CN1277969A - Process for producing tripotassium glycyrrhetate and use thereof - Google Patents
Process for producing tripotassium glycyrrhetate and use thereof Download PDFInfo
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- CN1277969A CN1277969A CN 00119121 CN00119121A CN1277969A CN 1277969 A CN1277969 A CN 1277969A CN 00119121 CN00119121 CN 00119121 CN 00119121 A CN00119121 A CN 00119121A CN 1277969 A CN1277969 A CN 1277969A
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- potenlini
- glycyrrhetate
- tripotassium glycyrrhetate
- ethanol
- tripotassium
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Abstract
The present invention relates to a production technology of tripotassium glycyrrhizate and its usage. It uses crude glycyrrhizic acid is used as raw material to react with ethyl alcohol, then it is neutralized with alcoholic solution of potassium hydroxide, filtered, and dried to obtain the product. It is simple in process, easy to operate, and stable in product quality.
Description
The present invention relates to the production technique and the purposes of tripotassium glycyrrhetate
Tripotassium glycyrrhetate, English name are Glycyrrhizic Aicd Potassium, and molecular formula is C
42H
59O
16K
3, structural formula is:
Be a kind of yellow powder, contain tripotassium glycyrrhetate 〉=85%, soluble in water, be insoluble to organic solvents such as dehydrated alcohol, ether.Its preparation, separation and Extraction from glycyrrhizic legume normally, but concrete preparation technology does not appear in the newspapers.That tripotassium glycyrrhetate has is clearing heat and detoxicating, cough-relieving, reduce phlegm, protect the liver, manage pharmacological actions such as lung, can be used in medicine, the protective foods, but the purposes that is used for others is not appeared in the newspapers.
The purpose of this invention is to provide a kind of production technique and purposes of tripotassium glycyrrhetate, can prepare tripotassium glycyrrhetate, the technology uniqueness, preparation cost is low, makes the effect of tripotassium glycyrrhetate be able to comprehensive performance.
For achieving the above object, the present invention is by the following technical solutions:
The production technique of tripotassium glycyrrhetate, concrete steps are:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 50-60 ℃ of temperature, reacting by heating 6-8 hour, cooling, vacuum filtration use the washing with alcohol filter cake, drains, and discards filter residue, merging filtrate and washings in still in;
(2) filtrate to be neutralized to PH with potassium hydroxide ethanol liquid be 7-8, generate yellow tripotassium glycyrrhetate precipitation, or else disconnected the stirring, in 50-60 ℃ of heating 1-2 hour, cooled and filtered was used washing with alcohol, is drying to obtain finished product.
Thick Potenlini can be made by following processing method:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 6-8 hour, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.
The ethanol that adopts in the technology is 95% food grade ethanol.
Contain the 65-85% Potenlini in the thick Potenlini.
The potassium hydroxide ethanol liquid that adopts in the technology is dissolved in 6-8 with 1 kilogram of potassium hydroxide and rises in the ethanol and make.
It is used for cigarette, makes cigaret additive, and cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
The present invention has following effect:
(1) production technique is simple, easy handling, constant product quality.
(2) purposes uniqueness to the additive as cigarette, has flavouring, combustion-supporting, the effect that reduces tar content to cigarette, can protect smoker's health, the smoker is had health-care effecies such as sterilization, reason lung.
The invention will be further described below in conjunction with embodiment.
Embodiment one:
The production technique of tripotassium glycyrrhetate is:
At first obtain thick Potenlini, technology is:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 6 hours, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH=2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.Contain 75% Potenlini in this thick Potenlini
Tripotassium glycyrrhetate according to the following steps then:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 50 ℃ of temperature, reacting by heating 6 hours, cooling, vacuum filtration with 95% food grade washing with alcohol filter cake, is drained, and discards filter residue, merging filtrate and washings in still in;
(2) with 1 kilogram of potassium hydroxide be dissolved in 6 liters of ethanol potassium hydroxide ethanol liquid, it is 7 that the filtrate in the back is neutralized to PH with this potassium hydroxide ethanol liquid, generates yellow tripotassium glycyrrhetate and precipitates, or else disconnected the stirring is in 50 ℃ of heating 1 hour, cooled and filtered, use washing with alcohol, be drying to obtain finished product.
Embodiment two:
The production technique of tripotassium glycyrrhetate is:
At first obtain thick Potenlini, technology is:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 8 hours, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.Contain 75% Potenlini in this thick Potenlini
Tripotassium glycyrrhetate according to the following steps then:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 60 ℃ of temperature, reacting by heating 7 hours, cooling, vacuum filtration with 95% food grade washing with alcohol filter cake, is drained, and discards filter residue, merging filtrate and washings in still in;
(2) with 1 kilogram of potassium hydroxide be dissolved in 8 liters of ethanol potassium hydroxide ethanol liquid, it is 8 that the filtrate in the back is neutralized to PH with this potassium hydroxide ethanol liquid, generates yellow tripotassium glycyrrhetate and precipitates, or else disconnected the stirring is in 55 ℃ of heating 2 hours, cooled and filtered, use washing with alcohol, be drying to obtain finished product.
Embodiment three:
The production technique of tripotassium glycyrrhetate is:
At first on market, buy thick Potenlini, contain 75% Potenlini in this thick Potenlini
Tripotassium glycyrrhetate according to the following steps then:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 55 ℃ of temperature, reacting by heating 8 hours, cooling, vacuum filtration with 95% food grade washing with alcohol filter cake, is drained, and discards filter residue, merging filtrate and washings in still in;
(2) with 1 kilogram of potassium hydroxide be dissolved in 8 liters of ethanol potassium hydroxide ethanol liquid, it is 8 that filtrate in the back is neutralized to PH with this potassium hydroxide ethanol liquid, generate yellow tripotassium glycyrrhetate precipitation, or else disconnected the stirring, in 60 ℃ of heating 1-2 hour, cooled and filtered is used washing with alcohol, is drying to obtain finished product.
The finished licorice root that obtains among above embodiment one, embodiment two, the embodiment three acid tripotassium is used for cigarette, makes cigaret additive, and cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
Specific embodiment is:
Use in Wuzhong cigar mill, Yunnan cigar mill, make cigaret additive, cigarette before and after using is made comparisons, cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
Before the use:
1. cigarette fragrance is light
2. cigarette burning is insufficient
3. tar content is a generally held standard
Use the back:
1. cigarette thick flavor
2. cigarette burning is abundant
3. tar content is lower than generally held standard
Claims (6)
1. the production technique of a tripotassium glycyrrhetate, concrete steps are:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 50-60 ℃ of temperature, reacting by heating 6-8 hour, cooling, vacuum filtration use the washing with alcohol filter cake, drains, and discards filter residue, merging filtrate and washings in still in;
(2) filtrate to be neutralized to PH with potassium hydroxide ethanol liquid be 7-8, generate yellow tripotassium glycyrrhetate precipitation, or else disconnected the stirring, in 50-60 ℃ of heating 1-2 hour, cooled and filtered was used washing with alcohol, is drying to obtain finished product.
2. the production technique of tripotassium glycyrrhetate as claimed in claim 1 is characterized in that described thick Potenlini can be made by following processing method:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 6-8 hour, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.
3. the production technique of tripotassium glycyrrhetate as claimed in claim 1 is characterized in that the ethanol that adopts in the described technology is 95% food grade ethanol.
4. the production technique of tripotassium glycyrrhetate as claimed in claim 1 or 2 is characterized in that containing the 65-85% Potenlini in the described thick Potenlini.
5. the production technique of tripotassium glycyrrhetate as claimed in claim 1 is characterized in that the potassium hydroxide ethanol liquid that adopts in the described technology is dissolved in 6-8 with 1 kilogram of potassium hydroxide and rises in the ethanol and make.
6. the purposes of a tripotassium glycyrrhetate is characterized in that it is used for cigarette, makes cigaret additive, and cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00119121 CN1110502C (en) | 2000-06-17 | 2000-06-17 | Process for producing tripotassium glycyrrhetate and use thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00119121 CN1110502C (en) | 2000-06-17 | 2000-06-17 | Process for producing tripotassium glycyrrhetate and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1277969A true CN1277969A (en) | 2000-12-27 |
| CN1110502C CN1110502C (en) | 2003-06-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00119121 Expired - Fee Related CN1110502C (en) | 2000-06-17 | 2000-06-17 | Process for producing tripotassium glycyrrhetate and use thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744362B (en) * | 2008-12-04 | 2012-12-19 | 安徽中烟工业公司 | Processing material for improving quality of black coral tobacco |
| CN111072731A (en) * | 2019-12-31 | 2020-04-28 | 中国医药健康产业股份有限公司 | Method for purifying and obtaining glycyrrhetate from liquorice |
-
2000
- 2000-06-17 CN CN 00119121 patent/CN1110502C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744362B (en) * | 2008-12-04 | 2012-12-19 | 安徽中烟工业公司 | Processing material for improving quality of black coral tobacco |
| CN111072731A (en) * | 2019-12-31 | 2020-04-28 | 中国医药健康产业股份有限公司 | Method for purifying and obtaining glycyrrhetate from liquorice |
| CN111072731B (en) * | 2019-12-31 | 2021-11-16 | 中国医药健康产业股份有限公司 | Method for purifying and obtaining glycyrrhetate from liquorice |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1110502C (en) | 2003-06-04 |
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