CN1331463C - 用于前列腺癌化学预防的方法 - Google Patents

用于前列腺癌化学预防的方法 Download PDF

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Publication number
CN1331463C
CN1331463C CNB008182280A CN00818228A CN1331463C CN 1331463 C CN1331463 C CN 1331463C CN B008182280 A CNB008182280 A CN B008182280A CN 00818228 A CN00818228 A CN 00818228A CN 1331463 C CN1331463 C CN 1331463C
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China
Prior art keywords
prostate cancer
use according
prostate
toremifene
medicament
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Expired - Fee Related
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CNB008182280A
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English (en)
Chinese (zh)
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CN1420765A (zh
Inventor
米切尔·S·施泰纳
沙兰·拉高
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University of Tennessee Research Foundation
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University of Tennessee Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB008182280A 1999-11-08 2000-11-08 用于前列腺癌化学预防的方法 Expired - Fee Related CN1331463C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43620899A 1999-11-08 1999-11-08
US09/436,208 1999-11-08
US09/531,472 2000-03-20
US09/531,472 US6413533B1 (en) 1998-05-07 2000-03-20 Method for chemoprevention of prostate cancer
PCT/US2000/030658 WO2001034117A1 (en) 1999-11-08 2000-11-08 A method for chemoprevention of prostate cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007101121910A Division CN101176787A (zh) 1999-11-08 2000-11-08 用于前列腺癌化学预防的方法

Publications (2)

Publication Number Publication Date
CN1420765A CN1420765A (zh) 2003-05-28
CN1331463C true CN1331463C (zh) 2007-08-15

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CNB008182280A Expired - Fee Related CN1331463C (zh) 1999-11-08 2000-11-08 用于前列腺癌化学预防的方法

Country Status (19)

Country Link
US (1) US6413533B1 (enExample)
EP (1) EP1229903A4 (enExample)
JP (1) JP2003513903A (enExample)
KR (2) KR20060130788A (enExample)
CN (1) CN1331463C (enExample)
AU (1) AU782444B2 (enExample)
BG (1) BG65794B1 (enExample)
CA (1) CA2390295C (enExample)
CZ (1) CZ20021763A3 (enExample)
HR (1) HRP20020422A2 (enExample)
HU (1) HUP0203304A3 (enExample)
IL (1) IL149545A0 (enExample)
IS (1) IS6375A (enExample)
MX (1) MXPA02004676A (enExample)
NO (1) NO20022221L (enExample)
PL (1) PL354726A1 (enExample)
SK (1) SK8162002A3 (enExample)
WO (1) WO2001034117A1 (enExample)
YU (1) YU43002A (enExample)

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US20040176470A1 (en) * 1998-05-07 2004-09-09 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US7737185B2 (en) 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
DK1411916T3 (da) 2001-07-09 2008-12-15 Repros Therapeutics Inc Fremgangsmåder og materialer til behandling af testosteronmangel hos mænd
US7524866B2 (en) * 2001-11-29 2009-04-28 Gtx, Inc. Prevention and treatment of androgen—deprivation induced osteoporosis
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20040213841A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S Methods for treating hot flashes and gynecomastia
PT1666033E (pt) 2001-11-29 2009-02-09 Gtx Inc Prevenção e tratamento de osteoporose induzida pela falta de androgénio
US20040096510A1 (en) * 2001-11-29 2004-05-20 Steiner Mitchell S. Prevention and treatment of androgen-deprivation induced osteoporosis
US20060269611A1 (en) * 2001-11-29 2006-11-30 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20040214898A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S. Methods for treating hot flashes
US20050080143A1 (en) * 2001-11-29 2005-04-14 Steiner Mitchell S. Treatment of androgen-deprivation induced osteoporosis
US20070197664A1 (en) * 2001-11-29 2007-08-23 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
KR20030061474A (ko) * 2002-01-14 2003-07-22 한미약품 주식회사 서트랄린 제조용 중간체로서 사용되는 시스-라세메이트화합물의 개선된 제조방법
FI114917B (fi) * 2002-08-29 2005-01-31 Hormos Nutraceutical Oy Ltd Lignaanikomplekseja
US7332525B2 (en) * 2003-01-17 2008-02-19 Castle Erik P Method of treatment of prostate cancer and composition for treatment thereof
US7467119B2 (en) * 2003-07-21 2008-12-16 Aureon Laboratories, Inc. Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
US7461048B2 (en) * 2003-07-21 2008-12-02 Aureon Laboratories, Inc. Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
WO2005050563A2 (en) * 2003-11-17 2005-06-02 Aureon Biosciences Corporation Pathological tissue mapping
US7070816B2 (en) * 2003-12-05 2006-07-04 New Chapter, Inc. Methods for treating prostatic intraepithelial neoplasia with herbal compositions
WO2005086068A2 (en) * 2004-02-27 2005-09-15 Aureon Laboratories, Inc. Methods and systems for predicting occurrence of an event
BRPI0513129A (pt) * 2004-07-14 2008-04-29 Repros Therapeutics Inc método de tratamento de condição selecionada do grupo que consiste em hipertrofia benigna de próstata, cáncer de próstata, trigliceridos elevados, colesterol alto e hipogonadismo
JP5785680B2 (ja) 2005-03-22 2015-09-30 リプロス セラピューティクス インコーポレイテッド トランス−クロミフェン用の投与レジメン
US20060270641A1 (en) * 2005-05-31 2006-11-30 Steiner Mitchell S Method for chemoprevention of prostate cancer
RU2480207C2 (ru) * 2006-05-22 2013-04-27 Хормос Медикал Лтд. Способ лечения хронического абактериального простатита селективными модуляторами рецепторов эстрогена или ингибиторами ароматазы
US9301987B2 (en) * 2007-09-24 2016-04-05 Laila Nutraceuticals Anti-adipogenic compositions containing Piper betle and Dolichos biflorus
CN102940619A (zh) 2007-10-16 2013-02-27 利普生物药剂公司 用于治疗代谢综合征的珠氯米芬
EA201300341A1 (ru) 2010-09-16 2013-09-30 Шимода Байотек (Пти) Лтд. Композиция фулвестранта и способы применения
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
HK1216502A1 (zh) 2012-11-02 2016-11-18 Repros Therapeutics Inc. 用於癌症治療的反式-克羅米芬

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US4696949A (en) * 1982-06-25 1987-09-29 Farmos Group Ltd. Novel tri-phenyl alkane and alkene derivatives and their preparation and use
US5491173A (en) * 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
US5571534A (en) * 1991-12-10 1996-11-05 Orion-Yhtyma Oy Drug formulations for parenteral use
US5728707A (en) * 1995-07-21 1998-03-17 Constantia Gruppe Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide
WO1998045288A1 (en) * 1997-04-09 1998-10-15 Eli Lilly And Company Treatment or prophylaxis of prostatic cancer and benign prostatic hyperplasia with selective estrogen receptor modulators

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US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4696949A (en) * 1982-06-25 1987-09-29 Farmos Group Ltd. Novel tri-phenyl alkane and alkene derivatives and their preparation and use
US5491173A (en) * 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
US5571534A (en) * 1991-12-10 1996-11-05 Orion-Yhtyma Oy Drug formulations for parenteral use
US5728707A (en) * 1995-07-21 1998-03-17 Constantia Gruppe Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide
WO1998045288A1 (en) * 1997-04-09 1998-10-15 Eli Lilly And Company Treatment or prophylaxis of prostatic cancer and benign prostatic hyperplasia with selective estrogen receptor modulators

Also Published As

Publication number Publication date
CZ20021763A3 (cs) 2003-02-12
US6413533B1 (en) 2002-07-02
YU43002A (sh) 2005-09-19
WO2001034117A9 (en) 2002-05-10
HUP0203304A2 (hu) 2003-02-28
HK1057000A1 (en) 2004-03-12
EP1229903A4 (en) 2006-06-07
AU782444B2 (en) 2005-07-28
HRP20020422A2 (en) 2004-04-30
HUP0203304A3 (en) 2006-02-28
NO20022221D0 (no) 2002-05-08
SK8162002A3 (en) 2003-03-04
CN1420765A (zh) 2003-05-28
IL149545A0 (en) 2002-11-10
CA2390295A1 (en) 2001-05-17
PL354726A1 (en) 2004-02-09
KR100793721B1 (ko) 2008-01-10
CA2390295C (en) 2009-09-29
MXPA02004676A (es) 2004-09-10
BG65794B1 (bg) 2009-12-31
KR20060130788A (ko) 2006-12-19
AU1588401A (en) 2001-06-06
BG106738A (en) 2003-02-28
NO20022221L (no) 2002-06-28
EP1229903A1 (en) 2002-08-14
KR20020070276A (ko) 2002-09-05
IS6375A (is) 2002-05-08
JP2003513903A (ja) 2003-04-15
WO2001034117A1 (en) 2001-05-17

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