HK1048299A1 - 在合成基本纯比卡鲁胺(bicalutamide)过程中的中间产物的分辨 - Google Patents

在合成基本纯比卡鲁胺(bicalutamide)过程中的中间产物的分辨 Download PDF

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Publication number
HK1048299A1
HK1048299A1 HK03100398.5A HK03100398A HK1048299A1 HK 1048299 A1 HK1048299 A1 HK 1048299A1 HK 03100398 A HK03100398 A HK 03100398A HK 1048299 A1 HK1048299 A1 HK 1048299A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
carbon atoms
substantially pure
heterocyclic
bicalutamide
Prior art date
Application number
HK03100398.5A
Other languages
English (en)
Chinese (zh)
Inventor
N. Ekwuribe Nnochiri
D. James Kenneth
Rajagopalan Jayanthi
Original Assignee
Biocon Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Limited filed Critical Biocon Limited
Publication of HK1048299A1 publication Critical patent/HK1048299A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK03100398.5A 1999-10-27 2000-10-25 在合成基本纯比卡鲁胺(bicalutamide)过程中的中间产物的分辨 HK1048299A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16188499P 1999-10-27 1999-10-27
US60/161,884 1999-10-27
PCT/US2000/041609 WO2001034563A1 (en) 1999-10-27 2000-10-25 Resolution of intermediates in the synthesis of substantially pure bicalutamide

Publications (1)

Publication Number Publication Date
HK1048299A1 true HK1048299A1 (zh) 2003-03-28

Family

ID=22583193

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100398.5A HK1048299A1 (zh) 1999-10-27 2000-10-25 在合成基本纯比卡鲁胺(bicalutamide)过程中的中间产物的分辨

Country Status (19)

Country Link
US (1) US6593492B1 (https=)
EP (1) EP1224167A1 (https=)
JP (1) JP4778178B2 (https=)
KR (1) KR20020067509A (https=)
CN (1) CN1413188A (https=)
AU (1) AU2619501A (https=)
BR (1) BR0015124A (https=)
CA (1) CA2389100A1 (https=)
CZ (1) CZ20021434A3 (https=)
HK (1) HK1048299A1 (https=)
HU (1) HUP0203186A2 (https=)
IL (2) IL149256A0 (https=)
MX (1) MXPA02004225A (https=)
NO (1) NO20021999L (https=)
NZ (1) NZ518552A (https=)
PL (1) PL360059A1 (https=)
TW (1) TWI271397B (https=)
WO (1) WO2001034563A1 (https=)
ZA (1) ZA200203228B (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US6071957A (en) 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
EP1406855A4 (en) * 2001-06-13 2006-04-19 Teva Gyogyszergyar Reszvenytar NOVEL PROCESS FOR THE PREPARATION OF RAC-BICALUTAMIDE AND INTERMEDIATE PRODUCTS THEREOF
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
DK1463497T3 (da) 2001-12-06 2012-01-30 Gtx Inc Behandling af muskelsvind med selektive androgenreceptormodulatorer
NZ533943A (en) * 2001-12-13 2006-06-30 Sumitomo Chemical Co Crystal of bicalutamide and production method thereof
CA2475108A1 (en) 2002-02-07 2003-08-14 Mitchell S. Steiner Treating benign prostate hyperplasia with sarms
AU2003217304A1 (en) 2002-02-28 2003-09-16 The University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7705182B2 (en) 2002-02-28 2010-04-27 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
JP2005529952A (ja) 2002-06-17 2005-10-06 ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション Ｎ架橋選択的アンドロゲン受容体修飾物質及びその使用方法
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
EP1669347A1 (en) * 2004-12-10 2006-06-14 Helm AG Process for the preparation of 3-¬(4-fluorophenyl) sulfonyl|-2-hydroxy-2-methyl propionic acid
US20060269596A1 (en) * 2005-01-12 2006-11-30 Gary Liversidge Controlled release compositions comprising an acylanilide
KR20070114343A (ko) * 2005-03-29 2007-12-03 유에스브이 리미티드 비칼루타미드의 제조 방법
US7550505B2 (en) * 2006-07-24 2009-06-23 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
ES2581765T3 (es) 2006-08-24 2016-09-07 University Of Tennessee Research Foundation Acilanilidas sustituidas y métodos de uso de las mismas
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
US8450374B2 (en) * 2009-06-29 2013-05-28 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
WO2012042532A1 (en) 2010-09-29 2012-04-05 Shilpa Medicare Limited Process for preparing bicalutamide
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
LT2872482T (lt) 2012-07-13 2020-12-28 Oncternal Therapeutics, Inc. Krūties vėžių gydymo būdas selektyviu androgeno receptoriaus moduliatoriumi
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
CN104897818A (zh) * 2015-06-19 2015-09-09 重庆医药高等专科学校 一种同时测定比卡鲁胺中6种有关物质的uplc方法
CN108069887B (zh) * 2016-11-17 2021-04-20 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183669A (ja) * 1982-04-19 1983-10-26 Teikoku Chem Ind Corp Ltd 光学活性なプロピオン酸誘導体の製造方法
ATE28864T1 (de) * 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
GB8617652D0 (en) * 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
PL308473A1 (en) * 1992-10-21 1995-08-07 Pfizer Enabntiomeric cis-3-(4,6-dihydoxychroman-3-yl methyl)bezoic acids
AU1687395A (en) 1994-01-21 1995-08-08 Sepracor, Inc. Methods and compositions for treating androgen-dependent diseases using optically pure r-(-)-casodex
WO1998055153A1 (en) 1997-06-04 1998-12-10 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging

Also Published As

Publication number Publication date
WO2001034563A1 (en) 2001-05-17
PL360059A1 (en) 2004-09-06
IL149256A (en) 2011-05-31
HUP0203186A2 (hu) 2003-01-28
NO20021999D0 (no) 2002-04-26
CZ20021434A3 (cs) 2002-11-13
AU2619501A (en) 2001-06-06
KR20020067509A (ko) 2002-08-22
ZA200203228B (en) 2003-07-23
JP2003513955A (ja) 2003-04-15
CN1413188A (zh) 2003-04-23
TWI271397B (en) 2007-01-21
NO20021999L (no) 2002-06-20
IL149256A0 (en) 2002-11-10
BR0015124A (pt) 2002-07-02
JP4778178B2 (ja) 2011-09-21
MXPA02004225A (es) 2002-10-17
NZ518552A (en) 2003-10-31
EP1224167A1 (en) 2002-07-24
US6593492B1 (en) 2003-07-15
CA2389100A1 (en) 2001-05-17

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