CN1284854A - 口腔护理组合物 - Google Patents
口腔护理组合物 Download PDFInfo
- Publication number
- CN1284854A CN1284854A CN98813665A CN98813665A CN1284854A CN 1284854 A CN1284854 A CN 1284854A CN 98813665 A CN98813665 A CN 98813665A CN 98813665 A CN98813665 A CN 98813665A CN 1284854 A CN1284854 A CN 1284854A
- Authority
- CN
- China
- Prior art keywords
- compositions
- oral care
- care composition
- calcium carbonate
- polyacrylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 45
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 41
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 20
- 239000011737 fluorine Substances 0.000 claims abstract description 17
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 17
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 15
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 12
- 239000004075 cariostatic agent Substances 0.000 claims abstract description 7
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000007935 neutral effect Effects 0.000 claims description 15
- 239000003599 detergent Substances 0.000 claims description 10
- 238000005498 polishing Methods 0.000 claims description 10
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 10
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- 229910052783 alkali metal Inorganic materials 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 7
- 150000001340 alkali metals Chemical class 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 230000003993 interaction Effects 0.000 abstract description 2
- 239000012459 cleaning agent Substances 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 15
- 239000000606 toothpaste Substances 0.000 description 10
- 229940034610 toothpaste Drugs 0.000 description 10
- 229920000058 polyacrylate Polymers 0.000 description 8
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- -1 silicon aluminate Chemical class 0.000 description 5
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 229910001515 alkali metal fluoride Inorganic materials 0.000 description 4
- 239000000551 dentifrice Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 229940074371 monofluorophosphate Drugs 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 235000011180 diphosphates Nutrition 0.000 description 2
- WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical group OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 235000011007 phosphoric acid Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 229910021532 Calcite Inorganic materials 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241001147468 Chondrus ocellatus Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000276489 Merlangius merlangus Species 0.000 description 1
- TXXIWPTXQBKYOE-UHFFFAOYSA-N OC(=O)CC(CC(O)=O)(OP(=O)=O)C(O)=O Chemical class OC(=O)CC(CC(O)=O)(OP(=O)=O)C(O)=O TXXIWPTXQBKYOE-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical group [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
- 229950010221 alexidine Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
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- 150000004781 alginic acids Chemical class 0.000 description 1
- 229960005363 aluminium oxide Drugs 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002690 anti-lithiasic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
- 229940095618 calcium glycerophosphate Drugs 0.000 description 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- TVQLLNFANZSCGY-UHFFFAOYSA-N disodium;dioxido(oxo)tin Chemical compound [Na+].[Na+].[O-][Sn]([O-])=O TVQLLNFANZSCGY-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
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- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
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- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
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- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
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- 239000007788 liquid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
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- 210000000214 mouth Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229960001774 octenidine Drugs 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical class O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- 229940079864 sodium stannate Drugs 0.000 description 1
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
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- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
Abstract
本发明提供口腔护理组合物,含有:作为主要研磨清洁剂的碳酸钙颗粒和作为抗龋剂的含氟化合物;在口腔护理组合物中含有完全中和的聚丙烯酸以降低由碳酸钙和含氟化合物之间相互作用引起的可用氟的损失。
Description
本发明涉及含有颗粒碳酸钙作为主要研磨清洁剂的口腔护理组合物。
在口腔护理组合物例如牙膏中，碳酸钙颗粒是公知的研磨清洁剂，含有这种研磨清洁剂的牙膏已经进入市场。这种研磨清洁剂从其研磨特性上看是可接受的研磨清洁剂，但它有一个主要缺点：它和牙膏中含氟活性成分(例如碱金属氟化物)不兼容，然而为了达到抗龋的效果，通常需要在牙膏中加入含氟成分。
长期以来就已认识到这个问题，在GB-A-907,417(Ericsson)中，提出用碱金属一氟磷酸盐代替碱金属氟化物作为抗龋剂以克服上述缺陷。
在FR-A-2,251,309(Beecham)中，提出应用碱金属氟化物和碱金属一氟磷酸盐的混合物以克服碳酸钙使氟化物失活的问题。然而，应用这些系统确实可以使碳酸钙对含氟试剂的失活更少一些，但对于提供可接受的有效抗龋用途来说，仍然导致活性氟的大量损失。
现在已经发现：在含有作为主要研磨清洁剂的碳酸钙颗粒与含氟抗龋试剂的口腔护理组合物中，含有完全中和的聚丙烯酸盐能够显著提高碳酸钙和含氟试剂的兼容性、降低失活作用和因此减少可用活性氟的损失。
在此方面，在GB-A-1,476,063(Boots)中观测到：如果牙膏中含有碳酸钙和阴离子粘合剂例如羧甲基纤维素钠、藻酸、黄原胶、角叉菜素(carragheenin)和Carbopol_，则其容易产生贮存稳定性不足的问题，例如冷却和/或存放时成团。“Carbopol”商品包括丙烯酸均聚物和共聚物。在GB-A-1,476,063中提出应用硅铝酸盐来克服稳定性不足的问题。
我们已经发现：含有完全中和的聚丙烯酸盐完全不会引起贮存稳定性不足的问题，因此不必应用硅铝酸盐。
在ZA-A-86/0599(Blendax)中记载的牙膏含有碳酸钙作为研磨清洁剂。加入酸调节这些牙膏的pH值为7.5-8.5，以提供钙离子贮藏来补充牙釉质中的矿质。特别地，这些牙膏含有增稠剂例如聚丙烯酸的碱金属盐。然而，本发明的口腔护理组合物的pH大于8.5而且不含有酸，以避免游离钙离子和含氟抗龋剂之间不受欢迎的相互作用。
本发明所用的完全中和的聚丙烯酸盐是完全被下列物质中和的聚丙烯酸：合适的碱金属、铵离子或(烷醇)氨化合物，例如钠和钾的氢氧化物或碳酸盐、氨和三乙醇氨等。优选的完全中和的聚丙烯酸盐为钠盐。聚丙烯酸是丙烯酸的均聚物，分子量为1000-250,000、优选2500-100,000，更优选4000-70,000。特别优选的完全中和的聚丙烯酸盐为分子量8000的聚丙烯酸的钠盐，该产品可以购自BASF，商品名为Sokalan PA 30 CL。
在本发明的口腔护理组合物中，完全中和的聚丙烯酸盐的含量为组合物的0.05-5％重量、通常为0.1-3％重量。自然，还可以应用完全中和的聚丙烯酸盐的混合物。
尽管在最终的口腔护理组合物中可以通过提供足够量碱金属以完全中和聚丙烯酸从而就地产生完全中和的聚丙烯酸盐，但这并不是本发明的优选方案，因为在不破坏组合物其他成分的情况下很难控制就地进行的中和反应。优选地，把完全中和的聚丙烯酸加入到最终口腔护理组合物中，即中和反应独立地进行之后加入到组合物中。
本发明所用的碳酸钙颗粒研磨清洁剂可以是已知用于本领域口腔护理组合物中的任何合适类型的碳酸钙。其可以是天然来源例如霰石或方解石，如精细研磨的大理石和白云石等，或者它可以是合成来源的，例如微细的碳酸钙沉淀。其通常的平均粒子大小为1-60μm、一般为1-40μm。本发明的碳酸钙颗粒的用量为所述口腔护理组合物的10-60％重量、优选20-50％重量、更优选25-45％重量。
本发明所用的含氟抗龋剂为碱金属氟化物和/或碱金属一氟磷酸盐，其中后者是优选的。它们的通常用量足以提供50-1500ppm的可用氟。
所述口腔护理组合物可以制备成任意的合适应用形式，例如凝胶、牙粉和牙膏。它们可以制备成单剂型，或者它们可以制备成含有不同制剂的多隔室容器，例如一个容器含有碳酸钙及其可兼容成分，另一个容器含有其余成分。
本发明的口腔护理组合物还可以含有任选的常规成分例如可药用载体如淀粉、蔗糖、水或水/醇系统等。还可以含有少量表面活性剂例如阴离子、非离子、阳离子和两性表面活性剂。
当制备成牙粉时，这样的制剂可以含有任意的常用牙粉成分。
因此，它们可以含有其它的颗粒研磨材料例如硅酸盐、氧化铝、磷酸二钙、焦磷酸钙、羟磷灰石、三偏磷酸酯和不溶性六偏磷酸酯等，其用量低于碳酸钙的用量。研磨材料的总含量不高于组合物的60％重量。
而且，该牙粉制剂可以含有湿润剂例如甘油、山梨糖醇、丙二醇、木糖醇和乳糖醇等等。
还可以含有粘合剂和增稠剂例如羧甲基纤维素钠、黄原胶和阿拉伯树胶等。
还可以含有调味剂例如薄荷油和绿薄荷油以及防腐剂、不透明剂、调色剂、pH调节剂、甜味剂、牙齿增白剂和过氧化物漂白剂等等。还可以有益地含有过氧化物漂白剂的稳定剂例如吡啶二羧酸或锡酸钠。
还可以含有抗菌剂例如三氯苯氧氯酚、洗必太、铜盐、锌盐和亚锡盐，例如柠檬酸锌、柠檬酸锌钠和焦磷酸亚锡、血根硷提取物和甲硝唑。抗菌剂的其他例子为季铵化合物例如氯化十六烷基吡啶鎓；双胍类例如洗必太双葡萄糖酸盐、氨己嘧啶、奥替尼淀、阿来西定；氯化双苯酚化合物例如2,2＇-亚甲基双-(4-氯-6-溴苯酚)。
还可以含有能够增强活性成分例如抗菌剂释放的聚合体化合物。这些聚合物的例子如：聚乙烯基甲基醚和顺丁烯二酸酐的共聚物，和其他类似增强释放的聚合物，例如：在DE-A-3942643(Colgate)中描述的那些聚合物。
而且，还可以含有抗炎试剂例如布洛芬、氟比洛芬、阿斯匹林和消炎痛等。
还可以含有其它的抗龋剂如氟化亚锡、氟化铵、plaque缓冲剂例如脲、乳酸钙、甘油磷酸钙和聚丙烯酸锶等。其它任选的成分包括维生素(例如维生素C)和植物提取物。还可以含有脱敏剂例如柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾以及锶盐等。
还可以含有缓冲剂和盐以缓冲组合物的pH值和离子强度，例如正磷酸一钠或正磷酸三钠。为了提高活性成分的释放和稳定性，还可以应用脂质体和其它胶囊成分。
而且，所述口腔组合物可以含有抗结石剂例如碱金属焦磷酸盐、含次磷酸盐的聚合物、有机磷酸酯(盐)和含磷柠檬酸酯(盐)(phosphocitrates)等。
另外，所述组合物可以含有生物分子官能团例如细菌素、抗体和酶等等。
还可以含有的其它任选的成分例如：漂白剂，如在EP-A-0,545,594中所述，起泡系统例如碳酸氢钠/柠檬酸系统和颜色改变系统等。
下列实施例更详细地说明本发明。
实施例1
在一模型系统中，完全中和的聚丙烯酸盐对颗粒碳酸钙和一氟磷酸钠之间相互作用的影响的测试如下：
把20g碳酸钙颗粒(Pacal H)和0.057g一氟磷酸钠分散在25g去离子水中，加入0.04g福尔马林和27g山梨糖醇(70％)。再把各种含量的聚丙烯酸钠的水溶液(pH10)(聚丙烯酸的MW为8,000)加入到上述分散液中，得到的混合物在37℃下储存6天，然后，过滤上清液，测定溶液中剩余的一氟磷酸钠的含量和游离氟的含量。
应用气相色谱和阴离子选择电极分析分别测定总氟含量和游离氟离子的含量。
结果如下：
| 聚丙烯酸钠(g，以100％活性材料计算) | 6天后溶液中剩余的一氟磷酸钠(单位：ppm) |
| 0.00000 | 105 |
| 0.03625 | 104 |
| 0.0725 | 126 |
| 0.145 | 120 |
| 0.435 | 122 |
| 0.725 | 128 |
实施例2
下列制剂为本发明的牙膏：
％重量
山梨糖醇(70％) 27.00
天然白垩细粉 40.00
一氟磷酸钠 1．14
糖精 0.20
增稠二氧化硅 2.00
羧甲基纤维素钠 0.90
月桂基硫酸钠 2.50
聚丙烯酸钠(如实施例1所述)0.75
福尔马林 0.04
调味剂 1.10
去离子水 24.37
实施例3
按照实施例2的方法，但应用不同量的聚丙烯酸钠(0.25％、0.75％和1.30％)制备制剂。同时还制备下列对照品试剂：不含聚丙烯酸钠、含0.5％正磷酸三钠和0.5％正磷酸一钠的制剂。把这些制剂在20℃和40℃下储存3个月。测定pH(20g蒸馏水中含5g糊剂，搅拌10分钟，然后测定pH)。按照实施例1的方法确定可提取氟的含量。得到下列结果。
制剂 pH(20℃) 可提取氟(40℃)
比照品 8.99 388
0％聚丙烯酸钠(对照) 8.27 944
0.25％聚丙烯酸钠(对照) 8.53 1081
0.75％聚丙烯酸钠(对照) 8.92 1088
1.30％聚丙烯酸钠(对照) 9.12 1152
Claims (8)
1、口腔护理组合物，含有：作为主要研磨清洁剂的碳酸钙颗粒和作为抗龋剂的含氟化合物；其特征在于：组合物的pH值大于8.5，该组合物还含有分子量为1000-250,000、完全中和的聚丙烯酸。
2、权利要求1的组合物，其特征在于分子量为2500-100,000。
3、权利要求2的组合物，其特征在于分子量为4000-70,000。
4、权利要求1-3的组合物，其特征在于：聚丙烯酸被碱金属、铵或(烷醇)胺化合物完全中和。
5、权利要求4的组合物，其特征在于：完全中和的聚丙烯酸为聚丙烯酸钠。
6、权利要求1-5的组合物，其特征在于：组合物中完全中和的聚丙烯酸含量为组合物重量的0.05-5％。
7、权利要求6的组合物，其特征在于：含量为组合物的0.1-3％重量。
8、含有分子量为1000-250,000的聚丙烯酸的、完全中和的聚丙烯酸在制备口腔护理组合物中的应用，其中所述的口腔护理组合物含有：作为主研磨清洁剂的碳酸钙颗粒和作为抗龋剂的含氟化合物，以降低可用活性氟的损失。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97310400 | 1997-12-18 | ||
| EP97310400.3 | 1997-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1284854A true CN1284854A (zh) | 2001-02-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98813665A Pending CN1284854A (zh) | 1997-12-18 | 1998-12-14 | 口腔护理组合物 |
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| Country | Link |
|---|---|
| US (1) | US6106811A (zh) |
| CN (1) | CN1284854A (zh) |
| AR (1) | AR017880A1 (zh) |
| AU (1) | AU2612999A (zh) |
| BR (1) | BR9813677A (zh) |
| EA (1) | EA002367B1 (zh) |
| HU (1) | HUP0100090A3 (zh) |
| PL (1) | PL341605A1 (zh) |
| WO (1) | WO1999032074A2 (zh) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1713884B (zh) * | 2002-11-26 | 2010-11-10 | 宝洁公司 | 可咀嚼的固体单位剂型和可用于将活性剂递送到牙齿咬合面的方法 |
| CN106232086A (zh) * | 2014-05-15 | 2016-12-14 | 宝洁公司 | 具有牙斑减少或改善的氟离子摄取的牙粉组合物 |
| CN106456474A (zh) * | 2014-05-15 | 2017-02-22 | 宝洁公司 | 具有牙斑减少或改善的氟离子摄取的牙粉组合物 |
| CN106456462A (zh) * | 2014-05-15 | 2017-02-22 | 宝洁公司 | 具有改善的氟离子稳定性的牙粉组合物 |
| CN106456463A (zh) * | 2014-05-15 | 2017-02-22 | 宝洁公司 | 具有改善的氟离子稳定性或氟化物摄取的牙粉组合物 |
| CN108348408A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有改善的氟化物稳定性的牙粉组合物 |
| CN108348409A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有改善的氟化物稳定性的牙粉组合物 |
| CN108348429A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有改善的氟化物摄取的牙粉组合物 |
| CN108348414A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有双氟化物源与改善的氟化物摄取的牙粉组合物 |
| CN113975184A (zh) * | 2015-11-13 | 2022-01-28 | 宝洁公司 | 具有改善的消费者体验的洁齿剂组合物 |
| CN108348408B (zh) * | 2015-11-13 | 2024-04-19 | 宝洁公司 | 具有改善的氟化物稳定性的牙粉组合物 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| PL373913A1 (en) * | 2001-10-02 | 2005-09-19 | Unilever N.V. | Oral composition comprising fine ground natural chalk |
| US7942669B2 (en) * | 2002-12-02 | 2011-05-17 | Centrix, Inc. | Gingival tissue retraction device and method |
| FR2899825B1 (fr) * | 2006-04-14 | 2010-08-13 | Coatex Sas | Dispersion aqueuse de carbonate de calcium precipite a partir d'au moins un agent dispersant contenant un compose porteur d'ion fluorure. |
| US8753613B2 (en) * | 2007-03-30 | 2014-06-17 | Centrix, Inc. | Dental retraction material having enhanced fluid absorption |
| US7850453B2 (en) * | 2007-08-08 | 2010-12-14 | Coll Partners Ltd. | Reshapable device for fixation at a dental site |
| GB0809253D0 (en) * | 2008-05-21 | 2008-06-25 | King S College London | Abrasive agents |
| ITMI20111272A1 (it) * | 2011-07-08 | 2013-01-09 | Luigi Pietro Roveda | Composizione per la prevenzione della carie dentaria e dispositivo per il suo rilascio |
| US9668844B2 (en) | 2013-11-06 | 2017-06-06 | Colldent Y.A Ltd | Device for fixation at a dental site |
| PL3154503T3 (pl) | 2014-05-15 | 2018-12-31 | The Procter And Gamble Company | Kompozycje środków do czyszczenia zębów ze optymalizowanymi środkami konserwującymi |
| PL3142627T3 (pl) | 2014-05-15 | 2020-06-29 | The Procter & Gamble Company | Kompozycje do higieny jamy ustnej o ulepszonym wrażeniu świeżości |
| WO2015172346A1 (en) | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Oral care compositions containing polyethylene glycol for physical stability |
| CN106232090B (zh) | 2014-05-15 | 2020-07-31 | 宝洁公司 | 包含聚乙二醇以提供物理稳定性的口腔护理组合物 |
| FR3047414B1 (fr) * | 2016-02-08 | 2021-07-30 | Produits Dentaires Pierre Rolland | Composition pour l'aero-polissage |
| JP7172028B2 (ja) * | 2017-11-30 | 2022-11-16 | ライオン株式会社 | 口腔用組成物 |
| JP2022007409A (ja) * | 2020-06-26 | 2022-01-13 | ライオン株式会社 | 口腔用組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL254647A (zh) * | 1959-08-07 | |||
| DE2302485A1 (de) * | 1973-01-19 | 1974-08-01 | Blendax Werke Schneider Co | Zahnpasta |
| US3966863A (en) * | 1974-12-04 | 1976-06-29 | Beecham Group Limited | Oral hygiene compositions |
| GB1476063A (en) * | 1976-01-26 | 1977-06-10 | Boots Co Ltd | Dentifrice |
| DE2935763C2 (de) * | 1979-09-05 | 1981-11-26 | Eisele Apparate- und Gerätebau GmbH, 7070 Schwäbisch Gmünd | Vorrichtung zum Herstellen von aus Stichgruppen bestehenden Nahtbildern |
| FR2531444A1 (fr) * | 1982-08-06 | 1984-02-10 | Coatex Sa | Agent de broyage a base de polymeres et/ou copolymeres acryliques pour suspension aqueuse de materiaux mineraux grossiers en vue d'applications pigmentaires |
| US4701319A (en) * | 1984-09-14 | 1987-10-20 | The Procter & Gamble Company | Toothpaste compositions |
| US4661341A (en) * | 1984-10-30 | 1987-04-28 | The Procter & Gamble Company | Oral compositions |
| US4892725A (en) * | 1988-05-09 | 1990-01-09 | The B. F. Goodrich Company | Tartar inhibition on teeth |
| SE507731C2 (sv) * | 1988-12-29 | 1998-07-06 | Colgate Palmolive Co | Antibakteriell oral antiplaquekomposition |
| ATE165252T1 (de) * | 1989-06-06 | 1998-05-15 | Pluss Stauffer Ag | Hochkonzentrierte wässrige suspension aus mineralien und/oder füllstoffen und/oder pigmenten |
| DE4206857C2 (de) * | 1992-03-05 | 1996-08-29 | Stockhausen Chem Fab Gmbh | Polymerzusammensetzung, Absorptionsmaterialzusammensetzung, deren Herstellung und Verwendung |
| FR2694756B1 (fr) * | 1992-08-12 | 1994-10-07 | Atochem Elf Sa | Perfectionnement pour la préparation de polyacrylates superabsorbants. |
| GB9414721D0 (en) * | 1994-07-21 | 1994-09-07 | Smithkline Beecham Plc | Dentifrice composition |
| US5728742A (en) * | 1996-04-04 | 1998-03-17 | The Dow Chemical Company | Absorbent polymers having a reduced caking tendency |
| US5856410A (en) * | 1997-05-23 | 1999-01-05 | Amcol International Corporation | Polyacrylate superabsorbent post-polymerization neutralized with solid, non-hydroxyl neutralizing agent. |
-
1998
- 1998-12-14 EA EA200000671A patent/EA002367B1/ru not_active IP Right Cessation
- 1998-12-14 HU HU0100090A patent/HUP0100090A3/hu unknown
- 1998-12-14 WO PCT/EP1998/008161 patent/WO1999032074A2/en active Application Filing
- 1998-12-14 PL PL98341605A patent/PL341605A1/xx unknown
- 1998-12-14 AU AU26129/99A patent/AU2612999A/en not_active Abandoned
- 1998-12-14 BR BR9813677-1A patent/BR9813677A/pt not_active IP Right Cessation
- 1998-12-14 CN CN98813665A patent/CN1284854A/zh active Pending
- 1998-12-15 US US09/211,832 patent/US6106811A/en not_active Expired - Fee Related
- 1998-12-17 AR ARP980106430A patent/AR017880A1/es unknown
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1713884B (zh) * | 2002-11-26 | 2010-11-10 | 宝洁公司 | 可咀嚼的固体单位剂型和可用于将活性剂递送到牙齿咬合面的方法 |
| CN106232086A (zh) * | 2014-05-15 | 2016-12-14 | 宝洁公司 | 具有牙斑减少或改善的氟离子摄取的牙粉组合物 |
| CN106456474A (zh) * | 2014-05-15 | 2017-02-22 | 宝洁公司 | 具有牙斑减少或改善的氟离子摄取的牙粉组合物 |
| CN106456462A (zh) * | 2014-05-15 | 2017-02-22 | 宝洁公司 | 具有改善的氟离子稳定性的牙粉组合物 |
| CN106456463A (zh) * | 2014-05-15 | 2017-02-22 | 宝洁公司 | 具有改善的氟离子稳定性或氟化物摄取的牙粉组合物 |
| CN106456474B (zh) * | 2014-05-15 | 2019-11-22 | 宝洁公司 | 具有牙斑减少或改善的氟离子摄取的牙粉组合物 |
| CN108348408A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有改善的氟化物稳定性的牙粉组合物 |
| CN108348409A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有改善的氟化物稳定性的牙粉组合物 |
| CN108348429A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有改善的氟化物摄取的牙粉组合物 |
| CN108348414A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有双氟化物源与改善的氟化物摄取的牙粉组合物 |
| CN113975184A (zh) * | 2015-11-13 | 2022-01-28 | 宝洁公司 | 具有改善的消费者体验的洁齿剂组合物 |
| CN108348408B (zh) * | 2015-11-13 | 2024-04-19 | 宝洁公司 | 具有改善的氟化物稳定性的牙粉组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EA002367B1 (ru) | 2002-04-25 |
| EA200000671A1 (ru) | 2000-12-25 |
| AU2612999A (en) | 1999-07-12 |
| WO1999032074A3 (en) | 1999-09-30 |
| US6106811A (en) | 2000-08-22 |
| WO1999032074A2 (en) | 1999-07-01 |
| HUP0100090A3 (en) | 2002-11-28 |
| HUP0100090A2 (hu) | 2001-05-28 |
| BR9813677A (pt) | 2000-10-03 |
| PL341605A1 (en) | 2001-04-23 |
| AR017880A1 (es) | 2001-10-24 |
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