CN1304375C - 用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物 - Google Patents

用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物 Download PDF

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CN1304375C
CN1304375C CNB008143870A CN00814387A CN1304375C CN 1304375 C CN1304375 C CN 1304375C CN B008143870 A CNB008143870 A CN B008143870A CN 00814387 A CN00814387 A CN 00814387A CN 1304375 C CN1304375 C CN 1304375C
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compound
alkyl
disease
jnk
oxyl
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Expired - Fee Related
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CNB008143870A
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Chinese (zh)
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CN1379763A (zh
Inventor
B·L·本尼特
S·S·巴瓦特
A·M·曼宁
B·W·墨雷
E·C·奥莱里
Y·萨托
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Signal Pharmaceuticals LLC
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Signal Pharmaceuticals LLC
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB008143870A 1999-08-19 2000-08-19 用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物 Expired - Fee Related CN1304375C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37823499A 1999-08-19 1999-08-19
US09/378234 1999-08-19
US09/642,557 US7119114B1 (en) 1999-08-19 2000-08-18 Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto
US09/642557 2000-08-18

Publications (2)

Publication Number Publication Date
CN1379763A CN1379763A (zh) 2002-11-13
CN1304375C true CN1304375C (zh) 2007-03-14

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CNB008143870A Expired - Fee Related CN1304375C (zh) 1999-08-19 2000-08-19 用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物

Country Status (10)

Country Link
EP (1) EP1218347A1 (fr)
JP (1) JP2003532626A (fr)
KR (2) KR20080028516A (fr)
CN (1) CN1304375C (fr)
AU (1) AU780306B2 (fr)
CA (1) CA2383268A1 (fr)
HK (1) HK1053107A1 (fr)
NZ (1) NZ517578A (fr)
WO (1) WO2001012609A1 (fr)
ZA (1) ZA200201312B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119114B1 (en) 1999-08-19 2006-10-10 Signal Pharmaceuticals, Llc Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto
US20040072888A1 (en) * 1999-08-19 2004-04-15 Bennett Brydon L. Methods for treating inflammatory conditions or inhibiting JNK
US7429599B2 (en) * 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
ATE449763T1 (de) 2001-04-16 2009-12-15 Eisai R&D Man Co Ltd 1h-indazolverbindungen die jnk hemmen
US7018999B2 (en) * 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
JP4414219B2 (ja) 2001-07-23 2010-02-10 メルク セローノ ソシエテ アノニム Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）インヒビターとしてのアリールスルホンアミド誘導体
WO2003072550A1 (fr) 2002-02-28 2003-09-04 Eisai Co., Ltd. Nouveaux composes indazole a anneaux fusionnes
KR20040111445A (ko) 2002-03-28 2004-12-31 에자이 가부시키가이샤 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌
CN100338062C (zh) 2002-03-28 2007-09-19 卫材株式会社 作为c－Jun N－末端激酶抑制剂的氮杂吲哚类化合物
AU2003224025A1 (en) * 2002-04-05 2003-10-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg p38 kinase inhibitors for treating mucus hypersecretion
WO2003102151A2 (fr) * 2002-05-30 2003-12-11 Celgene Corporation Procedes d'utilisation d'inhibiteurs de jnk ou de mkk en vue de moduler la differenciation cellulaire et de traiter des troubles myeloproliferatifs et des syndromes myelodysplasiques
EP1510516A4 (fr) 2002-05-31 2005-11-02 Eisai Co Ltd Compose de pyrazole et composition medicinale le contenant
US20040087642A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
US20040092568A1 (en) * 2002-10-31 2004-05-13 Zeldis Jerome B. Methods for the treatment, prevention and management of macular degeneration
US20050019366A1 (en) * 2002-12-31 2005-01-27 Zeldis Jerome B. Drug-coated stents and methods of use therefor
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
US7612086B2 (en) 2003-05-16 2009-11-03 Eisai R & D Management Co. Ltd. JNK inhibitors
ZA200603719B (en) * 2003-11-06 2007-09-26 Celgene Corp Methods of using and compositions comprising a JNK inhibitor for the treatment and management of asbestos-related diseases and disorders
WO2005074921A1 (fr) * 2004-02-09 2005-08-18 University Of Zurich Traitement de l'atherosclerose
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
US20060094753A1 (en) * 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
US7803824B2 (en) * 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
MX2007006066A (es) * 2004-11-23 2007-07-11 Celgene Corp Inhibidores de jnk para el tratamiento de lesiones del snc.
US20060223807A1 (en) 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
CN101374941A (zh) 2005-12-29 2009-02-25 人类起源公司 采集和保存胎盘干细胞的改良组合物及其使用方法
KR102484810B1 (ko) 2016-05-25 2023-01-05 (주)아모레퍼시픽 피부 미백용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2167626A1 (fr) * 1972-01-03 1973-08-24 Basf Ag
FR2401915A1 (fr) * 1977-09-02 1979-03-30 Ciba Geigy Ag Procede pour la preparation de pyrazolanthrones portant un substituant sur la position 3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH538527A (de) * 1968-11-07 1973-06-30 Hoechst Ag Verfahren zur Herstellung von faserreaktiven Farbstoffen
DE2558813C2 (de) * 1975-12-27 1984-10-31 Hoechst Ag, 6230 Frankfurt Lichtempfindliches Gemisch mit synergistischem Initiatorsystem

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2167626A1 (fr) * 1972-01-03 1973-08-24 Basf Ag
FR2401915A1 (fr) * 1977-09-02 1979-03-30 Ciba Geigy Ag Procede pour la preparation de pyrazolanthrones portant un substituant sur la position 3

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ZA200201312B (en) 2003-02-17
AU6786300A (en) 2001-03-13
HK1053107A1 (zh) 2003-10-10
CA2383268A1 (fr) 2001-02-22
KR20080028516A (ko) 2008-03-31
CN1379763A (zh) 2002-11-13
WO2001012609A1 (fr) 2001-02-22
AU780306B2 (en) 2005-03-17
EP1218347A1 (fr) 2002-07-03
NZ517578A (en) 2004-02-27
KR100835700B1 (ko) 2008-06-09
JP2003532626A (ja) 2003-11-05
KR20020038733A (ko) 2002-05-23

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