CN1400968A - 制备α－磺酰基异羟肟酸衍生物的方法 - Google Patents

制备α－磺酰基异羟肟酸衍生物的方法 Download PDF

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Publication number
CN1400968A
CN1400968A CN01804199A CN01804199A CN1400968A CN 1400968 A CN1400968 A CN 1400968A CN 01804199 A CN01804199 A CN 01804199A CN 01804199 A CN01804199 A CN 01804199A CN 1400968 A CN1400968 A CN 1400968A
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carbon atom
general formula
atom
alkyl
compound
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Chinese (zh)
Inventor
V·P·桑达纳亚卡
A·扎斯克
A·M·文卡特桑
J·L·巴克尔
L·克里斯南
S·梅加蒂
J·泽尔迪斯
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Wyeth Holdings LLC
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American Cyanamid Co
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4

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CN01804199A 2000-01-27 2001-01-25 制备α－磺酰基异羟肟酸衍生物的方法 Pending CN1400968A (zh)

Applications Claiming Priority (2)

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US49297500A 2000-01-27 2000-01-27
US09/492,975 2000-01-27

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CN1400968A true CN1400968A (zh) 2003-03-05

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EP (1) EP1252143A1 (pt)
JP (1) JP2003520852A (pt)
CN (1) CN1400968A (pt)
AR (1) AR031550A1 (pt)
AU (1) AU2001233034A1 (pt)
BR (1) BR0107862A (pt)
CA (1) CA2398561A1 (pt)
MX (1) MXPA02007291A (pt)
WO (1) WO2001055112A1 (pt)

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US20040146561A1 (en) * 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
EP1432431B1 (en) 2001-10-04 2017-05-10 Genetics Institute LLC Methods and compositions for modulating interleukin-21 activity
EP1511488B1 (en) 2002-06-12 2013-05-22 Symphony Evolution, Inc. Human adam-10 inhibitors
JP4566006B2 (ja) * 2002-12-26 2010-10-20 カルナバイオサイエンス株式会社 アルキニル基置換アザ糖誘導体およびそれを有効成分とする薬剤
NZ542306A (en) 2003-03-14 2008-04-30 Wyeth Corp Antibodies against human IL-21 receptor and uses therefor
CN103169965A (zh) 2004-11-19 2013-06-26 比奥根艾迪克Ma公司 治疗多发性硬化
CN101124213B (zh) * 2004-12-21 2012-02-01 默克雪兰诺有限公司 磺酰氨基环状衍生物及其应用
EP1859277A4 (en) 2005-02-17 2010-03-17 Biogen Idec Inc TREATMENT OF NEUROLOGICAL DISORDERS
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
JP5339901B2 (ja) 2005-05-10 2013-11-13 バイオジェン・アイデック・エムエイ・インコーポレイテッド 炎症傷害の処置および評価
TW200744634A (en) 2006-02-21 2007-12-16 Wyeth Corp Methods of using antibodies against human IL-22
TWI417301B (zh) 2006-02-21 2013-12-01 Wyeth Corp 對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途
US7728032B2 (en) 2006-08-04 2010-06-01 Decode Genetics Ehf Phenoxymethylalkyne inhibitors of LTA4H for treating inflammation
PL2170390T3 (pl) 2007-06-14 2019-05-31 Biogen Ma Inc Preparaty przeciwciała natalizumab
EP2070899A1 (en) * 2007-12-14 2009-06-17 F. Hoffmann-La Roche Ag Deprotection of N-BOC compounds
US20140161794A1 (en) 2010-04-16 2014-06-12 Biogen Idec Ma Inc. Anti-vla-4 antibodies
HUE043339T2 (hu) 2011-05-31 2019-08-28 Biogen Ma Inc Módszer a PML kockázatának megállapítására
ES2818823T3 (es) 2014-02-27 2021-04-14 Biogen Ma Inc Método de evaluación del riesgo de LMP
CN112867394B (zh) 2018-06-04 2024-09-13 马萨诸塞州渤健公司 具有降低的效应功能的抗vla-4抗体
US20210393632A1 (en) 2018-10-04 2021-12-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Egfr inhibitors for treating keratodermas

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Publication number Priority date Publication date Assignee Title
DE69823019T2 (de) * 1997-02-27 2005-03-31 Wyeth Holdings Corp. N-hydroxy-2-(alkyl, aryl oder heteroaryl sulfanyl, sulfinyl oder sulfonyl)-3-substituierte alkyl-, aryl- oder heteroarylamide als matrixmetalloproteinaseinhibitoren
ID25639A (id) * 1998-02-19 2000-10-19 American Cyanamid Co Alkil, aril atau heteroarilamida tersubstitusi n-hidroksi-2-(alkil, aril, atau heteroaril sulfanil, sulfinil atau sulfonil)-3 sebagai inhibitor matriks mataloproteinase
BR0007784A (pt) * 1999-01-27 2002-02-05 American Cyanamid Co Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto
US6583299B1 (en) * 1999-05-20 2003-06-24 G.D. Searle & Co. α-amino-β-sulfonyl hydroxamic acid compounds

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MXPA02007291A (es) 2002-11-29
AR031550A1 (es) 2003-09-24
JP2003520852A (ja) 2003-07-08
WO2001055112A1 (en) 2001-08-02
EP1252143A1 (en) 2002-10-30
CA2398561A1 (en) 2001-08-02
BR0107862A (pt) 2002-11-05

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