CN1368122A - Nano antivirus medicine and its preparing process - Google Patents
Nano antivirus medicine and its preparing process Download PDFInfo
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- CN1368122A CN1368122A CN 01102353 CN01102353A CN1368122A CN 1368122 A CN1368122 A CN 1368122A CN 01102353 CN01102353 CN 01102353 CN 01102353 A CN01102353 A CN 01102353A CN 1368122 A CN1368122 A CN 1368122A
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Abstract
A nanometre (0.1-200 nm) antivirus medicine is prepared from the nanometre powders of 9 Chinese medicinal materials including gypsum, anemarrhena rhizome, isatis root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano antivirus medicine of a kind of clearing heat and expelling damp, removing pathogenic heat from blood and toxic substance from the body, the invention still further relates to the method for this medication preparation.
The antiviral bolt is a kind of classical Chinese patent medicine, mainly contains effects such as analgesic, antiviral, is used for anemopyretic cold, epidemic febrile disease heating and upper respiratory tract infection, influenza, parotitis, epidemic hemorrhagic conjunctivitis viral illness such as (pink eye disease).But traditional antiviral bolt uses inconvenient, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano antivirus medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano antivirus medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Gypsum Fibrosum 50-120 part nanometer Rhizoma Anemarrhenae 15-60 part nano Radix Isatidis 120-250 part
Nanometer Fructus Forsythiae 40-90 part nanometer Radix Rehmanniae 25-80 part nanometer Rhizoma Acori Graminei 20-55 part
Nanometer Rhizoma Phragmitis 50-120 part nanometer Radix Curcumae 20-55 part nanometer Herba Pogostemonis 25-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Gypsum Fibrosum 60-100 part nanometer Rhizoma Anemarrhenae 20-50 part nano Radix Isatidis 150-210 part
Nanometer Fructus Forsythiae 50-80 part nanometer Radix Rehmanniae 30-60 part nanometer Rhizoma Acori Graminei 25-45 part
Nanometer Rhizoma Phragmitis 60-100 part nanometer Radix Curcumae 25-45 part nanometer Herba Pogostemonis 30-50 part
The optimum weight proportioning of medicine of the present invention is:
180 parts of 35 parts of nano Radix Isatidis of 80 parts of nanometer Rhizoma Anemarrhenaes of nanometer Gypsum Fibrosum
35 parts of 45 parts of nanometer Rhizoma Acori Graminei of 65 parts of nanometer Radix Rehmanniae of nanometer Fructus Forsythiae
40 parts of 35 parts of nanometer Herba Pogostemonis of 85 parts of nanometer Radix Curcumaes of nanometer Rhizoma Phragmitis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the anti-virus formulation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano antivirus medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common antiviral bolt preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano antivirus medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of conditions such as flu, inflammation of upper respiratory tract, bronchitis, pneumonia, parotitis and epidemic hemorrhagic conjunctivitis due to the viral infection, and clinical efficacy significantly is better than traditional antiviral bolt.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
180 parts of 35 parts of nano Radix Isatidis of 80 parts of nanometer Rhizoma Anemarrhenaes of nanometer Gypsum Fibrosum
35 parts of 45 parts of nanometer Rhizoma Acori Graminei of 65 parts of nanometer Radix Rehmanniae of nanometer Fructus Forsythiae
40 parts of 35 parts of nanometer Herba Pogostemonis of 85 parts of nanometer Radix Curcumaes of nanometer Rhizoma Phragmitis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
180 parts of 35 parts of nano Radix Isatidis of 80 parts of nanometer Rhizoma Anemarrhenaes of nanometer Gypsum Fibrosum
35 parts of 45 parts of nanometer Rhizoma Acori Graminei of 65 parts of nanometer Radix Rehmanniae of nanometer Fructus Forsythiae
40 parts of 35 parts of nanometer Herba Pogostemonis of 85 parts of nanometer Radix Curcumaes of nanometer Rhizoma Phragmitis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano antivirus powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
180 parts of 35 parts of nano Radix Isatidis of 80 parts of nanometer Rhizoma Anemarrhenaes of nanometer Gypsum Fibrosum
35 parts of 45 parts of nanometer Rhizoma Acori Graminei of 65 parts of nanometer Radix Rehmanniae of nanometer Fructus Forsythiae
40 parts of 35 parts of nanometer Herba Pogostemonis of 85 parts of nanometer Radix Curcumaes of nanometer Rhizoma Phragmitis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano antivirus membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano antivirus medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Gypsum Fibrosum 50-120 part nanometer Rhizoma Anemarrhenae 15-60 part nano Radix Isatidis 120-250 part
Nanometer Fructus Forsythiae 40-90 part nanometer Radix Rehmanniae 25-80 part nanometer Rhizoma Acori Graminei 20-55 part
Nanometer Rhizoma Phragmitis 50-120 part nanometer Radix Curcumae 20-55 part nanometer Herba Pogostemonis 25-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano antivirus medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Gypsum Fibrosum 60-100 part nanometer Rhizoma Anemarrhenae 20-50 part nano Radix Isatidis 150-210 part
Nanometer Fructus Forsythiae 50-80 part nanometer Radix Rehmanniae 30-60 part nanometer Rhizoma Acori Graminei 25-45 part
Nanometer Rhizoma Phragmitis 60-100 part nanometer Radix Curcumae 25-45 part nanometer Herba Pogostemonis 30-50 part
3, nano antivirus medicine according to claim 1, wherein the weight proportion of each nano raw material is:
180 parts of 35 parts of nano Radix Isatidis of 80 parts of nanometer Rhizoma Anemarrhenaes of nanometer Gypsum Fibrosum
35 parts of 45 parts of nanometer Rhizoma Acori Graminei of 65 parts of nanometer Radix Rehmanniae of nanometer Fructus Forsythiae
40 parts of 35 parts of nanometer Herba Pogostemonis of 85 parts of nanometer Radix Curcumaes of nanometer Rhizoma Phragmitis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano antivirus medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano antivirus medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102353 CN1368122A (en) | 2001-02-02 | 2001-02-02 | Nano antivirus medicine and its preparing process |
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| CN 01102353 CN1368122A (en) | 2001-02-02 | 2001-02-02 | Nano antivirus medicine and its preparing process |
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| CN 01102353 Pending CN1368122A (en) | 2001-02-02 | 2001-02-02 | Nano antivirus medicine and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306930C (en) * | 2003-05-05 | 2007-03-28 | 广州白云山医药科技发展有限公司 | Soft antiviral capsule and its prepn |
| CN105477558A (en) * | 2016-01-04 | 2016-04-13 | 成都富豪斯生物科技有限公司 | Decoction drug for treating upper respiratory infection and preparation method thereof |
-
2001
- 2001-02-02 CN CN 01102353 patent/CN1368122A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306930C (en) * | 2003-05-05 | 2007-03-28 | 广州白云山医药科技发展有限公司 | Soft antiviral capsule and its prepn |
| CN105477558A (en) * | 2016-01-04 | 2016-04-13 | 成都富豪斯生物科技有限公司 | Decoction drug for treating upper respiratory infection and preparation method thereof |
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