CN1305995A - 制备1,4－二氢吡啶化合物的方法 - Google Patents

制备1,4－二氢吡啶化合物的方法 Download PDF

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Publication number
CN1305995A
CN1305995A CN00135278A CN00135278A CN1305995A CN 1305995 A CN1305995 A CN 1305995A CN 00135278 A CN00135278 A CN 00135278A CN 00135278 A CN00135278 A CN 00135278A CN 1305995 A CN1305995 A CN 1305995A
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CN
China
Prior art keywords
alkyl
reaction
acid
base
metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00135278A
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English (en)
Chinese (zh)
Inventor
佐竹邦夫
村濑德晃
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1305995A publication Critical patent/CN1305995A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CN00135278A 1999-12-10 2000-12-08 制备1,4－二氢吡啶化合物的方法 Pending CN1305995A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17021799P 1999-12-10 1999-12-10
US60/170,217 1999-12-10

Publications (1)

Publication Number Publication Date
CN1305995A true CN1305995A (zh) 2001-08-01

Family

ID=22619029

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00135278A Pending CN1305995A (zh) 1999-12-10 2000-12-08 制备1,4－二氢吡啶化合物的方法

Country Status (16)

Country Link
US (1) US6649767B2 (https=)
EP (1) EP1110962A1 (https=)
JP (1) JP2001163884A (https=)
KR (1) KR100423188B1 (https=)
CN (1) CN1305995A (https=)
AU (1) AU7212700A (https=)
BR (1) BR0005842A (https=)
CA (1) CA2327944A1 (https=)
CZ (1) CZ20004595A3 (https=)
HU (1) HUP0004884A3 (https=)
ID (1) ID28601A (https=)
IL (1) IL140074A0 (https=)
PL (1) PL344390A1 (https=)
RU (1) RU2223267C2 (https=)
YU (1) YU77400A (https=)
ZA (1) ZA200007253B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017024953A1 (zh) * 2014-12-03 2017-02-16 广州市恒诺康医药科技有限公司 尼莫地平水溶性衍生物及其制备方法和应用
CN114989072A (zh) * 2022-05-27 2022-09-02 四川大学 一种不对称催化合成手性1,4-二氢吡啶化合物的方法及其应用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101151932B1 (ko) * 2004-04-08 2012-06-01 다우 아그로사이언시즈 엘엘씨 살충성 ｎ-치환된 설폭시민
TW201309635A (zh) 2006-02-10 2013-03-01 Dow Agrosciences Llc 殺蟲性之ｎ-取代（６-鹵烷基吡啶-３-基）烷基磺醯亞胺（二）
TWI381811B (zh) * 2006-06-23 2013-01-11 Dow Agrosciences Llc 用以防治可抵抗一般殺蟲劑之昆蟲的方法
TWI387585B (zh) * 2006-09-01 2013-03-01 Dow Agrosciences Llc 殺蟲性之ｎ-取代（雜芳基）烷基烴基硫亞胺
MX2009002302A (es) * 2006-09-01 2009-03-13 Dow Agrosciences Llc Sulfoximinas de (2-sustituido-1,3-tiazol) alquilo n-sustituidas insecticidas.
TWI395737B (zh) * 2006-11-08 2013-05-11 Dow Agrosciences Llc 作為殺蟲劑之雜芳基（取代的）烷基ｎ-取代的磺醯亞胺
US7709648B2 (en) * 2007-02-09 2010-05-04 Dow Agrosciences Llc Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
AR066366A1 (es) * 2007-05-01 2009-08-12 Dow Agrosciences Llc Mezclas sinergicas plaguicidas
MX2010000593A (es) * 2007-07-20 2010-08-04 Dow Agrosciences Llc Aumentador del vigor de una planta.
US20090221424A1 (en) * 2008-03-03 2009-09-03 Dow Agrosciences Llc Pesticides
JP5747740B2 (ja) * 2011-08-30 2015-07-15 国立大学法人北海道大学 α−ヒドロキシ酸塩の製造方法
CN111728948A (zh) * 2020-08-19 2020-10-02 湖北潜龙药业有限公司 一种苯磺酸氨氯地平片的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2057122C1 (ru) * 1992-11-10 1996-03-27 Научно-производственное объединение "Кристалл" Способ получения 2,6-диметил-3,5-ди(карбометокси)-4-(2-нитрофенил)-1,4-дигидропиридина (нифедипина)
WO1996006083A1 (en) * 1994-08-24 1996-02-29 Pfizer Pharmaceuticals Inc. 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists
DE4443168A1 (de) * 1994-12-05 1996-06-13 Bayer Ag Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten
EP0727691A1 (en) * 1995-02-14 1996-08-21 Sagem S.A. Active matrix liquid crystal display device having homogeneously aligned non-twisted liquid crystal configuration and retardation compensation
MX9701245A (es) * 1996-02-19 1998-04-30 Pfizer Compuestos de 1,4 dihidropiridina.
TNSN97037A1 (fr) * 1996-02-19 2005-03-15 Pfizer Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017024953A1 (zh) * 2014-12-03 2017-02-16 广州市恒诺康医药科技有限公司 尼莫地平水溶性衍生物及其制备方法和应用
CN114989072A (zh) * 2022-05-27 2022-09-02 四川大学 一种不对称催化合成手性1,4-二氢吡啶化合物的方法及其应用
CN114989072B (zh) * 2022-05-27 2023-07-21 四川大学 一种不对称催化合成手性1,4-二氢吡啶化合物的方法及其应用

Also Published As

Publication number Publication date
ZA200007253B (en) 2002-06-07
JP2001163884A (ja) 2001-06-19
YU77400A (sh) 2003-04-30
KR20010062286A (ko) 2001-07-07
HU0004884D0 (https=) 2001-02-28
CA2327944A1 (en) 2001-06-10
US6649767B2 (en) 2003-11-18
BR0005842A (pt) 2001-07-24
CZ20004595A3 (cs) 2002-06-12
US20030078430A1 (en) 2003-04-24
EP1110962A1 (en) 2001-06-27
ID28601A (id) 2001-06-14
RU2223267C2 (ru) 2004-02-10
HUP0004884A2 (hu) 2001-10-28
HUP0004884A3 (en) 2003-03-28
KR100423188B1 (ko) 2004-03-18
AU7212700A (en) 2001-06-14
IL140074A0 (en) 2002-02-10
PL344390A1 (en) 2001-06-18

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