CN1288135C - 某些作为丝氨酸蛋白酶xa因子抑制剂的1－(d－环丙基甘氨酰基)－4－(哌啶－4－基)哌嗪化合物 - Google Patents
某些作为丝氨酸蛋白酶xa因子抑制剂的1－(d－环丙基甘氨酰基)－4－(哌啶－4－基)哌嗪化合物 Download PDFInfo
- Publication number
- CN1288135C CN1288135C CNB038074141A CN03807414A CN1288135C CN 1288135 C CN1288135 C CN 1288135C CN B038074141 A CNB038074141 A CN B038074141A CN 03807414 A CN03807414 A CN 03807414A CN 1288135 C CN1288135 C CN 1288135C
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- piperazine
- salt
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36852302P | 2002-04-01 | 2002-04-01 | |
| US60/368,523 | 2002-04-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1642914A CN1642914A (zh) | 2005-07-20 |
| CN1288135C true CN1288135C (zh) | 2006-12-06 |
Family
ID=28791889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038074141A Expired - Fee Related CN1288135C (zh) | 2002-04-01 | 2003-03-24 | 某些作为丝氨酸蛋白酶xa因子抑制剂的1－(d－环丙基甘氨酰基)－4－(哌啶－4－基)哌嗪化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7166606B2 (https=) |
| EP (1) | EP1492767B1 (https=) |
| JP (1) | JP2005531529A (https=) |
| KR (1) | KR20040094892A (https=) |
| CN (1) | CN1288135C (https=) |
| AT (1) | ATE303990T1 (https=) |
| AU (1) | AU2003218147A1 (https=) |
| BR (1) | BR0308870A (https=) |
| CA (1) | CA2478340A1 (https=) |
| CR (1) | CR7497A (https=) |
| DE (1) | DE60301569T2 (https=) |
| DK (1) | DK1492767T3 (https=) |
| EA (1) | EA007300B1 (https=) |
| EC (1) | ECSP045329A (https=) |
| ES (1) | ES2248737T3 (https=) |
| HR (1) | HRP20040900B1 (https=) |
| IL (1) | IL164018A0 (https=) |
| MX (1) | MXPA04009640A (https=) |
| NO (1) | NO20044688L (https=) |
| NZ (1) | NZ535402A (https=) |
| PL (1) | PL373066A1 (https=) |
| UA (1) | UA76849C2 (https=) |
| WO (1) | WO2003084929A1 (https=) |
| ZA (1) | ZA200407418B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6834308B1 (en) | 2000-02-17 | 2004-12-21 | Audible Magic Corporation | Method and apparatus for identifying media content presented on a media playing device |
| US7363278B2 (en) | 2001-04-05 | 2008-04-22 | Audible Magic Corporation | Copyright detection and protection system and method |
| US8972481B2 (en) | 2001-07-20 | 2015-03-03 | Audible Magic, Inc. | Playlist generation method and apparatus |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| EP3541381B1 (en) * | 2016-11-18 | 2022-12-28 | Merck Sharp & Dohme LLC | Inhibitors of factor xiia |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999011658A1 (en) | 1997-08-29 | 1999-03-11 | Proteus Molecular Design Ltd. | Meta-benzamidine derivatives as serin protease inhibitors |
| EP1192135A2 (en) | 1999-06-14 | 2002-04-03 | Eli Lilly And Company | Serine protease inhibitors |
| DE60022508T2 (de) | 1999-06-14 | 2006-06-08 | Eli Lilly And Co., Indianapolis | Inhibitoren von serin proteasen |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| TWI257389B (en) | 2001-06-12 | 2006-07-01 | Lilly Co Eli | Pharmaceutical compound |
| EP1409479B1 (en) * | 2001-07-26 | 2008-01-23 | Eli Lilly And Company | 1-glycinyl-4-(1-methylpiperidin-4-yl)piperazines and -piperidines as factor xa antagonists |
-
2003
- 2003-03-24 CN CNB038074141A patent/CN1288135C/zh not_active Expired - Fee Related
- 2003-03-24 JP JP2003582128A patent/JP2005531529A/ja active Pending
- 2003-03-24 PL PL03373066A patent/PL373066A1/xx unknown
- 2003-03-24 NZ NZ535402A patent/NZ535402A/en unknown
- 2003-03-24 MX MXPA04009640A patent/MXPA04009640A/es active IP Right Grant
- 2003-03-24 ES ES03714138T patent/ES2248737T3/es not_active Expired - Lifetime
- 2003-03-24 IL IL16401803A patent/IL164018A0/xx unknown
- 2003-03-24 WO PCT/US2003/007794 patent/WO2003084929A1/en not_active Ceased
- 2003-03-24 DK DK03714138T patent/DK1492767T3/da active
- 2003-03-24 HR HR20040900A patent/HRP20040900B1/xx not_active IP Right Cessation
- 2003-03-24 KR KR10-2004-7015486A patent/KR20040094892A/ko not_active Ceased
- 2003-03-24 EP EP03714138A patent/EP1492767B1/en not_active Expired - Lifetime
- 2003-03-24 AT AT03714138T patent/ATE303990T1/de not_active IP Right Cessation
- 2003-03-24 BR BR0308870-7A patent/BR0308870A/pt not_active IP Right Cessation
- 2003-03-24 AU AU2003218147A patent/AU2003218147A1/en not_active Abandoned
- 2003-03-24 CA CA002478340A patent/CA2478340A1/en not_active Abandoned
- 2003-03-24 US US10/486,138 patent/US7166606B2/en not_active Expired - Fee Related
- 2003-03-24 EA EA200401290A patent/EA007300B1/ru not_active IP Right Cessation
- 2003-03-24 DE DE60301569T patent/DE60301569T2/de not_active Expired - Fee Related
- 2003-03-24 UA UA20041008649A patent/UA76849C2/uk unknown
-
2004
- 2004-09-15 ZA ZA200407418A patent/ZA200407418B/en unknown
- 2004-09-24 CR CR7497A patent/CR7497A/es unknown
- 2004-09-29 EC EC2004005329A patent/ECSP045329A/es unknown
- 2004-10-29 NO NO20044688A patent/NO20044688L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1492767T3 (da) | 2005-11-28 |
| EP1492767A1 (en) | 2005-01-05 |
| EA007300B1 (ru) | 2006-08-25 |
| HRP20040900A2 (en) | 2004-12-31 |
| IL164018A0 (en) | 2005-12-18 |
| KR20040094892A (ko) | 2004-11-10 |
| CR7497A (es) | 2005-01-17 |
| CN1642914A (zh) | 2005-07-20 |
| JP2005531529A (ja) | 2005-10-20 |
| MXPA04009640A (es) | 2005-01-11 |
| DE60301569T2 (de) | 2006-06-14 |
| WO2003084929A1 (en) | 2003-10-16 |
| UA76849C2 (uk) | 2006-09-15 |
| US20050096328A1 (en) | 2005-05-05 |
| BR0308870A (pt) | 2005-01-04 |
| US7166606B2 (en) | 2007-01-23 |
| ECSP045329A (es) | 2004-11-26 |
| HK1070363A1 (en) | 2005-06-17 |
| HRP20040900B1 (en) | 2006-02-28 |
| EA200401290A1 (ru) | 2005-02-24 |
| PL373066A1 (en) | 2005-08-08 |
| ES2248737T3 (es) | 2006-03-16 |
| DE60301569D1 (de) | 2005-10-13 |
| NZ535402A (en) | 2006-02-24 |
| CA2478340A1 (en) | 2003-10-16 |
| ATE303990T1 (de) | 2005-09-15 |
| WO2003084929A8 (en) | 2004-05-21 |
| EP1492767B1 (en) | 2005-09-07 |
| NO20044688L (no) | 2004-10-29 |
| AU2003218147A1 (en) | 2003-10-20 |
| ZA200407418B (en) | 2005-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061206 |