CN1368060A - Nano defervescent and digestion-promoting medicine and its preparing process - Google Patents
Nano defervescent and digestion-promoting medicine and its preparing process Download PDFInfo
- Publication number
- CN1368060A CN1368060A CN 01100899 CN01100899A CN1368060A CN 1368060 A CN1368060 A CN 1368060A CN 01100899 CN01100899 CN 01100899 CN 01100899 A CN01100899 A CN 01100899A CN 1368060 A CN1368060 A CN 1368060A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- part nanometer
- digestion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) medicine for helping digestion and reducing fever is prepared from the nanometre powders of 10 Chinese medicinal materials including bupleurum root, scutellaria root, anemarrhena rhizome, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, the relieving constipation that helps digestion, cure mainly the stagnate nano defervescent and digestion-promoting medicine of excess-heat of child's diseases caused by exogenous pathogenic factor folders, the invention still further relates to the method for this medication preparation.
The syrup of bringing down a fever of helping digestion is a kind of classical Chinese patent medicine, mainly contains heat-clearing and toxic substances removing, effect such as the relieving constipation that helps digestion, and is used for the excess-heat that child's diseases caused by exogenous pathogenic factor folder stagnates.Syrup absorbs not exclusively but traditional helping digestion brought down a fever, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano defervescent and digestion-promoting medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano defervescent and digestion-promoting medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bupleurum 10-50 part nanometer Radix Scutellariae 5-50 part nanometer Rhizoma Anemarrhenae 10-50 part
Nanometer Herba Artemisiae Annuae 10-50 part nanometer Semen Arecae 5-50 part nanometer Cortex Magnoliae Officinalis 10-50 part
Nanometer Pulvis Cornus Bubali Concentratus 5-40 part nanometer Cortex Moutan 10-50 part
Nanometer Herba Schizonepetae 10-50 part nano rhubarb 10-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano bupleurum 20-40 part nanometer Radix Scutellariae 15-35 part nanometer Rhizoma Anemarrhenae 20-40 part
Nanometer Herba Artemisiae Annuae 20-40 part nanometer Semen Arecae 15-40 part nanometer Cortex Magnoliae Officinalis 20-40 part
Nanometer Pulvis Cornus Bubali Concentratus 10-30 part nanometer Cortex Moutan 20-40 part
Nanometer Herba Schizonepetae 20-40 part nano rhubarb 20-40 part
The optimum weight proportioning of medicine of the present invention is:
28 parts of 25 parts of nanometer Rhizoma Anemarrhenaes of 30 parts of nanometer Radix Scutellariaes of nano bupleurum
30 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 30 portions of nanometer Semen Arecaes of nanometer Herba Artemisiae Annuae
30 parts of 20 parts of nanometer Cortex Moutans of nanometer Pulvis Cornus Bubali Concentratus
30 parts of 28 parts of nano rhubarbs of nanometer Herba Schizonepetae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the defervescent and digestion-promoting nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano defervescent and digestion-promoting medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common help digestion bring down a fever the syrup preparation material be the micron or the millimeter above particle diameter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum of nano defervescent and digestion-promoting medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of conditions such as excess-heat that virgin diseases caused by exogenous pathogenic factor folder stagnates, and clinical efficacy significantly is better than traditional syrup of bringing down a fever that helps digestion.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Rhizoma Anemarrhenaes of 30 parts of nanometer Radix Scutellariaes of nano bupleurum
30 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 30 portions of nanometer Semen Arecaes of nanometer Herba Artemisiae Annuae
30 parts of 20 parts of nanometer Cortex Moutans of nanometer Pulvis Cornus Bubali Concentratus
30 parts of 28 parts of nano rhubarbs of nanometer Herba Schizonepetae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Rhizoma Anemarrhenaes of 30 parts of nanometer Radix Scutellariaes of nano bupleurum
30 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 30 portions of nanometer Semen Arecaes of nanometer Herba Artemisiae Annuae
30 parts of 20 parts of nanometer Cortex Moutans of nanometer Pulvis Cornus Bubali Concentratus
30 parts of 28 parts of nano rhubarbs of nanometer Herba Schizonepetae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making help digestion acetanilide powder needle injection, every injection content of nanometer is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer Rhizoma Anemarrhenaes of 30 parts of nanometer Radix Scutellariaes of nano bupleurum
30 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 30 portions of nanometer Semen Arecaes of nanometer Herba Artemisiae Annuae
30 parts of 20 parts of nanometer Cortex Moutans of nanometer Pulvis Cornus Bubali Concentratus
30 parts of 28 parts of nano rhubarbs of nanometer Herba Schizonepetae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer membrane of bringing down a fever that helps digestion, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano defervescent and digestion-promoting medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano bupleurum 10-50 part nanometer Radix Scutellariae 5-50 part nanometer Rhizoma Anemarrhenae 10-50 part
Nanometer Herba Artemisiae Annuae 10-50 part nanometer Semen Arecae 5-50 part nanometer Cortex Magnoliae Officinalis 10-50 part
Nanometer Pulvis Cornus Bubali Concentratus 5-40 part nanometer Cortex Moutan 10-.50 part
Nanometer Herba Schizonepetae 10-50 part nano rhubarb 10-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano defervescent and digestion-promoting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bupleurum 20-40 part nanometer Radix Scutellariae 15-35 part nanometer Rhizoma Anemarrhenae 20-40 part
Nanometer Herba Artemisiae Annuae 20-40 part nanometer Semen Arecae 15-40 part nanometer Cortex Magnoliae Officinalis 20-40 part
Nanometer Pulvis Cornus Bubali Concentratus 10-30 part nanometer Cortex Moutan 20-40 part
Nanometer Herba Schizonepetae 20-40 part nano rhubarb 20-40 part
3, nano defervescent and digestion-promoting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
28 parts of 25 parts of nanometer Rhizoma Anemarrhenaes of 30 parts of nanometer Radix Scutellariaes of nano bupleurum
30 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 30 portions of nanometer Semen Arecaes of nanometer Herba Artemisiae Annuae
30 parts of 20 parts of nanometer Cortex Moutans of nanometer Pulvis Cornus Bubali Concentratus
30 parts of 28 parts of nano rhubarbs of nanometer Herba Schizonepetae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano defervescent and digestion-promoting medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano defervescent and digestion-promoting medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100899 CN1368060A (en) | 2001-01-31 | 2001-01-31 | Nano defervescent and digestion-promoting medicine and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100899 CN1368060A (en) | 2001-01-31 | 2001-01-31 | Nano defervescent and digestion-promoting medicine and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368060A true CN1368060A (en) | 2002-09-11 |
Family
ID=4651987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100899 Pending CN1368060A (en) | 2001-01-31 | 2001-01-31 | Nano defervescent and digestion-promoting medicine and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368060A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166295A (en) * | 2011-04-15 | 2011-08-31 | 但照荣 | Traditional Chinese medicine composition for treating carcinosis |
-
2001
- 2001-01-31 CN CN 01100899 patent/CN1368060A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166295A (en) * | 2011-04-15 | 2011-08-31 | 但照荣 | Traditional Chinese medicine composition for treating carcinosis |
| CN102166295B (en) * | 2011-04-15 | 2012-05-23 | 但照荣 | Traditional Chinese medicine composition for treating carcinosis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368110A (en) | Nano medicine 'Yaoai' and its preparing process | |
| CN1368060A (en) | Nano defervescent and digestion-promoting medicine and its preparing process | |
| CN1368187A (en) | Nano medicine 'Tongqiaobiyan' and its preparing process | |
| CN1364505A (en) | Nano seven ingredient iron filing medicine and its prepairng method | |
| CN1368302A (en) | Nano medicine for treating infantile dysentery and its preparing process | |
| CN1366966A (en) | Nano pinellia preparation medicine and preparation method | |
| CN1365676A (en) | Nano medicine 'Compound berberine' and its preparing process | |
| CN1365778A (en) | Nano medicine 'Qinlian' and its preparing process | |
| CN1364581A (en) | Nano Children heat fast clearing away medicine and its preparing method | |
| CN1368099A (en) | Nano medicine 'Xiaoyin' and its preparing process | |
| CN1368357A (en) | Nano medicine 'Weitongding' and its preparing process | |
| CN1365735A (en) | Nano medicine for treating burn and its preparing process | |
| CN1368071A (en) | Nano medicine 'Qianzihong' and its preparing process | |
| CN1364558A (en) | Nano wet and heat astralgia treating medicine and its preparing method | |
| CN1368183A (en) | Nano medicine for treating diseases due to summer heat and its preparing process | |
| CN1365715A (en) | Nano medicine 'Jiuqi Niantong' and its preparing process | |
| CN1365683A (en) | Nano medicine 'Dahuang Qingwei' and its preparing process | |
| CN1365709A (en) | Nano medicine for child to relieve cough and its preparing process | |
| CN1365736A (en) | Nano medicine for treating coronary heart disease and its preparing process | |
| CN1364583A (en) | Nano chilren heat clearing away medicine and its preparing method | |
| CN1368199A (en) | Nano medicine for treating deafness and its preparing process | |
| CN1365802A (en) | Nano antitussive loquat medicine and its preparing process | |
| CN1368170A (en) | Nano medicine 'Shenshu' and its preparing process | |
| CN1362121A (en) | Nano Shangqing medicine and its preparation | |
| CN1368259A (en) | Nano medicine 'Yangweining' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |