CN1422279A - A82846糖肽类似物的选择性n－酰化 - Google Patents

A82846糖肽类似物的选择性n－酰化 Download PDF

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Publication number
CN1422279A
CN1422279A CN01807738A CN01807738A CN1422279A CN 1422279 A CN1422279 A CN 1422279A CN 01807738 A CN01807738 A CN 01807738A CN 01807738 A CN01807738 A CN 01807738A CN 1422279 A CN1422279 A CN 1422279A
Authority
CN
China
Prior art keywords
alkyl
glycopeptide
group
acidylate
following formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01807738A
Other languages
English (en)
Chinese (zh)
Inventor
R·C·汤普森
S·C·维尔基
M·J·兹韦费尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1422279A publication Critical patent/CN1422279A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN01807738A 2000-02-11 2001-02-12 A82846糖肽类似物的选择性n－酰化 Pending CN1422279A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18168300P 2000-02-11 2000-02-11
US60/181,683 2000-02-11

Publications (1)

Publication Number Publication Date
CN1422279A true CN1422279A (zh) 2003-06-04

Family

ID=22665319

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01807738A Pending CN1422279A (zh) 2000-02-11 2001-02-12 A82846糖肽类似物的选择性n－酰化

Country Status (17)

Country Link
US (1) US7365053B2 (https=)
EP (1) EP1254164B1 (https=)
JP (1) JP2003522197A (https=)
KR (1) KR100796079B1 (https=)
CN (1) CN1422279A (https=)
AT (1) ATE308560T1 (https=)
AU (2) AU3818001A (https=)
BR (1) BR0108268A (https=)
CA (1) CA2399640A1 (https=)
CZ (1) CZ20022722A3 (https=)
DE (1) DE60114567T2 (https=)
MX (1) MXPA02007739A (https=)
NO (1) NO20023761L (https=)
NZ (1) NZ520482A (https=)
PL (1) PL356966A1 (https=)
WO (1) WO2001058933A2 (https=)
ZA (1) ZA200206360B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107198778A (zh) * 2003-10-10 2017-09-26 伊缪诺金公司 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物
CN108484719A (zh) * 2018-01-19 2018-09-04 四川大学 硫酸酯化十二指肠糖肽制备方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1534316A2 (en) * 2002-08-30 2005-06-01 K.U. Leuven Research and Development Glycopeptide antibiotics and semisynthetic derivatives thereof and their use as antiviral agents
CN1557479A (zh) * 2004-01-16 2004-12-29 深圳市海王英特龙生物技术股份有限公 干扰素脂质体乳膏
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
GB2577420B (en) 2017-05-22 2022-07-06 Insmed Inc Glycopeptide derivative compounds and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
CA2031803C (en) * 1989-12-13 2001-05-29 Ramakrishnan Nagarajan Improvements in or relating to glycopeptide deriveratives
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
WO1999056760A1 (en) * 1998-05-01 1999-11-11 Eli Lilly And Company N1-modified glycopeptides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107198778A (zh) * 2003-10-10 2017-09-26 伊缪诺金公司 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物
CN108484719A (zh) * 2018-01-19 2018-09-04 四川大学 硫酸酯化十二指肠糖肽制备方法

Also Published As

Publication number Publication date
WO2001058933A2 (en) 2001-08-16
AU3818001A (en) 2001-08-20
EP1254164B1 (en) 2005-11-02
JP2003522197A (ja) 2003-07-22
US7365053B2 (en) 2008-04-29
EP1254164A2 (en) 2002-11-06
DE60114567D1 (de) 2005-12-08
NO20023761D0 (no) 2002-08-08
NO20023761L (no) 2002-08-26
CZ20022722A3 (cs) 2003-01-15
CA2399640A1 (en) 2001-08-16
KR20020073546A (ko) 2002-09-26
WO2001058933A3 (en) 2002-02-14
NZ520482A (en) 2004-12-24
ATE308560T1 (de) 2005-11-15
HK1049171A1 (en) 2003-05-02
ZA200206360B (en) 2003-11-10
MXPA02007739A (es) 2002-10-11
US20070219123A1 (en) 2007-09-20
AU2001238180B2 (en) 2005-12-15
PL356966A1 (en) 2004-07-12
BR0108268A (pt) 2003-03-05
DE60114567T2 (de) 2006-07-27
AU2001238180B8 (en) 2006-07-27
KR100796079B1 (ko) 2008-01-21

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Open date: 20030604