CN1110502C - Process for producing tripotassium glycyrrhetate and use thereof - Google Patents
Process for producing tripotassium glycyrrhetate and use thereof Download PDFInfo
- Publication number
- CN1110502C CN1110502C CN 00119121 CN00119121A CN1110502C CN 1110502 C CN1110502 C CN 1110502C CN 00119121 CN00119121 CN 00119121 CN 00119121 A CN00119121 A CN 00119121A CN 1110502 C CN1110502 C CN 1110502C
- Authority
- CN
- China
- Prior art keywords
- glycyrrhetate
- tripotassium glycyrrhetate
- potenlini
- ethanol
- tripotassium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a process for producing tripotassium glycyrrhetate and the application thereof. The present invention overcomes the defect of difficult preparation of tripotassium glycyrrhetate; tripotassium glycyrrhetate is first used as an additive of cigarettes so that tripotassium glycyrrhetate can take effect comprehensively. Crude glycyrrhizic acid is used as a raw material and reacts with ethanol; then, ethanol liquid of potassium hydroxide is used for neutralization; tripotassium glycyrrhetate is obtained after filtration and drying. The present invention has the advantages of simple technology, easy operation and stable quality of products.
Description
Technical field
The present invention relates to the production technique and the purposes of tripotassium glycyrrhetate
Background technology
Tripotassium glycyrrhetate, English name are Glycyrrhizic Aicd Potassium, and molecular formula is C
42H
59O
16K
3, structural formula is:
Be a kind of yellow powder, contain tripotassium glycyrrhetate 〉=85%, soluble in water, be insoluble to organic solvents such as dehydrated alcohol, ether.Its preparation, separation and Extraction from glycyrrhizic legume normally, but concrete preparation technology does not appear in the newspapers.That tripotassium glycyrrhetate has is clearing heat and detoxicating, cough-relieving, reduce phlegm, protect the liver, manage pharmacological actions such as lung, can be used in medicine, the protective foods, but the purposes that is used for others is not appeared in the newspapers.
Summary of the invention
The purpose of this invention is to provide a kind of production technique and purposes of tripotassium glycyrrhetate, can prepare tripotassium glycyrrhetate, the technology uniqueness, preparation cost is low, makes the effect of tripotassium glycyrrhetate be able to comprehensive performance.
For achieving the above object, the present invention is by the following technical solutions:
The production technique of tripotassium glycyrrhetate, concrete steps are:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 50-60 ℃ of temperature, reacting by heating 6-8 hour, cooling, vacuum filtration use the washing with alcohol filter cake, drains, and discards filter residue, merging filtrate and washings in still in;
(2) filtrate to be neutralized to PH with potassium hydroxide ethanol liquid be 7-8, generate yellow tripotassium glycyrrhetate precipitation, or else disconnected the stirring, in 50-60 ℃ of heating 1-2 hour, cooled and filtered was used washing with alcohol, is drying to obtain finished product.
Thick Potenlini can be made by following processing method:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 6-8 hour, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.
The ethanol that adopts in the technology is 95% food grade ethanol.
Contain the 65-85% Potenlini in the thick Potenlini.
The potassium hydroxide ethanol liquid that adopts in the technology is dissolved in 6-8 with 1 kilogram of potassium hydroxide and rises in the ethanol and make.
It is used for cigarette, makes cigaret additive, and cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
The present invention has following effect:
(1) production technique is simple, easy handling, constant product quality.
(2) purposes uniqueness to the additive as cigarette, has flavouring, combustion-supporting, the effect that reduces tar content to cigarette, can protect smoker's health, the smoker is had health-care effecies such as sterilization, reason lung.
Specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment one:
The production technique of tripotassium glycyrrhetate is:
At first obtain thick Potenlini, technology is:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 6 hours, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH=2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.Contain 75% Potenlini in this thick Potenlini
Tripotassium glycyrrhetate according to the following steps then:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 50 ℃ of temperature, reacting by heating 6 hours, cooling, vacuum filtration with 95% food grade washing with alcohol filter cake, is drained, and discards filter residue, merging filtrate and washings in still in;
(2) with 1 kilogram of potassium hydroxide be dissolved in 6 liters of ethanol potassium hydroxide ethanol liquid, it is 7 that the filtrate in the back is neutralized to PH with this potassium hydroxide ethanol liquid, generates yellow tripotassium glycyrrhetate and precipitates, or else disconnected the stirring is in 50 ℃ of heating 1 hour, cooled and filtered, use washing with alcohol, be drying to obtain finished product.
Embodiment two:
The production technique of tripotassium glycyrrhetate is:
At first obtain thick Potenlini, technology is:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 8 hours, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.Contain 75% Potenlini in this thick Potenlini
Tripotassium glycyrrhetate according to the following steps then:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 60 ℃ of temperature, reacting by heating 7 hours, cooling, vacuum filtration with 95% food grade washing with alcohol filter cake, is drained, and discards filter residue, merging filtrate and washings in still in;
(2) with 1 kilogram of potassium hydroxide be dissolved in 8 liters of ethanol potassium hydroxide ethanol liquid, it is 8 that the filtrate in the back is neutralized to PH with this potassium hydroxide ethanol liquid, generates yellow tripotassium glycyrrhetate and precipitates, or else disconnected the stirring is in 55 ℃ of heating 2 hours, cooled and filtered, use washing with alcohol, be drying to obtain finished product.
Embodiment three:
The production technique of tripotassium glycyrrhetate is:
At first on market, buy thick Potenlini, contain 75% Potenlini in this thick Potenlini
Tripotassium glycyrrhetate according to the following steps then:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 55 ℃ of temperature, reacting by heating 8 hours, cooling, vacuum filtration with 95% food grade washing with alcohol filter cake, is drained, and discards filter residue, merging filtrate and washings in still in;
(2) with 1 kilogram of potassium hydroxide be dissolved in 8 liters of ethanol potassium hydroxide ethanol liquid, it is 8 that filtrate in the back is neutralized to PH with this potassium hydroxide ethanol liquid, generate yellow tripotassium glycyrrhetate precipitation, or else disconnected the stirring, in 60 ℃ of heating 1-2 hour, cooled and filtered is used washing with alcohol, is drying to obtain finished product.
The finished licorice root that obtains among above embodiment one, embodiment two, the embodiment three acid tripotassium is used for cigarette, makes cigaret additive, and cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
Specific embodiment is:
Use in Wuzhong cigar mill, Yunnan cigar mill, make cigaret additive, cigarette before and after using is made comparisons, cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
Before the use:
1. cigarette fragrance is light
2. cigarette burning is insufficient
3. tar content is a generally held standard
Use the back:
1. cigarette thick flavor
2. cigarette burning is abundant
3. tar content is lower than generally held standard
Claims (6)
1. the production technique of a tripotassium glycyrrhetate, concrete steps are:
(1) thick Potenlini is placed reactor add ethanol in 1: 3 ratio, under 50-60 ℃ of temperature, reacting by heating 6-8 hour, cooling, vacuum filtration use the washing with alcohol filter cake, drains, and discards filter residue, merging filtrate and washings in still in;
(2) filtrate to be neutralized to PH with potassium hydroxide ethanol liquid be 7-8, generate yellow tripotassium glycyrrhetate precipitation, or else disconnected the stirring, in 50-60 ℃ of heating 1-2 hour, cooled and filtered was used washing with alcohol, is drying to obtain finished product.
2. the production technique of tripotassium glycyrrhetate as claimed in claim 1 is characterized in that described thick Potenlini can be made by following processing method:
The Radix Glycyrrhizae of the pulverizing clear water with 6 times of amounts was soaked 6-8 hour, filter the removal residue, obtain the aqueous solution of glycyrrhetate, be neutralized to PH2 with 1: 1 sulphuric acid soln, Potenlini is precipitated to get off, and leaves standstill 12 hours, remove supernatant liquor, use the clear water rinsing again three times, centrifuging, washing leaching cake is to PH4, drying promptly gets thick Potenlini.
3. the production technique of tripotassium glycyrrhetate as claimed in claim 1 is characterized in that the ethanol that adopts in the described technology is 95% food grade ethanol.
4. the production technique of tripotassium glycyrrhetate as claimed in claim 1 or 2 is characterized in that containing the 65-85% Potenlini in the described thick Potenlini.
5. the production technique of tripotassium glycyrrhetate as claimed in claim 1 is characterized in that the potassium hydroxide ethanol liquid that adopts in the described technology is dissolved in 6-8 with 1 kilogram of potassium hydroxide and rises in the ethanol and make.
6. the purposes of a tripotassium glycyrrhetate is characterized in that it is used for cigarette, makes cigaret additive, and cigarette is had flavouring, combustion-supporting, the effect that reduces tar content.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00119121 CN1110502C (en) | 2000-06-17 | 2000-06-17 | Process for producing tripotassium glycyrrhetate and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00119121 CN1110502C (en) | 2000-06-17 | 2000-06-17 | Process for producing tripotassium glycyrrhetate and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1277969A CN1277969A (en) | 2000-12-27 |
CN1110502C true CN1110502C (en) | 2003-06-04 |
Family
ID=4587502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 00119121 Expired - Fee Related CN1110502C (en) | 2000-06-17 | 2000-06-17 | Process for producing tripotassium glycyrrhetate and use thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1110502C (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101744362B (en) * | 2008-12-04 | 2012-12-19 | 安徽中烟工业公司 | Processing material for improving quality of black coral tobacco |
CN111072731B (en) * | 2019-12-31 | 2021-11-16 | 中国医药健康产业股份有限公司 | Method for purifying and obtaining glycyrrhetate from liquorice |
-
2000
- 2000-06-17 CN CN 00119121 patent/CN1110502C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1277969A (en) | 2000-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101519458B (en) | Method for extracting tea polysaccharides and tea polyphenol from coarse old green tea | |
CN112028865A (en) | Method for extracting and preparing high-content dihydromyricetin from vine tea | |
CN1173997C (en) | Process for extracting high-purity kanjak glucomannosan | |
CN1850979A (en) | Chinese starjasmine stem lignin aglycone total extract and its extracting process | |
CN1359905A (en) | Process for extracting licoflavone, lycyrrhizic acid and licopolyose from liquorice root | |
CN1844095A (en) | Method for extracting dihydro-quercetin from larch | |
CN104974033A (en) | Method for extracting tanshinol | |
CN1110502C (en) | Process for producing tripotassium glycyrrhetate and use thereof | |
CN110592292A (en) | Pretreatment method for promoting biomass to efficiently extract xylose by mechanical method | |
CN1793136A (en) | Process for producing kuh-seng total flavone and flavone salt | |
CN113501759A (en) | Method for obtaining chlorogenic acid and isochlorogenic acid from stevia rebaudiana residue | |
CN110679996B (en) | Tobacco leaf containing selenium-enriched polysaccharide | |
CN1064680A (en) | The production technique of nicotine salt and pure nicotine products | |
CN115594775B (en) | Preparation method and application of tremella polysaccharide | |
CN103965153B (en) | Utilize rutin to prepare the method for Quercetin and rhamnose | |
CN104497163A (en) | Korla pear polysaccharide extracting method and method for applying korla pear polysaccharide to cigarettes | |
CN1253462C (en) | Process for preparing morinda officinalis total oligosaccharide | |
US2871235A (en) | Process for obtaining polysaccharide material from plants of the genus cecropia | |
CN1273573C (en) | Method for extracting sun choke essential oil and sun choke brain by enzymolysis-vapor distillation process | |
CN112062871B (en) | Preparation method of red algae polysaccharide | |
JPH0725797B2 (en) | Twain manufacturing method | |
CN110679997B (en) | Tobacco shred containing tobacco leaf polysaccharide and derived polysaccharide with high moisturizing property | |
CN110857323B (en) | Comprehensive utilization method of konjac flying powder | |
CN113480673A (en) | Method for extracting cinnamon polysaccharide and cinnamon polyphenol from cinnamon branch and leaf oil extraction residues | |
CN1235852C (en) | Method for extracting curcumin from peltate yam |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |