CN1395617A - 抗乙肝病毒表面抗原s的人源化抗体及其制备方法 - Google Patents

抗乙肝病毒表面抗原s的人源化抗体及其制备方法 Download PDF

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Publication number
CN1395617A
CN1395617A CN01802990A CN01802990A CN1395617A CN 1395617 A CN1395617 A CN 1395617A CN 01802990 A CN01802990 A CN 01802990A CN 01802990 A CN01802990 A CN 01802990A CN 1395617 A CN1395617 A CN 1395617A
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CN
China
Prior art keywords
heavy chain
mutant
humanized antibody
humanization
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01802990A
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English (en)
Chinese (zh)
Inventor
洪孝贞
金根洙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Bioscience and Biotechnology KRIBB
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Korea Research Institute of Bioscience and Biotechnology KRIBB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR10-2001-0060966A external-priority patent/KR100484054B1/ko
Application filed by Korea Research Institute of Bioscience and Biotechnology KRIBB filed Critical Korea Research Institute of Bioscience and Biotechnology KRIBB
Publication of CN1395617A publication Critical patent/CN1395617A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN01802990A 2000-10-02 2001-10-04 抗乙肝病毒表面抗原s的人源化抗体及其制备方法 Pending CN1395617A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR2000/57891 2000-10-02
KR20000057891 2000-10-02
KR10-2001-0060966A KR100484054B1 (ko) 2000-10-02 2001-09-29 Ｂ형 간염 바이러스의 표면항원 ｓ에 대한 인간화 항체 및그의 제조방법
KR2001/60966 2001-09-29

Publications (1)

Publication Number Publication Date
CN1395617A true CN1395617A (zh) 2003-02-05

Family

ID=26638435

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01802990A Pending CN1395617A (zh) 2000-10-02 2001-10-04 抗乙肝病毒表面抗原s的人源化抗体及其制备方法

Country Status (4)

Country Link
EP (1) EP1322761A4 (lt)
JP (1) JP2004517636A (lt)
CN (1) CN1395617A (lt)
WO (1) WO2002059318A1 (lt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1324049C (zh) * 2003-08-04 2007-07-04 中国疾病预防控制中心病毒病预防控制所 人源抗sars冠状病毒基因工程抗体
CN1980956B (zh) * 2004-04-14 2011-09-28 株式会社柳韩洋行 抗乙型肝炎病毒s-表面抗原的人源化抗体

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539403A (ja) 2006-06-13 2009-11-19 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌を診断および処置するための組成物および方法
EP2125887A4 (en) 2007-01-24 2010-11-10 Oncomed Pharm Inc COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF CANCER
SG192467A1 (en) 2008-07-08 2013-08-30 Oncomed Pharm Inc Notch1 receptor binding agents and methods of use thereof
WO2015153997A2 (en) * 2014-04-04 2015-10-08 Oncomed Pharmaceuticals, Inc. Notch3 antibodies and uses thereof
AU2016334290B2 (en) 2015-10-09 2020-06-18 Xiamen University Antibody to hepatitis B surface antigen and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9202796D0 (en) * 1992-02-11 1992-03-25 Wellcome Found Antiviral antibody
KR960002358B1 (ko) * 1993-05-26 1996-02-16 대우통신주식회사 전전자 교환기에서의 시스템 과부하에 의한 교환기 연계 제어방법
IL118625A0 (en) * 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibodies
KR100345463B1 (ko) * 1998-11-19 2003-01-08 주)녹십자 B형간염바이러스의표면항원프리-s1에대한인간화항체및이의제조방법
KR100308758B1 (ko) * 1999-02-12 2001-09-24 박호군 Ｂ형 간염 바이러스의 표면항원 프리-ｓ2에 대한 인간화 항체 및그의 제조방법

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1324049C (zh) * 2003-08-04 2007-07-04 中国疾病预防控制中心病毒病预防控制所 人源抗sars冠状病毒基因工程抗体
CN1980956B (zh) * 2004-04-14 2011-09-28 株式会社柳韩洋行 抗乙型肝炎病毒s-表面抗原的人源化抗体

Also Published As

Publication number Publication date
EP1322761A4 (en) 2005-03-23
WO2002059318A1 (en) 2002-08-01
EP1322761A1 (en) 2003-07-02
JP2004517636A (ja) 2004-06-17

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