CN1283803C - 减毒hsv-1基因治疗载体 - Google Patents
减毒hsv-1基因治疗载体 Download PDFInfo
- Publication number
- CN1283803C CN1283803C CN 200410006492 CN200410006492A CN1283803C CN 1283803 C CN1283803 C CN 1283803C CN 200410006492 CN200410006492 CN 200410006492 CN 200410006492 A CN200410006492 A CN 200410006492A CN 1283803 C CN1283803 C CN 1283803C
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- Prior art keywords
- hsv
- gene
- plasmid
- dna
- icp6
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
体重 | 注射前 | 注射后1周 | 2周 | 3周 | 4周 |
对照组实验组 | 21.1±0.821.3±1.1 | 21.9±1.022.1±0.7 | 22.6±0.922.9±0.6 | 23.3±0.823.5±0.7 | 24.2±0.724.4±0.7 |
肿瘤种类 | 注射前 | 注射后2周 | 注射后4周 | 注射后6周 |
结肠腺癌淋巴瘤黑色素瘤前列腺癌对照(注射PBS缓冲液) | 3.6±0.74.0±0.84.1±0.63.8±0.84.0±0.8 | 3.0±0.92.9±0.72.9±0.62.4±0.86.7±0.8 | 2.1±0.31.8±0.31.5±0.21.7±0.312.1±1.4 | 1.0±0.20.8±0.20.6±0.20.3±0.3- |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410006492 CN1283803C (zh) | 2004-02-09 | 2004-03-10 | 减毒hsv-1基因治疗载体 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200410039552 | 2004-02-09 | ||
CN200410039552.X | 2004-02-09 | ||
CN 200410006492 CN1283803C (zh) | 2004-02-09 | 2004-03-10 | 减毒hsv-1基因治疗载体 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1654667A CN1654667A (zh) | 2005-08-17 |
CN1283803C true CN1283803C (zh) | 2006-11-08 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410006492 Ceased CN1283803C (zh) | 2004-02-09 | 2004-03-10 | 减毒hsv-1基因治疗载体 |
Country Status (1)
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CN (1) | CN1283803C (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018228538A1 (zh) | 2017-06-15 | 2018-12-20 | 杭州睿可特生物科技有限公司 | 重组单纯疱疹病毒及其制备方法和应用 |
WO2019196617A1 (zh) | 2018-04-13 | 2019-10-17 | 北京唯源立康生物科技有限公司 | 重组溶瘤病毒组合物及其用途 |
WO2022006745A1 (en) * | 2020-07-07 | 2022-01-13 | Oriengene Biotechnology Ltd | Guide rna for hsv-1 gene editing and method thereof |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101230334B (zh) * | 2007-01-22 | 2011-06-01 | 北京奥源和力生物技术有限公司 | 单纯疱疹病毒和重组病毒及宿主细胞及其药物组合物 |
CN101376893B (zh) * | 2007-08-28 | 2011-07-13 | 李小鹏 | 单纯疱疹病毒载体和重组病毒及宿主细胞及其药物组合物 |
EP2726102A4 (en) * | 2011-07-01 | 2015-04-08 | Immport Therapeutics Inc | PROCESSES AND COMPOSITIONS OF PROTEIN ANTIGENES FOR DIAGNOSIS AND TREATMENT OF HERPES SIMPLEX VIRUS TYPES 1 AND 2 |
CN105219738A (zh) * | 2015-09-21 | 2016-01-06 | 北京神源德生物科技有限公司 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
CN113046331B (zh) | 2020-03-05 | 2022-09-13 | 北京唯源立康生物科技股份有限公司 | 非复制性重组疱疹病毒及其用途 |
CN116334010B (zh) * | 2023-05-30 | 2023-08-29 | 中义(北京)健康研究院 | 一种重组单纯疱疹病毒及其制备方法和应用 |
-
2004
- 2004-03-10 CN CN 200410006492 patent/CN1283803C/zh not_active Ceased
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018228538A1 (zh) | 2017-06-15 | 2018-12-20 | 杭州睿可特生物科技有限公司 | 重组单纯疱疹病毒及其制备方法和应用 |
WO2019196617A1 (zh) | 2018-04-13 | 2019-10-17 | 北京唯源立康生物科技有限公司 | 重组溶瘤病毒组合物及其用途 |
WO2022006745A1 (en) * | 2020-07-07 | 2022-01-13 | Oriengene Biotechnology Ltd | Guide rna for hsv-1 gene editing and method thereof |
Also Published As
Publication number | Publication date |
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CN1654667A (zh) | 2005-08-17 |
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