JP3953511B2 - 幹細胞増殖インヒビターおよびその使用 - Google Patents

幹細胞増殖インヒビターおよびその使用 Download PDF

Info

Publication number
JP3953511B2
JP3953511B2 JP51195796A JP51195796A JP3953511B2 JP 3953511 B2 JP3953511 B2 JP 3953511B2 JP 51195796 A JP51195796 A JP 51195796A JP 51195796 A JP51195796 A JP 51195796A JP 3953511 B2 JP3953511 B2 JP 3953511B2
Authority
JP
Japan
Prior art keywords
chain
cells
hemoglobin
inprol
stem cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP51195796A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10509422A (ja
JPH10509422A5 (enExample
Inventor
ブラディミール コズロフ,
アイリーナ ツィルロバ,
ディー. ウォルペ,スティーブン
Original Assignee
ウェルスタット セラピューティクス コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/316,424 external-priority patent/US6022848A/en
Application filed by ウェルスタット セラピューティクス コーポレイション filed Critical ウェルスタット セラピューティクス コーポレイション
Publication of JPH10509422A publication Critical patent/JPH10509422A/ja
Publication of JPH10509422A5 publication Critical patent/JPH10509422A5/ja
Application granted granted Critical
Publication of JP3953511B2 publication Critical patent/JP3953511B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/002—Telephonic communication systems specially adapted for combination with other electrical systems with telemetering systems
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/04—Telephonic communication systems specially adapted for combination with other electrical systems with alarm systems, e.g. fire, police or burglar alarm systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
JP51195796A 1994-09-30 1995-09-29 幹細胞増殖インヒビターおよびその使用 Expired - Fee Related JP3953511B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/316,424 US6022848A (en) 1993-03-31 1994-09-30 Inhibitor of stem cell proliferation and uses thereof
US316,424 1994-09-30
US08/535,882 US5939391A (en) 1993-03-31 1995-09-28 Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US535,882 1995-09-28
PCT/US1995/012268 WO1996010634A1 (en) 1994-09-30 1995-09-29 Inhibitor of stem cell proliferation and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004147081A Division JP4188279B2 (ja) 1994-09-30 2004-05-17 幹細胞増殖インヒビターおよびその使用

Publications (3)

Publication Number Publication Date
JPH10509422A JPH10509422A (ja) 1998-09-14
JPH10509422A5 JPH10509422A5 (enExample) 2004-09-24
JP3953511B2 true JP3953511B2 (ja) 2007-08-08

Family

ID=26980434

Family Applications (3)

Application Number Title Priority Date Filing Date
JP51195796A Expired - Fee Related JP3953511B2 (ja) 1994-09-30 1995-09-29 幹細胞増殖インヒビターおよびその使用
JP2004147081A Expired - Fee Related JP4188279B2 (ja) 1994-09-30 2004-05-17 幹細胞増殖インヒビターおよびその使用
JP2007317741A Withdrawn JP2008088186A (ja) 1994-09-30 2007-12-07 幹細胞増殖インヒビターおよびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2004147081A Expired - Fee Related JP4188279B2 (ja) 1994-09-30 2004-05-17 幹細胞増殖インヒビターおよびその使用
JP2007317741A Withdrawn JP2008088186A (ja) 1994-09-30 2007-12-07 幹細胞増殖インヒビターおよびその使用

Country Status (17)

Country Link
US (2) US5939391A (enExample)
EP (1) EP0784677B1 (enExample)
JP (3) JP3953511B2 (enExample)
CN (2) CN1321688C (enExample)
AT (1) ATE263236T1 (enExample)
CA (1) CA2201105C (enExample)
DE (1) DE69532813T2 (enExample)
DK (1) DK0784677T3 (enExample)
ES (1) ES2216019T3 (enExample)
FI (1) FI117468B (enExample)
IL (1) IL115473A (enExample)
MX (1) MX9702266A (enExample)
NO (1) NO319575B1 (enExample)
NZ (2) NZ335108A (enExample)
PT (1) PT784677E (enExample)
RU (1) RU2186579C2 (enExample)
WO (1) WO1996010634A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US6610654B2 (en) 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
DE69431473T2 (de) 1993-03-31 2003-08-07 Pro-Neuron, Inc. Inhibitor der stammzellproliferation und seine verwendung
EP1897553A1 (en) * 1994-09-30 2008-03-12 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
GB9700154D0 (en) * 1997-01-07 1997-02-26 Primapharma Ltd Peptides
JP2000095794A (ja) * 1998-09-22 2000-04-04 Itoham Foods Inc エンケファリン分解酵素の阻害剤
US6488828B1 (en) * 2000-07-20 2002-12-03 Roche Diagnostics Corporation Recloseable biosensor
US20080220444A1 (en) * 2003-09-10 2008-09-11 Koratich Michael S Bone Marrow Proliferation Assay
KR101381337B1 (ko) 2005-07-26 2014-04-11 씨엠에스 펩티드 패턴트 홀딩 컴퍼니 리미티드 신규한 생물학적 활성 펩티드 및 그의 신규한 용도
RU2317074C1 (ru) * 2006-03-16 2008-02-20 Общество с ограниченной ответственностью "МБФ" Ингибитор дифференцировки кроветворных клеток-предшественников
RU2320364C1 (ru) * 2006-08-21 2008-03-27 Закрытое Акционерное Общество "Центр "Пептос" Способ лечения злокачественных новообразований
RU2328304C1 (ru) * 2007-03-22 2008-07-10 Общество с ограниченной ответственностью "Геленпол" Агент защиты клеток крови и восстановления кроветворной системы и фармакологическая комбинация для лечения онкологических больных
WO2008136699A1 (fr) * 2007-05-04 2008-11-13 Igor Alexandrovich Bazikov Patch transdermique à microcapsules et procédé de fabrication correspondant
US9782452B2 (en) * 2011-11-22 2017-10-10 Cornell University Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling
US9220706B2 (en) 2012-06-01 2015-12-29 National Institutes Of Health (Nih) Inhibition of leukemic stem cells by PP2A activating agents
WO2014078787A1 (en) * 2012-11-19 2014-05-22 Wellstat Therapeutics Corporation Stem cell mobilization and tissue repair and regeneration
RU2535972C2 (ru) * 2012-12-24 2014-12-20 Андрей Степанович БРЮХОВЕЦКИЙ Противоопухолевый индивидуальный протеом-основанный таргетный клеточный препарат, способ его получения и применение этого препарата для терапии рака и других злокачественных новообразований
RU2537141C1 (ru) * 2013-11-20 2014-12-27 государственное бюджетное образовательное учреждение высшего профессионального образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ определения способности клеток костного мозга к делению
CN104817613A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd06及其制备方法和应用
CN104817615A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd05及其制备方法和应用
CN104817625A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd03及其制备方法和应用
CN104817622A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd04及其制备方法和应用
CN105294830A (zh) * 2014-06-18 2016-02-03 陈光健 一种二肽分子及其制备方法和应用
WO2019241609A1 (en) * 2018-06-15 2019-12-19 Trustees Of Boston University Polypeptide compositions and methods for site-specific targeting of therapeutic agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1142466A (en) * 1979-01-09 1983-03-08 National Research Development Corporation Cell lines
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
KR920701434A (ko) * 1989-05-10 1992-08-11 원본미기재 박테리아 및 이스트 내에서의 헤모글로빈 및 그의 동족체의 제조방법
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
DE69020573T3 (de) * 1989-09-25 1999-12-16 Crc Technology Ltd., London Verfahren zur wachstumshemmung von stammzellen.
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
CA2098818A1 (en) * 1990-12-20 1992-06-21 Tim Townes Transgenic, cross-linked hemoglobin
WO1992020369A1 (en) * 1991-05-14 1992-11-26 Dana Farber Cancer Institute Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5786334A (en) * 1992-08-14 1998-07-28 Technology Resources International, Inc. Hexapeptide having immunostimulatory activity
DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof

Also Published As

Publication number Publication date
JPH10509422A (ja) 1998-09-14
WO1996010634A1 (en) 1996-04-11
JP2004256553A (ja) 2004-09-16
DE69532813T2 (de) 2005-03-17
US5939391A (en) 1999-08-17
CA2201105A1 (en) 1996-04-11
CN1565627A (zh) 2005-01-19
HK1006642A1 (zh) 1999-03-12
PT784677E (pt) 2004-08-31
ES2216019T3 (es) 2004-10-16
DE69532813D1 (de) 2004-05-06
DK0784677T3 (da) 2004-08-02
EP0784677A4 (en) 2002-01-30
HK1071517A1 (en) 2005-07-22
NZ335108A (en) 2000-11-24
FI971000A0 (fi) 1997-03-11
IL115473A0 (en) 1995-12-31
IL115473A (en) 2005-08-31
CA2201105C (en) 2009-11-24
NO971444D0 (no) 1997-03-26
JP4188279B2 (ja) 2008-11-26
MX9702266A (es) 1997-06-28
RU2186579C2 (ru) 2002-08-10
EP0784677A1 (en) 1997-07-23
NO319575B1 (no) 2005-08-29
CN1328285C (zh) 2007-07-25
EP0784677B1 (en) 2004-03-31
FI117468B (fi) 2006-10-31
JP2008088186A (ja) 2008-04-17
FI971000L (fi) 1997-05-28
CN1321688C (zh) 2007-06-20
NZ294446A (en) 1999-07-29
HK1108701A1 (zh) 2008-05-16
US6090782A (en) 2000-07-18
ATE263236T1 (de) 2004-04-15
NO971444L (no) 1997-05-26
CN1168695A (zh) 1997-12-24

Similar Documents

Publication Publication Date Title
JP4188279B2 (ja) 幹細胞増殖インヒビターおよびその使用
US5861483A (en) Inhibitor of stem cell proliferation and uses thereof
US6432917B1 (en) Inhibitor of stem cell proliferation and uses thereof
WO1997036922A9 (en) Inhibitor and stimulator of stem cell proliferation and uses thereof
US20100041147A1 (en) Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
AU712204B2 (en) Inhibitor of stem cell proliferation and uses thereof
AU768081B2 (en) Inhibitor and stimulator of stem cell proliferation and uses thereof
KR100619599B1 (ko) 간세포증식의억제제및자극제및그것들의용도
NZ504512A (en) Peptide from alpha-hemoglobin as a stimulator of stem cell proliferation and used thereof
HK1006642B (en) Inhibitor of stem cell proliferation and uses thereof
HK1108701B (en) Inhibitor of stem cell proliferation and uses thereof
HK1071517B (en) Inhibitor of stem cell proliferation and uses thereof

Legal Events

Date Code Title Description
A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20040217

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20040405

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040517

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20061003

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061006

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070220

A72 Notification of change in name of applicant

Free format text: JAPANESE INTERMEDIATE CODE: A721

Effective date: 20070131

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070221

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20070410

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20070425

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110511

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120511

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120511

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130511

Year of fee payment: 6

LAPS Cancellation because of no payment of annual fees