CN1324647A - Prepn. of hematopoietic tortoise-deer capsule - Google Patents

Abstract

The present invention relates to a production method of tortoise plastron and velvet deerhorn blood-producing capsule with good therapeutic effect for curing anemi and low cost. Said medicine capsule is made up by using component A formed from the Chinese medicinal materials of turble shell, pangolin scales, ass hide glue pellets. American ginseng and salvia root, component B formed from the Chiense medicinal materials of ginseng, velvet deerhorn, seal's genitals, placenta, flowery knot weed root and nux vomica, component C formed from tortoise plastron, tortoise plastron glue, ass hide glue pellets and notogenseng and component D formed from cordyceps, tortoise plastron glue, chicken's blood block and astragalus root as raw material, grinding them into fine powders, seiving with 80-100 meshes seive, and mixing them according to ratio of 1:1:1:1 and capsulizing to obtain the invented finished product.

Description

The manufacture method of hematopoietic tortoise-deer capsule

The present invention relates to a kind of manufacture method for the treatment of the hematopathy medicine.

Aplastic anemia (AA) is because physical chemistry, biological and agnogenic factor causes that by different pathogenesis bone marrow (BM) hematopoietic stem cell and hematopoieticmicroenviron-ment damage cause the BM nonfunction to cause one group of syndrome of pancytopenia, and Clinical symptoms is corresponding anemia and the infection that pancytopenia causes.The annual morbidity of China is about 1.02/10 ten thousand populations (0.48-1.72/10 ten thousand philtrum mouths).Clinical typing is divided into two kinds of acute and chronic types.Motherland's medical science thinks that aplastic anemia is that a kind of refractory anemia belongs to traditional Chinese medical science asthenia, exhaustion of blood category, and the cause of disease is that the volt consumption essence of being impairment of the kidney causes in the exopathogen, also can be because of due to the deficiency of the kidney deficiency of kidney-QI.Kidney is the root of QI and blood biochemistry, the then biochemical hematopenia of suffering from a deficiency of the kidney, and Clinical typing is divided into: the marrow labor of suffering from a deficiency of the kidney blood stasis type; Deficiency of the kidney spleen deficiency and blood stasis type.Western medical treatment (BMT) bone marrow transplantation, BMT has made the prognosis of serious symptom aplastic anemia be significantly improved, its mechanism is to implant normal hematopoietic stem cell to make patient's hemopoietic obtain rebuilding, but have (GVHD) graft versus host disease takes place about 35-50%, expensive expense and strict indication, contraindication non-general masses can accept.Immunosuppressant treatment ALG (antilymphocyte globulin), the most report of treatment SAA effective percentage is that the 45-50% curative effect is used the good of androgen and supporting treatment than list, 15% recurrence, 4.3% in treatment other hematopathy took place in back 5 months-3 years tries out cyclosporin A (CSA) to the invalid people that has of ALG, and CTX is all effective.Androgen and albumen synthesize anabolic hormone, clinical testosterone propionate commonly used, but the influence of the normal phase local formation in injection back lump absorbs and easily causes infection again, side effect has hirsutism, skin acne, hydropexis and manlike performance, stanozolol can cause liver function injury, should make regular check on liver function between the operating period, this type of drug effect is slow, the effective time majority in medication 2 to 4 months even 5-6 month.Healing and remission rate are 26.6%, and this medicine adds prednisone treatment serious symptom aplastic anemia effective percentage and is about about 40%.Hemopoietic generates one of the factor, hugely bites obviously leukocyte increasing of assembly G-CSF (GM-CSF), but most erythrocyte and platelet do not have improvement.At present, data shows that rhGM-CSF can not cure aplastic anemia, but the severe infections that granulocytopenia is caused is effective.The fragrant report of the Wu of traditional Chinese medical herbal treatment Shanghai College of Traditional Chinese Medicine writing brush is single to be 68% with invigorate the spleen and warm the kidney treatment by Chinese herbs chronic aplastic anemia effective percentage.Heilongjiang Traditional Chinese Medicine university is that main effective percentage is 83.7% with marrow-supplementing and blood-engendering side's medicine, and Shandong College of Traditional Chinese Medicine's Chinese medicine that nourishes blood to tonify Qi of the kidney is that main effective percentage is 87.7%.Other therapies, still certainly difficult as the cobaltous chloride curative effect, behind the splenectomy operative treatment, part A A case makes moderate progress and does not make conventional therapy, blood transfusion can not be cured AA, is temporary transient supporting treatment, can increase transfusion reaction even cause hemosiderosis because of repeatedly transfusing blood, even liver and kidney failure, so should not frequently transfuse blood.Add on the basis of therapy of combining Chinese and Western medicine Chinese medicine with kidney-replenishing, kidney tonifying, essence replenishing regulating YIN and YANG and use stanozolol, prednisone etc., effect is excellent far beyond simple doctor trained in Western medicine medical treatment.Because the different cases of the standard of effect have weight again, are not easy to contrast.It is 79% that the blood seminar of holding in Hangzhou in November, 1987 is discussed the report effective percentage.

The object of the invention is to provide a kind of medical expense low and good effect, the manufacture method of the hematopathy medicine that side effect is little.

The present invention who the present invention seeks to realize like this is made of A component (percentage by weight) following A, B, C, D combination partner: Carapax Trionycis 25-35%, roasted SQUAMA MANITIS into puffy with sand 23-27%, Colla Corii Asini bead (stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE) 12-18%, Radix Panacis Quinquefolii 18-22%, Radix Salviae Miltiorrhizae 8-12%; B component (percentage by weight): Radix Ginseng 25-35%, Cornu Cervi Pantotrichum 8-12%, Testis et penis callorhini (or tame Testis et Pentis Canis) 26-34%, Placenta Hominis 18-22%, the Radix Polygoni Multiflori (system) 6.5-9.5%, Semen Strychni 1.5-2.5%; C component (percentage by weight): Carapax et Plastrum Testudinis 25-35%, Colla Plastri Testudinis 12-18%, Colla Corii Asini bead 25-35%, Radix Notoginseng 22-28%:D component (percentage by weight): Cordyceps 22-28%, Colla Plastri Testudinis 25-35%, JIXUEDING 22-28%, Radix Astragali 15-25%, above-mentioned four kinds of components are worn into powder respectively, after crossing the 80-100 mesh sieve, by weight 1: 1: 1: 1 proportioning incapsulates promptly to be made.

The present invention increases erythrocyte by brightening cell, increases platelet, and WBC, the PLT decline of chemotherapy, caused by radiation is made up of the A that controls effect, B, C, D four class Chinese medicine composition component parts.

A component: brighten cell:

(1) is used for immunologic hypofunction.

(2) hemopoietic hypofunction anemia and leukopenia.Carapax Trionycis leads to conception vessel, Squama Manis, and this three flavor of Colla Corii Asini bead (stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE) is the in love thing of flesh and blood, instant effect, Radix Panacis Quinquefolii, YIN nourishing and QI supplementing, qi being the governor of blood, Radix Salviae Miltiorrhizae, blood circulation promoting and enriching.

B component: increase erythrocyte:

(1), enliven the hemopoietic organ pipe, can make the function of erythrocyte, hemoglobin increase.

(2), stimulate bone marrow hematogenesis, Radix Ginseng strongly invigorating primordial QI, the living tangible blood of gas energy speed of no type.Cornu Cervi Pantotrichum, the in love thing of flesh and blood, energy dredging DU Meridian arteries and veins stimulates bone marrow to make erythrocyte, and Testis et penis callorhini or tame Testis et Pentis Canis are for it, and the in love thing of flesh and blood contains androgen, can the hemopoietic function.Placenta Hominis, the thing that flesh and blood is in love; Semen Strychni five stones, five beans are concocted altogether and are formed, the Radix Polygoni Multiflori (system) nourishing the liver and kidney.

C component: platelet increasing

(1) YIN nourishing invigorating the liver and kidney, essence and blood alternate yi and Kui are derived from the same origin.

(2) stimulate bone marrow.Carapax et Plastrum Testudinis, the in love thing of Colla Plastri Testudinis flesh and blood, stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE Cheng Zhu, the in love thing of Colla Corii Asini bead (stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE) flesh and blood.Radix Notoginseng is made powder, can enrich blood and can stop blooding, and the blood circulation promoting and blood stasis dispelling of holding concurrently, the blood stasis fresh blood of not dispelling is not given birth to.

The D component: WBC, the PLT decline to chemotherapy, caused by radiation has therapeutical effect:

Cordyceps, this two flavor of Colla Plastri Testudinis also are the in love things of flesh and blood, the JIXUEDING qi and blood tonifying; Radix Astragali spleen invigorating QI invigorating, taste are source of generating QI and blood.

A of the present invention, B, four kinds of components of C, D, (1) can get through Conception Vessel and Governor Vessel, and (2) can be stung bone marrow hemopoietic, kidney → main bone and give birth to marrow, and marrow can hemopoietic, and (3) spleen is a source of generating QI and blood, the spleen blood of uniting can reach the also method of marrow of detoxicating.Have the Chinese medicine the kidney invigorating and replace the hormone of doctor trained in Western medicine not have knock-on, have no side effect.

Medicine of the present invention is worn into and is dressed up capsule after powder is crossed the 80-100 mesh sieve, twice of oral every day, each 5-6g (can adorn 10 balls), each once unites utilization sooner or later, can increase whole blood, also can divide list to control leukopenia with the A component, it is low that the B component is used for erythrocyte, C component treatment thrombocytopenia, WBC, PLT descend after D component treatment radiotherapy, the chemotherapy, act on stronger.

Medicine of the present invention is applicable to and causes that anemia and all kinds of anemia behind anemia, the cancer chemotherapy all can use after leucanaemia, MDS anemia, aplastic anemia, the uremia's dialysis.

Medicine of the present invention can effectively improve therapeutic effect, alleviate patient's real economy burden, vast amount of clinical that I pass through was accepted 120 routine patients for medical treatment in 3 years curative effect is as follows, basic 60 examples of curing, alleviate 30 examples, obviously progressive 20 examples, countless 10 examples, total effective rate is 91.67%, and criterion of therapeutical effect was by the 4th standard that national aplastic anemia academic conference is formulated in 1987.

The embodiment of the invention is shown in following table 1,2,3,4:

Table 1 (A component components by weight percentage)

Component	Content (%)
				Carapax Trionycis	????25	????30	????35
The Squama Manis ball	????23	????25	????27
				Colla Corii Asini bead	????18	????15	????12
Radix Panacis Quinquefolii	????22	????20	????18
				Radix Salviae Miltiorrhizae	????12	????10	????8
Add up to	????100	????100	????100
				Embodiment	????1	????2	????3

Table 2 (B component components by weight percentage)

Component	Content (%)
				Radix Ginseng	????25	????30	????35
Cornu Cervi Pantotrichum	????8	????10	????12
				Testis et penis callorhini	????34	????30	????26
Bavin river car	????22	????20	????18
				The Radix Polygoni Multiflori	????9.5	????8	????6.5
Semen Strychni	????1.5	????2	????2.5
				Add up to	????100	????100	????100
Embodiment	????1	????2	????3

Table 3 (C component components by weight percentage)

Component	Content (%)
				Carapax et Plastrum Testudinis	?25	????30	????35
Colla Plastri Testudinis	?12	????15	????18
				Colla Corii Asini bead	?35	????30	????25
Radix Notoginseng	?28	????25	????22
				Add up to	?100	????100	????100
Embodiment	?1	????2	????3

Table 4 (D component components by weight percentage)

Component	Content (%)
				Cordyceps	?22	????25	????28
Colla Plastri Testudinis	?25	????30	????35
				JIXUEDING	?28	????25	????22
The Radix Astragali	?25	????20	????15
				Add up to	?100	????100	????100
Embodiment	?1	????2	????3

The present invention presses embodiment 1,2,3 proportionings, and 4 kinds of components are worn into powder respectively, can select 80,90,100 mesh sieves, and by weight 1: 1: 1: 1 proportioning was promptly made.

Claims (1)

1. A kind of manufacture method of hematopoietic tortoise-deer capsule, it is characterized in that constituting A component (percentage by weight): Carapax Trionycis 25-35%, roasted SQUAMA MANITIS into puffy with sand 23-27%, Colla Corii Asini bead (stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE) 12-18%, Radix Panacis Quinquefolii 18-22%, Radix Salviae Miltiorrhizae 8-12% by following A, B, four kinds of combinations of C, D component; B component (percentage by weight): Radix Ginseng 25-35%, Cornu Cervi Pantotrichum 8-12%, Testis et penis callorhini (or tame Testis et Pentis Canis) 26-34%, Placenta Hominis 18-22%, the Radix Polygoni Multiflori (system) 6.5-9.5%, Semen Strychni 1.5-2.5%; C component (percentage by weight): Carapax et Plastrum Testudinis 25-35%, Colla Plastri Testudinis 12-18%, Colla Corii Asini bead 25-35%, Radix Notoginseng 22-28%:D component (percentage by weight): Cordyceps 22-28%, Colla Plastri Testudinis 25-35%, JIXUEDING 22-28%, Radix Astragali 15-25%, above-mentioned four kinds of components are worn into powder respectively, after crossing the 80-100 mesh sieve, by weight 1: 1: 1: 1 proportioning incapsulates promptly to be made.