CN1323625A - Hypolycemic traditional Chinese medicine composite - Google Patents
Hypolycemic traditional Chinese medicine composite Download PDFInfo
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- CN1323625A CN1323625A CN 01115415 CN01115415A CN1323625A CN 1323625 A CN1323625 A CN 1323625A CN 01115415 CN01115415 CN 01115415 CN 01115415 A CN01115415 A CN 01115415A CN 1323625 A CN1323625 A CN 1323625A
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Abstract
The present invention discloses a Chinese medicinal composition for lowering blood sugar, it is composed of wuxue rattan extract, green tea extract and solid preparation acceptable auxiliary material, in which the weight ratio of wuxue rattan extract to green tea extract is 20:1 to 2:1. Animal experiments showed that the invented Chinese medicinal composition possesses apparatus sugar lowering action, it can be used in the prevention of diabetes.
Description
The present invention relates to have the Chinese medicine composition of blood sugar reducing function, be specifically related to contain the Chinese medicine composition of Radix Gymnematis Sylvestris and green tea extract.
Diabetes are diseases of a kind of endocrine and metabolic disorders of multi-pathogenesis, and the traditional Chinese medical science claims " quench one's thirst and levy ", are a kind of common clinical, frequently-occurring disease.Along with raising and social senilization's aggravation of people's living standard, this sick sickness rate rises year by year, and mortality rate is only second to tumor and cardiovascular diseases.Usually, the treatment diabetes have three kinds of methods: keep on a diet, insulin substitution therapy and Drug therapy.It is reported that ancient times, all there was the record of using medicine treatment diabetes among the people various countries, were important channels that prevents and treats diabetes so seek new active skull cap components from conventional medicament and plant.Gymnemic acid and conduritol A that the asclepiadaceae plant Radix Gymnematis Sylvestris of having found at present (be called for short GS, have another name called Largeleaf Gymnema) is contained have tangible blood sugar reducing function.
Radix Gymnematis Sylvestris mainly originates in India, Africa, Vietnam and provinces such as China Guangdong, Guangxi, Fujian, Taiwan and Yunnan.Ancient India just is used for blood sugar lowering with GS, Japan has set up the research association of GS in recent years, carry out artificial culture GS at Okinawa, the antihypelipidemic health tea of making at the trial sale GS of Tokyo circle Mingzhi sugaring company in 1988, then, the products such as tablet, chewing gum, the oral dose of sobriety, lozenge and ice cream that contain GS are also come out one after another, and Japan, the U.S., European application 20 multinomial patents.China Qin Jun is good to be waited the people (the 28th page of 2000 the 3rd phase has also been done the report that GS has blood sugar reducing function at Chinese Chinese medicine information magazine.
The tea polysaccharide that contains in the Folium Camelliae sinensis has obvious hypoglycemic activity (effective percentage 70%) and effect for reducing fat, can also raise immunity; Tea polyphenols is a kind of natural inhibitor, and effects such as the free radical of elimination are arranged, the effect with aspects such as blood sugar lowering, blood fat reducing, blood pressure lowerings, and its effect for reducing fat is better than inositol niacinate, demonstrates tea polyphenols to have the prevention hyperlipemia, reduces blood viscosity and lipid peroxidation.Because it is definite that it adjusts blood fat function, so clinical use value is arranged.
The Chinese nation have the custom of drinking tea, so be equipped with the green tea extract with function of polysaccharide in GS, not only significantly improves its blood sugar reducing function, and this prescription has mouthfeel preferably during with the boiled water Instant Drinks, is convenient to accept for masses.
The object of the present invention is to provide a kind of Chinese medicine composition that contains Radix Gymnematis Sylvestris, green tea extract, the two is collaborative mutually, can bring into play better effect.
Chinese medicine composition with blood sugar reducing function of the present invention, be made up of Gymnema P.E, green tea extract and solid preparation acceptable auxiliary, the weight ratio that wherein is used to extract the Radix Gymnematis Sylvestris of Radix Gymnematis Sylvestris and green tea extract and green tea raw material in described compositions is between 20: 1 to 2: 1.
The weight ratio that is used to extract the Radix Gymnematis Sylvestris of Radix Gymnematis Sylvestris and green tea extract and green tea raw material in compositions is preferably between 12: 1 to 6: 1.
In the present invention, Gymnema P.E, green tea extract are meant the extract that Radix Gymnematis Sylvestris, green tea obtain through the Chinese medicine water extracting method of routine.
In the present invention, the position that Radix Gymnematis Sylvestris can medication is stem and leaf.
In the present invention, the main effective ingredient of Gymnema P.E is gymnemic acid and conduritol A.The main effective ingredient of green tea extract is tea polysaccharide and tea polyphenols.
In Chinese medicine composition of the present invention, can add conventional solid preparation adjuvant and food additive, comprise filler, binding agent, disintegrating agent, sweeting agent and lubricant etc., preferably add sweeting agent stevioside and oligofructose or polydextrose.
The preparation of Chinese medicine composition of the present invention is to adopt earlier conventional Chinese medicine extraction method to extract Radix Gymnematis Sylvestris and green tea respectively, wherein Radix Gymnematis Sylvestris and extract from green tea also can further be condensed into clear paste, adopt the preparation method of solid preparation routine then, make conventional solid preparation, as granule, tablet, capsule etc., preferably make granule.
The dosage of Chinese medicine composition of the present invention is the conventional using dosage of Radix Gymnematis Sylvestris and green tea, and the inventor recommends take every day to be equivalent to the former medicine 40-60 gram of Radix Gymnematis Sylvestris, the former medicine 5-10 gram of green tea.
Chinese medicine composition of the present invention is given full play to the synergism of the two with Radix Gymnematis Sylvestris and green tea extract compatibility, and mouse experiment shows that blood sugar reducing function obviously improves.Chinese medicine composition of the present invention is applicable to prevent diabetes, can be used as the health food with function of polysaccharide, is convenient for carrying and takes.
Embodiment 1:
Each component is prepared into granule by following proportioning.Gymnema P.E 2.25g (being equivalent to primary dose 20.0g) green tea extract 0.20g (being equivalent to green tea 2g) stevioside 0.04g oligofructose 1g preparation method:
Get Radix Gymnematis Sylvestris, water heating extraction three times (2h, 1.5h, 1h), merge extractive liquid,, filter, filtrate is concentrated in right amount, through clarifying treatment, get filtrate, concentrating under reduced pressure becomes clear paste, and other gets green tea extract, after adding stevioside, oligofructose mixing again, with above-mentioned clear paste mixing, make soft material again, sieve, make can be oral granule, drying, weighing packs promptly.Experimental example 1 pharmacodynamics test: (one), given the test agent:
The compositions of embodiment 1 and Gymnema P.E, face with preceding and be made into desired concn (two) positive control drug with distilled water:
JIANGZHILING PIAN, Jintan, Jiangsu Province county pharmaceutical factory produces, lot number: 980604 (three) reagent:
Blood sugar detection reagent, lot number: 980904, east, Wenzhou bowl biological engineering company limited (four) instrument:
722 grating spectrophotometers, Shanghai the 3rd analytical tool factory (five) animal:
Kunming mouse, body weight 20 ± 2g, Guangxi Chinese medicine institute animal housing provides.(6) experiment condition:
25 ± 2 ℃ of room temperatures, relative humidity 60 ± 5% (seven) method and results:
Get 50 of mices, male female half and half, reserve 10 not moulding, all the other make diabetes model with alloxan.After the moulding 24 hours, be divided into 4 groups by body weight, every group of 10 mices, irritate stomach with distilled water, insoral, embodiment 1 compositions various dose I and II and Gymnema P.E respectively by body weight, successive administration 4 days, and after the last administration, got blood in 1 hour and survey the serum glucose value, with the moulding group relatively, use the t check analysis, the result is as follows: table 1
Annotate: compare with the moulding matched group,
*＜0.05
*P＜0.01
| Group | Dosage g/kg | Number of animals (only) | Blood glucose value (mmol/L) |
| The normal control group | Water 20ml | ????10 | ????3.495±1.55 |
| The moulding matched group | Water 20ml | ????10 | ????20.55±13.27 |
| Insoral | ????0.08g | ????10 | ????6.73±3.32 ** |
| ?Ⅰ | ????0.99g | ????10 | ????3.37±6.06 ** |
| ?Ⅱ | ????0.63g | ????10 | ????3.72±4.60 * |
The result shows that the compositions various dose of the embodiment of the invention 1 all has significant hypoglycemic effect, and obviously is better than the effect that reaches when Gymnema P.E uses separately.Experimental example 2
According to the method identical with experimental example 1, measure the hypoglycemic effect of Gymnema P.E, Radix Gymnematis Sylvestris+green tea extract, Radix Gymnematis Sylvestris+Folium Mori extract and Radix Gymnematis Sylvestris+wolfberry fruit extract, the result is as shown in table 2.Table 2
Annotate: compare with the moulding matched group,
*P＜0.01
| Group | Dosage g/kg | Number of animals (only) | Blood glucose value (mmol/L) |
| The normal control group | Water 20ml | ????10 | ????4.10±2.79 |
| The moulding matched group | Water 20ml | ????10 | ????22.30±4.70 |
| Insoral | ????0.08 | ????10 | ????7.94±4.38 ** |
| Gymnema P.E | ????0.8 | ????10 | ????10.07±6.56 ** |
| Radix Gymnematis Sylvestris+Folium Mori extract | ????0.8 | ????10 | ????12.46±5.84 ** |
| Radix Gymnematis Sylvestris+wolfberry fruit extract | ????0.8 | ????10 | ????18.72±6.68 |
| Radix Gymnematis Sylvestris+green tea extract | ????0.8 | ????10 | ????8.05±2.36 ** |
The result shows that the hypoglycemic effect of Radix Gymnematis Sylvestris+green tea extract not only is better than Gymnema P.E, and is better than Radix Gymnematis Sylvestris+Folium Mori extract and Radix Gymnematis Sylvestris+wolfberry fruit extract.Experimental example 3
According to the method identical with experimental example 1, measure the influence of Radix Gymnematis Sylvestris leaf, Radix Gymnematis Sylvestris stem and Radix Gymnematis Sylvestris base of leaf extract to euglycemia, the result is as shown in table 3.Table 3
| Group | Dosage g/kg | Blood glucose value (mmol/L) |
| The Radix Gymnematis Sylvestris leaf extract | ???????0.8 | ????????5.56±1.85 |
| The Radix Gymnematis Sylvestris stem extract | ???????0.8 | ????????5.48±1.09 |
| Radix Gymnematis Sylvestris base of leaf extract | ???????0.8 | ????????5.37±1.07 |
| The normal control group | Water 20ml | ????????4.78±0.87 |
| The insoral group | ???????0.08 | ????????3.59±3.02 |
The result shows that the mixed extract of GS leaf and GS stem and GS base of leaf does not have obvious influence to euglycemia, does not promptly reduce euglycemia.
Claims (5)
1. Chinese medicine composition with blood sugar reducing function, be made up of Gymnema P.E, green tea extract and solid preparation acceptable auxiliary, the weight ratio that wherein is used to extract the Radix Gymnematis Sylvestris of Radix Gymnematis Sylvestris and green tea extract and green tea raw material of Chinese medicine in described compositions is between 20: 1 to 2: 1.
2. according to the described compositions of claim 1, the weight ratio that wherein is used to extract the Radix Gymnematis Sylvestris of Radix Gymnematis Sylvestris and green tea extract and green tea raw material of Chinese medicine is between 12: 1 to 6: 1.
3. according to the described compositions of claim 1, wherein effective ingredient is gymnemic acid and conduritol A in the Gymnema P.E, and effective ingredient is tea polysaccharide and tea polyphenols in the green tea extract.
4. according to the described compositions of claim 1, wherein the agents area of Radix Gymnematis Sylvestris is stem and leaf.
5. according to the described compositions of claim 1, it is characterized in that being the granule dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011154152A CN1141125C (en) | 2001-04-24 | 2001-04-24 | Hypolycemic traditional Chinese medicine composite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011154152A CN1141125C (en) | 2001-04-24 | 2001-04-24 | Hypolycemic traditional Chinese medicine composite |
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| CN1323625A true CN1323625A (en) | 2001-11-28 |
| CN1141125C CN1141125C (en) | 2004-03-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB011154152A Expired - Fee Related CN1141125C (en) | 2001-04-24 | 2001-04-24 | Hypolycemic traditional Chinese medicine composite |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999668A (en) * | 2010-10-11 | 2011-04-06 | 孙羽蒙 | Formula for treating diabetes mellitus |
| CN102793798A (en) * | 2012-07-25 | 2012-11-28 | 青岛文创科技有限公司 | Medicinal composition for auxiliary treatment of diabetic coronary artery disease |
| CN102793799A (en) * | 2012-07-25 | 2012-11-28 | 青岛文创科技有限公司 | Buccal tablets with weight reduction effect |
| CN103211859A (en) * | 2013-04-09 | 2013-07-24 | 桂林莱茵生物科技股份有限公司 | Pharmaceutical composition with hypoglycemic effect as well as preparation method and use of pharmaceutical composition |
-
2001
- 2001-04-24 CN CNB011154152A patent/CN1141125C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999668A (en) * | 2010-10-11 | 2011-04-06 | 孙羽蒙 | Formula for treating diabetes mellitus |
| CN101999668B (en) * | 2010-10-11 | 2012-05-23 | 孙羽蒙 | Composition for treating diabetes mellitus |
| CN102793798A (en) * | 2012-07-25 | 2012-11-28 | 青岛文创科技有限公司 | Medicinal composition for auxiliary treatment of diabetic coronary artery disease |
| CN102793799A (en) * | 2012-07-25 | 2012-11-28 | 青岛文创科技有限公司 | Buccal tablets with weight reduction effect |
| CN102793798B (en) * | 2012-07-25 | 2014-07-23 | 青岛文创科技有限公司 | Medicinal composition for auxiliary treatment of diabetic coronary artery disease |
| CN102793799B (en) * | 2012-07-25 | 2014-10-08 | 青岛文创科技有限公司 | Buccal tablets with weight reduction effect |
| CN103211859A (en) * | 2013-04-09 | 2013-07-24 | 桂林莱茵生物科技股份有限公司 | Pharmaceutical composition with hypoglycemic effect as well as preparation method and use of pharmaceutical composition |
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| Publication number | Publication date |
|---|---|
| CN1141125C (en) | 2004-03-10 |
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