CN1321208C - 改进的用于医用器械和移植物的金属合金 - Google Patents

改进的用于医用器械和移植物的金属合金 Download PDF

Info

Publication number
CN1321208C
CN1321208C CNB2004100038787A CN200410003878A CN1321208C CN 1321208 C CN1321208 C CN 1321208C CN B2004100038787 A CNB2004100038787 A CN B2004100038787A CN 200410003878 A CN200410003878 A CN 200410003878A CN 1321208 C CN1321208 C CN 1321208C
Authority
CN
China
Prior art keywords
medical implant
weight ratio
described medical
apparatuses
alloy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004100038787A
Other languages
English (en)
Other versions
CN1521284A (zh
Inventor
H·J·韦希特尔
J·特罗茨舍尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heraeus Materials Technology GmbH & Co.
WC Heraus GmbH and Co KG
Osram GmbH
Original Assignee
WC Heraus GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32605362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1321208(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by WC Heraus GmbH and Co KG filed Critical WC Heraus GmbH and Co KG
Publication of CN1521284A publication Critical patent/CN1521284A/zh
Application granted granted Critical
Publication of CN1321208C publication Critical patent/CN1321208C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C27/00—Alloys based on rhenium or a refractory metal not mentioned in groups C22C14/00 or C22C16/00
    • C22C27/02—Alloys based on vanadium, niobium, or tantalum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C27/00—Alloys based on rhenium or a refractory metal not mentioned in groups C22C14/00 or C22C16/00
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C30/00—Alloys containing less than 50% by weight of each constituent

Abstract

本发明涉及至少部分由合金构成的医用器械或移植物，所述合金是由铌、钽以及选自锆、钨或钼中至少一种元素构成的高强度、低膜数的金属合金。本发明的医用器械具有出色的生物相容性、不穿透射线性以及MRI兼容性。

Description

改进的用于医用器械和移植物的金属合金
技术领域
本发明涉及具有医用移植物或器械所需材料特性的改进的金属合金。
背景技术
医用移植物或器械必须满足许多要求。选择医用移植物或器械及其材料的影响因素主要是所有机械特性以及生物相容性。所用材料一定不能引起炎症反应或者过敏反应。常用材料通常包括镍，诸如医用级别316L不锈钢，其包含约16％的镍。对于有过敏反应的病人则不应当使用该类材料的移植物。材料选择过程中还要考虑到能够使移植医生在将移植物移植到机体所需靶点部位的过程中能够看到医用移植物或器械，同时还要满足移植后对移植部位进行检查，例如利用X-光荧光进行检查。
由于磁共振成像(MRI)越来越重要，因此还需要具有与MRI的兼容性。通常用于移植的金属合金(如不锈钢316)对MRI中使用的磁场具有局部干扰，该干扰使周围组织的成像不良。尽管诸如镍钛诺等合金能使MRI行为趋于更加有利，但其MRI兼容性还没有达到足够优秀。
本发明涉及医用器械或移植物，通常包括导管、导丝、支架、支架移植物以及心脏瓣膜修复器械等。
支架通常为薄壁管状、由支柱互相连接的复杂模式组成的器械，该支柱使得血管或诸如食管和尿道等其他机体腔管的一部分保持张开的状态。支架移植物是具有圆周状覆盖层或内层的支架，其可用于支撑造成管腔闭塞的动脉夹层或内膜瓣。典型地，支架和支架移植物是利用导管进行移植的。最初它们保持放射状压缩状态从而可操纵它们通过管腔。一旦到达所需位置后则呈展开状态。构成诸如支架或支架移植物的血管假体材料必须使该血管假体能够扩张，其特别需要实质性的变形。支架一旦扩张，必须保持其大小及形状，且必须能够承受当支架支持血管内腔壁时加到其上的结构负载，即压缩成放射状的力。根据支架材料的种类，假体的壁必须足够厚，不仅为了承受血管壁的回弹力，同时还要在荧光检查时可见。最后，假体材料必须是生物相容的以使在移植后的血管中不会引发生成诸如再狭窄或血栓等不利的血管反应。
对于所有类别的导管和导丝所需的特殊机械特性，其为在导入过程中具有理想的跟踪能力和扩展能力。而且，为通过X-射线和MRI对医疗过程进行检测，还需要有良好的不穿透射线性和MRI兼容性。最后，这些医用器械必须还有生物相容性。
在过去几年中已经在找寻新的医用移植物和器械的材料方面付出了许多努力，与常规使用的诸如不锈钢或者钛等材料相比，这些材料具有出色的特性。许多出版物集中于有抗腐蚀性的钛合金、高强度和具有生物相容性的合金。如在US6,312,455、US2001/0007953和WO99/58184中所述，许多钛合金是高弹性的或形状记忆的合金。在US6,258,182中描述了由钛、钼、铝、任选的铌、铬和钒构成的伪弹性β-钛合金。EP0 788802提供了一种可自我扩张的支架，其由钛合金组成，所述钛合金包括至少约68％重量比的钛和任选的铌、锆和钼。US6,238,491和WO00/68448描述了用于医用器械的铌-钛-锆-钼合金，其能提供均一的β-结构，具有抗腐蚀性，并可以被处理以具有高强度和低模数。该合金包含29～70％重量百分比的铌，10～46％重量百分比的锆，3-15％重量百分比的钼，余量为钛。在另一方法中，Davidson(EP0 601 804)使用了主要由钛组成的合金，该合金还含有10～20％或者25～50％重量百分比的铌，以及任选的多至20％重量百分比的锆。该合金具有少于90GPa的弹性模数。Davidson还公开了用于医疗移植物的类似的钛合金，其包括钛、10～20％或者35～50％重量百分比的铌，以及任选的每种重量百分比为20％的锆和钽(EP0 437 079)或者钛，每种重量百分比为10～20％或35～50％的铌和钽以及任选的20％重量百分比的锆(US5,690,670)。EP0 707 085还提供了用作医用器械的、具有低模数并具有生物相容性的钛合金，其包括20～40％重量百分比的铌，4.5～25％重量百分比的钽，2.5～13％重量百分比的锆，余量为钛。US4,857,269和EP0 359 446公开了具有更高强度、低模数并具有生物相容性的钛合金，其包括钛和最高可达25％重量比的铌、锆和钼。EP1 046 722描述了用作医用器械的具有抗腐蚀性的钛-锆型合金，其包括25～50％重量比的钛，5～30％重量比的铌，5～40％重量比的钽和25～60％重量比的锆。
US6,478,815和WO02/43787描述了进一步产生同样具有不穿透射线性并且不含钛的、并具有生物相容性以及高强度的合金的方法。两份文件都公开了由至少90％重量比的铌构成的支架。铌是一种相对软且易延展的金属，其通过补充痕量的其它元素，例如锆、钽或钛而加强合金。然而，由于铌易于被涂掉，因此铌表面不能用电解法抛光。WO02/05863公开了由两种钽合金，即钽-铌和钽-钨组成的支架。
发明内容
本发明的目的在于提供一种用于医用移植物和器械的材料，其具有有利的机械特性，优秀的生物相容性，理想的不穿透射线性，同时在MRI检测中具有较小的赝象图像(MRI相容性)，从而能克服近期医用金属的缺点。
该合金满足其作为医用移植物或器械的所有机械和结构的必要条件。此外，所述器械还具有良好的不穿透射线性，在无需额外加入不穿透射线物质层或组成部分的情况下，该器械在X-射线下有良好的成像特性。而且，该器械的亮光不过度，因此不会使周围组织成像模糊，该问题却存在于由极高密度材料制成的器械中。另外，该器械对MRI是安全的并且兼容的，优选地，在MRI下还是可见的。
已经令人惊讶地发现包含钽、铌和至少一种选自钨、锆和钼元素所构成的金属合金可得到所需的特性。
钽是一种非常坚硬的金属，其具有高熔点、高强度、以及良好的延展性，并且在室温下几乎完全惰性。钽具有很高的原子数(73)，密度为16.6g/cm3，这使得它具有很高的不穿透射线性。因此，完全由钽制得的医用移植物或者器械具有过度不穿透射线性的缺点，从而在X-射线成像时，医用移植物或器械所在的位置为完全黑色的区域。
本发明金属合金的不穿透射线性通过在钽合金中进一步加入具有较高或较低原子数的元素进行调节，从而使合金的密度降低。铌的原子质量大约为钽的一半。因此，通过改变铌的含量来调整本发明合金的密度，可使至少部分由本发明合金制备的每个医用器械或移植物都具有合适的不穿透射线性能。可以根据本发明制造一种合金，其在X-射线下具有充足的不穿透射线性，在医疗过程中其清楚可见，然而其不穿透射线性并不干扰周围机体组织的可见性。
由于铌和钽可以任意混合，因此本发明的合金具有优秀的融化和混合特性以及良好的均一性。可通过改变钨、锆和钼的含量，或者任选改变铈、铼或铪的量来调整合金颗粒的大小。
令人惊讶地，本发明的合金比纯钽更坚硬，特定组分组成的合金硬度甚至要强于不锈钢。在一个优选实施例中，由本发明合金制备的支架具有合适的不穿透射线性，但其壁的厚度却降低了。当用于血管中时，该支架具有在X-射线下所需的可见性及放射状力，同时具有最小的传送外形以及最少的紊乱性。
本发明合金的另一优点是形成了主要由氧化钽(Ta2O5)组成的钝态氧化膜，其与不锈钢钝化过程中形成的诸如氧化铬膜相比，通常更耐用且具有更好的抗腐蚀性。
本发明的合金易于通过冷加工来增加其强度并减小其弹性模数。利用本领域技术人员已知的常规氧化和氮化的方法可在本发明合金上形成坚硬、且抗磨损的表面。由于医用移植物及器械需要有更低的摩擦和磨损、需要电绝缘性以及更好的抗腐蚀性，因此合金的坚硬、惰性且抗磨损的表层是医用移植物及器械进行选择的很重要条件。
为了进一步改善至少部分由本发明合金制备的医用移植物或器械的生物相容性，至少本发明合金表面的一部分可以是被硬化的和/或涂层的转换表面。该涂层可以包括，但不限于：聚合物、聚合物混合物、金属、金属混合物、陶瓷和/或生物分子，尤其是肽、蛋白质、脂类、碳水化合物和/或核酸(例如胶原质、肝素、纤维蛋白、磷酸胆碱、纤维素、形态生成蛋白或肽、生长因子)。此外，合金表面或涂层可以包含干细胞和/或生物活性物质，尤其是药物、抗生素、生长因子、抗炎剂和/或抗血栓剂。进一步地，该表面可用电解法抛光或机械法抛光从而形成完全光滑的表面，可如EP0601804所述进行烧结形成多孔的涂层，或者通过糙化处理或微喷射处理，尤其是喷砂而使其具有粗糙表面。
本发明合金可用于制备多种医用移植物或器械。利用本发明合金制备的医用器械包括极小的介入型器械，尤其是导丝、导管(球形导管、引导管、血管造影导管、功能性导管等)，管腔内移植物，尤其是食管内、尿道内、气管内移植物，以及血管内移植物，尤其是支架、支架移植物、支架移植连接器，心脏瓣膜修复器械或过滤器等。
优选的合金包括下述成分：
(a)约0.1～70％重量比的铌；
(b)总共约0.1～30％重量比的选自钨、锆或钼的至少一种元素；
(c)总共最多为5％重量比的选自铪、铼、或镧系元素，尤其是铈的至少一种元素；
(d)余量为钽。
该合金优选提供均一的β结构，其具有均一性及抗腐蚀性，具有通过氧化或氮化转换表面的能力，从而使医用移植物或器械硬度增加。
钨的含量优选为0.1～15％重量比。
锆的含量优选为0.1～10％重量比。
钼的含量优选为0.1～20％重量比，更优选为0.1～10％重量比。
铌的含量优选为5～25％重量比。
特别优选的合金包含约10％重量比的铌和约2.5％重量比的钨。
优选的合金还包括约10％重量比的铌和约7.5％重量比的钨。
优选的合金还包括约10％重量比的铌和约1％重量比的锆。
优选的合金还包括约10％重量比的铌和约3％重量比的锆。
本发明还涉及由上述合金制备的医用移植物或器械，例如极小的介入型器械，尤其是导管或导丝，或管腔内移植物，尤其是血管内移植物，诸如支架、支架移植物、支架移植连接器或心脏瓣膜修复器械等。
在上述的移植物或器械中，金属合金的表面可通过氧化或氮化反应钝化，或者通过电解法抛光或机械抛光，微喷射，糙化或烧结，或者采用聚合物、聚合物混合物、金属、金属混合物、陶瓷和/或生物分子尤其是肽、蛋白质、脂类、碳水化合物和/或核酸进行涂层，也可采用干细胞和/或生物活性物质尤其是药物、抗生素、生长因子、抗炎剂和/或抗血栓剂进行涂层。
具体实施方式
可采用下述组成的合金实施本发明：
实施例1
Nb：27.5；Zr：1.0；Ta：71.5；
实施例2
Nb：10；W：2.5；Ta：87.5
实施例3
Nb：10；Mo：7.5；Ta：82.5
实施例4
Nb：20；Mo：3；Ta：77
实施例5
Nb：50；Zr：5，Ce：5；Ta：40
实施例6
Nb：55；W：1.0；Re：1.0；Ta：43
实施例7
Nb：26.5；Mo：1.0，Hf：1.0；Ta：71.5
制备合金的方法是本领域技术人员公知的。

Claims (19)

1.由金属合金制备的医用移植物或器械，所述医用移植物或器械至少部分包含一种金属合金，该合金包括：
(a)5～55％重量比的铌；
(b)0.1～15％重量比的钨和/或0.1～10％重量比的锆和/或0.1～20％重量比的钼；
(c)总共最多为5％重量比的选自铪、铼、或镧系元素的至少一种元素；
(d)余量为钽；
其中，所述合金提供了均一的β结构，其具有均一性及抗腐蚀性，并具有通过氧化或氮化转换表面的能力，从而使医用移植物或器械的硬度增加。
2.权利要求1所述的医用移植物或器械，其中所述镧系元素是铈。
3.权利要求1所述的医用移植物或器械，其中所述合金包括10％重量比的铌、7.5％重量比的钨，余量为钽。
4.权利要求1或2所述的医用移植物或器械，其中所述合金包括5～25％重量比的铌。
5.权利要求1或2所述的医用移植物或器械，其中所述合金包括10％重量比的铌和2.5％重量比的钨。
6.权利要求1或2所述的医用移植物或器械，其中所述合金包括10％重量比的铌和7.5％重量比的钨。
7.权利要求1或2所述的医用移植物或器械，其中所述合金包括10％重量比的铌和1％重量比的锆。
8.权利要求1或2所述的医用移植物或器械，其中所述合金包括10％重量比的铌和3％重量比的锆。
9.权利要求1或2所述的医用移植物或器械，其中所述医用器械是极小的介入型器械。
10.权利要求9所述的医用移植物或器械，其中所述极小的介入型器械是导管或导丝。
11.权利要求1或2所述的医用移植物或器械，其中所述医用移植物是管腔内移植物。
12.权利要求11所述的医用移植物或器械，其中所述管腔内移植物是血管内移植物。
13.权利要求1或2所述的医用移植物或器械，其中所述医用移植物是支架、支架移植物、支架移植连接器或心脏瓣膜修复器械。
14.权利要求1或2所述的医用移植物或器械，其中所述金属合金的表面通过氧化或氮化反应进行钝化。
15.权利要求1或2所述的医用移植物或器械，其中所述金属合金的表面是通过电解法抛光、机械抛光、微喷射、糙化或烧结处理的。
16.权利要求1或2所述的医用移植物或器械，其中所述金属合金的表面采用聚合物、聚合物混合物、金属、金属混合物、陶瓷和/或生物分子进行涂层。
17.权利要求16所述的医用移植物或器械，其中所述生物分子是肽、蛋白质、脂类、碳水化合物和/或核酸。
18.权利要求1或2所述的医用移植物或器械，其中所述金属合金的表面采用干细胞和/或生物活性物质进行涂层。
19.权利要求18所述的医用移植物或器械，其中所述生物活性物质是药物、抗生素、生长因子、抗炎剂和/或抗血栓剂。
CNB2004100038787A 2003-02-10 2004-02-10 改进的用于医用器械和移植物的金属合金 Expired - Fee Related CN1321208C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002905.2A EP1444993B2 (en) 2003-02-10 2003-02-10 Improved metal alloy for medical devices and implants
EP03002905.2 2003-02-10

Publications (2)

Publication Number Publication Date
CN1521284A CN1521284A (zh) 2004-08-18
CN1321208C true CN1321208C (zh) 2007-06-13

Family

ID=32605362

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100038787A Expired - Fee Related CN1321208C (zh) 2003-02-10 2004-02-10 改进的用于医用器械和移植物的金属合金

Country Status (7)

Country Link
US (5) US20040158309A1 (zh)
EP (1) EP1444993B2 (zh)
JP (1) JP2004244726A (zh)
CN (1) CN1321208C (zh)
AT (1) ATE343403T1 (zh)
DE (1) DE60309281T3 (zh)
PT (1) PT1444993E (zh)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6893772B2 (en) * 1993-11-19 2005-05-17 Medtronic, Inc. Current collector for lithium electrode
US6461364B1 (en) 2000-01-05 2002-10-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US7842068B2 (en) 2000-12-07 2010-11-30 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US6391048B1 (en) 2000-01-05 2002-05-21 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
EP1294288B1 (en) 2000-09-08 2011-03-30 Abbott Vascular Inc. Surgical staple
US6626918B1 (en) 2000-10-06 2003-09-30 Medical Technology Group Apparatus and methods for positioning a vascular sheath
US7211101B2 (en) 2000-12-07 2007-05-01 Abbott Vascular Devices Methods for manufacturing a clip and clip
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7806904B2 (en) 2000-12-07 2010-10-05 Integrated Vascular Systems, Inc. Closure device
US7905900B2 (en) 2003-01-30 2011-03-15 Integrated Vascular Systems, Inc. Clip applier and methods of use
US6623510B2 (en) 2000-12-07 2003-09-23 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
IES20010547A2 (en) 2001-06-07 2002-12-11 Christy Cummins Surgical Staple
US6749621B2 (en) 2002-02-21 2004-06-15 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US7850709B2 (en) 2002-06-04 2010-12-14 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US7857828B2 (en) 2003-01-30 2010-12-28 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
EP1444993B2 (en) * 2003-02-10 2013-06-26 W.C. Heraeus GmbH Improved metal alloy for medical devices and implants
US20070276488A1 (en) * 2003-02-10 2007-11-29 Jurgen Wachter Medical implant or device
US20090093875A1 (en) 2007-05-01 2009-04-09 Abbott Laboratories Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
US8100923B2 (en) 2003-09-15 2012-01-24 Abbott Laboratories Suture locking device and methods
US20050098241A1 (en) * 2003-11-11 2005-05-12 W. C. Heraeus Gmbh & Co. Kg Niobium-Zirconium Alloy for medical devices or their parts
IES20040368A2 (en) 2004-05-25 2005-11-30 James E Coleman Surgical stapler
US20070280850A1 (en) * 2004-09-27 2007-12-06 Carlson James M Mri Compatible Devices
US7727273B2 (en) 2005-01-13 2010-06-01 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
WO2006080381A1 (ja) * 2005-01-28 2006-08-03 Terumo Kabushiki Kaisha 血管内インプラント
CN104146795B (zh) 2005-04-05 2017-11-10 万能医药公司 可降解的植入式医疗装置
US20060259126A1 (en) * 2005-05-05 2006-11-16 Jason Lenz Medical devices and methods of making the same
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
GB0707671D0 (en) * 2007-04-20 2007-05-30 Invibio Ltd Fiducial marker
CN100348756C (zh) * 2005-12-27 2007-11-14 北京航空航天大学 一种单相铌钨铪超高温合金材料
US20070178383A1 (en) * 2006-01-31 2007-08-02 Viavattine Joseph J Current collector
EP1998846B1 (en) * 2006-03-24 2012-07-25 Medtronic, Inc. Implantable medical device
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US20080103543A1 (en) * 2006-10-31 2008-05-01 Medtronic, Inc. Implantable medical device with titanium alloy housing
US7831096B2 (en) * 2006-11-17 2010-11-09 General Electric Company Medical navigation system with tool and/or implant integration into fluoroscopic image projections and method of use
US7972375B2 (en) * 2007-02-05 2011-07-05 Boston Scientific Scimed, Inc. Endoprostheses including metal matrix composite structures
JP2010526625A (ja) 2007-05-15 2010-08-05 カメレオン バイオサーフェセズ リミテッド 医療器具へのポリマー・コーティング
US8226681B2 (en) 2007-06-25 2012-07-24 Abbott Laboratories Methods, devices, and apparatus for managing access through tissue
US20090157101A1 (en) 2007-12-17 2009-06-18 Abbott Laboratories Tissue closure system and methods of use
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US7841502B2 (en) 2007-12-18 2010-11-30 Abbott Laboratories Modular clip applier
WO2009079282A1 (en) * 2007-12-19 2009-06-25 Icon Medical Corp. A method for forming a tubular medical device
CA2711589A1 (en) * 2008-01-10 2009-07-16 Ethicon, Inc. Tungsten alloy suture needles with surface coloration
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
EP2364376A1 (en) * 2008-09-23 2011-09-14 Sandvik Intellectual Property AB Titanium-based alloy
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US20100179589A1 (en) 2009-01-09 2010-07-15 Abbott Vascular Inc. Rapidly eroding anchor
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US20100179567A1 (en) 2009-01-09 2010-07-15 Abbott Vascular Inc. Closure devices, systems, and methods
US20100185234A1 (en) 2009-01-16 2010-07-22 Abbott Vascular Inc. Closure devices, systems, and methods
EP2393627B1 (en) 2009-02-03 2018-05-09 Abbott Cardiovascular Systems Inc. Multiple beam laser system for forming stents
US8639352B2 (en) * 2009-04-06 2014-01-28 Medtronic, Inc. Wire configuration and method of making for an implantable medical apparatus
DE102009036298A1 (de) 2009-08-06 2011-02-17 W.C. Heraeus Gmbh Verwendung von pulvermetallurgischem Vormaterial zur Herstellung einer Legierung
US20110054492A1 (en) 2009-08-26 2011-03-03 Abbott Laboratories Medical device for repairing a fistula
DE102009056504B4 (de) * 2009-12-02 2015-05-28 Heraeus Precious Metals Gmbh & Co. Kg Verfahren zur Herstellung einer einschlussfreien Nb-Legierung aus pulvermetallurgischem Vormaterial für eine implantierbare medizinische Vorrichtung
US20110146361A1 (en) * 2009-12-22 2011-06-23 Edwards Lifesciences Corporation Method of Peening Metal Heart Valve Stents
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
DE102010018303B4 (de) 2010-04-23 2015-02-12 Heraeus Precious Metals Gmbh & Co. Kg Schmelzverfahren zur Herstellung einer einschlussfreien Ta-Basislegierung für eine implantierbare medizinische Vorrichtung
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
US8480597B2 (en) * 2010-09-13 2013-07-09 Abbott Laboratories Color coded guide wire and methods of making same
US8333801B2 (en) * 2010-09-17 2012-12-18 Medtronic Vascular, Inc. Method of Forming a Drug-Eluting Medical Device
US8603137B2 (en) 2010-11-01 2013-12-10 Abbott Cardiovascular Systems, Inc. Methods and systems for establishing hemostasis relative to a puncture
US11298251B2 (en) 2010-11-17 2022-04-12 Abbott Cardiovascular Systems, Inc. Radiopaque intraluminal stents comprising cobalt-based alloys with primarily single-phase supersaturated tungsten content
US8685047B2 (en) 2011-02-07 2014-04-01 Abbott Vascular, Inc. Scaffold device for preventing tissue trauma
US9149265B2 (en) 2011-02-26 2015-10-06 Abbott Cardiovascular Systems, Inc. Hinged tissue support device
US9149276B2 (en) 2011-03-21 2015-10-06 Abbott Cardiovascular Systems, Inc. Clip and deployment apparatus for tissue closure
US9409008B2 (en) 2011-04-22 2016-08-09 Medtronic, Inc. Cable configurations for a medical device
US8660662B2 (en) 2011-04-22 2014-02-25 Medtronic, Inc. Low impedance, low modulus wire configurations for a medical device
US8340759B2 (en) 2011-04-22 2012-12-25 Medtronic, Inc. Large-pitch coil configurations for a medical device
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9724494B2 (en) 2011-06-29 2017-08-08 Abbott Cardiovascular Systems, Inc. Guide wire device including a solderable linear elastic nickel-titanium distal end section and methods of preparation therefor
US9055932B2 (en) 2011-08-26 2015-06-16 Abbott Cardiovascular Systems, Inc. Suture fastener combination device
US8852220B2 (en) 2011-09-07 2014-10-07 Abbott Cardiovascular Systems, Inc. Thrombus penetrating devices, systems, and methods
US20130096666A1 (en) * 2011-10-12 2013-04-18 Abbott Cardiovascular Systems, Inc. Implantable medical devices including a heat-treated tantalum-alloy body having a drug-eluting coating thereon, and methods of making and using same
US20130092555A1 (en) * 2011-10-12 2013-04-18 Abbott Cardiovascular Systems, Inc. Removal of an island from a laser cut article
US8790393B2 (en) 2011-10-12 2014-07-29 Abbott Cardiovascular Systems, Inc. Heat-treated tantalum-alloy products, implantable medical devices incorporating same, and methods of processing tantalum-alloy products
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9399262B2 (en) 2011-12-15 2016-07-26 Lake Region Manufacturing, Inc. Method of joining titanium and titanium-based alloys to ferrous metals using tantalum
JP2013181190A (ja) * 2012-02-29 2013-09-12 Seiko Instruments Inc 生体用Ｃｏ基合金およびステント
US9456814B2 (en) 2012-04-09 2016-10-04 Abbott Cardiovascular Systems, Inc. Closure devices, systems, and methods
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US8992761B2 (en) 2012-07-13 2015-03-31 Abbott Cardiovascular Systems, Inc. Methods for passivating metallic implantable medical devices including radiopaque markers
US9345475B2 (en) 2012-09-11 2016-05-24 Abbott Cardiovascular Systems, Inc. Needle harvesting devices, systems and methods
US9345474B2 (en) 2012-09-11 2016-05-24 Abbott Cardiovascular Systems, Inc. Needle removal devices, systems, and methods
US9470462B2 (en) 2012-12-14 2016-10-18 TITAN Metal Fabricators Heat exchanger for heating hydrochloric acid pickling solution, a system and method for pickling, and a method of manufacturing steel products
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US9486132B2 (en) 2013-01-17 2016-11-08 Abbott Cardiovascular Systems, Inc. Access device for accessing tissue
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
WO2015054183A1 (en) 2013-10-08 2015-04-16 The Johns Hopkins University Cell impregnated sleeve for paracrine and other factor production
CN103805798A (zh) * 2014-02-20 2014-05-21 中南大学 多孔钽铌合金及其制备方法
BR102014006114B1 (pt) * 2014-03-14 2022-05-10 Antônio Francisco Neves Filho Stent com válvula cardíaca mecânica ou biológica para procedimento de troca de válvula minimamente invasivo e dispositivo aplicador de stent
EP3160397A4 (en) 2014-06-24 2018-03-21 Icon Medical Corp. Improved metal alloys for medical devices
US9546837B1 (en) 2015-10-09 2017-01-17 Bh5773 Ltd Advanced gun barrel
DE202017007326U1 (de) 2016-01-29 2020-10-20 Neovasc Tiara Inc. Klappenprothese zum Verhindern einer Abflussobstruktion
US11766506B2 (en) 2016-03-04 2023-09-26 Mirus Llc Stent device for spinal fusion
CN107794425B (zh) * 2016-10-31 2020-01-24 中南大学 一种低弹模钽锆牙科种植体材料及其制备方法
EP3541462A4 (en) 2016-11-21 2020-06-17 Neovasc Tiara Inc. METHODS AND SYSTEMS FOR RAPID RETRACTION OF A TRANSCATHETER HEART VALVE DELIVERY SYSTEM
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. TRANSCATHETER MITRAL VALVULE PROSTHESIS WITH SEQUENTIAL DEPLOYMENT
CA3118599A1 (en) 2018-11-08 2020-05-14 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
EP3946163A4 (en) 2019-04-01 2022-12-21 Neovasc Tiara Inc. ADJUSTABLE VALVE PROSTHESIS
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM
AU2020295566B2 (en) 2019-06-20 2023-07-20 Neovasc Tiara Inc. Low profile prosthetic mitral valve
US11439383B2 (en) 2019-08-20 2022-09-13 Abbott Cardiovascular Systems, Inc. Self locking suture and self locking suture mediated closure device
US20210220513A1 (en) * 2020-01-22 2021-07-22 Warsaw Orthopedic, Inc. High-Modulus Alloy for Medical Devices
JP2023512663A (ja) 2020-01-24 2023-03-28 パッチクランプ メドテック， インコーポレイテッド 着脱可能な移植片・留め具アセンブリを有する組織修復・シーリングデバイスおよびそれを使用するための方法
KR102532068B1 (ko) * 2020-09-22 2023-05-11 서울대학교산학협력단 고강도 고성형성 탄탈륨 합금 및 그 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005863A1 (en) * 2000-07-14 2002-01-24 Advanced Cardiovascular Systems, Inc. Radiopaque stent composed of a binary alloy

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2907654A (en) 1957-07-01 1959-10-06 Sierra Metals Corp High temperature tantalum-columbium base alloys
DE1123836B (de) 1958-06-20 1962-02-15 Plansee Metallwerk Verwendung einer Tantal- bzw. Nioblegierung
GB933712A (en) 1958-08-14 1963-08-14 Fansteel Metallurgical Corp Alloys of columbium and tantalum
US3173784A (en) * 1958-12-22 1965-03-16 Union Carbide Corp Columbium base alloy
US3317314A (en) * 1959-11-18 1967-05-02 Union Carbide Corp Columbium-base alloy
US3128178A (en) 1961-02-28 1964-04-07 California Research Corp Tantalum-titanium base alloy
US3186837A (en) * 1961-02-28 1965-06-01 California Research Corp Columbium-tantalum base alloy
US3183085A (en) * 1961-09-15 1965-05-11 Westinghouse Electric Corp Tantalum base alloys
US3188206A (en) † 1961-12-20 1965-06-08 Fansteel Metallurgical Corp Columbium alloy
US3140943A (en) * 1962-01-17 1964-07-14 Westinghouse Electric Corp Tantalum base alloys
US3254995A (en) * 1962-04-13 1966-06-07 Powder Alloys Corp Heavy metal alloys
US3163563A (en) 1962-07-13 1964-12-29 Nat Res Corp Composite body formed of a tantalum alloy having an outer carburized surface layer
US3341370A (en) * 1963-12-10 1967-09-12 United Aircraft Corp Hafnium-containing columbium-base alloys
US3249429A (en) * 1963-12-27 1966-05-03 Clo E Armantrout Tantalum brazing alloy
US3297438A (en) * 1964-04-06 1967-01-10 United Aircraft Corp High temperature strength columbium base alloys
GB1103724A (en) * 1964-11-10 1968-02-21 Birmingham Small Arms Co Ltd Improvements in or relating to niobium alloys
US3592639A (en) * 1968-08-19 1971-07-13 Fansteel Inc Tantalum-tungsten alloy
US3549429A (en) * 1968-08-27 1970-12-22 Surface Technology Corp Wear and abrasion resistant materials
US3679494A (en) 1969-04-30 1972-07-25 Iit Res Inst Nitrided hafnium-tantalum alloys and method of making the same
US3674572A (en) * 1970-03-04 1972-07-04 Surface Technology Corp Nitrided tantalum columbium and vanadium-rich alloys
ES521441A0 (es) 1982-04-15 1984-01-16 Creusot Loire Procedimiento de fabricacion de un lingote hueco de acero.
US4526749A (en) * 1984-07-02 1985-07-02 Cabot Corporation Tantalum-columbium-molybdenum-tungsten alloy
JPS61124566A (ja) 1984-11-19 1986-06-12 Mitsubishi Metal Corp スパツタリング用Ａｌ−Ｓｉ系合金タ−ゲツト板材の製造法
US5176762A (en) * 1986-01-02 1993-01-05 United Technologies Corporation Age hardenable beta titanium alloy
US4859257A (en) * 1986-01-29 1989-08-22 Fansteel Inc. Fine grained embrittlement resistant tantalum wire
US4799977A (en) 1987-09-21 1989-01-24 Fansteel Inc. Graded multiphase oxycarburized and oxycarbonitrided material systems
AT391435B (de) * 1988-04-14 1990-10-10 Plansee Metallwerk Verfahren zur herstellung einer odssinterlegierung
US4857269A (en) * 1988-09-09 1989-08-15 Pfizer Hospital Products Group Inc. High strength, low modulus, ductile, biopcompatible titanium alloy
ZA9010217B (en) 1989-12-21 1991-10-30 Smith & Nephew Richards Inc Biocompatible low modulus titanium alloy for medical implants
US5477864A (en) * 1989-12-21 1995-12-26 Smith & Nephew Richards, Inc. Cardiovascular guidewire of enhanced biocompatibility
US5545227A (en) * 1989-12-21 1996-08-13 Smith & Nephew Richards, Inc. Biocompatible low modulus medical implants
JPH04184732A (ja) 1990-11-20 1992-07-01 Seiko Epson Corp スパッタリングターゲットおよび、そのスパッタリングターゲットを用いた保護膜
CA2380683C (en) * 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
DE4243757A1 (de) 1992-12-23 1994-06-30 Leybold Materials Gmbh Target für eine Kathodenzerstäubungsanlage aus einer ferromagnetischen Legierung
US5630840A (en) 1993-01-19 1997-05-20 Schneider (Usa) Inc Clad composite stent
DE59507205D1 (de) * 1994-06-09 1999-12-16 Ald Vacuum Techn Gmbh Verfahren zum Herstellen von Gussteilen aus reaktiven Metallen und wiederverwendbare Giessform zur Durchführung des Verfahrens
JPH0841611A (ja) * 1994-07-27 1996-02-13 Mitsui Eng & Shipbuild Co Ltd 撥水性、抗菌性かつ耐食性のアモルファス合金並びに医療用器具
AU705336B2 (en) 1994-10-14 1999-05-20 Osteonics Corp. Low modulus, biocompatible titanium base alloys for medical devices
JPH09215753A (ja) * 1996-02-08 1997-08-19 Schneider Usa Inc チタン合金製自己拡張型ステント
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US6387121B1 (en) * 1996-10-21 2002-05-14 Inflow Dynamics Inc. Vascular and endoluminal stents with improved coatings
US5930332A (en) * 1996-12-03 1999-07-27 General Electric Company Method for connecting a molybdenum-based alloy structure to a structure formed from a more ductile alloy, and related articles
US5954724A (en) * 1997-03-27 1999-09-21 Davidson; James A. Titanium molybdenum hafnium alloys for medical implants and devices
US6312455B2 (en) * 1997-04-25 2001-11-06 Nitinol Devices & Components Stent
KR20010041604A (ko) * 1998-03-05 2001-05-25 메므리 코퍼레이션 의사탄성 베타티타늄합금 및 그의 용도
US6581669B2 (en) * 1998-03-10 2003-06-24 W.C. Heraeus Gmbh & Co., Kg Sputtering target for depositing silicon layers in their nitride or oxide form and a process for its preparation
US6187037B1 (en) * 1998-03-11 2001-02-13 Stanley Satz Metal stent containing radioactivatable isotope and method of making same
DE29806959U1 (de) 1998-04-17 1999-09-02 Thull Roger Implantat zum Einzementieren in einen Knochen
WO1999058184A1 (en) 1998-05-08 1999-11-18 Scimed Life Systems, Inc. Medical apparatus formed of beta-titanium alloys
US6348113B1 (en) * 1998-11-25 2002-02-19 Cabot Corporation High purity tantalum, products containing the same, and methods of making the same
NL1011779C2 (nl) * 1999-04-13 2000-10-16 Elephant Dental Bv Biomedisch hulpmiddel of implantaat.
JP4152050B2 (ja) * 1999-04-23 2008-09-17 テルモ株式会社 Ｔｉ−Ｚｒ系合金
US6767418B1 (en) 1999-04-23 2004-07-27 Terumo Kabushiki Kaisha Ti-Zr type alloy and medical appliance formed thereof
US6238491B1 (en) * 1999-05-05 2001-05-29 Davitech, Inc. Niobium-titanium-zirconium-molybdenum (nbtizrmo) alloys for dental and other medical device applications
RU2178958C2 (ru) * 2000-02-17 2002-01-27 Институт физики твердого тела РАН Жаростойкий материал
DE10043748B4 (de) 2000-09-05 2004-01-15 W. C. Heraeus Gmbh & Co. Kg Zylinderförmiges Sputtertarget, Verfahren zu seiner Herstellung und Verwendung
WO2002020873A2 (de) 2000-09-05 2002-03-14 Zeptosens Ag Verfahren zur abscheidung von mono- und mehrfachschichten von organophosphor- und -phosphonsäuren und deren salzen sowie deren verwendung
US6478815B1 (en) † 2000-09-18 2002-11-12 Inflow Dynamics Inc. Vascular and endoluminal stents
AU2002233936A1 (en) † 2000-11-07 2002-05-21 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal stent, self-fupporting endoluminal graft and methods of making same
EP1337286A1 (en) † 2000-11-28 2003-08-27 Fortimedix B.V. Stent
US7192445B2 (en) † 2000-12-06 2007-03-20 Astra Tech Ab Medical prosthetic devices and implants having improved biocompatibility
US7128757B2 (en) * 2000-12-27 2006-10-31 Advanced Cardiovascular, Inc. Radiopaque and MRI compatible nitinol alloys for medical devices
KR100532631B1 (ko) * 2001-01-15 2005-12-01 데루모 가부시끼 가이샤 인공관
CN2515794Y (zh) * 2001-03-23 2002-10-09 东莞南光电器有限公司 闪光灯管
US6827828B2 (en) * 2001-03-29 2004-12-07 Honeywell International Inc. Mixed metal materials
ATE505216T1 (de) * 2001-12-06 2011-04-15 Smith & Nephew Inc In-situ oxydierte strukturierte oberflächen von prothesen und methode zu deren herstellung
US20040168751A1 (en) * 2002-06-27 2004-09-02 Wu Ming H. Beta titanium compositions and methods of manufacture thereof
DE10245516B4 (de) * 2002-09-27 2004-09-30 W. C. Heraeus Gmbh & Co. Kg Legierung zur Verwendung für Stents
US7491234B2 (en) 2002-12-03 2009-02-17 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents
US6767653B2 (en) * 2002-12-27 2004-07-27 General Electric Company Coatings, method of manufacture, and the articles derived therefrom
US20070276488A1 (en) 2003-02-10 2007-11-29 Jurgen Wachter Medical implant or device
US20120231048A1 (en) 2003-02-10 2012-09-13 Heraeus Precious Metals Gmbh & Co. Kg Medical Devices and Implants from Nb-Ta-W-Zr Alloys
US20080038146A1 (en) 2003-02-10 2008-02-14 Jurgen Wachter Metal alloy for medical devices and implants
EP1444993B2 (en) 2003-02-10 2013-06-26 W.C. Heraeus GmbH Improved metal alloy for medical devices and implants
US20040243133A1 (en) * 2003-03-05 2004-12-02 Therics, Inc. Method and system for manufacturing biomedical articles, such as using biomedically compatible infiltrant metal alloys in porous matrices
US7727273B2 (en) † 2005-01-13 2010-06-01 Boston Scientific Scimed, Inc. Medical devices and methods of making the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005863A1 (en) * 2000-07-14 2002-01-24 Advanced Cardiovascular Systems, Inc. Radiopaque stent composed of a binary alloy

Also Published As

Publication number Publication date
EP1444993B2 (en) 2013-06-26
US8349249B2 (en) 2013-01-08
US8403980B2 (en) 2013-03-26
US20100222866A1 (en) 2010-09-02
US20070221300A1 (en) 2007-09-27
US20080312740A1 (en) 2008-12-18
DE60309281D1 (de) 2006-12-07
US20040158309A1 (en) 2004-08-12
ATE343403T1 (de) 2006-11-15
DE60309281T2 (de) 2007-04-12
JP2004244726A (ja) 2004-09-02
DE60309281T3 (de) 2013-12-12
EP1444993A1 (en) 2004-08-11
CN1521284A (zh) 2004-08-18
EP1444993B1 (en) 2006-10-25
PT1444993E (pt) 2007-01-31
US20130166019A1 (en) 2013-06-27

Similar Documents

Publication Publication Date Title
CN1321208C (zh) 改进的用于医用器械和移植物的金属合金
US20120330390A1 (en) Medical devices and implants from Ta-Nb-W alloys
US20080038146A1 (en) Metal alloy for medical devices and implants
EP2121055B1 (en) Mri compatible, radiopaque alloys for use in medical devices
CN112584876B (zh) 用于可植入医疗器械的铁基生物可降解金属
US8772672B2 (en) Hybrid stent and method of making
Cristea et al. Tantalum based materials for implants and prostheses applications
US20060276910A1 (en) Endoprostheses
WO1998043550A1 (en) Titanium molybdenum hafnium alloys for medical implants and devices
JP2005510317A (ja) 生体活性物質を組み入れた金属構造体と、同構造体の製造方法
EP2769742A1 (en) MRI visible medical device.
WO2008033603A2 (en) Medical devices having alloy compositions
EP2457601A2 (de) Markerkomposit und medizinisches Implantat mit einem Röntgenmarker
Biscarini et al. Enhanced nitinol properties for biomedical applications
EA013514B1 (ru) Способ изготовления эндоваскулярного устройства с покрытием
US20120231048A1 (en) Medical Devices and Implants from Nb-Ta-W-Zr Alloys
US20050098241A1 (en) Niobium-Zirconium Alloy for medical devices or their parts
JP4137327B2 (ja) Ｔｉ−Ｚｒ系合金からなる医療器具
Narnaware Metallic biomaterials for human body implant: a review study
Hasirci et al. Metals as biomaterials
Cui et al. Biocompatibility and fabrication of in situ bioceramic coating
JP2022049329A (ja) 医療用複合材料
Bartorelli The Carbostent: a Carbofilm™-coated stent

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: HERAEUS PRECIOUS METALS GMBH + CO. KG

Free format text: FORMER OWNER: HERAEUS MATERIALS TECHNOLOGY GMBH + CO. KG

Effective date: 20120829

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: HERAEUS MATERIALS TECHNOLOGY GMBH + CO. KG

Free format text: FORMER NAME: W.C. HERAEUS GMBH

Owner name: W.C. HERAEUS GMBH

Free format text: FORMER NAME: W.C. HERAEUS GMBH + CO.

CP01 Change in the name or title of a patent holder

Address after: Hanau, Germany

Patentee after: Heraeus Materials Technology GmbH & Co.

Address before: Hanau, Germany

Patentee before: W.C. HERAEUS GmbH

Address after: Hanau, Germany

Patentee after: W.C. HERAEUS GmbH

Address before: Hanau, Germany

Patentee before: W. C. Heraeus GmbH & Co.KG

TR01 Transfer of patent right

Effective date of registration: 20120829

Address after: Hanau, Germany

Patentee after: Patent-Treuhand-Gesellschaft fur elektrische Gluhlampen MBH

Address before: Hanau, Germany

Patentee before: Heraeus Materials Technology GmbH & Co.

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070613

Termination date: 20170210

CF01 Termination of patent right due to non-payment of annual fee