentis 13.5 parts, Herba Cirsii 7.5 parts, Bulbus Lilii 12 parts, 12.5 parts, Radix Notoginseng, Radix Ophiopogonis 7.5 parts, Semen Arecae 12.5 parts.
As another kind of embodiment preferred for this invention, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Rhizoma Picrorhizae 52.5 parts, Fructus Forsythiae 6.5 parts, Radix Et Rhizoma Rhei 35 parts, 27.5 parts, Rhizoma Curcumae Longae, Rhizoma Alismatis 32.5 parts, Rhizoma Corydalis 87.5 parts, Pollen Typhae 17.5 parts, Radix Sophorae Flavescentis 13.5 parts, Herba Cirsii 7.5 parts, Bulbus Lilii 12 parts, 12.5 parts, Radix Notoginseng, Radix Ophiopogonis 7.5 parts, Semen Arecae 12.5 parts, Radix Polygoni Multiflori Preparata 16.5 parts, Herba Plantaginis 12 parts.
The present invention also provides described a kind of preparation method being used for the treatment of the Chinese medicine composition of simple obesity, and it comprises the steps:
(1) get Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Sophorae Flavescentis, Bulbus Lilii and Radix Notoginseng and soak 1 hour, extract volatile oil with volatile oil extractor, then obtain volatile oil with anhydrous sodium sulfate drying, then use beta-cyclodextrin inclusion compound, obtained clathrate, clathrate and medicinal residues for subsequent use;
(2) get Rhizoma Corydalis, Rhizoma Picrorhizae, Herba Cirsii, Pollen Typhae and Herba Plantaginis and add 70% ethanol extraction 2 times, each 1.5 hours, merge medicinal liquid, leave standstill 24 hours, for subsequent use;
(3) getting Rhizoma Curcumae Longae, Fructus Forsythiae, Radix Ophiopogonis, Semen Arecae and Radix Polygoni Multiflori Preparata to be ground into after fine powder and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collects extracting solution, leaves standstill 24 hours, for subsequent use;
(4) supernatant obtained in (2) and (3) step is got, decompression recycling ethanol, be concentrated into 60 DEG C ~ 70 DEG C, density is the extractum of 1.03 ~ 1.09, for subsequent use after dry, in extractum, add Benexate Hydrochloride obtained in (1) step, measure its weight, add the lactose of its weight 10% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80 ~ 90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
The present invention also provides a kind of medical usage of above-mentioned Chinese medicine composition, the purposes of namely described Chinese medicine composition in preparation treatment Simple Obesity disease drug.The embodiment of the present invention 7 experimental result shows, result shows, compared with existing clinical main flow medicine, the treated effect of pharmaceutical composition of the present invention is higher, clinical symptoms is improved more obvious, and after medicine composite for curing of the present invention, in patient's hemorheology, shear rate and Plasma Viscosity obviously reduce (P < 0.05 and <0.01) simultaneously; In blood, in estrogen, progestogen and endometrium, estrogen receptor, progesterone receptor level obviously decline (P < 0.05 or 0.01); In blood, LDL, TG level obviously declines (P < 0.05 or 0.01).
When Chinese medicine composition of the present invention is used for simple obesity treatment, compared with prior art there is following advantage:
(1) compared with existing medicine, Chinese medicine composition prescription of the present invention is more reasonable, therapeutic effect for simple obesity is better, and effect experiment of the present invention confirms, compared with existing clinical main flow medicine, the treated effect of pharmaceutical composition of the present invention is higher, clinical symptoms is improved more obvious, and after medicine composite for curing of the present invention, in patient's hemorheology, shear rate and Plasma Viscosity obviously reduce (P < 0.05 and <0.01) simultaneously; In blood, in estrogen, progestogen and endometrium, estrogen receptor, progesterone receptor level obviously decline (P < 0.05 or 0.01); In blood, LDL, TG level obviously declines (P < 0.05 or 0.01).。
(2) the present invention is made up of plurality of Chinese, and preparation method is simple, and its side effect side effect compared with chemotherapeutic agent is lower, and not easily produces drug resistance.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 one kinds of Chinese medicine compositions being used for the treatment of simple obesity and preparation method thereof
Be used for the treatment of a Chinese medicine composition for simple obesity, it is prepared by the Chinese medicinal components of following weight Kg: Rhizoma Picrorhizae 45Kg, Fructus Forsythiae 5.5Kg, Radix Et Rhizoma Rhei 30Kg, Rhizoma Curcumae Longae 25Kg, Rhizoma Alismatis 30Kg, Rhizoma Corydalis 85Kg, Pollen Typhae 15Kg, Radix Sophorae Flavescentis 12Kg, Herba Cirsii 5Kg, Bulbus Lilii 9Kg, Radix Notoginseng 10Kg, Radix Ophiopogonis 6Kg, Semen Arecae 10Kg.
Be used for the treatment of a preparation method for the Chinese medicine composition of simple obesity, it comprises the steps:
(1) get Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Sophorae Flavescentis, Bulbus Lilii and Radix Notoginseng and soak 1 hour, extract volatile oil with volatile oil extractor, then obtain volatile oil with anhydrous sodium sulfate drying, then use β ~ cyclodextrin inclusion compound, obtained clathrate, clathrate and medicinal residues for subsequent use;
(2) get Rhizoma Corydalis, Rhizoma Picrorhizae, Herba Cirsii, Pollen Typhae and Herba Plantaginis and add 70% ethanol extraction 2 times, each 1.5 hours, merge medicinal liquid, leave standstill 24 hours, for subsequent use;
(3) getting Rhizoma Curcumae Longae, Fructus Forsythiae, Radix Ophiopogonis, Semen Arecae and Radix Polygoni Multiflori Preparata to be ground into after fine powder and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collects extracting solution, leaves standstill 24 hours, for subsequent use;
(4) supernatant obtained in (2) and (3) step is got, decompression recycling ethanol, be concentrated into 70 DEG C, density is the extractum of 1.03, for subsequent use after dry, in extractum, add Benexate Hydrochloride obtained in (1) step, measure its weight, add the lactose of its weight 10% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 2 one kinds of Chinese medicine compositions being used for the treatment of simple obesity and preparation method thereof
Be used for the treatment of a Chinese medicine composition for simple obesity, it is prepared by the Chinese medicinal components of following weight Kg: Rhizoma Picrorhizae 60Kg, Fructus Forsythiae 7Kg, Radix Et Rhizoma Rhei 40Kg, Rhizoma Curcumae Longae 30Kg, Rhizoma Alismatis 35Kg, Rhizoma Corydalis 90Kg, Pollen Typhae 20Kg, Radix Sophorae Flavescentis 15Kg, Herba Cirsii 10Kg, Bulbus Lilii 15Kg, Radix Notoginseng 15Kg, Radix Ophiopogonis 9Kg, Semen Arecae 15Kg.
Be used for the treatment of a preparation method for the Chinese medicine composition of simple obesity, it comprises the steps:
(1) get Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Sophorae Flavescentis, Bulbus Lilii and Radix Notoginseng and soak 1 hour, extract volatile oil with volatile oil extractor, then obtain volatile oil with anhydrous sodium sulfate drying, then use beta-cyclodextrin inclusion compound, obtained clathrate, clathrate and medicinal residues for subsequent use;
(2) get Rhizoma Corydalis, Rhizoma Picrorhizae, Herba Cirsii, Pollen Typhae and Herba Plantaginis and add 70% ethanol extraction 2 times, each 1.5 hours, merge medicinal liquid, leave standstill 24 hours, for subsequent use;
(3) getting Rhizoma Curcumae Longae, Fructus Forsythiae, Radix Ophiopogonis, Semen Arecae and Radix Polygoni Multiflori Preparata to be ground into after fine powder and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collects extracting solution, leaves standstill 24 hours, for subsequent use;
(4) supernatant obtained in (2) and (3) step is got, decompression recycling ethanol, be concentrated into 60 DEG C, density is the extractum of 1.09, for subsequent use after dry, in extractum, add β ~ cyclodextrin clathrate obtained in (1) step, measure its weight, add the lactose of its weight 10% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 3 one kinds of Chinese medicine compositions being used for the treatment of simple obesity and preparation method thereof
Be used for the treatment of a Chinese medicine composition for simple obesity, it is prepared by the Chinese medicinal components of following weight Kg: Rhizoma Picrorhizae 52.5Kg, Fructus Forsythiae 6.5Kg, Radix Et Rhizoma Rhei 35Kg, Rhizoma Curcumae Longae 27.5Kg, Rhizoma Alismatis 32.5Kg, Rhizoma Corydalis 87.5Kg, Pollen Typhae 17.5Kg, Radix Sophorae Flavescentis 13.5Kg, Herba Cirsii 7.5Kg, Bulbus Lilii 12Kg, Radix Notoginseng 12.5Kg, Radix Ophiopogonis 7.5Kg, Semen Arecae 12.5Kg.
Be used for the treatment of a preparation method for the Chinese medicine composition of simple obesity, it comprises the steps:
(1) get Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Sophorae Flavescentis, Bulbus Lilii and Radix Notoginseng and soak 1 hour, extract volatile oil with volatile oil extractor, then obtain volatile oil with anhydrous sodium sulfate drying, then use beta-cyclodextrin inclusion compound, obtained clathrate, clathrate and medicinal residues for subsequent use;
(2) get Rhizoma Corydalis, Rhizoma Picrorhizae, Herba Cirsii, Pollen Typhae and Herba Plantaginis and add 70% ethanol extraction 2 times, each 1.5 hours, merge medicinal liquid, leave standstill 24 hours, for subsequent use;
(3) getting Rhizoma Curcumae Longae, Fructus Forsythiae, Radix Ophiopogonis, Semen Arecae and Radix Polygoni Multiflori Preparata to be ground into after fine powder and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collects extracting solution, leaves standstill 24 hours, for subsequent use;
(4) supernatant obtained in (2) and (3) step is got, decompression recycling ethanol, be concentrated into 65 DEG C, density is the extractum of 1.06, for subsequent use after dry, in extractum, add Benexate Hydrochloride obtained in (1) step, measure its weight, add the lactose of its weight 10% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 85 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 4 one kinds of Chinese medicine compositions being used for the treatment of simple obesity and preparation method thereof
Be used for the treatment of a Chinese medicine composition for simple obesity, it is prepared by the Chinese medicinal components of following weight Kg: Rhizoma Picrorhizae 45Kg, Fructus Forsythiae 5.5Kg, Radix Et Rhizoma Rhei 30Kg, Rhizoma Curcumae Longae 25Kg, Rhizoma Alismatis 30Kg, Rhizoma Corydalis 85Kg, Pollen Typhae 15Kg, Radix Sophorae Flavescentis 12Kg, Herba Cirsii 5Kg, Bulbus Lilii 9Kg, Radix Notoginseng 10Kg, Radix Ophiopogonis 6Kg, Semen Arecae 10Kg, Radix Polygoni Multiflori Preparata 15Kg, Herba Plantaginis 18Kg.
A kind of preparation method being used for the treatment of the Chinese medicine composition of simple obesity is with embodiment 1.
Embodiment 5 one kinds of Chinese medicine compositions being used for the treatment of simple obesity and preparation method thereof
Be used for the treatment of a Chinese medicine composition for simple obesity, it is prepared by the Chinese medicinal components of following weight Kg: Rhizoma Picrorhizae 60Kg, Fructus Forsythiae 7Kg, Radix Et Rhizoma Rhei 40Kg, Rhizoma Curcumae Longae 30Kg, Rhizoma Alismatis 35Kg, Rhizoma Corydalis 90Kg, Pollen Typhae 20Kg, Radix Sophorae Flavescentis 15Kg, Herba Cirsii 10Kg, Bulbus Lilii 15Kg, Radix Notoginseng 15Kg, Radix Ophiopogonis 9Kg, Semen Arecae 15Kg, Radix Polygoni Multiflori Preparata 18Kg, Herba Plantaginis 14Kg.
A kind of preparation method being used for the treatment of the Chinese medicine composition of simple obesity is with embodiment 2.
Embodiment 6 one kinds of Chinese medicine compositions being used for the treatment of simple obesity and preparation method thereof
Be used for the treatment of a Chinese medicine composition for simple obesity, it is prepared by the Chinese medicinal components of following weight Kg: Rhizoma Picrorhizae 52.5Kg, Fructus Forsythiae 6.5Kg, Radix Et Rhizoma Rhei 35Kg, Rhizoma Curcumae Longae 27.5Kg, Rhizoma Alismatis 32.5Kg, Rhizoma Corydalis 87.5Kg, Pollen Typhae 17.5Kg, Radix Sophorae Flavescentis 13.5Kg, Herba Cirsii 7.5Kg, Bulbus Lilii 12Kg, Radix Notoginseng 12.5Kg, Radix Ophiopogonis 7.5Kg, Semen Arecae 12.5Kg, Radix Polygoni Multiflori Preparata 16.5Kg, Herba Plantaginis 12Kg.
A kind of preparation method being used for the treatment of the Chinese medicine composition of simple obesity is with embodiment 3.
Embodiment 7 Chinese medicine composition of the present invention is to the therapeutical effect of simple obesity rat model
1, modelling and index determining:
80 rats are divided into two groups at random by weight, general food group 10, model group 70.Model group adopts high lipid food to set up obese rat model, in the 6th week, 40 rats of modeling success (rat weight exceedes general food group weight 20%) are divided into 4 groups at random by weight, be respectively dosage group, Chinese medicine composition low dose group in the blank group of model, Chinese medicine composition high dose group, Chinese medicine composition, often organize 10; General food group is blank group (blank group).Except blank group, model blank group gavage are made up a prescription with except distilled water, all the other 3 groups of equal gavages give matched doses medicine (dosage is in table 1), every day time recording food-intake and amount of drinking water, body weight is surveyed in timing.Successive administration 6 weeks.Experimental session is all freely ingested and is drunk water, and normal diet is fed, and feeding environment cleans, and temperature, humidity are suitable, well-ventilated.Timing every day observes and record activities in rats degree, build, ingest, drink water, the situation such as feces and urine; In modeling the 3rd week, within the 6th week, claim weight; Rat neck scratched by re-treatm ent cutter, peels off carotid artery, extracts carotid artery blood with 1ml syringe, pretreatment such as centrifugal grade, and automatic biochemistry analyzer surveys TG, TC content in serum, and method and step operate by test kit requirement; After putting to death blood-letting, take around kidney, around testis all fatty respectively, take weight in wet base.
2. result of the test:
2.1 Chinese medicine compositions of the present invention are on the impact of obese rat general status and body weight
At duration of test, each group rat mental status, Excreta are normal, have no loose stool, during modeling the 6th week, and model group rats average body quality no significant difference.At the end of experiment, compare with the blank group of model, Chinese medicine composition each dosage group rat average body quality obviously reduces, and difference has statistical significance (P < 0.01); Show that Chinese medicine composition of the present invention can alleviate rat weight.
Table 1 Chinese medicine composition of the present invention is on the impact of obese rat general status and body weight
| Group | Number of elements | Dosage (mgkg-1) | Modeling the 6th week | After medicine the 6th week |
| Blank group | 10 | - | 236.4±15.3 | 458.3±23.4 |
| The blank group of model | 10 | - | 301.6±19.7 ** | 518.7±26.9 ** |
| Chinese medicine composition high dose group | 10 | 500 | 301.8±19.4 | 470.6±25.7 ## |
| Dosage group in Chinese medicine composition | 10 | 300 | 301.5±20.4 | 468.3±26.0 ## |
| Chinese medicine composition low dose group | 10 | 100 | 301.1±20.4 | 474.5±25.4 ## |
Compare with blank group,
*p < 0.01, compares with the blank group of model,
##p < 0.01
2.2 Chinese medicine compositions of the present invention are on the impact of TG, TC in rat blood serum
Compare with the blank group of model, in Chinese medicine composition each dosage group mice serum, TG, TC content obviously reduces, and difference has statistical significance (P < 0.01); Show that Chinese medicine composition of the present invention can reduce the content of TG, TC in serum.
Table 2 Chinese medicine composition of the present invention is on the impact of TG, TC in rat blood serum
| Group | Number of elements | Dosage (mgkg-1) | TG | TC |
| Blank group | 10 | - | 0.52±0.13 | 2.24±0.36 |
| The blank group of model | 10 | - | 1.21±0.35 ** | 4.63±0.55 ** |
| Chinese medicine composition high dose group | 10 | 500 | 0.71±0.04 ## | 2.89±3.05 ## |
| Dosage group in Chinese medicine composition | 10 | 300 | 0.63±0.36 ## | 2.77±2.46 ## |
| Chinese medicine composition low dose group | 10 | 100 | 0.77±0.48 ## | 3.01±3.33 ## |
Compare with blank group,
*p < 0.01, compares with the blank group of model,
##p < 0.01.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for simple obesity, it is prepared by the Chinese medicinal components of following weight portion: Rhizoma Picrorhizae 45 ~ 60 parts, Fructus Forsythiae 5.5 ~ 7 parts, Radix Et Rhizoma Rhei 30 ~ 40 parts, 25 ~ 30 parts, Rhizoma Curcumae Longae, Rhizoma Alismatis 30 ~ 35 parts, Rhizoma Corydalis 85 ~ 90 parts, Pollen Typhae 15 ~ 20 parts, Radix Sophorae Flavescentis 12 ~ 15 parts, Herba Cirsii 5 ~ 10 parts, Bulbus Lilii 9 ~ 15 parts, 10 ~ 15 parts, Radix Notoginseng, Radix Ophiopogonis 6 ~ 9 parts, Semen Arecae 10 ~ 15 parts.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition also comprises 15 ~ 18 parts of Radix Polygoni Multiflori Preparatas and 10 ~ 14 portions of Herba Plantaginiss.
3. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Rhizoma Picrorhizae 52.5 parts, Fructus Forsythiae 6.5 parts, Radix Et Rhizoma Rhei 35 parts, 27.5 parts, Rhizoma Curcumae Longae, Rhizoma Alismatis 32.5 parts, Rhizoma Corydalis 87.5 parts, Pollen Typhae 17.5 parts, Radix Sophorae Flavescentis 13.5 parts, Herba Cirsii 7.5 parts, Bulbus Lilii 12 parts, 12.5 parts, Radix Notoginseng, Radix Ophiopogonis 7.5 parts, Semen Arecae 12.5 parts.
4. Chinese medicine composition as claimed in claim 2, it is characterized in that, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Rhizoma Picrorhizae 52.5 parts, Fructus Forsythiae 6.5 parts, Radix Et Rhizoma Rhei 35 parts, 27.5 parts, Rhizoma Curcumae Longae, Rhizoma Alismatis 32.5 parts, Rhizoma Corydalis 87.5 parts, Pollen Typhae 17.5 parts, Radix Sophorae Flavescentis 13.5 parts, Herba Cirsii 7.5 parts, Bulbus Lilii 12 parts, 12.5 parts, Radix Notoginseng, Radix Ophiopogonis 7.5 parts, Semen Arecae 12.5 parts, Radix Polygoni Multiflori Preparata 16.5 parts, Herba Plantaginis 12 parts.
5. prepare the method containing the Chinese medicine composition of Rhizoma Corydalis and Rhizoma Curcumae Longae described in claim 1 or 2, it comprises the steps:
(1) get Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Sophorae Flavescentis, Bulbus Lilii and Radix Notoginseng and soak 1 hour, extract volatile oil with volatile oil extractor, then obtain volatile oil with anhydrous sodium sulfate drying, then use beta-cyclodextrin inclusion compound, obtained clathrate, clathrate and medicinal residues for subsequent use;
(2) get Rhizoma Corydalis, Rhizoma Picrorhizae, Herba Cirsii, Pollen Typhae and Herba Plantaginis and add 70% ethanol extraction 2 times, each 1.5 hours, merge medicinal liquid, leave standstill 24 hours, for subsequent use;
(3) getting Rhizoma Curcumae Longae, Fructus Forsythiae, Radix Ophiopogonis, Semen Arecae and Radix Polygoni Multiflori Preparata to be ground into after fine powder and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collects extracting solution, leaves standstill 24 hours, for subsequent use;
(4) supernatant obtained in (2) and (3) step is got, decompression recycling ethanol, be concentrated into 60 DEG C ~ 70 DEG C, density is the extractum of 1.03 ~ 1.09, for subsequent use after dry, in extractum, add Benexate Hydrochloride obtained in (1) step, measure its weight, add the lactose of its weight 10% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80 ~ 90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
6. the purposes of the Chinese medicine composition described in claim 1 or 2 in preparation treatment Simple Obesity disease drug.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424102A (en) * | 2002-12-27 | 2003-06-18 | 王�琦 | Chinese medicine preparation for weight-off and reducing fat |
| CN101129487A (en) * | 2007-08-30 | 2008-02-27 | 尹克山 | Traditional Chinese medicine for treating simple obesity |
| CN101167906A (en) * | 2007-11-14 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Medicinal composition for reducing blood lipid and reducing weight and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424102A (en) * | 2002-12-27 | 2003-06-18 | 王�琦 | Chinese medicine preparation for weight-off and reducing fat |
| CN101129487A (en) * | 2007-08-30 | 2008-02-27 | 尹克山 | Traditional Chinese medicine for treating simple obesity |
| CN101167906A (en) * | 2007-11-14 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Medicinal composition for reducing blood lipid and reducing weight and preparation process thereof |
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