CN1331751A - 改进的头孢菌素的体内生产方法 - Google Patents

改进的头孢菌素的体内生产方法 Download PDF

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Publication number
CN1331751A
CN1331751A CN99814782A CN99814782A CN1331751A CN 1331751 A CN1331751 A CN 1331751A CN 99814782 A CN99814782 A CN 99814782A CN 99814782 A CN99814782 A CN 99814782A CN 1331751 A CN1331751 A CN 1331751A
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CN
China
Prior art keywords
aca
nucleotide sequence
acidylate
acid
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99814782A
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English (en)
Chinese (zh)
Inventor
R·A·L·博文博格
R·科克曼
E·科汉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
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DSM NV
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Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Publication of CN1331751A publication Critical patent/CN1331751A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN99814782A 1998-12-22 1999-12-21 改进的头孢菌素的体内生产方法 Pending CN1331751A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204469 1998-12-22
EP98204469.5 1998-12-22

Publications (1)

Publication Number Publication Date
CN1331751A true CN1331751A (zh) 2002-01-16

Family

ID=8234568

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99814782A Pending CN1331751A (zh) 1998-12-22 1999-12-21 改进的头孢菌素的体内生产方法

Country Status (7)

Country Link
EP (1) EP1141372A2 (fr)
JP (1) JP2002533092A (fr)
KR (1) KR20010089672A (fr)
CN (1) CN1331751A (fr)
AU (1) AU3042600A (fr)
HK (1) HK1041610A1 (fr)
WO (1) WO2000037671A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101555463B (zh) * 2008-04-08 2012-05-30 中国科学院上海生命科学研究院湖州工业生物技术中心 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法
CN110214188A (zh) * 2016-08-26 2019-09-06 艾美科健株式会社 7-氨基头孢烷酸的高浓度生产重组顶头孢霉菌株的制造方法及利用其方法所制造的菌株

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ES2522622T3 (es) 2007-11-20 2014-11-17 Dsm Ip Assets B.V. Producción de ácido succínico en una célula eucariota
ES2389989T3 (es) 2007-11-20 2012-11-05 Dsm Ip Assets B.V. Producción de ácido dicarboxílico en levadura recombinante
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US9353387B2 (en) 2009-04-15 2016-05-31 Dsm Ip Assets B.V. Dicarboxylic acid production process
UA108853C2 (uk) 2009-07-10 2015-06-25 Спосіб ферментації галактози
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EP2388331A1 (fr) 2010-05-21 2011-11-23 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Promoteur constitutif
EP2627765B1 (fr) 2010-10-13 2017-05-10 DSM IP Assets B.V. Cellules de levure de fermentation à base de pentose et de glucose
EP2699589A2 (fr) 2011-04-22 2014-02-26 DSM IP Assets B.V. Cellule de levure pouvant convertir des sucres comprenant l'arabinose et le xylose
EP2554668A1 (fr) 2011-08-04 2013-02-06 DSM IP Assets B.V. Cellule de fermentation de sucre de pentose
AR087423A1 (es) 2011-08-04 2014-03-19 Dsm Ip Assets Bv Celula capaz de fermentar azucares pentosas
AU2013211605B2 (en) 2012-01-23 2017-04-06 Dsm Ip Assets B.V. Diterpene production
CN112195145A (zh) 2012-10-16 2021-01-08 帝斯曼知识产权资产管理有限公司 具有改善的戊糖转化的细胞
EP2772545A1 (fr) 2013-03-01 2014-09-03 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Protéines d'amidon actives
WO2014161988A1 (fr) 2013-04-05 2014-10-09 Université Du Luxembourg Production biotechnologique d'acide itaconique
EP2992105A1 (fr) 2013-05-02 2016-03-09 Dutch DNA Biotech B.V. Nouvelle voie de l'acide organique
WO2014191581A2 (fr) 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Microorganismes utilisables en vue de la production de diterpène
WO2015007748A1 (fr) 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Production de diterpène
US20160185813A1 (en) 2013-07-31 2016-06-30 Dsm Ip Assets B.V. Recovery of steviol glycosides
US10443077B2 (en) 2015-02-16 2019-10-15 Dsm Ip Assets B.V. Fermentation process for producing itaconic acid under nitrogen free conditions
BR112017019625A2 (pt) 2015-03-16 2018-05-08 Dsm Ip Assets Bv udp-glicosiltransferases
EP3274448B1 (fr) 2015-03-23 2021-08-11 DSM IP Assets B.V. Udp-glycosyltransférases de solanum lycopersicum
EP3277829B1 (fr) 2015-04-03 2020-07-08 DSM IP Assets B.V. Glycosides de stéviol
CN107532141A (zh) 2015-04-21 2018-01-02 帝斯曼知识产权资产管理有限公司 香叶基香叶基焦磷酸合酶
CN107636144B (zh) 2015-05-22 2021-02-19 帝斯曼知识产权资产管理有限公司 消耗乙酸盐/酯的酵母细胞
EP3320104B1 (fr) 2015-07-10 2021-11-10 DSM IP Assets B.V. Procédé de préparation d'une composition de glycoside de stéviol
CN107922913B (zh) 2015-08-13 2022-04-05 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷转运
WO2017050652A1 (fr) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
CA2999638A1 (fr) 2015-10-05 2017-04-13 Dsm Ip Assets B.V. Hydroxylases de l'acide kaurenoique
PL3359655T3 (pl) 2015-10-06 2020-05-18 Dsm Ip Assets B.V. Komórka eukariotyczna ze zwiększonym wytwarzaniem produktu fermentacji
BR112018013385A2 (pt) 2015-12-30 2018-12-04 Dsm Ip Assets Bv hidrólise enzimática parcial de triacilgliceróis
JP2019500041A (ja) 2015-12-30 2019-01-10 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． トリアシルグリセロールの部分的酵素加水分解
EP3435770A1 (fr) 2016-03-31 2019-02-06 DSM IP Assets B.V. Production de lait à faible teneur en lactose
WO2017167849A1 (fr) 2016-03-31 2017-10-05 Dsm Ip Assets B.V. Composition enzymatique et préparation d'un produit laitier aux propriétés améliorées
WO2017167848A1 (fr) 2016-03-31 2017-10-05 Dsm Ip Assets B.V. Composition enzymatique et préparation d'un produit laitier ayant des propriétés améliorées
WO2017216136A1 (fr) 2016-06-14 2017-12-21 Dsm Ip Assets B.V. Cellule de levure recombinée
CN109689864B (zh) 2016-07-13 2023-04-04 帝斯曼知识产权资产管理有限公司 苹果酸脱氢酶
BR112019002417B1 (pt) 2016-08-09 2023-05-02 Dsm Ip Assets B.V. Cristalização de glicosídeos de esteviol
US20190169220A1 (en) 2016-08-09 2019-06-06 Dsm Ip Assets B.V. Crystallization of steviol glycosides
US11066681B2 (en) 2016-08-26 2021-07-20 Lesaffre Et Compagnie Production of itaconic acid
WO2018073107A1 (fr) 2016-10-19 2018-04-26 Dsm Ip Assets B.V. Cellule eucaryote comprenant de la xylose isomérase
CN109890961B (zh) 2016-10-27 2024-03-08 帝斯曼知识产权资产管理有限公司 香叶基香叶基焦磷酸酯合酶
CN110072995B (zh) 2016-12-08 2024-05-10 帝斯曼知识产权资产管理有限公司 贝壳杉烯酸羟化酶
WO2018114912A1 (fr) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Variants d'enzyme lipolytique
US10918113B2 (en) 2016-12-21 2021-02-16 Dsm Ip Assets B.V. Lipolytic enzyme variants
US10889807B2 (en) 2016-12-21 2021-01-12 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114938A1 (fr) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Variants d'enzyme lipolytique
WO2018114995A1 (fr) 2016-12-22 2018-06-28 Dsm Ip Assets B.V. Procédés de fermentation pour la production de glycosides de stéviol
EP3638770B1 (fr) 2017-06-13 2023-01-18 DSM IP Assets B.V. Cellule de levure de recombinaison
CN110892068B (zh) 2017-06-27 2024-03-08 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
CA3074001A1 (fr) 2017-09-26 2019-04-04 Dsm Ip Assets B.V. Souche consommatrice d'acide acetique
EP3533878A1 (fr) 2018-02-28 2019-09-04 Dutch DNA Biotech B.V. Procédé de production d'acide 2-hydroxy-2-méthylsuccinique en utilisant d'aspergillus
CN112292037B (zh) 2018-06-19 2024-03-22 帝斯曼知识产权资产管理有限公司 脂解酶变体
EP4232568A1 (fr) 2020-10-22 2023-08-30 DSM IP Assets B.V. Microorganismes pour la production de diterpènes
CA3225417A1 (fr) 2021-06-24 2022-12-29 Fonterra Co-Operative Group Limited Proteines de recombinaison
WO2023285294A1 (fr) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Cellule de levure recombinée
WO2023285281A1 (fr) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Cellule de levure recombinée
WO2023285280A1 (fr) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Cellule de levure recombinante
CN117916381A (zh) 2021-07-12 2024-04-19 丹尼斯科美国公司 重组酵母细胞
CN117940570A (zh) 2021-07-12 2024-04-26 丹尼斯科美国公司 重组酵母细胞
CN118215740A (zh) 2021-11-04 2024-06-18 丹尼斯科美国公司 用于生产乙醇的方法和重组酵母细胞
CN118176296A (zh) 2021-11-04 2024-06-11 丹尼斯科美国公司 重组酵母细胞
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101555463B (zh) * 2008-04-08 2012-05-30 中国科学院上海生命科学研究院湖州工业生物技术中心 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法
CN110214188A (zh) * 2016-08-26 2019-09-06 艾美科健株式会社 7-氨基头孢烷酸的高浓度生产重组顶头孢霉菌株的制造方法及利用其方法所制造的菌株
CN110214188B (zh) * 2016-08-26 2023-06-06 艾美科健株式会社 7-氨基头孢烷酸的高浓度生产重组顶头孢霉菌株的制造方法及利用其方法所制造的菌株

Also Published As

Publication number Publication date
KR20010089672A (ko) 2001-10-08
WO2000037671A2 (fr) 2000-06-29
EP1141372A2 (fr) 2001-10-10
HK1041610A1 (zh) 2002-07-12
AU3042600A (en) 2000-07-12
JP2002533092A (ja) 2002-10-08
WO2000037671A3 (fr) 2000-09-14

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