CN1342144A - 用作雌激素药物的n－取代的苯甲酰基吲哚类化合物 - Google Patents

用作雌激素药物的n－取代的苯甲酰基吲哚类化合物 Download PDF

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Publication number
CN1342144A
CN1342144A CN00804545A CN00804545A CN1342144A CN 1342144 A CN1342144 A CN 1342144A CN 00804545 A CN00804545 A CN 00804545A CN 00804545 A CN00804545 A CN 00804545A CN 1342144 A CN1342144 A CN 1342144A
Authority
CN
China
Prior art keywords
compound
pharmaceutically useful
alkyl
formula
useful salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00804545A
Other languages
English (en)
Chinese (zh)
Inventor
M·C·科科
J·W·乌尔里奇
A·A·桑蒂利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of CN1342144A publication Critical patent/CN1342144A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CN00804545A 1999-03-04 2000-02-22 用作雌激素药物的n－取代的苯甲酰基吲哚类化合物 Pending CN1342144A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26241399A 1999-03-04 1999-03-04
US09/262,413 1999-03-04

Publications (1)

Publication Number Publication Date
CN1342144A true CN1342144A (zh) 2002-03-27

Family

ID=22997395

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00804545A Pending CN1342144A (zh) 1999-03-04 2000-02-22 用作雌激素药物的n－取代的苯甲酰基吲哚类化合物

Country Status (8)

Country Link
EP (1) EP1159268A1 (fr)
JP (1) JP2002538141A (fr)
CN (1) CN1342144A (fr)
AR (1) AR022797A1 (fr)
AU (1) AU3859400A (fr)
CA (1) CA2364914A1 (fr)
MX (1) MXPA01008911A (fr)
WO (1) WO2000051983A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100506795C (zh) * 2003-06-18 2009-07-01 中国科学院上海药物研究所 茚酮并吲哚类化合物、制备方法及它的医学用途

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998402A (en) 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
US6933316B2 (en) 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
EP1542967A1 (fr) 2002-09-20 2005-06-22 Pfizer Products Inc. Ligands d'amides et de sulfonamides du recepteur oestrogenique
US7250440B2 (en) * 2003-08-12 2007-07-31 Wyeth (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
JP5635493B2 (ja) 2008-04-16 2014-12-03 カロ バイオ アクチェブラーグ 新規エストロゲン受容体リガンド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2135160A1 (fr) * 1992-05-08 1993-11-25 Masatoshi Inai Derive de l'indole
EP0802183B1 (fr) * 1996-04-19 2001-10-10 American Home Products Corporation Composés oestrogènes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100506795C (zh) * 2003-06-18 2009-07-01 中国科学院上海药物研究所 茚酮并吲哚类化合物、制备方法及它的医学用途

Also Published As

Publication number Publication date
JP2002538141A (ja) 2002-11-12
CA2364914A1 (fr) 2000-09-08
AR022797A1 (es) 2002-09-04
MXPA01008911A (es) 2002-10-23
WO2000051983A1 (fr) 2000-09-08
EP1159268A1 (fr) 2001-12-05
AU3859400A (en) 2000-09-21

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent for invention or patent application
CB02 Change of applicant information

Applicant after: Wyeth Corp.

Applicant before: American Home Products Corp.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: AMERICAN HOME PRODUCTS CORP. TO: WYETH CORP.

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication