CN1304375C - 用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物 - Google Patents

用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物 Download PDF

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CN1304375C
CN1304375C CNB008143870A CN00814387A CN1304375C CN 1304375 C CN1304375 C CN 1304375C CN B008143870 A CNB008143870 A CN B008143870A CN 00814387 A CN00814387 A CN 00814387A CN 1304375 C CN1304375 C CN 1304375C
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compound
alkyl
disease
jnk
oxyl
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Expired - Fee Related
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CNB008143870A
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Chinese (zh)
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CN1379763A (zh
Inventor
B·L·本尼特
S·S·巴瓦特
A·M·曼宁
B·W·墨雷
E·C·奥莱里
Y·萨托
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Signal Pharmaceuticals LLC
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Signal Pharmaceuticals LLC
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB008143870A 1999-08-19 2000-08-19 用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物 Expired - Fee Related CN1304375C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37823499A 1999-08-19 1999-08-19
US09/378234 1999-08-19
US09/642557 2000-08-18
US09/642,557 US7119114B1 (en) 1999-08-19 2000-08-18 Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto

Publications (2)

Publication Number Publication Date
CN1379763A CN1379763A (zh) 2002-11-13
CN1304375C true CN1304375C (zh) 2007-03-14

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CNB008143870A Expired - Fee Related CN1304375C (zh) 1999-08-19 2000-08-19 用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物

Country Status (10)

Country Link
EP (1) EP1218347A1 (ko)
JP (1) JP2003532626A (ko)
KR (2) KR100835700B1 (ko)
CN (1) CN1304375C (ko)
AU (1) AU780306B2 (ko)
CA (1) CA2383268A1 (ko)
HK (1) HK1053107A1 (ko)
NZ (1) NZ517578A (ko)
WO (1) WO2001012609A1 (ko)
ZA (1) ZA200201312B (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119114B1 (en) 1999-08-19 2006-10-10 Signal Pharmaceuticals, Llc Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto
US20040072888A1 (en) * 1999-08-19 2004-04-15 Bennett Brydon L. Methods for treating inflammatory conditions or inhibiting JNK
US7429599B2 (en) * 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
US6982274B2 (en) 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
AR035971A1 (es) 2001-05-16 2004-07-28 Cephalon Inc Metodos para el tratamiento y la prevencion del dolor
ATE419247T1 (de) 2001-07-23 2009-01-15 Serono Lab Arylsulfonamidderivate als hemmer c-jun- terminaler kinasen (jnk)
US7390797B2 (en) 2002-02-28 2008-06-24 Eisai Co., Ltd. Fused indazole compounds
JP2005534619A (ja) 2002-03-28 2005-11-17 エーザイ株式会社 C−junn−末端キナーゼ阻害剤としてのアザインドール
US7534800B2 (en) 2002-03-28 2009-05-19 Eisai R & D Development Co., Ltd. 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders
PL372963A1 (en) * 2002-04-05 2005-08-08 Boehringer Ingelheim Pharma Gmb & Co.Kg Method of treating mucus hypersecretion
KR20050008757A (ko) * 2002-05-30 2005-01-21 셀진 코포레이션 세포 분화를 조절하고 골수증식성 질환 및 골수형성이상증후군을 치료하기 위하여 jnk 또는 mkk 저해제를사용하는 방법
TW200406385A (en) 2002-05-31 2004-05-01 Eisai Co Ltd Pyrazole compound and pharmaceutical composition containing the same
US20040087642A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
US20040092568A1 (en) * 2002-10-31 2004-05-13 Zeldis Jerome B. Methods for the treatment, prevention and management of macular degeneration
US20050019366A1 (en) * 2002-12-31 2005-01-27 Zeldis Jerome B. Drug-coated stents and methods of use therefor
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
EP1628975A2 (en) 2003-05-16 2006-03-01 Eisai Co., Ltd. Jnk inhibitors
CA2544591A1 (en) * 2003-11-06 2005-05-26 Celgene Corporation Methods of using and compositions comprising a jnk inhibitor for the treatment and management of asbestos-related diseases and disorders
WO2005074921A1 (en) * 2004-02-09 2005-08-18 University Of Zurich Treatment of atherosclerosis
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
US7803824B2 (en) 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
US20060094753A1 (en) * 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
AU2005309732A1 (en) * 2004-11-23 2006-06-01 Celgene Corporation JNK inhibitors for treatment of CNS injury
US20060223807A1 (en) 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 jnk 억제제
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
CN101374941A (zh) 2005-12-29 2009-02-25 人类起源公司 采集和保存胎盘干细胞的改良组合物及其使用方法
KR102484810B1 (ko) 2016-05-25 2023-01-05 (주)아모레퍼시픽 피부 미백용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2167626A1 (ko) * 1972-01-03 1973-08-24 Basf Ag
FR2401915A1 (fr) * 1977-09-02 1979-03-30 Ciba Geigy Ag Procede pour la preparation de pyrazolanthrones portant un substituant sur la position 3

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
CH538528A (de) * 1968-11-07 1973-06-30 Hoechst Ag Verfahren zur Herstellung von faserreaktiven Farbstoffen
DE2558813C2 (de) * 1975-12-27 1984-10-31 Hoechst Ag, 6230 Frankfurt Lichtempfindliches Gemisch mit synergistischem Initiatorsystem

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2167626A1 (ko) * 1972-01-03 1973-08-24 Basf Ag
FR2401915A1 (fr) * 1977-09-02 1979-03-30 Ciba Geigy Ag Procede pour la preparation de pyrazolanthrones portant un substituant sur la position 3

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ZA200201312B (en) 2003-02-17
WO2001012609A1 (en) 2001-02-22
JP2003532626A (ja) 2003-11-05
KR20020038733A (ko) 2002-05-23
CA2383268A1 (en) 2001-02-22
AU6786300A (en) 2001-03-13
NZ517578A (en) 2004-02-27
AU780306B2 (en) 2005-03-17
KR20080028516A (ko) 2008-03-31
HK1053107A1 (zh) 2003-10-10
KR100835700B1 (ko) 2008-06-09
EP1218347A1 (en) 2002-07-03
CN1379763A (zh) 2002-11-13

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