CN1294924A - Pregnancy promoting medicine to treat man's and woman's sterility and its preparation - Google Patents
Pregnancy promoting medicine to treat man's and woman's sterility and its preparation Download PDFInfo
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- CN1294924A CN1294924A CN99117197A CN99117197A CN1294924A CN 1294924 A CN1294924 A CN 1294924A CN 99117197 A CN99117197 A CN 99117197A CN 99117197 A CN99117197 A CN 99117197A CN 1294924 A CN1294924 A CN 1294924A
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Abstract
The medicine of the present invention uses the raw material including 15 Chinese medicinal materials, including Radix Scutellariae, dodder seed, Radix Paeoniae Alba, Codonopsis Pilosulae, Astragalus membranaceus, etc. The present invention also provides the preparation process complying with the stipulation of Chinese pharmacopeia. Clinical application shows that the medicine has obvious curative effect on sterility of ovulation dysfunciton, abnormal semen, excessive fetal movement, vaginal bleeding, etc. and is also suitable for spermatorrhea, asexuality, climacteric syndrome, etc.
Description
The present invention relates to a kind of pregnancy promoting medicine for the treatment of man's and woman's sterility, specifically belonging to the Chinese herbal medicine is the Chinese patent medicine of raw material, the invention still further relates to the preparation method of this medicine.
Infertility is meant under the situation of not taking any contraceptives, gestation arranged after the normality life more than 2 years yet or life birth person is arranged.Chinese medicine is accumulating rich experience aspect the treatment man's and woman's sterility, as Li Yunxiao based on the kidney invigorating, " the palace electuary is educated in the kidney invigorating " that assistant is formed with the liver benefiting replenishing essence, nourshing blood and promoting blood circulation medicine, form by 13 flavor medicines such as harts horn carbon, Fructus Corni, the Cortex Eucommiae, Fructus Lycii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Fluoritum, treatment uterine hypoplasia infertility (relation of uterine hypoplasia infertility and Chinese medical discrimination typing, journal of shanghai Chinese medicine 1998;＜8 〉: 40～41); Guan Xinmei uses the induced ovulation soup based on invigorating kidney, promoting blood circulation class Chinese medicine, its basic side is: Radix Rehmanniae Preparata, Semen Cuscutae, Herba Epimedii, Herba Cistanches, Fructus Schisandrae Chinensis, Cornu Cervi Degelatinatum, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae etc., treatment ovulatory dysfunction sterility (induced ovulation soup treatment ovulatory dysfunction barrenness 29 examples, traditional Chinese medical science research 1998; 11＜4 〉: 37～38).Above-mentioned Chinese medicine is paid attention to the tonifying liver the kidney invigorating not embodying whole the executing of seeing of the traditional Chinese medical science and controlling principle to cure infertility, uses the tonic of a large amount of the kidney invigorating tonifying livers in the side, is difficult for absorbing, and gets angry easily after eating, and curative effect is limited.
The objective of the invention is the existing problem of Chinese medicine of curing infertility at existing, proposes a kind of efficient, effect is wide, nature and flavor are gentle, be difficult for getting angry, be easy to the pregnancy promoting medicine and preparation method thereof of the treatment man's and woman's sterility of oral and absorption.
The present invention is based on and suffer from a deficiency of the kidney and the three dirty imbalances of liver spleen are the understanding that causes the mechanism of infertility, the rule of treatment of corresponding formulation " reinforce the kidney, spleen invigorating, accent liver and be in harmonious proportion three dirty ", select and " nature and flavor " compatibility according to medicine " return through ", select in kidney channel, spleen channel, the Liver Channel that clinical efficacy is good, effect is strong for use, have respectively reinforce the kidney, the Chinese medicine of spleen invigorating, accent liver, the purify composition of each medicine of refine is made the pregnancy promoting medicine of this treatment man's and woman's sterility.
Medicine of the present invention is made (consumption is a weight portion) by following component:
5～15 parts of Radix Scutellariaes, 10～50 parts of Semen Cuscutae, 6～15 parts of Radix Dipsaci, 5～30 parts of the Radix Paeoniae Albas, 9～60 parts of Radix Codonopsis, 9～20 parts of Radix Astragali, 4.5～10 parts in Colla Corii Asini, 3～9 parts of Radix Aucklandiae (Radix Vladimiriae), 5～15 parts of the Rhizoma Atractylodis Macrocephalaes, parasitic 9～18 parts, 9～20 parts in Fructus Mori, 9～15 parts of the Cortexs Eucommiae, 15～30 parts of Rhizoma Phragmitiss, 15～30 parts of Rhizoma Dioscoreaes, 4.5～9 parts of Caulis Bambusae In Taenia.
The preferred weight proportioning of preparation pharmaceutical formulation of the present invention is:
10 parts of Radix Scutellariaes, 15 parts of Semen Cuscutae, 15 parts of Radix Dipsaci, 18 parts of the Radix Paeoniae Albas, 15 parts of Radix Codonopsis, 20 parts of Radix Astragali, 10 parts in Colla Corii Asini, 9 parts of Radix Aucklandiae (Radix Vladimiriae), 12 parts of the Rhizoma Atractylodis Macrocephalaes, parasitic 15 parts, 20 parts in Fructus Mori, 15 parts of the Cortexs Eucommiae, 20 parts of Rhizoma Phragmitiss, 20 parts of Rhizoma Dioscoreaes, 8 parts of Caulis Bambusae In Taenia.
The dosage form of medicine of the present invention can be capsule or pill.
The preparation method of making medicine of the present invention comprises following processing step:
(1) Radix Scutellariae, Radix Astragali, Radix Dipsaci, Caulis Bambusae In Taenia, Radix Codonopsis, Radix Aucklandiae (Radix Vladimiriae), parasitism, Fructus Mori, Rhizoma Phragmitis 9 flavor medicines are cut respectively, are pulverized in the side of getting, mix, earlier with 80～100 ℃ of hot water lixiviates, to add ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) Radix Paeoniae Alba in the side of getting, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, the Cortex Eucommiae, Rhizoma Dioscoreae 5 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation (according to the operation of Chinese Pharmacopoeia percolation), collect 5 times of amounts of medicinal liquid behind the mixing, and filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, the Colla Corii Asini heating is stewed melt, with the thick paste mixing, use the Pulvis Talci disc, vacuum drying becomes dry extract, pulverizes, and crosses 80～100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
For improving the extraction ratio of each medicine composition, in above-mentioned steps (1), described 9 flavor medicines will be used hot water lixiviate secondary, the amount of water of each lixiviate is 10～12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
Semen Cuscutae, parasitism, Radix Dipsaci, Fructus Mori, the Cortex Eucommiae, Radix Paeoniae Alba the kidney invigorating nourishing the liver among the side of the present invention, normal ginseng, Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae replenishing QI to invigorate the spleen, the Gu Chong hemostasis, the Colla Corii Asini nourishing blood hemostasis, Radix Scutellariae, Caulis Bambusae In Taenia, Radix Aucklandiae (Radix Vladimiriae), the spleen invigorating of Rhizoma Phragmitis nourishing stomach-YIN and middle preventing or arresting vomiting, all medicines share, play altogether and transfer the tonifying liver spleen, be in harmonious proportion to dash and appoint the antiabortive merit of reinforcing the kidney.The present invention is reinforced the kidney except that having, also be added with medicine among a small amount of heat clearing away among the spleen invigorating, accent liver the medicine, so that flavour of a drug are gentle, can not get angry after eating.
Preparation method of the present invention, the composition of refine purification material medicine, method for making meets the Chinese Pharmacopoeia regulation, and capsule of making or pill are easy to absorb and are oral, help improving curative effect.
Medicine of the present invention proves that this poison of drug is very low, clinical consumption safety through the animal acute toxicity test of Traditional Chinese Medicine University Of Guangzhou's taste institute;
All by the check of Shantou City medicine inspecting institute, the result meets the requirements for the capsule that the present invention makes, pill.
Medicine of the present invention passes through clinical use and shows, is adapted to frequent fetal movement, vaginal bleeding during pregnancy, and the control of infertility such as tire cunning also is adapted to spermatorrhea, men and women's hyposexuality, female climacteric syndromes etc. have significant curative effect to treating following three kinds of infertilities:
1, ovulatory dysfunction barrenness;
2, dysspermatism sterility;
3, threatened abortion, spontaneous abortion, habitual abortion etc.
Be the curative effect of proof medicine of the present invention, the present invention transfers reinforcing the kidney and dashes, and each the disease patient who controls card genus deficiency of the liver and kindey, taste deficiency carries out clinical treatment observation, oral medicine of the present invention.And to select the suitable patient of symptom be matched group, does contrast with other existing Chinese and western drugses treatments and observe, and the case observation phase continues to observe after for 2 weeks of observation to normal pregnancy more than 4 months or to normal labor again.Clinical test results is as follows:
1, cures mainly symptom: frequent fetal movement, vaginal bleeding during pregnancy, habitual abortion (in 8 weeks)
Take medicine of the present invention (capsule or pill) treatment 31 examples, cure 24 examples, 5 examples that take a turn for the better, invalid 2 examples.Effective percentage 93.6%;
Use the matched group Drug therapy:
A, use Western medicine HCG treat 31 examples, cure 22 examples, effective 1 example, invalid 8 examples.Effective percentage 74.2%;
B, use medicine of the present invention add HCG and treat 31 examples, cure 28 examples, effective 2 examples, invalid 1 example.Effective percentage 96.3%;
2, cure mainly symptom: the sexual dysfunction on female climacteric syndrome and man or the wife's side
Take Drug therapy 120 examples of the present invention, cure 99 examples, 19 examples that take a turn for the better, invalid 2 examples.Effective percentage 98.3%;
3, cure mainly symptom: spermatorrhea, cacospermia
Take Drug therapy 320 examples of the present invention, effective 308 examples, effective percentage 96.3%;
Take kylin ball (Shantou City Factory of Traditional Chinese Medicine's product) 36 examples, effective 19 examples, effective percentage 52.8%.
Can find out that from above-mentioned clinical test results drug effect of the present invention is wide, good effect, its price is cheap far beyond Western medicine again, adds that this medicinal flavor is gentle, is difficult for getting angry, and can uninterruptedly take medicine, and is efficient, easily absorbs selection more easy for patients to accept.
Embodiment one
Take by weighing raw material by following proportioning:
10 kilograms of Radix Scutellariaes, 15 kilograms of Semen Cuscutae, 15 kilograms of Radix Dipsaci, 18 kilograms of the Radix Paeoniae Albas, 15 kilograms of Radix Codonopsis, 20 kilograms of Radix Astragali, 10 kilograms in Colla Corii Asini, 9 kilograms of Radix Aucklandiae (Radix Vladimiriae), 12 kilograms of the Rhizoma Atractylodis Macrocephalaes, parasitic 15 kilograms, 20 kilograms in Fructus Mori, 15 kilograms of the Cortexs Eucommiae, 20 kilograms of Rhizoma Phragmitiss, 20 kilograms of Rhizoma Dioscoreaes, 8 kilograms of Caulis Bambusae In Taenia.
Preparation method is as follows:
(1) Radix Scutellariae, Radix Astragali, Radix Dipsaci, Caulis Bambusae In Taenia, Radix Codonopsis, Radix Aucklandiae (Radix Vladimiriae), parasitism, Fructus Mori, Rhizoma Phragmitis 9 flavor medicines are cut respectively, are pulverized in the side of getting, and mix, and described 9 flavor medicines add 12 times of amounts of water, and heated and boiled was collected medicinal liquid after 2 hours; Medicinal residues are added 10 times of amounts of water again, and heated and boiled was collected medicinal liquid after 2 hours; The medicinal liquid of twice collection is merged, filter, be condensed into 1: 1 extractum, put cold back and add ethanol, left standstill 48 hours, and then filter, reclaim ethanol, be condensed into thick paste (30 ℃ are surveyed relative density 1.20～1.25) to containing alcohol 70%;
(2) Radix Paeoniae Alba in the side of getting, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, the Cortex Eucommiae, Rhizoma Dioscoreae 5 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, filtration, and behind the filtrate recycling ethanol, vacuum concentration becomes thick paste;
(3) merge above-mentioned two kinds of thick pastes, the Colla Corii Asini heating is stewed melt, with the thick paste mixing, use the Pulvis Talci disc, vacuum drying (below 80 ℃) becomes dry extract, pulverizes, and crosses 80 mesh sieve secondaries, is filled in " 0 " number capsule, i.e. cost capsule formulation medicine.
Made capsule character: its content is the sepia medicine, and mildly bitter flavor is puckery, sweet, gas perfume (or spice).
Embodiment two
Take by weighing raw material by following proportioning:
5 kilograms of Radix Scutellariaes, 10 kilograms of Semen Cuscutae, 6 kilograms of Radix Dipsaci, 5 kilograms of the Radix Paeoniae Albas, 9 kilograms of Radix Codonopsis, 9 kilograms of Radix Astragali, 5 kilograms in Colla Corii Asini, 3 kilograms of Radix Aucklandiae (Radix Vladimiriae), 5 kilograms of the Rhizoma Atractylodis Macrocephalaes, parasitic 9 kilograms, 9 kilograms in Fructus Mori, 9 kilograms of the Cortexs Eucommiae, 15 kilograms of Rhizoma Phragmitiss, 10 kilograms of Rhizoma Dioscoreaes, 5 kilograms of Caulis Bambusae In Taenia.
Its preparation method (1), (2) two steps are identical with embodiment one, and (3) goes on foot and to become piller with processed with honey for prepared medicated powder is added water, pill medicine of the present invention.
Made pill character: be light, rounding, the uniform brownish black piller of color and luster, ball heart taupe, feeble QI perfume (or spice), sweet in the mouth, hardship, suffering, little salty.
Claims (5)
1. pregnancy promoting medicine for the treatment of man's and woman's sterility is characterized in that it is the medicament of being made by the following weight proportion raw material:
5～15 parts of Radix Scutellariaes, 10～50 parts of Semen Cuscutae, 6～15 parts of Radix Dipsaci, 5～30 parts of the Radix Paeoniae Albas, 9～60 parts of Radix Codonopsis, 9～20 parts of Radix Astragali, 4.5～10 parts in Colla Corii Asini, 3～9 parts of Radix Aucklandiae (Radix Vladimiriae), 5～15 parts of the Rhizoma Atractylodis Macrocephalaes, parasitic 9～18 parts, 9～20 parts in Fructus Mori, 9～15 parts of the Cortexs Eucommiae, 15～30 parts of Rhizoma Phragmitiss, 15～30 parts of Rhizoma Dioscoreaes, 4.5～9 parts of Caulis Bambusae In Taenia.
2. the pregnancy promoting medicine of treatment man's and woman's sterility according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
10 parts of Radix Scutellariaes, 15 parts of Semen Cuscutae, 15 parts of Radix Dipsaci, 18 parts of the Radix Paeoniae Albas, 15 parts of Radix Codonopsis, 20 parts of Radix Astragali, 10 parts in Colla Corii Asini, 9 parts of Radix Aucklandiae (Radix Vladimiriae), 12 parts of the Rhizoma Atractylodis Macrocephalaes, parasitic 15 parts, 20 parts in Fructus Mori, 15 parts of the Cortexs Eucommiae, 20 parts of Rhizoma Phragmitiss, 20 parts of Rhizomadioscoreae, 8 parts of Caulis Bambusae In Taenia.
3. the pregnancy promoting medicine of treatment man's and woman's sterility according to claim 1 and 2, the dosage form that it is characterized in that said medicament is capsule or pill.
4. the preparation method of the pregnancy promoting medicine of the described treatment man's and woman's sterility of claim 3 is characterized in that step of preparation process is as follows:
(1) Radix Scutellariae, Radix Astragali, Radix Dipsaci, Caulis Bambusae In Taenia, Radix Codonopsis, Radix Aucklandiae (Radix Vladimiriae), parasitism, Fructus Mori, Rhizoma Phragmitis 9 flavor medicines are cut respectively, are pulverized in the side of getting, mix, earlier with 80～100 ℃ of hot water lixiviates, to add ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) Radix Paeoniae Alba in the side of getting, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, the Cortex Eucommiae, Rhizomadioscoreae 5 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, and filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, the Colla Corii Asini heating is stewed melt, with the thick paste mixing, use the Pulvis Talci disc, vacuum drying becomes dry extract, pulverizes, and crosses 80～100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
5. the preparation method of the pregnancy promoting medicine of treatment man's and woman's sterility according to claim 4, it is characterized in that in the step (1), the medicinal hot water lixiviate secondary of described 9 flavors, the amount of water of each lixiviate is 10～12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99117197A CN1079262C (en) | 1999-11-09 | 1999-11-09 | Pregnancy promoting medicine to treat man's and woman's sterility and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99117197A CN1079262C (en) | 1999-11-09 | 1999-11-09 | Pregnancy promoting medicine to treat man's and woman's sterility and its preparation |
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| Publication Number | Publication Date |
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| CN1294924A true CN1294924A (en) | 2001-05-16 |
| CN1079262C CN1079262C (en) | 2002-02-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN99117197A Expired - Fee Related CN1079262C (en) | 1999-11-09 | 1999-11-09 | Pregnancy promoting medicine to treat man's and woman's sterility and its preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100350961C (en) * | 2003-07-05 | 2007-11-28 | 姚克敏 | Formulation for treating fetal leakage and fetal irritability and its preparing process |
| CN102764322A (en) * | 2012-08-10 | 2012-11-07 | 陈俊梅 | Traditional Chinese medicine composite for curing sterility and irregular menstruation |
| CN102836382A (en) * | 2012-10-09 | 2012-12-26 | 彭少芳 | Kidney-tonifying and embryo-developing externally-applied plaster |
| CN103565908A (en) * | 2013-11-12 | 2014-02-12 | 广州市云桥生物科技有限公司 | Traditional Chinese medicine effective part composition for treating semen abnormality |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095944A (en) * | 1993-06-04 | 1994-12-07 | 成胤祖 | Tonic wine with Yang-strengthening function |
| CN1096205A (en) * | 1993-06-07 | 1994-12-14 | 赵志国 | Anti-weakness nutrition oral liquid |
| CN1100640A (en) * | 1993-09-21 | 1995-03-29 | 昆明市北郊龙光健康品厂 | Invigorating Yang oral liquid and method for prepn. |
-
1999
- 1999-11-09 CN CN99117197A patent/CN1079262C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100350961C (en) * | 2003-07-05 | 2007-11-28 | 姚克敏 | Formulation for treating fetal leakage and fetal irritability and its preparing process |
| CN102764322A (en) * | 2012-08-10 | 2012-11-07 | 陈俊梅 | Traditional Chinese medicine composite for curing sterility and irregular menstruation |
| CN102764322B (en) * | 2012-08-10 | 2014-03-05 | 陈俊梅 | Traditional Chinese medicine composite for curing sterility and irregular menstruation |
| CN102836382A (en) * | 2012-10-09 | 2012-12-26 | 彭少芳 | Kidney-tonifying and embryo-developing externally-applied plaster |
| CN102836382B (en) * | 2012-10-09 | 2013-09-04 | 彭少芳 | Kidney-tonifying and embryo-developing externally-applied plaster |
| CN103565908A (en) * | 2013-11-12 | 2014-02-12 | 广州市云桥生物科技有限公司 | Traditional Chinese medicine effective part composition for treating semen abnormality |
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| Publication number | Publication date |
|---|---|
| CN1079262C (en) | 2002-02-20 |
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