CN1280258C - 4,5－二氨基莽草酸衍生物的制备方法 - Google Patents

4,5－二氨基莽草酸衍生物的制备方法 Download PDF

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Publication number
CN1280258C
CN1280258C CNB011046805A CN01104680A CN1280258C CN 1280258 C CN1280258 C CN 1280258C CN B011046805 A CNB011046805 A CN B011046805A CN 01104680 A CN01104680 A CN 01104680A CN 1280258 C CN1280258 C CN 1280258C
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China
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formula
derivative
compound
defined above
process according
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Expired - Lifetime
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CNB011046805A
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English (en)
Chinese (zh)
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CN1310170A (zh
Inventor
S·阿布里切特
M·卡普夫
R·特鲁萨迪
B·沃尔兹
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CNB011046805A 2000-02-22 2001-02-21 4,5－二氨基莽草酸衍生物的制备方法 Expired - Lifetime CN1280258C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00103673 2000-02-22
EP00103673.0 2000-02-22

Publications (2)

Publication Number Publication Date
CN1310170A CN1310170A (zh) 2001-08-29
CN1280258C true CN1280258C (zh) 2006-10-18

Family

ID=8167922

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB011046805A Expired - Lifetime CN1280258C (zh) 2000-02-22 2001-02-21 4,5－二氨基莽草酸衍生物的制备方法

Country Status (13)

Country Link
US (1) US6403824B2 (https=)
EP (1) EP1127872B1 (https=)
JP (1) JP4954378B2 (https=)
KR (1) KR100743305B1 (https=)
CN (1) CN1280258C (https=)
AT (1) ATE316952T1 (https=)
CA (1) CA2337452C (https=)
DE (1) DE60116909T2 (https=)
DK (1) DK1127872T3 (https=)
ES (1) ES2256096T3 (https=)
IN (1) IN192890B (https=)
JO (1) JO2251B1 (https=)
PT (1) PT1127872E (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518048B2 (en) * 2000-04-10 2003-02-11 Hoffmann-La Roche Inc. Stereo-specific synthesis of shimikic acid derivatives with improved efficiency
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
EP1602730A3 (en) * 2004-06-04 2006-01-25 DSM IP Assets B.V. Biosynthetic production of 4-amino-4-deoxychorismate (ADC) and [3R,4R]-4-amino-3-hydroxycyclohexa-1,5-diene-1-carboxylic acid (3,4-CHA)
EP1791808B1 (en) * 2004-09-02 2010-07-14 F.Hoffmann-La Roche Ag Process for the preparation of 4,5-diamino shikimicacid
US7977077B2 (en) 2006-01-30 2011-07-12 Board Of Trustees Of Michigan State University Synthesis of intermediates of oseltamivir carboxylates
US20080009639A1 (en) * 2006-07-10 2008-01-10 Apotex Pharmachem Inc. Preparation of oseltamivir phosphate (Tamiflu) and intermediates starting from D-glucose or D-xylose
WO2008077809A1 (en) * 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Process for the manufacture of 7-oxa-bicyclo derivatives
JP5384504B2 (ja) * 2007-09-18 2014-01-08 エフ．ホフマン−ラ ロシュ アーゲー シキミ酸からオセルタミビルリン酸エステルへの方法
KR101049475B1 (ko) * 2008-12-22 2011-07-15 (주)팜스웰바이오 아자-바이사이클로[2.2.1]헵텐 유도체, 이의 제조방법 및 이를 이용한 오셀타미비르의 중간체의 제조방법
JP5796762B2 (ja) * 2010-10-18 2015-10-21 国立大学法人豊橋技術科学大学 光学活性なシクロヘキセン誘導体の製造方法
CN102464596A (zh) * 2010-11-10 2012-05-23 南开大学 “一锅法”获得达菲合成反应的关键中间体
EP2754716B1 (en) 2011-09-07 2018-03-28 Masanobu Kojima Method for producing shikimic acid and an antitumour agent from basidiomycetes by light stimulation
CN105801445B (zh) * 2016-04-13 2017-08-25 福建师范大学 一种具有抗菌活性的非蛋白质氨基酸及其制备方法
US10385010B1 (en) * 2018-03-28 2019-08-20 Georgia State University Research Foundation, Inc. Expedient synthesis of oseltamivir and related compounds via direct olefin diazidation-diamidation reaction

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69711395T2 (de) 1996-08-23 2002-11-07 Gilead Sciences, Inc. Verfahren zur herstellung von cyclohexen-carboxylatderivate
NZ502988A (en) 1997-09-17 2002-08-28 Gilead Sciences Inc 5-Acetamido-4-amino-2-propionyloxy-6-isopropoxy-1-cyclohexene useful for treating influenza
BR0010525A (pt) 1999-10-19 2002-11-26 Abbott Lab cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase

Also Published As

Publication number Publication date
DE60116909T2 (de) 2006-09-28
CA2337452A1 (en) 2001-08-22
JP4954378B2 (ja) 2012-06-13
ES2256096T3 (es) 2006-07-16
JO2251B1 (en) 2004-10-07
KR100743305B1 (ko) 2007-07-26
JP2001288152A (ja) 2001-10-16
US20020006960A1 (en) 2002-01-17
EP1127872A1 (en) 2001-08-29
EP1127872B1 (en) 2006-02-01
KR20010083189A (ko) 2001-08-31
CN1310170A (zh) 2001-08-29
DK1127872T3 (da) 2006-06-12
CA2337452C (en) 2008-04-15
US6403824B2 (en) 2002-06-11
PT1127872E (pt) 2006-06-30
ATE316952T1 (de) 2006-02-15
IN192890B (https=) 2004-05-29
DE60116909D1 (de) 2006-04-13

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Application publication date: 20010829

Assignee: Dongyangguang Industry Development Co., Ltd., Shenzhen

Assignor: HOFFMANN LA ROCHE

Contract record no.: 2013990000524

Denomination of invention: Double layer cyclic 4-belts filtered well

Granted publication date: 20061018

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Record date: 20130827

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