CN1381449A - 芳烷酮哌嗪衍生物及其应用 - Google Patents
芳烷酮哌嗪衍生物及其应用 Download PDFInfo
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- CN1381449A CN1381449A CN02111786A CN02111786A CN1381449A CN 1381449 A CN1381449 A CN 1381449A CN 02111786 A CN02111786 A CN 02111786A CN 02111786 A CN02111786 A CN 02111786A CN 1381449 A CN1381449 A CN 1381449A
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- China
- Prior art keywords
- piperazine
- phenacyl
- benzyl
- ethyl
- chloro
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
镇痛 | 镇静 | 镇痛 | 镇静 | 镇痛 | 镇静 | |||
IV-1 | 68.2 | 65.6 | IV-3 | 56.6 | 70.8 | IV-4 | 93.2 | 39.6 |
IV-5 | 14 | 44 | IV-6 | 43 | 73 | IV-7 | 25 | 43 |
IV-8 | 39 | 64 | IV-9 | 74 | 32 | IV-10 | 100 | 99 |
IV-11 | 86 | 91 | IV-12 | 100 | 97 | IV-13 | 100 | 86 |
IV-14 | 94 | 92 | IV-15 | 80 | 93 | IV-16 | 63 | 51 |
IV-17 | 45 | 75 | IV-18 | 64 | 65 | IV-19 | 97 | 93 |
IV-20 | 45 | 60 | IV-21 | 100 | 92 | IV-22 | 100 | 84 |
IV-23 | 87 | 96 | IV-24 | 64 | 47 | IV-25 | 100 | 88 |
IV-27 | 57 | 74 | IV-31 | 45 | 7 | IV-37 | 100 | 90.1 |
IV-38 | 51 | 99 | VI-39 | 42 | 35 | IV-41 | 60 | 72 |
IV-42 | 44 | 0 | VI-43 | 42 | 4 | IV-47 | 28.8 | 26.4 |
IV-55 | 21 | 52 | IV-58 | 49 | 32 | IV-59 | 45 | 0 |
IV-60 | 37 | 66 | IV-61 | 6 | 56 | IV-62 | 64 | 42 |
化合物20mg/kg | 光电甩尾痛阈延长率(秒) | P值 | 热板法痛阈延长一倍以上 | 镇静作用 | 扭体反应(Ki) | 镇静作用 |
IV-12IV-14IV-21 | 34%37.9%28% | 0.0050.0050.001 | 100%100%100% | +++++++ | 10094100 | 979292 |
停药后不同时间(h) | 吗啡组 | IV-12(75mg/kg) | IV-12(75mg/kg) | 温开水组 | |||||
体重(g) | 增长(%) | 体重(g) | 增长(%) | 体重(g) | 增长(%) | 体重(g) | 增长(%) | ||
停药前 | 286.2±40 | 241.1±38 | 254.8±32 | 260.7±33 | |||||
12 | 284.7±40 | -0.5 | 248.1±42 | 2.9 | 259.8±34 | 2.0 | 264.3±37 | 1.4 | |
18 | 276.9±39 | -3.2 | 250.5±39 | 3.9 | 259.8±33 | 2.0 | 261.3±35 | 0.2 | |
24 | 267.9±37 | -6.4 | 246.3±37 | 2.2 | 255.9±32 | 0.4 | 263.2±33 | 1.0 | |
36 | 262.7±37 | -8.2 | 253.9±38 | 5.3 | 259.5±33 | 1.9 | 270.6±36 | 3.8 | |
42 | 258.4±35 | -9.7 | 251.3±37 | 4.3 | 258.5±32 | 1.4 | 264.3±34 | 1.4 | |
48 | 257.0±33 | -10.2 | 249.1±36 | 3.3 | 256.8±31 | 0.8 | 265.0±34 | 1.7 | |
60 | 256.6±31 | -10.3 | 258.5±38 | 7.2 | 259.6±31 | 1.9 | 268.3±30 | 2.9 | |
66 | 256.0±34 | -10.5 | 252.8±37 | 4.8 | 256.8±27 | 0.8 | 264.6±31 | 1.5 | |
72 | 260.4±36 | -9.0 | 251.6±36 | 4.4 | 255.7±29 | 0.4 | 265.6±34 | 1.9 | |
84 | 268.7±37 | -6.1 | 263.7±40 | 9.4 | 263.6±30 | 3.4 | 272.5±37 | 4.5 | |
90 | 264.7±37 | -7.5 | 257.4±39 | 6.8 | 258.2±30 | 1.3 | 267.4±36 | 2.6 | |
96 | 269.0±40 | -6.0 | 254.2±43 | 5.4 | 257.1±28 | 0.9 | 267.2±36 | 2.5 | |
108 | 277.6±38 | -3.0 | 268.6±42 | 11.4 | 266.3±33 | 4.5 | 274.1±39 | 5.1 | |
114 | 272.9±38 | -4.7 | 261.6±40 | 8.5 | 260.1±30 | 2.1 | 268.8±38 | 3.1 | |
120 | 275.4±40 | -3.8 | 260.3±40 | 8.0 | 258.3±29 | 1.4 | 270.1±39 | 3.6 | |
132 | 284.6±38 | -0.5 | 275.8±41 | 14.4 | 272.6±35 | 7.0 | 273.9±37 | 5.1 | |
138 | 279.3±38 | -2.4 | 268.3±41 | 11.3 | 264.9±32 | 4.0 | 269.6±37 | 3.4 | |
144 | 282.0±41 | -1.5 | 264.7±42 | 9.8 | 263.6±32 | 3.5 | 271.1±39 | 4.0 | |
156 | 291.0±40 | 1.7 | 279.0±44 | 15.7 | 271.5±40 | 6.6 | 279.5±40 | 7.2 | |
162 | 284.2±40 | -0.6 | 271.0±44 | 12.4 | 267.2±38 | 4.9 | 273.8±39 | 5.0 | |
168 | 286.5±42 | 0.1 | 269.2±45 | 11.7 | 266.3±36 | 4.5 | 272.9±40 | 4.7 |
组别 | 动物数 | 伴药盒停留时间百分率(%) |
对照组 | 10 | 48.8±10.3 |
吗啡组 | 8 | 62.0±8.0* |
IV-12 10mg/kg | 10 | 46.1±16.3 |
IV-12 20mg/kg | 10 | 51.9±9.8 |
IV-12 50mg/kg | 9 | 62.9±5.4* |
Claims (8)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021117861A CN1150176C (zh) | 2002-05-22 | 2002-05-22 | 芳烷酮哌嗪衍生物及其应用 |
AU2003236133A AU2003236133A1 (en) | 2002-05-22 | 2003-04-16 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent |
US10/515,308 US7332495B2 (en) | 2002-05-22 | 2003-04-16 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent |
PCT/CN2003/000274 WO2003097623A1 (fr) | 2002-05-22 | 2003-04-16 | Derives de piperazine aralkyle cetone et leurs utilisations en tant qu'agents antalgiques ou ataraxiques |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021117861A CN1150176C (zh) | 2002-05-22 | 2002-05-22 | 芳烷酮哌嗪衍生物及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1381449A true CN1381449A (zh) | 2002-11-27 |
CN1150176C CN1150176C (zh) | 2004-05-19 |
Family
ID=4741745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021117861A Expired - Lifetime CN1150176C (zh) | 2002-05-22 | 2002-05-22 | 芳烷酮哌嗪衍生物及其应用 |
Country Status (4)
Country | Link |
---|---|
US (1) | US7332495B2 (zh) |
CN (1) | CN1150176C (zh) |
AU (1) | AU2003236133A1 (zh) |
WO (1) | WO2003097623A1 (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009152647A1 (zh) | 2008-06-20 | 2009-12-23 | 江苏恩华药业股份有限公司 | 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用 |
WO2011012075A1 (zh) * | 2009-07-29 | 2011-02-03 | 江苏恩华药业股份有限公司 | 取代苯基哌嗪芳烷酮衍生物及其在制备镇痛药物中的应用 |
CN101260075B (zh) * | 2007-03-07 | 2011-03-16 | 江苏恩华药业股份有限公司 | 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用 |
CN101759665B (zh) * | 2008-12-23 | 2012-03-28 | 江苏恩华药业股份有限公司 | 取代苯基哌嗪芳烷醇衍生物及其在制备镇痛药物中的应用 |
CN102603679A (zh) * | 2012-03-12 | 2012-07-25 | 中国药科大学 | 一类苯丙基哌嗪衍生物及其镇痛用途 |
CN103360305A (zh) * | 2012-04-09 | 2013-10-23 | 江苏恩华药业股份有限公司 | 取代芳基哌嗪芳烷酮衍生物及其在制备镇痛药物中的应用 |
CN103420940A (zh) * | 2012-05-17 | 2013-12-04 | 上海医药工业研究院 | 芳烷环烷胺哌嗪衍生物及作为多靶点抗抑郁药的应用 |
CN105418506A (zh) * | 2014-09-19 | 2016-03-23 | 上海医药工业研究院 | 乙酰苄胺哌嗪类衍生物及其作为脑神经保护剂的应用 |
CN107021940A (zh) * | 2017-05-03 | 2017-08-08 | 天津国际生物医药联合研究院 | 一种双哌嗪类化合物及其应用 |
US10800757B2 (en) | 2017-10-27 | 2020-10-13 | Boehringer Ingelheim International Gmbh | Inhibitors of TRPC6 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009506987A (ja) | 2005-08-02 | 2009-02-19 | ニューロゲン コーポレイション | ジピペラジニルケトンおよび関連する類似体 |
CA2651732C (en) | 2006-05-18 | 2014-10-14 | Mannkind Corporation | Intracellular kinase inhibitors |
EP2142529B1 (en) | 2007-04-27 | 2013-12-25 | Purdue Pharma LP | Trpv1 antagonists and uses thereof |
EP2149373A1 (en) * | 2008-08-01 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | 5HT7 receptor ligands and compositions comprising the same |
RU2621708C2 (ru) | 2011-06-22 | 2017-06-07 | ПУРДЬЮ ФАРМА Эл. Пи. | Антагонисты trpv1, включающие дигидроксигруппу в качестве заместителя, и их применение |
EP3027607B1 (en) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
US9714232B2 (en) | 2013-12-20 | 2017-07-25 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8827189D0 (en) * | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
EP0558245A1 (en) | 1992-02-25 | 1993-09-01 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors |
RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
AU6050500A (en) * | 1999-07-21 | 2001-02-13 | Eli Lilly And Company | Benzothiophene derivatives |
-
2002
- 2002-05-22 CN CNB021117861A patent/CN1150176C/zh not_active Expired - Lifetime
-
2003
- 2003-04-16 US US10/515,308 patent/US7332495B2/en not_active Expired - Lifetime
- 2003-04-16 AU AU2003236133A patent/AU2003236133A1/en not_active Abandoned
- 2003-04-16 WO PCT/CN2003/000274 patent/WO2003097623A1/zh not_active Application Discontinuation
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101260075B (zh) * | 2007-03-07 | 2011-03-16 | 江苏恩华药业股份有限公司 | 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用 |
US8501778B2 (en) | 2008-06-20 | 2013-08-06 | Nhwa Pharma. Corporation | Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent |
WO2009152647A1 (zh) | 2008-06-20 | 2009-12-23 | 江苏恩华药业股份有限公司 | 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用 |
CN101759665B (zh) * | 2008-12-23 | 2012-03-28 | 江苏恩华药业股份有限公司 | 取代苯基哌嗪芳烷醇衍生物及其在制备镇痛药物中的应用 |
WO2011012075A1 (zh) * | 2009-07-29 | 2011-02-03 | 江苏恩华药业股份有限公司 | 取代苯基哌嗪芳烷酮衍生物及其在制备镇痛药物中的应用 |
CN102603679B (zh) * | 2012-03-12 | 2014-10-08 | 中国药科大学 | 一类苯丙基哌嗪衍生物及其镇痛用途 |
CN102603679A (zh) * | 2012-03-12 | 2012-07-25 | 中国药科大学 | 一类苯丙基哌嗪衍生物及其镇痛用途 |
CN103360305A (zh) * | 2012-04-09 | 2013-10-23 | 江苏恩华药业股份有限公司 | 取代芳基哌嗪芳烷酮衍生物及其在制备镇痛药物中的应用 |
CN103360305B (zh) * | 2012-04-09 | 2015-12-16 | 江苏恩华药业股份有限公司 | 取代芳基哌嗪芳烷酮衍生物及其在制备镇痛药物中的应用 |
CN103420940B (zh) * | 2012-05-17 | 2014-09-17 | 上海医药工业研究院 | 芳烷环烷胺哌嗪衍生物及作为多靶点抗抑郁药的应用 |
CN103420940A (zh) * | 2012-05-17 | 2013-12-04 | 上海医药工业研究院 | 芳烷环烷胺哌嗪衍生物及作为多靶点抗抑郁药的应用 |
CN105418506A (zh) * | 2014-09-19 | 2016-03-23 | 上海医药工业研究院 | 乙酰苄胺哌嗪类衍生物及其作为脑神经保护剂的应用 |
CN105418506B (zh) * | 2014-09-19 | 2018-04-24 | 上海医药工业研究院 | 乙酰苄胺哌嗪类衍生物及其作为脑神经保护剂的应用 |
CN107021940A (zh) * | 2017-05-03 | 2017-08-08 | 天津国际生物医药联合研究院 | 一种双哌嗪类化合物及其应用 |
US10800757B2 (en) | 2017-10-27 | 2020-10-13 | Boehringer Ingelheim International Gmbh | Inhibitors of TRPC6 |
US10889568B2 (en) | 2017-10-27 | 2021-01-12 | Boehringer Ingelheim International Gmbh | Inhibitors of TRPC6 |
USRE49699E1 (en) | 2017-10-27 | 2023-10-17 | Boehringer Ingelheim International Gmbh | Inhibitors of TRPC6 |
Also Published As
Publication number | Publication date |
---|---|
CN1150176C (zh) | 2004-05-19 |
US20060148811A1 (en) | 2006-07-06 |
WO2003097623A1 (fr) | 2003-11-27 |
AU2003236133A1 (en) | 2003-12-02 |
US7332495B2 (en) | 2008-02-19 |
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Owner name: JIANGSU ENHUA PHARMACEUTICAL GROUP CO.,LTD.; SHAN Free format text: FORMER OWNER: SHANGHAI MEDICINE INDUSTRY ACADEME Effective date: 20061110 |
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Effective date of registration: 20061110 Address after: 221007 No. 289, Zhongshan North Road, Jiangsu, Xuzhou Patentee after: Jiangsu Nhwa Pharmaceutical Group Co., Ltd. Address before: 200040 No. 1320 West Beijing Road, Shanghai Co-patentee before: Shanghai Institute of pharmaceutical industry Patentee before: Shanghai Institute of pharmaceutical industry |
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C56 | Change in the name or address of the patentee |
Owner name: JIANGSU NHWA PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: JIANGSU NHUA PHARM GROUP CO.,LTD. |
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CP01 | Change in the name or title of a patent holder |
Address after: 221007 Zhongshan North Road, Jiangsu, No. 289, Co-patentee after: Shanghai Institute of pharmaceutical industry Patentee after: Jiangsu Nhwa Pharmaceutical Co., Ltd. Address before: 221007 Zhongshan North Road, Jiangsu, No. 289, Co-patentee before: Shanghai Institute of pharmaceutical industry Patentee before: Jiangsu Nhwa Pharmaceutical Group Co., Ltd. |
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C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 221007 Xuzhou Economic Development Zone, Jiangsu, Yang Road, No. 18 Patentee after: Jiangsu Nhwa Pharmaceutical Co., Ltd. Patentee after: Shanghai Institute of pharmaceutical industry Address before: 221007 Zhongshan North Road, Jiangsu, No. 289, Patentee before: Jiangsu Nhwa Pharmaceutical Co., Ltd. Patentee before: Shanghai Institute of pharmaceutical industry |
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CX01 | Expiry of patent term |
Granted publication date: 20040519 |
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CX01 | Expiry of patent term |