CN1313070C - 口腔用组合物 - Google Patents

口腔用组合物 Download PDF

Info

Publication number
CN1313070C
CN1313070C CNB018220274A CN01822027A CN1313070C CN 1313070 C CN1313070 C CN 1313070C CN B018220274 A CNB018220274 A CN B018220274A CN 01822027 A CN01822027 A CN 01822027A CN 1313070 C CN1313070 C CN 1313070C
Authority
CN
China
Prior art keywords
composition
peroxide
oral cavity
carboxylic acid
pyridine carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018220274A
Other languages
English (en)
Other versions
CN1638723A (zh
Inventor
M·巴库
A·乔伊纳
K·A·斯特勒
D·泰勒
K·M·汤普森
D·W·托恩斯维特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever NV
Original Assignee
Unilever NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever NV filed Critical Unilever NV
Publication of CN1638723A publication Critical patent/CN1638723A/zh
Application granted granted Critical
Publication of CN1313070C publication Critical patent/CN1313070C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38—Percompounds, e.g. peracids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/28—Heterocyclic compounds containing nitrogen in the ring
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/33—Amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3942—Inorganic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3947—Liquid compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A61K2800/874—Roll-on

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

一种包含吡啶甲酸和过氧化物类或其等效来源物的口腔用组合物，其特征在于吡啶甲酸与过氧化物类或其等效来源物的摩尔比为1∶30至100∶1。

Description

口腔用组合物
本发明涉及一种包含吡啶甲酸和过氧化物类或其等效来源物的口腔用组合物。
虽然未被广泛用于人体用除臭剂中，但过氧化物类，特别是过氧化氢及其来源的物质是众所周知的抗菌剂。还已知可以通过添加少量的过渡金属螯合剂来改善该类物质的稳定性。在一些出版物中描述了吡啶二羧酸用于该目的的应用，例如在EP 666,307A(Procter和Gamble)中进行了描述。还要求用吡啶二羧酸来改善过氧化氢的抗菌作用——见EP 845,526A(Eka Chemicals)。
在WO9007501(Solvay Interox)中已经对作为过氧羧酸漂白组合物稳定剂的吡啶甲酸进行了描述。以微量添加的吡啶甲酸可螯合能催化过氧化合物分解的过渡金属。在EP 1,074,607(Ausimont S.p.A.)中还将吡啶甲酸作为用于这种目的的任选组分列举出来。
我们已经发现，吡啶甲酸和过氧化物类或其等效来源物的增效混合物可以达到提供一种极佳的抗菌效益的目的并且其随后还具有抵抗蚀斑、龋和龈炎的保护作用。我们还发现吡啶甲酸和过氧化物类或其等效来源物的增效混合物可达到提供一种极佳的牙齿变白效益的目标。
现有技术从来没有公开或暗示过本发明的产品，也从来没有公开或暗示过用其可以获得极佳的抗菌和牙齿变白的效益。
我们发现使用吡啶甲酸和过氧化物类或其等效来源物的增效混合物可提供一种极佳的比单独使用这两种组分中的任一种所获得的效益更好的牙齿变白抗菌效益。此外，以可提供所说增效效益的水平所添加的吡啶甲酸确保了在用于人体的具有显著效益的产品中可以使用较少量的过氧化物类物质或其等效来源物。
因此，本发明的第一方面提供了一种如权利要求1的组合物。
在本发明的第二方面，其提供了一种使牙齿变白的美容方法，该方法包括使用吡啶甲酸和过氧化物类或其等效来源物。
在本发明的第三方面，其提供了一种通过将吡啶甲酸和过氧化物类或其等效来源物与可美容用的载体物质进行混合来制造治疗龈炎、龋和/或蚀斑的口腔用组合物的方法。
通过分别使用吡啶甲酸和过氧化物类或其等效来源物可以获得使用本发明组合物所获得的抗菌和牙齿变白效益。如果所处理的底物同时使用两种组分，则该类应用可以同时进行或连贯进行。当通过独立的组合物来应用该组分时，优选地该产品还包含一种将两种组合物应用于人体的使用方法和/或说明。在过酸和吡啶甲酸彼此独立地分别储存的情况中，该配方要求每种物质的稳定性都被优化。例如，如果一种制剂包含过酸如PAP，则该制剂的pH应在3.5至5之间，优选地为4。然后将该包含吡啶甲酸的制剂改进以使得当将这两种组分进行混合时，它们可以提供本发明所述的口腔用组合物并且具有6.5至7.5之间的可接受的pH。
优选地，用相同的组合物来提供吡啶甲酸和过氧化物类或其等效来源物。本发明优选的一种产品是一种既包含吡啶甲酸又包含过氧化物类或其等效来源物的单一组合物。
涉及本发明第二方面的可获得人体抗菌效益的美容方法优选地以1∶30至100∶1的摩尔比来使用吡啶甲酸和过氧化物类或其等效来源物。根据本发明第一方面，该组合物的这种摩尔比更优选地为1∶20至50∶1并且最优选地为1∶10至20∶1。
吡啶甲酸是本发明产品中的一种必需组分。以该组合物的总重量为基础，其可以以0.01％至10％，特别是0.1％至8％，并且尤其是0.15％至5％重量来使用。吡啶甲酸可以以其酸或盐的形式来进行应用。适宜的盐包括碱金属盐、碱土金属盐、胺盐、以及季铵盐。当该吡啶甲酸部分是或全部是盐的形式时，其优选的摩尔量等于上述的优选水平。
本发明的产品包含过氧化物类物质本身或可在原位产生过氧化物类物质的物质。过氧化物类物质是一种包含过氧基(-O-O-)的物质。适宜的过氧化物类物质的实例包括过氧化氢和过酸。其等效来源物的实例是在溶解于水时能产生过氧化氢的化合物，如过硼酸钠单水合物、过硼酸钠四水合物、过碳酸钠和过脲(脲-过氧化氢加合化合物)。另一些实例有与其适宜底物共存的酶的过氧化物产生体系如过氧化物酶、氧化酶和其它氧化还原酶的酶体系。优选的产品包含过酸，特别是式(1)的过酸
其中R是氢或C1-C4烷基；n是1至5；并且X是C＝O或SO2。
式1)的过氧酰胺基邻苯二酰胺本身是已知的并且已经在EP-A-325,288和EP-A-325,289中进行了描述。这种结构式的一种优选化合物是式1)的N-苯二酰亚氨基过氧己酸(“PAP”)，其中R＝H，n＝5并且X＝C＝O。其中X＝SO2的式1)化合物的一个实例是如在EP-A-485,927中所描述的糖精-过己酸(″糖精PAP″)。或者可以选择一种在溶解于水时可以产生过氧化氢的化合物而不是过氧化氢本身。适宜的过酸包括在WO96/05802中所提及的这些化合物中的任何一种，其涉及过酸的内容在这里被引入作为参考。
特别优选的产品包含一种在溶解于水时能产生过氧化氢的化合物，尤其优选在应用前不存在过氧化氢的产品。
以该组合物的总重量为基础，本发明组合物中的过氧化物类或其等效来源物可以在0.0001％至5％重量的范围内，更优选地为0.001至1.5％重量，最优选地为0.005％至0.5％重量。
在由于其抗菌作用而使用该口腔用组合物的情况中，该组合物还可以包含一种过渡金属螯合剂。虽然吡啶甲酸是一种过渡金属螯合剂，但是通过使用更多的这类物质可以增加其性能，特别是使用对铁(III)具有高结合常数的物质；就是说，对铁(III)的结合常数高于1015，优选地高于1020，并且最优选地高于1026。这类物质中特别优选地是二亚乙基三胺五乙酸(DTPA)。还可以使用该类物质的盐，适宜的盐是与所描述的作为适宜的吡啶甲酸盐的物质(参见上文)相类似的物质。所使用的作为组合物一部分添加的过渡金属螯合剂及其盐的总量一般为组合物的0.1％至5％，特别是0.2％至3％，并且尤其是0.4％至2％重量。
本发明的口腔用组合物还可包含现有技术中很常见的其它成分，如：
抗菌剂，例如三氯生、洗必太、铜-锌-和亚锡盐如枸橼酸锌、硫酸锌、甘氨酸锌、枸橼酸钠锌和焦磷酸亚锡、血根碱提取物、甲硝唑、季铵化合物如氯化十六烷基吡啶；双胍，如洗必太二葡萄糖酸盐、海克替啶、癸双辛胺啶、阿来西定；和卤化的双酚化合物，如2，2′亚甲基双-(4-氯-6-溴酚)；
抗炎剂如布洛芬、氟比洛芬、阿司匹林、消炎痛等等；
抗-龋剂如氟化钠和氟化亚锡、氟化胺类、单氟磷酸钠、三偏磷酸钠和酪蛋白；
蚀斑缓冲物如脲、乳酸钙、甘油磷酸钙和聚丙稀酸锶；
维生素如维生素A、C和E；
植物提取物；
脱敏剂，例如枸橼酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾和锶盐；
抗结石剂，例如焦磷酸碱金属盐、包含次磷酸盐的聚合物、有机膦酸酯和磷酸枸橼酸盐等等；
生物分子，例如细菌素、抗体、酶，等等；
矫味剂，例如薄荷和留兰香油；
蛋白质类物质如胶原蛋白；
防腐剂；
不透明剂；
着色剂；
pH-调节剂；
甜味剂；
可药用载体，例如淀粉、蔗糖、水或水/醇体系等等；
表面活性剂，如阴离子、非离子、阳离子和两性离子或两性表面活性剂；
微粒研磨材料如硅石、矾土、碳酸钙、磷酸二钙、焦磷酸钙、羟磷灰石、三偏磷酸盐、不溶性的六偏磷酸盐等等，包括成块的颗粒研磨材料，其通常为该口腔护理组合物重量的3至60％重量。
湿润剂如甘油、山梨醇、丙二醇、木糖醇、乳糖醇等等；
粘合剂和增稠剂如羧甲基纤维素钠、黄原胶、阿拉伯胶等等以及合成的聚合物如聚丙烯酸酯和羧乙烯聚合物如Carbopol；
还可以包括可增强活性成分如抗菌剂的传递的聚合物。该类聚合物的实例有聚乙烯甲基醚与马来酸酐的共聚物以及其它适宜的可增强传递的聚合物，例如这些在DE-A-3,942,643(Colgate)中所描述的聚合物；
缓冲剂和用于缓冲口腔护理组合物的pH和离子强度的盐；以及
其它可被包含在其中的可存在或不存在的成分有例如漂白剂如过氧化合物例如过氧二磷酸钾、泡腾体系如碳酸氢钠/枸橼酸系统、改色系统等等。
还可以用脂质体来改善活性成分的传递或稳定性。
该口腔用组合物可以是现有技术中任何常见形式，例如牙膏、凝胶、摩丝、气雾剂、胶、锭剂、粉末、乳膏等等，并且还可以被制备成双室型分配器中所使用的系统。
实施例1
用如下的方法来对该漂白剂进行评估：
(1)将合成的羟基磷灰石圆片磨光，然后将其在37℃下在无菌的唾液中放置一整夜以形成一种表膜。
(2)在37℃下用茶溶液将这些圆片处理7天使其染色。
(3)以所需时间将染色的圆盘浸入到漂白溶液中。
(4)用Minolta chromameter CR-300以L*a*b*方式来测定该圆片的颜色变化。用L*(开始)、L*(变脏)、以及L*(变清洁)来计算除去染色的百分比。负值表示变黑，正值表示漂白(变白)作用。
所用的所有制剂用0.5M NaHCO3来处理。负值表示变黑并且下面的表1表示了单独使用吡啶甲酸以及其与0.1％ H2O2或PAP一起使用所得的结果。
  除去染色％
  10分钟
  0.1％H2O2   2
  0.5 0.1％H2O2/5％吡啶甲酸   13
  1％PAP   27
  1％PAP/5％哌啶甲酸   46
  5％吡啶甲酸   8
表中所表示的结果表明，过酸中加入吡啶甲酸可以提供比单独使用吡啶甲酸或过酸更有效的漂白组合物。
实施例
下面的口腔用组合物包含两种制剂：一种PAP-凝胶制剂和一种pH-调节制剂。
       PAP-凝胶制剂
  成分   数量(％w/w)
  PAP   0.6
  Gantrez   3.0
  黄原胶   0.2
  硅石   9.0
  氢氧化钠   0.5
  水   至100
PAP可以以Eureco HC-17市售获得(ex.Ausimont)。
这种制剂的pH为4。
pH-调节制剂
  成分   数量(％w/w)
  Gantrez   3.0
  黄原胶   0.2
  硅石   6.0
  哌啶甲酸   5.0
  糖精   0.25
  PH剂(TSP或NaOH)   至pH11
  KNO3   5.0
  NaF/SMFP   至1500pmm
  颜料   适量
  水   至100
当将该PAP-制剂和pH-调节制剂混合到一起，所得组合物的pH在约6.5至8.5之间。

Claims (10)

1.一种包含吡啶甲酸和过氧化物类或其等效来源物的口腔用组合物，其特征在于吡啶甲酸与过氧化物类或其等效来源物的摩尔比为1∶30至100∶1，且所说的过氧化物类或其等效来源物是一种过酸或在溶解于水时能产生过氧化氢的化合物。
2.如权利要求1所述的口腔用组合物，其包含附加的过渡金属螯合剂。
3.如权利要求2所述的口腔用组合物，其中所说的组合物包含一种与铁(III)的结合系数高于1015的过渡金属螯合剂。
4.如权利要求2所述的口腔用组合物，其中所说的组合物包含作为过渡金属螯合剂的二亚乙基三胺五乙酸。
5.如权利要求1-4任意一项所述的口腔用组合物，其中吡啶甲酸与过氧化物类或其等效来源物的摩尔比为1∶10至20∶1。
6.如权利要求1-4任意一项权利要求所述的口腔用组合物，其中所说的吡啶甲酸以占组合物0.01％至10％重量的数量存在。
7.如权利要求6所述的口腔用组合物，其中所说的吡啶甲酸以占组合物0.15％至2.5％重量的数量存在。
8.如权利要求1-4任意一项权利要求所述的口腔用组合物，其中所说的过氧化物类或其等效来源物以占组合物0.0001％至1.5％重量的数量存在。
9.如权利要求8所述的口腔用组合物，其中所说的过氧化物类或其等效来源物以占组合物0.003％至0.5％重量的数量存在。
10.如权利要求1-4权利要求所述的口腔用组合物，其包含可美容用载体物质。
CNB018220274A 2001-01-16 2001-12-07 口腔用组合物 Expired - Fee Related CN1313070C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01300336 2001-01-16
EP01300336.3 2001-01-16

Publications (2)

Publication Number Publication Date
CN1638723A CN1638723A (zh) 2005-07-13
CN1313070C true CN1313070C (zh) 2007-05-02

Family

ID=8181646

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018220274A Expired - Fee Related CN1313070C (zh) 2001-01-16 2001-12-07 口腔用组合物

Country Status (15)

Country Link
US (2) US6709647B2 (zh)
EP (2) EP1351658B1 (zh)
CN (1) CN1313070C (zh)
AR (2) AR032394A1 (zh)
AT (2) ATE289796T1 (zh)
AU (1) AU2002249104B2 (zh)
BR (2) BR0116831A (zh)
DE (2) DE60109207T8 (zh)
ES (1) ES2237621T3 (zh)
HU (1) HUP0401100A2 (zh)
MX (1) MXPA03006241A (zh)
PL (1) PL203187B1 (zh)
RU (1) RU2278709C2 (zh)
WO (3) WO2002055043A1 (zh)
ZA (2) ZA200304592B (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652446B2 (en) 2000-03-17 2014-02-18 Lg Household & Healthcare Ltd. Apparatus and method for whitening teeth
EP1267812B1 (en) 2000-03-17 2009-01-28 LG Household & Health Care Ltd. Patches for teeth whitening
US7785572B2 (en) 2000-03-17 2010-08-31 Lg Household And Health Care Ltd. Method and device for teeth whitening using a dry type adhesive
US6689344B2 (en) 2000-03-17 2004-02-10 Lg Household & Healthcare Ltd. Patches for teeth whitening
HUP0401100A2 (hu) * 2001-01-16 2004-11-29 Unilever N.V. Fogápoló készítmény
AU2003245498B2 (en) 2002-02-12 2008-04-03 Diversey, Inc. Enhanced activity hydrogen peroxide disinfectant
US6916463B2 (en) * 2002-09-24 2005-07-12 The Procter & Gamble Company Oral products having an aesthetic layer
DE60328705D1 (de) 2002-11-15 2009-09-17 Virox Technologies Inc Eine säure und/oder alkohol enthaltendes wasserstoffperoxid-desinfektionsmittel
US20080305182A1 (en) 2002-11-15 2008-12-11 Ramirez Jose A Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
DE10259262B3 (de) * 2002-12-17 2004-08-05 Henkel Kgaa Verfahren zur Herstellung von bleichmittelhaltigen Suspensionen
US20070104809A1 (en) 2003-08-22 2007-05-10 Danisco A/S Composition comprising a bacteriocin and an extract from a plant of the labiatae family
GB2388581A (en) 2003-08-22 2003-11-19 Danisco Coated aqueous beads
PL1668105T3 (pl) 2003-09-29 2019-03-29 Deb Ip Limited Kompozycje żelopodobne i pieniące o dużej zawartości alkoholu
US8018850B2 (en) * 2004-02-23 2011-09-13 Sharp Laboratories Of America, Inc. Wireless video transmission system
BRPI0510259A (pt) * 2004-04-27 2008-01-02 Beiersdorf Ag formulação cosmética ou dermatológica transparente
WO2005110090A1 (en) 2004-05-14 2005-11-24 Virox Technologies Inc. Hydrogen peroxide-based skin disinfectant
US20050276772A1 (en) * 2004-06-10 2005-12-15 Boden Richard M Antiperspirant composition comprising polyol, antiperspirant active article containing same and method for using same
DE102004062775A1 (de) 2004-12-21 2006-06-29 Stockhausen Gmbh Alkoholischer Pumpschaum
EP1858323B1 (en) 2005-03-07 2017-11-08 Deb IP Limited High alcohol content foaming compositions with silicone-based surfactants
US20060204466A1 (en) * 2005-03-08 2006-09-14 Ecolab Inc. Hydroalcoholic antimicrobial composition with skin health benefits
US8337819B2 (en) 2005-06-28 2012-12-25 Tomas Bernardo Galvan Pharmaceutical composition for the oral hygiene, the treatment of the periodontal illnesses and the halitosis
US20070148101A1 (en) * 2005-12-28 2007-06-28 Marcia Snyder Foamable alcoholic composition
US8734867B2 (en) 2007-12-28 2014-05-27 Liveleaf, Inc. Antibacterial having an extract of pomegranate combined with hydrogen peroxide
US7842725B2 (en) * 2008-07-24 2010-11-30 Ecolab USA, Inc. Foaming alcohol compositions with selected dimethicone surfactants
JP2012519690A (ja) * 2009-03-04 2012-08-30 メタアクティブ、インコーポレイテッド 生体分子の部位活性化複合体形成方法及び材料
FR2957522B1 (fr) 2010-03-17 2012-04-20 Oreal Utilisation cosmetique d'un derive d'acide imido-peroxycarboxylique pour diminuer la taille des pores de la peau
FR2957521B1 (fr) 2010-03-17 2012-03-02 Oreal Composition cosmetique comprenant un derive d'acide imido-peroxycarboxylique et un copolymere d'acide 2-acrylamido-2-methylpropane-sulfonique
WO2012076345A1 (en) 2010-12-06 2012-06-14 L'oreal Cosmetic composition comprising an imidoperoxycarboxylic acid, an imidocarboxylic acid and copolymer of 2-acrylamido-2-methylpropanesulphonic acid
FR2968958B1 (fr) 2010-12-17 2015-06-26 Oreal Composition cosmetique comprenant un derive acide imido-peroxycarboxylique et un compose bis-akyl sulfosuccinate
DE102011089012A1 (de) 2011-12-19 2013-06-20 Henkel Ag & Co. Kgaa Textilschonende Antitranspirantien
US8716351B1 (en) 2012-12-23 2014-05-06 Liveleaf, Inc. Methods of treating gastrointestinal spasms
US9439841B2 (en) 2013-06-06 2016-09-13 Ecolab Usa Inc. Alcohol based sanitizer with improved dermal compatibility and feel
US20180092357A1 (en) * 2015-04-09 2018-04-05 Isp Investments Llc Synergistic preservative compositions
US10450535B2 (en) 2017-10-18 2019-10-22 Virox Technologies Inc. Shelf-stable hydrogen peroxide antimicrobial compositions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2329753A1 (de) * 1972-06-12 1973-12-13 Nat Patent Dev Corp Mittel zur mund- und zahnpflege
WO1990007501A1 (en) * 1988-12-24 1990-07-12 Interox Chemicals Limited Peroxycarboxylic acids
EP0545594A1 (en) * 1991-11-22 1993-06-09 Colgate-Palmolive Company Oral composition having improved tooth whitening effect
US5435808A (en) * 1993-09-03 1995-07-25 Birko Corporation Hide raceway treatment and improved method of curing hides
EP0906950A1 (en) * 1997-10-03 1999-04-07 The Procter & Gamble Company Peroxygen bleach-containing compositions comprising a particular chelating agent system
EP1010750A1 (en) * 1998-12-14 2000-06-21 The Procter & Gamble Company Bleaching compositions

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624655A (en) * 1949-10-13 1953-01-06 Buffalo Electro Chem Co Stable aqueous hydrogen peroxide and method of preparing same
US3156654A (en) * 1961-06-19 1964-11-10 Shell Oil Co Bleaching
US3671439A (en) * 1969-07-22 1972-06-20 American Home Prod Oxygen bleach-activator systems stabilized with puffed borax
CA984755A (en) 1972-08-24 1976-03-02 Jaroslav Vit Composition for treating teeth containing a hypochlorite and edta
US4105759A (en) * 1977-03-28 1978-08-08 Colgate-Palmolive Company Amine monofluorophosphates in dentifrices
NL8000085A (nl) * 1980-01-08 1981-08-03 Lambertus Bons Werkwijze ter bereiding van een huidconditioneringsmiddel, meer in het bijzonder tegen overmatige transpiratie en tegen transpiratiegeur.
JPS5849363A (ja) 1981-09-16 1983-03-23 Adeka Argus Chem Co Ltd ２，２，６，６−テトラメチル−４−オキソピペリジンの製造方法
US5188821A (en) 1987-01-30 1993-02-23 Colgate-Palmolive Company Antibacterial antiplaque oral composition mouthwash or liquid dentifrice
IT1215739B (it) 1988-01-20 1990-02-22 Ausimont Spa Perossiacidi immido aromatici come agenti sbiancanti.
IT1233846B (it) 1988-01-20 1992-04-21 Ausimont Spa Perossiacidi immido aromatici
US4877605A (en) * 1988-12-12 1989-10-31 David Hendricks Foot deodorant
GB8830235D0 (en) * 1988-12-24 1989-02-22 Interox Chemicals Ltd Percarboxylic acids
SE507731C2 (sv) 1988-12-29 1998-07-06 Colgate Palmolive Co Antibakteriell oral antiplaquekomposition
US5073285A (en) * 1989-06-12 1991-12-17 Lever Brothers Company, Division Of Conopco, Inc. Stably suspended organic peroxy bleach in a structured aqueous liquid
US4992194A (en) * 1989-06-12 1991-02-12 Lever Brothers Company, Division Of Conopco Inc. Stably suspended organic peroxy bleach in a structured aqueous liquid
AU7067991A (en) * 1989-12-23 1991-07-24 Interox Chemicals Limited Peroxycarboxylic acids
GB9012876D0 (en) * 1990-06-08 1990-08-01 Interox Chemicals Ltd Peroxycompounds
EP0485927A1 (de) 1990-11-16 1992-05-20 Hoechst Aktiengesellschaft Sulfimidoperoxicarbonsäuren
GB9027975D0 (en) * 1990-12-22 1991-02-13 Interox Chemicals Ltd Peroxycarboxylic acid
FR2704726B1 (fr) 1993-05-05 1995-06-16 Chemoxal Sa Composition aqueuse comportant un péroxyacide organique et ses utilisations comme agents désinfections.
US5419847A (en) * 1993-05-13 1995-05-30 The Procter & Gamble Company Translucent, isotropic aqueous liquid bleach composition
US5472619A (en) * 1993-09-03 1995-12-05 Birko Corporation Waste water treatment with peracetic acid compositions
EP0730632B1 (en) * 1993-11-25 1998-03-18 Warwick International Group Limited Bleach activators
GB9325558D0 (en) * 1993-12-14 1994-02-16 Solvay Interox Ltd Percaboxylic acids
EP0666307A3 (en) 1994-02-03 1996-07-03 Procter & Gamble Packaged liquid bleaching composition.
GB2290234B (en) 1994-06-07 1998-06-10 Janina International Oral care products
EP1155681B1 (en) 1994-08-22 2008-05-21 Unilever N.V. Oral composition with teeth whitening effect
US5785957A (en) 1995-12-12 1998-07-28 Losee; Paul Inclusion of tooth whitening oxidation chemistries into a tooth-paste composition
BR9710914A (pt) * 1996-07-29 1999-08-17 Procter & Gamble Ativadoares dealejante de imida ac¡clica assim-trica e composi-{es empregando os mesmos
EP0932657B1 (en) * 1996-10-15 2002-06-12 The Procter & Gamble Company Asymmetrical bleach activators and compositions employing the same
SE9604413D0 (sv) 1996-11-29 1996-11-29 Eka Chemicals Ab Chemical composition
US6136297A (en) 1997-06-06 2000-10-24 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
IT1293820B1 (it) 1997-08-05 1999-03-10 Ausimont Spa Composizioni a base di perossiacidi
US6015547A (en) * 1997-10-27 2000-01-18 Church & Dwight Co., Inc. Stable solution of zinc ions and bicarbonate and/or carbonate ions
ATE226622T1 (de) * 1997-11-10 2002-11-15 Procter & Gamble O-substitutierte n,n-diacylhydroxylamine als bleichaktivatoren und diese enthaltende zusammensetzungen
US5997764A (en) * 1997-12-04 1999-12-07 The B.F. Goodrich Company Thickened bleach compositions
JP2995470B1 (ja) * 1998-09-03 1999-12-27 オリエンタル ケミカル インダストリーズ 溶解性の改善された過炭酸ナトリウムの組成物
ID28828A (id) * 1998-09-25 2001-07-05 Unilever Nv Komposisi perawatan mulut dengan meningkatkan efek memutihkan gigi
IT1311889B1 (it) * 1999-03-12 2002-03-20 Farmaceutici Dott Ciccarelli S Paste dentifricie.
BR0009452A (pt) 1999-04-01 2002-01-08 Unilever Nv Composição de cuidado oral com um efeito de branqueamento aumentado dos dentes, e, uso de um composto peróxi e de um catalisador
IT1313598B1 (it) 1999-08-04 2002-09-09 Ausimont Spa Dispersioni acquose di acidi percarbossilici
HUP0401100A2 (hu) * 2001-01-16 2004-11-29 Unilever N.V. Fogápoló készítmény

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2329753A1 (de) * 1972-06-12 1973-12-13 Nat Patent Dev Corp Mittel zur mund- und zahnpflege
WO1990007501A1 (en) * 1988-12-24 1990-07-12 Interox Chemicals Limited Peroxycarboxylic acids
EP0545594A1 (en) * 1991-11-22 1993-06-09 Colgate-Palmolive Company Oral composition having improved tooth whitening effect
US5435808A (en) * 1993-09-03 1995-07-25 Birko Corporation Hide raceway treatment and improved method of curing hides
EP0906950A1 (en) * 1997-10-03 1999-04-07 The Procter & Gamble Company Peroxygen bleach-containing compositions comprising a particular chelating agent system
EP1010750A1 (en) * 1998-12-14 2000-06-21 The Procter & Gamble Company Bleaching compositions

Also Published As

Publication number Publication date
WO2002055647A1 (en) 2002-07-18
WO2002055643A3 (en) 2002-12-27
DE60109207T2 (de) 2006-01-12
DE60109208D1 (de) 2005-04-07
US6471947B2 (en) 2002-10-29
PL203187B1 (pl) 2009-09-30
US20030059396A1 (en) 2003-03-27
HUP0401100A2 (hu) 2004-11-29
ZA200304595B (en) 2004-06-24
MXPA03006241A (es) 2003-09-22
ATE289796T1 (de) 2005-03-15
AU2002249104B2 (en) 2004-10-14
WO2002055043A1 (en) 2002-07-18
EP1351658A1 (en) 2003-10-15
DE60109207D1 (de) 2005-04-07
EP1351659B1 (en) 2005-03-02
RU2003125275A (ru) 2005-01-20
PL365518A1 (en) 2005-01-10
AR032394A1 (es) 2003-11-05
EP1351658B1 (en) 2005-03-02
ES2237621T3 (es) 2005-08-01
US20020136698A1 (en) 2002-09-26
DE60109207T8 (de) 2006-08-24
ATE289797T1 (de) 2005-03-15
RU2278709C2 (ru) 2006-06-27
AR035731A1 (es) 2004-07-07
ZA200304592B (en) 2004-06-24
DE60109208T2 (de) 2006-01-12
CN1638723A (zh) 2005-07-13
US6709647B2 (en) 2004-03-23
BR0116832A (pt) 2004-02-03
EP1351659A2 (en) 2003-10-15
DE60109208T8 (de) 2006-08-24
WO2002055643A2 (en) 2002-07-18
BR0116831A (pt) 2004-02-03

Similar Documents

Publication Publication Date Title
CN1313070C (zh) 口腔用组合物
EP1115373B1 (en) Oral composition with an improved teeth whitening effect
CN1262265C (zh) 口腔漂白组合物
JPH07503707A (ja) 抗菌性歯磨き剤
EP1155683B1 (en) Oral composition with an improved teeth whitening effect
CN1284854A (zh) 口腔护理组合物
CN1155362C (zh) 包含细碳酸钙和粗碳酸钙的牙膏
US5298237A (en) Gel composition for reduction of gingival inflammation and retardation of dental plaque
CN101489628A (zh) 牙膏组合物
US6165448A (en) Oral composition with an improved teeth whitening effect
WO2009109533A1 (en) Bleach catalysts and their use as teeth whitening agents
CN1345223A (zh) 具有改进的牙齿增白效应的口腔组合物
CN1533266A (zh) 含有过氧酰氨基邻苯二酰胺衍生物的口腔组合物
CN1198575C (zh) 含白垩的口用组合物
WO2023031025A1 (en) Oral care composition

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070502

Termination date: 20101207