JP2004517636A5 - - Google Patents
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- Publication number
- JP2004517636A5 JP2004517636A5 JP2002559803A JP2002559803A JP2004517636A5 JP 2004517636 A5 JP2004517636 A5 JP 2004517636A5 JP 2002559803 A JP2002559803 A JP 2002559803A JP 2002559803 A JP2002559803 A JP 2002559803A JP 2004517636 A5 JP2004517636 A5 JP 2004517636A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- heavy chain
- chain gene
- humanized
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000539 amino acid group Chemical group 0.000 claims description 17
- 150000001413 amino acids Chemical group 0.000 claims description 17
- 102000004965 antibodies Human genes 0.000 claims description 17
- 108090001123 antibodies Proteins 0.000 claims description 17
- 239000004473 Threonine Substances 0.000 claims description 10
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims description 8
- 206010064571 Gene mutation Diseases 0.000 claims description 7
- 125000003607 serino group Chemical group [H]OC(=O)C([H])(N([H])*)C([H])([H])O[H] 0.000 claims description 7
- 102100002977 CDR1 Human genes 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000038129 antigens Human genes 0.000 claims description 6
- 108091007172 antigens Proteins 0.000 claims description 6
- 229960005261 Aspartic Acid Drugs 0.000 claims description 5
- 235000003704 aspartic acid Nutrition 0.000 claims description 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 5
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims description 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 3
- 101710040745 B19R Proteins 0.000 claims 3
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 229960000310 ISOLEUCINE Drugs 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 229960001230 Asparagine Drugs 0.000 claims 1
- 229960002989 Glutamic Acid Drugs 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 208000006454 Hepatitis Diseases 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 125000000012 isoleucine group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 102200042198 CIB1 S44T Human genes 0.000 description 4
- 102000027675 major histocompatibility complex family Human genes 0.000 description 4
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 2
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 2
- 238000003259 recombinant expression Methods 0.000 description 2
- 108091007521 restriction endonucleases Proteins 0.000 description 2
- NFGXHKASABOEEW-UHFFFAOYSA-N (+)-methoprene Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
- 102500000046 VDR Apa1 Human genes 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20000057891 | 2000-10-02 | ||
| KR10-2001-0060966A KR100484054B1 (ko) | 2000-10-02 | 2001-09-29 | Ｂ형 간염 바이러스의 표면항원 ｓ에 대한 인간화 항체 및그의 제조방법 |
| PCT/KR2001/001657 WO2002059318A1 (en) | 2000-10-02 | 2001-10-04 | A humanized antibody to surface antigen s of hepatitis b virus and a preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004517636A JP2004517636A (ja) | 2004-06-17 |
| JP2004517636A5 true JP2004517636A5 (lt) | 2005-01-06 |
Family
ID=26638435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559803A Pending JP2004517636A (ja) | 2000-10-02 | 2001-10-04 | Ｂ型肝炎ウイルスの表面抗原ｓに対するヒト化抗体及びその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1322761A4 (lt) |
| JP (1) | JP2004517636A (lt) |
| CN (1) | CN1395617A (lt) |
| WO (1) | WO2002059318A1 (lt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1324049C (zh) * | 2003-08-04 | 2007-07-04 | 中国疾病预防控制中心病毒病预防控制所 | 人源抗sars冠状病毒基因工程抗体 |
| KR100789645B1 (ko) * | 2004-04-14 | 2007-12-27 | 주식회사유한양행 | Ｂ형 간염바이러스의 ｓ-표면항원을 인식하는 인간화 항체및 이의 제조방법 |
| WO2007145840A2 (en) | 2006-06-13 | 2007-12-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| WO2008091641A2 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| DK2307051T3 (en) | 2008-07-08 | 2015-04-20 | Oncomed Pharm Inc | Notch-binding substances, and antagonists and methods of use thereof |
| WO2015153997A2 (en) * | 2014-04-04 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Notch3 antibodies and uses thereof |
| CA3001231C (en) * | 2015-10-09 | 2022-07-12 | Xiamen University | Antibody against hepatitis b surface antigen and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| GB9202796D0 (en) * | 1992-02-11 | 1992-03-25 | Wellcome Found | Antiviral antibody |
| KR960002358B1 (ko) * | 1993-05-26 | 1996-02-16 | 대우통신주식회사 | 전전자 교환기에서의 시스템 과부하에 의한 교환기 연계 제어방법 |
| IL118625A0 (en) * | 1996-06-11 | 1996-10-16 | Xtl Biopharmaceuticals Limited | Anti HBV antibodies |
| KR100345463B1 (ko) * | 1998-11-19 | 2003-01-08 | 주)녹십자 | B형간염바이러스의표면항원프리-s1에대한인간화항체및이의제조방법 |
| KR100308758B1 (ko) * | 1999-02-12 | 2001-09-24 | 박호군 | Ｂ형 간염 바이러스의 표면항원 프리-ｓ2에 대한 인간화 항체 및그의 제조방법 |
-
2001
- 2001-10-04 EP EP01974926A patent/EP1322761A4/en not_active Withdrawn
- 2001-10-04 WO PCT/KR2001/001657 patent/WO2002059318A1/en not_active Application Discontinuation
- 2001-10-04 JP JP2002559803A patent/JP2004517636A/ja active Pending
- 2001-10-04 CN CN01802990A patent/CN1395617A/zh active Pending
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