CN1315841C - 制备氯甲基头孢烯衍生物的改进方法 - Google Patents

制备氯甲基头孢烯衍生物的改进方法 Download PDF

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Publication number
CN1315841C
CN1315841C CNB2003801023937A CN200380102393A CN1315841C CN 1315841 C CN1315841 C CN 1315841C CN B2003801023937 A CNB2003801023937 A CN B2003801023937A CN 200380102393 A CN200380102393 A CN 200380102393A CN 1315841 C CN1315841 C CN 1315841C
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CN
China
Prior art keywords
formula
methoxybenzyl
solvent
acid
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2003801023937A
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English (en)
Chinese (zh)
Other versions
CN1708501A (zh
Inventor
S·尤达亚姆帕拉亚姆帕拉尼萨米
P·B·戴什潘德
S·N·卡拉勒
P·拉玛尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Pharma Ltd
Original Assignee
Orchid Chemicals and Pharmaceuticals Ltd
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Publication date
Application filed by Orchid Chemicals and Pharmaceuticals Ltd filed Critical Orchid Chemicals and Pharmaceuticals Ltd
Publication of CN1708501A publication Critical patent/CN1708501A/zh
Application granted granted Critical
Publication of CN1315841C publication Critical patent/CN1315841C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/08—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
CNB2003801023937A 2002-11-01 2003-10-23 制备氯甲基头孢烯衍生物的改进方法 Expired - Fee Related CN1315841C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN808/MAS/2002 2002-11-01
IN808CH2002 2002-11-01

Publications (2)

Publication Number Publication Date
CN1708501A CN1708501A (zh) 2005-12-14
CN1315841C true CN1315841C (zh) 2007-05-16

Family

ID=35561711

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003801023937A Expired - Fee Related CN1315841C (zh) 2002-11-01 2003-10-23 制备氯甲基头孢烯衍生物的改进方法

Country Status (5)

Country Link
JP (1) JP2006507289A (https=)
KR (1) KR20050087791A (https=)
CN (1) CN1315841C (https=)
AU (1) AU2003269416A1 (https=)
WO (1) WO2004039813A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100398547C (zh) * 2003-09-09 2008-07-02 日本化学工业株式会社 3-氯甲基-3-头孢烯衍生物的制造方法
CN101260116A (zh) * 2008-04-21 2008-09-10 湖南有色凯铂生物药业有限公司 7-苯乙酰胺-3-氯甲基-4-头孢烷酸对甲氧苄酯的合成方法
CN102344459B (zh) * 2011-07-27 2014-08-06 山西新天源医药化工有限公司 一种头孢中间体gcle的制备方法
CN102643294B (zh) * 2012-04-18 2014-11-26 山东普洛得邦医药有限公司 一种头孢母核中间体的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789740A (en) * 1983-03-10 1988-12-06 Otsuka Kagaku Yakuhin Kabushiki Kaisha Halogenation process for preparing 2-(oxoazetidinyl)-3-chloromethyl-3-butenoate
US4853468A (en) * 1981-04-10 1989-08-01 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for the preparation of cephem derivatives
EP0623622A1 (en) * 1992-07-27 1994-11-09 Otsuka Kagaku Kabushiki Kaisha Process for producing cephem compound
WO1998055485A1 (en) * 1997-06-04 1998-12-10 Otsuka Kagaku Kabushiki Kaisha Process for producing 3-alkenylcephem compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE35152B1 (en) * 1969-08-26 1975-11-26 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
NL7411505A (nl) * 1973-09-06 1975-03-10 Rhone Poulenc Sa Werkwijze voor de bereiding en toepassing van nieuwe 7-trichlooraceetamido-3-desacetoxy-cefa- losporanzuurpreparaten.
AU498131B2 (en) * 1974-02-26 1979-02-15 Ciba-Geigy Ag Production of cephems by cyclization
JPS6043340B2 (ja) * 1981-04-10 1985-09-27 大塚化学薬品株式会社 塩素化アゼチジノン誘導体及びその製造法
JPS5874689A (ja) * 1981-10-29 1983-05-06 Otsuka Chem Co Ltd ３−クロロメチル−３−セフエム誘導体の製造法
JPS60237061A (ja) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60115562A (ja) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
DE3933934A1 (de) * 1989-10-03 1991-04-11 Bayer Ag Verfahren zur herstellung von 7-amino-3-((z)-1-propen-1-yl)-3-cephem-4-carbonsaeure

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853468A (en) * 1981-04-10 1989-08-01 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for the preparation of cephem derivatives
US4789740A (en) * 1983-03-10 1988-12-06 Otsuka Kagaku Yakuhin Kabushiki Kaisha Halogenation process for preparing 2-(oxoazetidinyl)-3-chloromethyl-3-butenoate
EP0623622A1 (en) * 1992-07-27 1994-11-09 Otsuka Kagaku Kabushiki Kaisha Process for producing cephem compound
WO1998055485A1 (en) * 1997-06-04 1998-12-10 Otsuka Kagaku Kabushiki Kaisha Process for producing 3-alkenylcephem compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COPPER(I) BENZENESULFINATE AND COPPER(I)P-TOLUENESULFINATE BERTZ ET AL:,INORGANIC CHEMISTRY,Vol.24 No.21 1985 *

Also Published As

Publication number Publication date
KR20050087791A (ko) 2005-08-31
CN1708501A (zh) 2005-12-14
WO2004039813A1 (en) 2004-05-13
AU2003269416A1 (en) 2004-05-25
JP2006507289A (ja) 2006-03-02

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Granted publication date: 20070516

Termination date: 20091123