CN1328285C - 干细胞增殖抑制因子及其应用 - Google Patents

干细胞增殖抑制因子及其应用 Download PDF

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Publication number
CN1328285C
CN1328285C CNB951965557A CN95196555A CN1328285C CN 1328285 C CN1328285 C CN 1328285C CN B951965557 A CNB951965557 A CN B951965557A CN 95196555 A CN95196555 A CN 95196555A CN 1328285 C CN1328285 C CN 1328285C
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Prior art keywords
cells
inprol
bone marrow
hemoglobin
stem cell
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Expired - Fee Related
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CNB951965557A
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Chinese (zh)
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CN1168695A (zh
Inventor
V·科兹洛夫
I·楚尔洛娃
S·D·沃尔帕
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Pro Neuron Inc
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Pro Neuron Inc
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Priority claimed from US08/316,424 external-priority patent/US6022848A/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/002—Telephonic communication systems specially adapted for combination with other electrical systems with telemetering systems
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/04—Telephonic communication systems specially adapted for combination with other electrical systems with alarm systems, e.g. fire, police or burglar alarm systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
CNB951965557A 1994-09-30 1995-09-29 干细胞增殖抑制因子及其应用 Expired - Fee Related CN1328285C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/316,424 US6022848A (en) 1993-03-31 1994-09-30 Inhibitor of stem cell proliferation and uses thereof
US08/316,424 1994-09-30
US08/535,882 1995-09-28
US08/535,882 US5939391A (en) 1993-03-31 1995-09-28 Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNB021561842A Division CN1321688C (zh) 1994-09-30 1995-09-29 干细胞增殖抑制因子及其应用
CNB2007101063205A Division CN100572390C (zh) 1994-09-30 1995-09-29 干细胞增殖抑制因子及其应用

Publications (2)

Publication Number Publication Date
CN1168695A CN1168695A (zh) 1997-12-24
CN1328285C true CN1328285C (zh) 2007-07-25

Family

ID=26980434

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB951965557A Expired - Fee Related CN1328285C (zh) 1994-09-30 1995-09-29 干细胞增殖抑制因子及其应用
CNB021561842A Expired - Fee Related CN1321688C (zh) 1994-09-30 1995-09-29 干细胞增殖抑制因子及其应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB021561842A Expired - Fee Related CN1321688C (zh) 1994-09-30 1995-09-29 干细胞增殖抑制因子及其应用

Country Status (17)

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US (2) US5939391A (enExample)
EP (1) EP0784677B1 (enExample)
JP (3) JP3953511B2 (enExample)
CN (2) CN1328285C (enExample)
AT (1) ATE263236T1 (enExample)
CA (1) CA2201105C (enExample)
DE (1) DE69532813T2 (enExample)
DK (1) DK0784677T3 (enExample)
ES (1) ES2216019T3 (enExample)
FI (1) FI117468B (enExample)
IL (1) IL115473A (enExample)
MX (1) MX9702266A (enExample)
NO (1) NO319575B1 (enExample)
NZ (2) NZ335108A (enExample)
PT (1) PT784677E (enExample)
RU (1) RU2186579C2 (enExample)
WO (1) WO1996010634A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610654B2 (en) * 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
AU694111B2 (en) 1993-03-31 1998-07-16 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
EP1897553A1 (en) * 1994-09-30 2008-03-12 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
GB9700154D0 (en) 1997-01-07 1997-02-26 Primapharma Ltd Peptides
JP2000095794A (ja) * 1998-09-22 2000-04-04 Itoham Foods Inc エンケファリン分解酵素の阻害剤
US6488828B1 (en) * 2000-07-20 2002-12-03 Roche Diagnostics Corporation Recloseable biosensor
WO2005026380A2 (en) * 2003-09-10 2005-03-24 Southern Research Institute Bone marrow proliferation assay
RU2423375C2 (ru) * 2005-07-26 2011-07-10 СиЭмЭс ПЕПТАЙДЗ ПЭЙТЕНТ ХОЛДИНГ КОМПАНИ ЛИМИТЕД Новые биологически активные пептиды и их новое применение
RU2317074C1 (ru) * 2006-03-16 2008-02-20 Общество с ограниченной ответственностью "МБФ" Ингибитор дифференцировки кроветворных клеток-предшественников
RU2320364C1 (ru) * 2006-08-21 2008-03-27 Закрытое Акционерное Общество "Центр "Пептос" Способ лечения злокачественных новообразований
RU2328304C1 (ru) * 2007-03-22 2008-07-10 Общество с ограниченной ответственностью "Геленпол" Агент защиты клеток крови и восстановления кроветворной системы и фармакологическая комбинация для лечения онкологических больных
WO2008136699A1 (fr) * 2007-05-04 2008-11-13 Igor Alexandrovich Bazikov Patch transdermique à microcapsules et procédé de fabrication correspondant
US9782452B2 (en) * 2011-11-22 2017-10-10 Cornell University Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling
US9220706B2 (en) 2012-06-01 2015-12-29 National Institutes Of Health (Nih) Inhibition of leukemic stem cells by PP2A activating agents
US9428552B2 (en) * 2012-11-19 2016-08-30 Wellstat Therapeutics Corporation Stem cell mobilization and tissue repair and regeneration
RU2535972C2 (ru) * 2012-12-24 2014-12-20 Андрей Степанович БРЮХОВЕЦКИЙ Противоопухолевый индивидуальный протеом-основанный таргетный клеточный препарат, способ его получения и применение этого препарата для терапии рака и других злокачественных новообразований
RU2537141C1 (ru) * 2013-11-20 2014-12-27 государственное бюджетное образовательное учреждение высшего профессионального образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ определения способности клеток костного мозга к делению
CN104817622A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd04及其制备方法和应用
CN104817625A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd03及其制备方法和应用
CN104817615A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd05及其制备方法和应用
CN104817613A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd06及其制备方法和应用
CN105294830A (zh) * 2014-06-18 2016-02-03 陈光健 一种二肽分子及其制备方法和应用
US10953107B2 (en) * 2018-06-15 2021-03-23 Trustees Of Boston University Polypeptide compositions and methods for site-specific targeting of therapeutic agents

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Publication number Priority date Publication date Assignee Title
WO1991004274A1 (en) * 1989-09-25 1991-04-04 Genetics Institute, Inc. Method for inhibiting growth of stem cells

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IL94361A (en) * 1989-05-10 1995-07-31 Somatogenetics Int Polypeptides, revombinant dna molecules and method of producing a human hemoglobin-like protein
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
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US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
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DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004274A1 (en) * 1989-09-25 1991-04-04 Genetics Institute, Inc. Method for inhibiting growth of stem cells

Non-Patent Citations (1)

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Title
Maintenance and Proliferation Control of PrimitiveHemopoietic Progenitors in Long-Term Cultures of HumanMarrow Cells Eaves et al,Blood Cell,Vol.14 1988 *

Also Published As

Publication number Publication date
MX9702266A (es) 1997-06-28
HK1071517A1 (en) 2005-07-22
EP0784677A1 (en) 1997-07-23
JP2004256553A (ja) 2004-09-16
DE69532813T2 (de) 2005-03-17
NZ335108A (en) 2000-11-24
NO971444D0 (no) 1997-03-26
CA2201105C (en) 2009-11-24
DE69532813D1 (de) 2004-05-06
IL115473A (en) 2005-08-31
RU2186579C2 (ru) 2002-08-10
NZ294446A (en) 1999-07-29
EP0784677B1 (en) 2004-03-31
PT784677E (pt) 2004-08-31
CN1321688C (zh) 2007-06-20
ES2216019T3 (es) 2004-10-16
US6090782A (en) 2000-07-18
WO1996010634A1 (en) 1996-04-11
US5939391A (en) 1999-08-17
EP0784677A4 (en) 2002-01-30
NO971444L (no) 1997-05-26
CN1565627A (zh) 2005-01-19
CA2201105A1 (en) 1996-04-11
JP3953511B2 (ja) 2007-08-08
IL115473A0 (en) 1995-12-31
FI971000A0 (fi) 1997-03-11
FI971000L (fi) 1997-05-28
JP2008088186A (ja) 2008-04-17
HK1108701A1 (zh) 2008-05-16
FI117468B (fi) 2006-10-31
JPH10509422A (ja) 1998-09-14
DK0784677T3 (da) 2004-08-02
NO319575B1 (no) 2005-08-29
CN1168695A (zh) 1997-12-24
HK1006642A1 (zh) 1999-03-12
ATE263236T1 (de) 2004-04-15
JP4188279B2 (ja) 2008-11-26

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