CN1398181A - 治疗炎性疾病的方法和组合物 - Google Patents

治疗炎性疾病的方法和组合物 Download PDF

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Publication number
CN1398181A
CN1398181A CN01804708A CN01804708A CN1398181A CN 1398181 A CN1398181 A CN 1398181A CN 01804708 A CN01804708 A CN 01804708A CN 01804708 A CN01804708 A CN 01804708A CN 1398181 A CN1398181 A CN 1398181A
Authority
CN
China
Prior art keywords
sodium
rolipram
pde4
administration
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01804708A
Other languages
English (en)
Chinese (zh)
Inventor
伊丽莎白·T·基廷
詹姆斯·M·卡纳吉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1398181A publication Critical patent/CN1398181A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN01804708A 2000-02-08 2001-02-08 治疗炎性疾病的方法和组合物 Pending CN1398181A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18087900P 2000-02-08 2000-02-08
US60/180,879 2000-02-08

Publications (1)

Publication Number Publication Date
CN1398181A true CN1398181A (zh) 2003-02-19

Family

ID=22662062

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01804708A Pending CN1398181A (zh) 2000-02-08 2001-02-08 治疗炎性疾病的方法和组合物

Country Status (16)

Country Link
EP (1) EP1253919A4 (ko)
JP (1) JP2003522142A (ko)
KR (1) KR20020073577A (ko)
CN (1) CN1398181A (ko)
AU (1) AU7205701A (ko)
BR (1) BR0108087A (ko)
CA (1) CA2398184A1 (ko)
CZ (1) CZ20022682A3 (ko)
HK (1) HK1051319A1 (ko)
HU (1) HUP0300689A3 (ko)
IL (1) IL150963A0 (ko)
MX (1) MXPA02007688A (ko)
NO (1) NO20023737L (ko)
PL (1) PL356447A1 (ko)
WO (1) WO2001058441A1 (ko)
ZA (1) ZA200206252B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7338971B2 (en) * 2001-08-30 2008-03-04 El-Naggar Mawaheb M Treatment of inflammatory, cancer, and thrombosis disorders
US20040242597A1 (en) * 2001-09-19 2004-12-02 Thomas Klein Combination
JP2005515975A (ja) * 2001-10-31 2005-06-02 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ４型ホスホジエステラーゼ阻害剤およびこれらの使用
WO2004098605A1 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Pharmaceutical composition comprising a pde4 inhibitor and il-1 trap
WO2005020926A2 (en) * 2003-08-28 2005-03-10 Pharmacia Corporation Treatment or prevention of vascular disorders with cox-2 inhibitors in combination with cyclic amp-specific phosphodiesterase inhibitors
CA2753604A1 (en) * 2009-02-27 2010-09-02 Boehringer Ingelheim International Gmbh Drug combinations containing pde4-inhibitors and nsaids
US8592400B2 (en) * 2009-02-27 2013-11-26 Boehringer Ingelheim International Gmbh Drug combinations containing PDE4 inhibitors and NSAIDs
ES2622519T3 (es) 2010-07-14 2017-07-06 Novartis Ag Componentes heterocíclicos agonistas del receptor IP
ES2565826T3 (es) 2012-01-13 2016-04-07 Novartis Ag Pirroles fusionados como agonistas del receptor IP para el tratamiento de hipertensión arterial pulmonar (PAH) y trastornos relacionados
US9604981B2 (en) 2013-02-13 2017-03-28 Novartis Ag IP receptor agonist heterocyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061779A (en) * 1973-09-11 1977-12-06 Beecham Group Limited Naphthalene derivatives having anti-inflammatory activity
GB9108128D0 (en) * 1991-04-15 1991-06-05 Zambeletti Spa L Novel formulation
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
US6005118A (en) * 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
FR2753706B1 (fr) * 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
WO2001058441A1 (en) 2001-08-16
AU7205701A (en) 2001-08-20
NO20023737L (no) 2002-09-27
IL150963A0 (en) 2003-02-12
KR20020073577A (ko) 2002-09-27
CZ20022682A3 (cs) 2003-09-17
PL356447A1 (en) 2004-06-28
MXPA02007688A (es) 2002-12-13
NO20023737D0 (no) 2002-08-07
JP2003522142A (ja) 2003-07-22
BR0108087A (pt) 2002-10-29
HUP0300689A2 (hu) 2003-07-28
CA2398184A1 (en) 2001-08-16
EP1253919A4 (en) 2007-03-14
HK1051319A1 (zh) 2003-08-01
ZA200206252B (en) 2003-08-26
EP1253919A1 (en) 2002-11-06
HUP0300689A3 (en) 2003-09-29

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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication