CN1291984C - 2－硫－取代咪唑衍生物及其药学用途 - Google Patents

2－硫－取代咪唑衍生物及其药学用途 Download PDF

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CN1291984C
CN1291984C CNB028051548A CN02805154A CN1291984C CN 1291984 C CN1291984 C CN 1291984C CN B028051548 A CNB028051548 A CN B028051548A CN 02805154 A CN02805154 A CN 02805154A CN 1291984 C CN1291984 C CN 1291984C
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alkyl
phenyl
pyridyl
fluorophenyl
replaces
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CN1511149A (zh
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S·劳弗
D·科琴罗伊特
P·默克勒
K·托尔曼
H-G·施特里格尔
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Merckle GmbH
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
CNB028051548A 2001-02-19 2002-02-19 2－硫－取代咪唑衍生物及其药学用途 Expired - Fee Related CN1291984C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10107683A DE10107683A1 (de) 2001-02-19 2001-02-19 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10107683.5 2001-02-19

Publications (2)

Publication Number Publication Date
CN1511149A CN1511149A (zh) 2004-07-07
CN1291984C true CN1291984C (zh) 2006-12-27

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CNB028051548A Expired - Fee Related CN1291984C (zh) 2001-02-19 2002-02-19 2－硫－取代咪唑衍生物及其药学用途

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Country Link
US (1) US7253191B2 (https=)
EP (1) EP1362045B1 (https=)
JP (1) JP2004521913A (https=)
KR (1) KR100642231B1 (https=)
CN (1) CN1291984C (https=)
AT (1) ATE282605T1 (https=)
AU (1) AU2002247726C1 (https=)
BR (1) BR0207254A (https=)
CA (1) CA2453078A1 (https=)
CZ (1) CZ20032224A3 (https=)
DE (2) DE10107683A1 (https=)
DK (1) DK1362045T3 (https=)
ES (1) ES2233808T3 (https=)
HU (1) HUP0303155A3 (https=)
IL (1) IL157050A0 (https=)
IS (1) IS6914A (https=)
MX (1) MXPA03007380A (https=)
PL (1) PL367397A1 (https=)
PT (1) PT1362045E (https=)
RU (1) RU2284326C2 (https=)
SK (1) SK10242003A3 (https=)
WO (1) WO2002066458A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10222103A1 (de) * 2002-05-17 2003-11-27 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de) * 2002-08-20 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10256881A1 (de) * 2002-12-05 2004-06-24 Beiersdorf Ag Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten
CN1956976A (zh) * 2004-05-26 2007-05-02 詹森药业有限公司 作为ccr2受体拮抗剂的巯基咪唑化合物
BRPI0511599A (pt) 2004-05-26 2008-01-02 Janssen Pharmaceutica Nv mercaptoimidazóis como antagonistas receptores de ccr2
EP1778646A1 (en) * 2004-08-11 2007-05-02 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
CN101128453A (zh) * 2005-02-28 2008-02-20 默克勒有限公司 2-亚磺酰基-和2-磺酰基-取代的咪唑衍生物和它们作为细胞因子抑制剂的用途
EP1894925A1 (en) * 2006-08-24 2008-03-05 Merckle Gmbh Imidazole compounds having an antiinflammatory effect
WO2008085008A1 (en) * 2007-01-11 2008-07-17 Mogam Biotechnology Research Institute T-cell inhibiting compounds and their use for the treatment of t-cell-mediated diseases
US8143294B2 (en) 2007-12-31 2012-03-27 Michael Burnet 2-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors
CN102249992A (zh) * 2011-07-05 2011-11-23 广东工业大学 一种制备2-氨基异烟酸的方法
DE102013102069A1 (de) 2013-03-01 2014-09-04 Fsp Fluid Systems Partners Holding Ag Proportional-Wegeventil sowie hydraulische Schaltung und hydropneumatisches Federungssystem mit einem derartigen Ventil
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US11795160B2 (en) 2019-02-22 2023-10-24 Insilico Medicine Ip Limited Kinase inhibitors
CA3208490A1 (en) 2021-02-24 2022-09-01 Aleksandrs Zavoronkovs Analogs for the treatment of disease

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DK16778A (da) 1977-02-09 1978-08-10 Du Pont Imidazolderivater deres anvendelser og fremstilling
EP0004648B1 (de) * 1978-04-11 1982-08-25 Ciba-Geigy Ag Neue Mercaptoimidazolderivate, Verfahren zu deren Herstellung, Mercaptoimidazolderivate zur Behandlung entzündlicher Erkrankungen und diese enthaltende pharmazeutische Präparate
DE2823197A1 (de) 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
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DE3141063A1 (de) * 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
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US4686231A (en) 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
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DE19842833B4 (de) 1998-09-18 2005-04-14 Merckle Gmbh 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie

Also Published As

Publication number Publication date
JP2004521913A (ja) 2004-07-22
CN1511149A (zh) 2004-07-07
HUP0303155A2 (hu) 2003-12-29
AU2002247726C1 (en) 2006-08-17
SK10242003A3 (sk) 2004-03-02
PT1362045E (pt) 2005-04-29
US7253191B2 (en) 2007-08-07
AU2002247726B2 (en) 2006-01-19
RU2284326C2 (ru) 2006-09-27
HUP0303155A3 (en) 2007-08-28
IS6914A (is) 2003-08-15
PL367397A1 (en) 2005-02-21
KR100642231B1 (ko) 2006-11-02
DE50201565D1 (de) 2004-12-23
CA2453078A1 (en) 2002-08-29
ES2233808T3 (es) 2005-06-16
EP1362045A2 (de) 2003-11-19
ATE282605T1 (de) 2004-12-15
WO2002066458A3 (de) 2002-12-12
HK1056725A1 (en) 2004-02-27
DK1362045T3 (da) 2005-03-29
US20040116416A1 (en) 2004-06-17
DE10107683A1 (de) 2002-08-29
IL157050A0 (en) 2004-02-08
CZ20032224A3 (en) 2004-06-16
BR0207254A (pt) 2004-02-10
RU2003128068A (ru) 2005-01-27
KR20030082940A (ko) 2003-10-23
EP1362045B1 (de) 2004-11-17
WO2002066458A2 (de) 2002-08-29
MXPA03007380A (es) 2004-03-16

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