CN1413188A - 基本纯的比卡鲁胺合成中中间体的拆分 - Google Patents

基本纯的比卡鲁胺合成中中间体的拆分 Download PDF

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Publication number
CN1413188A
CN1413188A CN00817760A CN00817760A CN1413188A CN 1413188 A CN1413188 A CN 1413188A CN 00817760 A CN00817760 A CN 00817760A CN 00817760 A CN00817760 A CN 00817760A CN 1413188 A CN1413188 A CN 1413188A
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China
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alkyl
formula
carbon atoms
perfluoroalkyl
midbody compound
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CN00817760A
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English (en)
Chinese (zh)
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N·N·埃克乌里贝
K·D·詹姆斯
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NOBECOS Inc
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NOBECOS Inc
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Publication of CN1413188A publication Critical patent/CN1413188A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN00817760A 1999-10-27 2000-10-25 基本纯的比卡鲁胺合成中中间体的拆分 Pending CN1413188A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16188499P 1999-10-27 1999-10-27
US60/161,884 1999-10-27

Publications (1)

Publication Number Publication Date
CN1413188A true CN1413188A (zh) 2003-04-23

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CN00817760A Pending CN1413188A (zh) 1999-10-27 2000-10-25 基本纯的比卡鲁胺合成中中间体的拆分

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US (1) US6593492B1 (https=)
EP (1) EP1224167A1 (https=)
JP (1) JP4778178B2 (https=)
KR (1) KR20020067509A (https=)
CN (1) CN1413188A (https=)
AU (1) AU2619501A (https=)
BR (1) BR0015124A (https=)
CA (1) CA2389100A1 (https=)
CZ (1) CZ20021434A3 (https=)
HK (1) HK1048299A1 (https=)
HU (1) HUP0203186A2 (https=)
IL (2) IL149256A0 (https=)
MX (1) MXPA02004225A (https=)
NO (1) NO20021999L (https=)
NZ (1) NZ518552A (https=)
PL (1) PL360059A1 (https=)
TW (1) TWI271397B (https=)
WO (1) WO2001034563A1 (https=)
ZA (1) ZA200203228B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN104897818A (zh) * 2015-06-19 2015-09-09 重庆医药高等专科学校 一种同时测定比卡鲁胺中6种有关物质的uplc方法
CN108069887A (zh) * 2016-11-17 2018-05-25 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法

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US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US6071957A (en) 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7547728B2 (en) 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
WO2002100339A2 (en) * 2001-06-13 2002-12-19 Biogal Gyogyszergyar Rt. Novel process for preparing rac-bicalutamide and its intermediates
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
CN1602299A (zh) * 2001-12-13 2005-03-30 住友化学工业株式会社 比卡鲁胺晶体及其制造方法
PT1480634E (pt) 2002-02-07 2011-10-12 Univ Tennessee Res Foundation Moduladores selectivos do receptor do androgénio (sarms) para o tratamento da hiperplasia benigna da próstata
EP1487458B1 (en) 2002-02-28 2011-11-16 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7344700B2 (en) 2002-02-28 2008-03-18 University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
GEP20074191B (en) 2002-06-17 2007-09-10 Univ Tennessee Res Foundation N-bridged selective androgen receptor modulators and methods of use thereof
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
EP1669347A1 (en) * 2004-12-10 2006-06-14 Helm AG Process for the preparation of 3-¬(4-fluorophenyl) sulfonyl|-2-hydroxy-2-methyl propionic acid
US20060269596A1 (en) * 2005-01-12 2006-11-30 Gary Liversidge Controlled release compositions comprising an acylanilide
KR20070114343A (ko) * 2005-03-29 2007-12-03 유에스브이 리미티드 비칼루타미드의 제조 방법
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
CN101528214B (zh) 2006-08-24 2013-06-05 田纳西大学研究基金会 取代的n-酰基苯胺及其使用方法
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
US8450374B2 (en) * 2009-06-29 2013-05-28 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
WO2012042532A1 (en) 2010-09-29 2012-04-05 Shilpa Medicare Limited Process for preparing bicalutamide
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
PT2872482T (pt) 2012-07-13 2020-09-22 Oncternal Therapeutics Inc Método de tratamento de cancro de mama com modulador seletivo do recetor de andrógeno (sarm)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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JPS58183669A (ja) * 1982-04-19 1983-10-26 Teikoku Chem Ind Corp Ltd 光学活性なプロピオン酸誘導体の製造方法
EP0100172B1 (en) * 1982-07-23 1987-08-12 Imperial Chemical Industries Plc Amide derivatives
GB8617652D0 (en) * 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
PL308473A1 (en) 1992-10-21 1995-08-07 Pfizer Enabntiomeric cis-3-(4,6-dihydoxychroman-3-yl methyl)bezoic acids
CA2181358A1 (en) 1994-01-21 1995-07-27 Nancy M. Gray Methods and compositions for treating androgen-dependent diseases using optically pure r-(-)-casodex
WO1998055153A1 (en) 1997-06-04 1998-12-10 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104897818A (zh) * 2015-06-19 2015-09-09 重庆医药高等专科学校 一种同时测定比卡鲁胺中6种有关物质的uplc方法
CN108069887A (zh) * 2016-11-17 2018-05-25 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法
CN108069887B (zh) * 2016-11-17 2021-04-20 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法

Also Published As

Publication number Publication date
IL149256A0 (en) 2002-11-10
IL149256A (en) 2011-05-31
MXPA02004225A (es) 2002-10-17
KR20020067509A (ko) 2002-08-22
NO20021999D0 (no) 2002-04-26
BR0015124A (pt) 2002-07-02
HUP0203186A2 (hu) 2003-01-28
WO2001034563A1 (en) 2001-05-17
NO20021999L (no) 2002-06-20
HK1048299A1 (zh) 2003-03-28
JP4778178B2 (ja) 2011-09-21
PL360059A1 (en) 2004-09-06
CZ20021434A3 (cs) 2002-11-13
JP2003513955A (ja) 2003-04-15
CA2389100A1 (en) 2001-05-17
ZA200203228B (en) 2003-07-23
US6593492B1 (en) 2003-07-15
NZ518552A (en) 2003-10-31
TWI271397B (en) 2007-01-21
EP1224167A1 (en) 2002-07-24
AU2619501A (en) 2001-06-06

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