CN1331525C - Medicine for warming kidney, strengthening yang, dredging liver and activating channels and its preparation process - Google Patents
Medicine for warming kidney, strengthening yang, dredging liver and activating channels and its preparation process Download PDFInfo
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- CN1331525C CN1331525C CNB2004100263342A CN200410026334A CN1331525C CN 1331525 C CN1331525 C CN 1331525C CN B2004100263342 A CNB2004100263342 A CN B2004100263342A CN 200410026334 A CN200410026334 A CN 200410026334A CN 1331525 C CN1331525 C CN 1331525C
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Abstract
The present invention discloses medicine for warming the kidney to invigorate yang, soothing the liver and dredging the channel. The present invention is prepared from 11 kinds of traditional Chinese medicinal materials such as herba epimedii, deglued antler, silkworm king, common cnidium fruit, honeycomb (frying), coridius, polygala root, curcuma root, pangolin (scalded), cowherb seed (fried) as raw materials. The medicine has conspicuous curative effects on curing soreness and weakness of waists and knees, dizziness, tinnitus, swelling and discomfort caused by the insufficiency of the kidney-yang and stagnation of qi due to depression of the liver, has no adverse reaction to human bodies and has good clinical generalization value.
Description
Affiliated technical field
The invention belongs to the preparing technical field of pharmaceuticals, relating to a kind of is the medicine that is used for warming the kidney to invigorate YANG, dispersing the stagnated liver-QI and dredging collateral of feedstock production and the preparation method of this medicine with the Chinese herbal medicine.
Background technology
Soreness of the waist and knees due to the insufficiency of kidney-YANG, stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expand and not to relax that to wait disease be middle aged man's common disease, also are the cardinal symptoms that middle aged man is old and feeble sign.It is the frequently-occurring disease of puzzlement adult male.Add up according to interrelated data, the sickness rate of above-mentioned disease accounts for 20% in the male crowd in present domestic 40-59 year, sickness rate among the person of the being engaged in mental work crowd is higher, and it has caused huge psychic pain to the patient, and has hidden the hidden danger of fission for many families.In thought of people idea constantly open today, the soreness of the waist and knees due to the numerous insufficiency of kidney-YANG, stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expand not relax and wait the disease patient to thirst for improving function, improve the quality of living.Yet regrettably, worldwide also do not find the medicine that really deserves to be called the above-mentioned disease of ideal treatment so far.Present more known medicines such as Western medicine class multidigit synthetic androgen, someone studies and thinks that synthetic androgen methyl testosterone when low dose is used, can make some insufficiency of kidney-YANG, the soreness of the waist and knees due to the stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expands not relax and waits disease to be eased, but after heavy dose of the application, owing to can suppress male's hypothalamus one hypophysis one testis axle, and make atrophy of testis, as a result, can increase the weight of original symptom on the contrary, cause sterile or produce other side effect.For overcoming above-mentioned drawback, the many people in this area turn to natural Chinese medicine with the focus of research in recent years.Treatment by Chinese herbs focuses on conditioning, and can take for a long time, side effect is little, but present treatment Chinese medicine comprises name side, be based on kidney yang more, promptly according to the reason of " have sun then moving, depletion of YANG is then quiet ", the orphan keeps warming the kidney to activate YANG, ignored integral body adjustment to the viscera yang blood and qi, not only curative effect is not ideal enough, and the multiple impairment of YIN of the excess of YANG is arranged more, instead gives birth to scorching grade for side effect.
Summary of the invention
The objective of the invention is to the problem at the prior art existence, providing a kind of is the warming the kidney to invigorate YANG that is used for of feedstock production, the medicine of dispersing the stagnated liver-QI and dredging collateral and the preparation method that is used to produce this medicine with the Chinese herbal medicine.
Under motherland's medical science global theory instructs, development person of the present invention finds by clinical research for many years, insufficiency of kidney-YANG, soreness of the waist and knees due to the stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expands and not to relax that what wait disease is an extremely complicated pathological change, it decline with the deficiency of kidney essence sun or the life fire of suffering from a deficiency of the kidney weak be pathologic basis, its pathological change is reached the same goal by different routes and is had no way of starting in Yuanyang, and promptly " depletion of YANG is then quiet " concerns many internal organs yin and yang qi and blood disorder, the not poly-sun of refining of kidney, stagnation of liver-QI feelings will is curbed, and then the stasis of blood is coagulated venation for a long time, and blood does not pass through and is full of penis; The heart not regulation of mental activities is pleased will, and difficult main kidney department does strong, and then function fails and desires not put forth energy ...Medicine of the present invention is according to this multiple pattern of syndrome, and comprehensive multiple pathological factor is controlled when poly-smart from the kidney invigorating, and temperature is steamed Yuanyang, dispersing the stagnated liver-QI and dredging collateral, and smooth feelings put forth energy to desire.Based on above-mentioned cognition and comprehensive multiple pathological factor, adjust many internal organs yang blood and qi, designer of the present invention had both met the method for treatment theory by repeated screening, effect is arranged again at all times repeatly, and the specific drug that meets the modernity medicine principle, through number Yi Qifang, final development has obtained to adjust many internal organs yang blood and qi and has had the tonification pure Chinese medicinal preparation of specially good effect, quick-acting effects to realize goal of the invention.
The weight proportion that constitutes each component raw material of medicine of the present invention is:
Herba Epimedii 11～16.5, Cornu Cervi Degelatinatum 2.5～3.75, Bombycis mori 4～6,
Fructus Cnidii 10～15, Semen Astragali Complanati 4～6, Nidus Vespae (stir-fry) 5.5～8.25,
Aspongopus 4～6, Radix Polygalae 4～6, Radix Curcumae 4～6,
Squama Manis (scalding) 1～1.5, Semen Vaccariae (stir-fry) 3～4.5.
In medicament composing prescription of the present invention, Herba Epimedii Xin Ganwen, kidney invigorating and YANG supporting, warming and recuperating the gate of life is joined the Cornu Cervi Degelatinatum reinforcing the kidney and supporting YANG of salty temperature, the strong governor vessel of temperature, the kidney invigorating and oiliness heavy is monarch drug altogether; Two flavor the kidney invigorating monarch drug compatibilities, salty temperature is nourished, and asks in quiet, makes the kidney essense abundance, kidney yang Ji Wang, Yuanyang is steamed the kidney qi of refining, and the yang-energy temperature of kidney is filled penis; Governor vessel goes out perineum under arising among the born of the same parents again, all sun of main system whole body, and the prosperous then YANG pulse of governor vessel is strong, and Cornu Cervi Degelatinatum energy incubation governor vessel is superintended and directed and is sent out a yang-energy, makes governor vessel strong, and gas passes through penis.The salty temperature compensation liver of Bombycis mori kidney tonifying, the tonifying YANG arresting seminal emission is again the benefaction of worm medicine, habit is walked to scurry, join as driving its passages through which vital energy circulates that passes unimpeded in the kidney-reinforcing drug again especially, superintend and direct sun, the arduous temperature of Fructus Cnidii with Wen Zhuan, the sweet temperature of Semen Astragali Complanati and puckery, the kidney and enhancing body but equal kidney invigorating and YANG supporting, Semen Astragali Complanati and astringent or styptic treatment for spontaneous sweating vital essence effect is arranged, this three flavor are built up one's health by taking tonic, principal drug assistance is a usefulness, is ministerial drug altogether.Right kidney storing essence and be that envelope is stung this, kidney essense benefit Tibetan should not be let out, and kidney yang is expensive falls with fixed attention, and Bombycis mori, Semen Astragali Complanati the kidney invigorating still can arresting seminal emission gas, and arresting seminal emission is also promptly poly-smart, the cloudy smart quiet kidney that is hidden in of pinching; Astringent or styptic treatment for spontaneous sweatingly fall yang-energy in the kidney with fixed attention, be just accord with the physiological characteristics that kidney essense should the Tibetan should not be let out, the duty that kidney department envelope is stung has the adjuvant drug effect concurrently.Assistant is with the Aspongopus of salty temperature, and the warm tonifying YANG of the logical benefit of sweet flat Nidus Vespae is bright.The Radix Polygalae tepor of working hard is gone into lung heart kidney channel, mind tranquilizing and the heart calming, and restoring normal coordination between the heart and kidney, Radix Curcumae is arduous cold and return liver and gall heart channel, promoting QI circulation for relieving depression, with Radix Polygalae mutually 5, the smooth will of calming the nerves, medical treatment conscience, make insufficiency of kidney-YANG, the soreness of the waist and knees due to the stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expand not relax and wait disease to be improved; But Radix Curcumae is blood circulation promoting and blood stasis dispelling again, returns Liver Channel with salty being slightly cold, Squama Manis and bitter flat Semen Vaccariae phase 5 of returning Liver Channel, the promoting blood circulation to restore menstrual flow network altogether of doing good works away and scurrying; Strong and the through sick institute of two the collateral dredging effects in back, the dredging the meridian stasis of blood stagnates, and makes the liver blood smoothness, is full of and passes through penis, is the messenger drug of complete side, and the priming dredge the meridian passage draws all medicine GUIXIN, liver, kidney channel, the effect altogether of making a concerted effort.All medicine compatibilities are asked during the kidney invigorating is then quiet, steam the Yuanyang of refining; Tonifying YANG is the logical benefit of warming middle-JIAO residence again, and accent liver then QI and blood is ruled together, and the logical stasis of blood of smooth will stagnates.Full side is temperature partially, but temperature and not dry, the kidney invigorating smart warming YANG of meeting again, and it is orderly to catch (controlling nocturnal emission with astringent drugs) vertical (warming YANG activates yang), transfers the heavy smooth will collateral dredging of liver, and feelings will and accent are played kidney tonifying, essence replenishing, warm kidney-Yang invigorating, the effect of dispersing the stagnated liver-QI and dredging collateral altogether.
The above-mentioned warming the kidney to invigorate YANG that is used for, the medicine of dispersing the stagnated liver-QI and dredging collateral can be made said multiple dosage form on the pharmaceutics, as capsule, tablets and other formulations.The preparation method of its dosage form is as described below: (1), with ten raw material of Chinese medicine simply of above-mentioned weight proportion, get Cornu Cervi Degelatinatum, Squama Manis is ground into fine powder, and is standby; (2), get Fructus Cnidii in addition, with 70% alcohol reflux three times, alcohol adding amount is followed successively by 6 times, 4 times, 4 times of Fructus Cnidii amount, extraction time was followed successively by 2.5,2,1.5 hours, merge extractive liquid, leaves standstill, and filters, decompression filtrate recycling ethanol becomes relative density to be the clear paste of 1.15-1.20 (60 ℃), and is standby; (3), with eight flavors such as Fructus Cnidii medicinal residues and all the other Herba Epimedii, decoct with water three times, add 10 times of water gagings at every turn, decocting time was followed successively by 1.5,1,1 hours, filter, merging filtrate, concentrating under reduced pressure becomes the clear paste of 1.15-1.20 (70 ℃), and (4), will merge through step (2) alcohol extract that obtains and the water extract that obtains through step (3) continue to be concentrated into relative density 1.30-1.35 (50 ℃), add Cornu Cervi Degelatinatum, Squama Manis fine powder, mixing, drying is pulverized, encapsulated or tabletting promptly makes capsule of the present invention or tablet.
The present invention is to provide a kind of warming the kidney to invigorate YANG, the natural drug of dispersing the stagnated liver-QI and dredging collateral is applicable to insufficiency of kidney-YANG, and the soreness of the waist and knees due to the stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expand not relax and wait disease.In development process of the present invention, for proving its therapeutic effect and safety, the designer uses the tablet for preparing by the above-mentioned method that provides to carry out the experimental study of pharmacodynamics, toxicology and clinicing aspect, and result of study is as follows:
One, cures mainly relevant pharmacodynamic study with function
Through capsule result of the test of the present invention is shown, this medicine can improve " insufficiency of kidney-YANG " disease mice body weight that the injection hydrocortisone causes, body temperature, tolerance to cold and organ index descend, can improve castration ♂ rat seminal vesicle and prostate, preputial glands and levator ani ponderal index descend, also can swim the exhaustion time by " insufficiency of kidney-YANG " mice low temperature of hydrocortisone injection moulding by significant prolongation, increase teenage female Mus and the growth that does not become male mice sexual organ to a certain extent, can also improve the irritability of castration rat childhood penis, obviously shorten erection incubation period electricity irritation.
Two, toxicological study
Animal acute toxicity experiment shows the half amount of causing of capsule medicinal liquid mice lavage acute toxicity testing of the present invention greater than 80g/kg, belongs to nontoxic level medicine.Capsule of the present invention is to two kinds of sexes of rat, three kinds of meterings are irritated 60 days long malicious experiments experiment of stomach and are shown, the outward appearance behavior of animal is all normal, body weight, ingest, drinking-water etc. there is no unusual, it is all normal that blood routine and blood biochemical are learned inspection, each organizes the dirty body of rat than there was no significant difference, and the tectology inspection shows no obvious abnormalities.
Three, clinical research
Capsule of the present invention is carried out the II clinical trial phase, verify 437 examples altogether, testing the course of treatment was 2 weeks, adopted random-blind to divide treatment group and matched group.303 examples are organized in treatment, take capsule of the present invention, every day 1 time, each 3 (every heavy 0.5g), matched group 134 examples.Now be summarized as follows:
1, treatment group is cured 127 examples (41.9%) in the recent period, produce effects 85 examples (28.05%), and effective 72 examples (23.76%), invalid 19 examples (6.27%), total effective rate 9 3.73% has significant difference with matched group.To insufficiency of kidney-YANG, the soreness of the waist and knees due to the stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expand not relax and wait the improvement and the matched group comparing difference of disease remarkable.
2, treatment group onset time average 5.94 ± 2.70 has utmost point significant difference (p＜0.01) with 10.59 ± 2.51 of matched group.2 weeks were can reach satisfactory effect 1 course of treatment, and this product short treating period is described, acted on quick-acting.
3, the relation of analyze the state and curative effect shows, the state of an illness is than the lighter, and its obvious effective rate and total effective rate are all higher, shows that the state of an illness heals light curative effect significantly.And the heavier person of the state of an illness, curative effect is relatively poor.
4, in this clinical trial, except that 1 routine patient occurs not finding other untoward reaction the big dry stool.
By basis and clinical trial, all show capsule of the present invention to insufficiency of kidney-YANG, the soreness of the waist and knees due to the stagnation of QI due to depression of the liver, dizziness and tinnitus, the side of body expand not relax and wait disease evident in efficacy, can improve the senile symptom of suffering from a deficiency of the kidney simultaneously, and it is rapid to play a role, safety non-toxic, taking convenience.
Claims (2)
1, the medicine of a kind of warming the kidney to invigorate YANG, dispersing the stagnated liver-QI and dredging collateral is characterized in that it is the capsule of being made by the following weight Chinese medicinal raw materials:
Herba Epimedii 11～16.5, Cornu Cervi Degelatinatum 2.5～3.7 5, Bombycis mori 4～6,
Fructus Cnidii 10～15, Semen Astragali Complanati 4～6 is fried Nidus Vespae 5.5～8.25,
Aspongopus 4～6, Radix Polygalae 4～6, Radix Curcumae 4～6,
Scald Squama Manis 1～1.5, Semen Vaccariae (parched) 3～4.5.
2, a kind of method that is used to prepare the described warming the kidney to invigorate YANG of claim 1, dispersing the stagnated liver-QI and dredging collateral medicine is characterized in that may further comprise the steps:
2.1, get Cornu Cervi Degelatinatum, Squama Manis is ground into fine powder, and is standby;
2.2, get Fructus Cnidii in addition, with 70% alcohol reflux three times, alcohol adding amount is followed successively by 6 times, 4 times, 4 times of Fructus Cnidii amount, extraction time was followed successively by 2.5,2,1.5 hours, merge extractive liquid, leaves standstill, and filters, relative density was the clear paste of 1.15-1.20 when decompression filtrate recycling ethanol became 60 ℃ to survey, and is standby;
2.3, eight flavors such as all the other Herba Epimedii in the Fructus Cnidii medicinal residues of step 2.2 gained and prescription just, decoct with water three times, add 10 times of water gagings at every turn, decocting time was followed successively by 1.5,1,1 hours, filter, relative density was the clear paste of 1.15-1.20 when merging filtrate, concentrating under reduced pressure became 70 ℃ to survey;
2.4, will merge through the alcohol extract of step 2.2 gained and water extract through step 2.3 gained, continue to be concentrated into 50 ℃ of 1.30-1.35 of relative density when surveying, add step 2.1 gained fine powder, mixing, drying is pulverized, and is encapsulated, promptly makes capsule.
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| CNB2004100263342A CN1331525C (en) | 2004-07-16 | 2004-07-16 | Medicine for warming kidney, strengthening yang, dredging liver and activating channels and its preparation process |
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| CNB2004100263342A CN1331525C (en) | 2004-07-16 | 2004-07-16 | Medicine for warming kidney, strengthening yang, dredging liver and activating channels and its preparation process |
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| CN1331525C true CN1331525C (en) | 2007-08-15 |
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| CN102772739A (en) * | 2012-07-15 | 2012-11-14 | 李承平 | Recovery tablets for soothing livers and dredging collaterals |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1175445A (en) * | 1997-07-10 | 1998-03-11 | 迟经惠 | Brain refreshing pill for dizziness |
| CN1435215A (en) * | 2002-11-28 | 2003-08-13 | 贵阳德昌祥药业有限公司 | Zaizao Pill for treating woman diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1175445A (en) * | 1997-07-10 | 1998-03-11 | 迟经惠 | Brain refreshing pill for dizziness |
| CN1435215A (en) * | 2002-11-28 | 2003-08-13 | 贵阳德昌祥药业有限公司 | Zaizao Pill for treating woman diseases |
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Application publication date: 20060118 Assignee: Shaanxi momeide Qi and Pharmaceutical Co. Ltd. Assignor: Wang Baoan Contract record no.: 2018610000014 Denomination of invention: Medicine for warming kidney, strengthening yang, dredging liver and activating channels and its preparation process Granted publication date: 20070815 License type: Exclusive License Record date: 20180408 |