CN1064680A - The production technique of nicotine salt and pure nicotine products - Google Patents
The production technique of nicotine salt and pure nicotine products Download PDFInfo
- Publication number
- CN1064680A CN1064680A CN 92101315 CN92101315A CN1064680A CN 1064680 A CN1064680 A CN 1064680A CN 92101315 CN92101315 CN 92101315 CN 92101315 A CN92101315 A CN 92101315A CN 1064680 A CN1064680 A CN 1064680A
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- China
- Prior art keywords
- nicotine
- extraction agent
- described method
- solution
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 60
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 229960002715 nicotine Drugs 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 24
- 238000004519 manufacturing process Methods 0.000 title description 4
- 238000000605 extraction Methods 0.000 claims abstract description 39
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 26
- 241000208125 Nicotiana Species 0.000 claims abstract description 16
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 16
- 239000002253 acid Substances 0.000 claims abstract description 13
- 239000007864 aqueous solution Substances 0.000 claims abstract description 12
- 239000012266 salt solution Substances 0.000 claims abstract description 9
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 9
- 239000000243 solution Substances 0.000 claims abstract description 9
- 150000007513 acids Chemical class 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 239000003637 basic solution Substances 0.000 claims abstract description 6
- 238000010521 absorption reaction Methods 0.000 claims abstract description 5
- 238000007654 immersion Methods 0.000 claims abstract description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical group CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 claims description 4
- 239000000049 pigment Substances 0.000 claims description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 2
- 239000000920 calcium hydroxide Substances 0.000 claims description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- 238000004945 emulsification Methods 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 238000013467 fragmentation Methods 0.000 claims description 2
- 238000006062 fragmentation reaction Methods 0.000 claims description 2
- 238000010297 mechanical methods and process Methods 0.000 claims description 2
- 230000005226 mechanical processes and functions Effects 0.000 claims description 2
- 239000002808 molecular sieve Substances 0.000 claims description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 2
- 239000012467 final product Substances 0.000 abstract 1
- 235000019504 cigarettes Nutrition 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 2
- 238000003828 vacuum filtration Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000003350 kerosene Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
The present invention be a kind of from tobacco the method for extraction nicotine, tobacco is soaked in basic solution, made nicotine enter immersion liquid, with extraction agent nicotine is extracted again, use the nicotine in the acids solution absorption extraction agent then, obtain nicotine salt solution, remove acid group in the nicotine salt solution, obtain the nicotine aqueous solution through purifying with hydrated barta, extract with extraction agent again, obtain the saturated extraction agent of nicotine, saturated extraction agent carried out multi-effect distilling, get final product pure nicotine.
Description
The present invention relates to a kind of from tobacco the method for extraction nicotine, belong to the chemical treatment field of tobacco.
The place of China plantation tobacco is a lot, some inferior tobacco can't utilize, in making the pipe tobacco process, also there are a large amount of cigarette muscle to be removed simultaneously, these inferior tobaccos and cigarette muscle all go out of use and have wasted, contain 1.5～3% nicotine in tobacco leaf and the cigarette muscle, nicotine belongs to nitrogenous alkaloid, have been widely used in fields such as medicine, agricultural chemicals, scientific research, cigarette, national defence, therefore, extraction nicotine progressively obtains people's attention from tobacco leaf and cigarette muscle, but do not produce sophisticated production technique so far as yet, can't form the above industrial production of whole examination scale level.
The object of the present invention is to provide and a kind ofly can carry out the extraction nicotine salt from tobacco of technical scale lot production and the method for pure nicotine, and the product purity height, color and taste just, quality is good.
The present invention realizes like this, certain hour is soaked in the tobacco fragmentation in basic solution, make nicotine enter immersion liquid, nicotine is extracted through breakdown of emulsion with extraction agent again and use contained nicotine in the acids solution absorption extraction agent then, obtain nicotine salt solution, remove acid group in the nicotine salt solution with hydrated barta, obtain the nicotine aqueous solution, reduce its pigment content and reject peculiar smell with gac again, carry out the extraction second time with extraction agent again, the saturated extraction agent of the nicotine that is purified carries out multi-effect distilling to this saturated extraction agent, can obtain pure nicotine.
Accompanying drawing 1 is a process flow sheet of the present invention.
Now the present invention is described in detail in conjunction with the accompanying drawings:
1, cigarette muscle and inferior tobacco being crushed to the length of side is 0.2 or the cubes of 0.3mm, the aqueous solution (the pH value is 12) with basic solution such as sodium hydroxide or calcium hydroxide soaks, and solid-to-liquid ratio is 1: 7, soaks 6～12 hours, the nicotine leaching yield can reach more than 90%, obtains nicotine-containing immersion liquid thus.
2, solid-liquid separation: the residue after the water flushing is soaked, push residue again, the immersion liquid of soaking, wash, pushing gained is mixed, filter with the Plate Filtration method again, obtain filtrate.
3, make extraction agent with hydrochloric ether or blended organic solvent (as trieline and kerosene), in the spray-type extraction tower, nicotine-containing filtrate is extracted, dose method with mechanical process again or distillation method is abolished the emulsification that produces in the extraction process.The percentage extraction that nicotine enters extraction agent can reach 80～90%.
4, absorb contained nicotine in the extraction agent with 0.5～1 normal acids solution (as dilute hydrochloric acid or dilute sulphuric acid), the pH value that absorbs acids solution reaches till 4, can obtain nicotine salt solution.As with this nicotine salt solution at negative pressure 400～600mmHg, distill under 70～85 ℃ of conditions of temperature, promptly obtain the nicotine salt of content more than 40%, be nicotine salt finished product (general international standard), the work in-process of pure nicotine.
5, remove acid group in the nicotine salt solution with hydrated barta, obtain the nicotine aqueous solution, with vacuum filtration process that the filter of the nicotine aqueous solution is clean then.
6, with the active carbon purifying nicotine aqueous solution, weight ratio is that gac equals 1 to 25 than the nicotine aqueous solution, to reduce pigment content, rejects peculiar smell, filters the nicotine aqueous solution that is purified once more with vacuum filtration process.
7, make extraction agent with hydrochloric ether, the nicotine in the nicotine aqueous solution is carried out the extraction second time, the saturated extraction agent of the nicotine that is purified.
8, at negative pressure 400～500mmHg, under the condition that temperature is 60～70 ℃ the saturated extraction agent that contains pure nicotine is carried out multi-effect distilling, obtain the pure nicotine of content more than 98% with molecular sieve dehydration again, be finished product (general international standard).
Method of the present invention can be used for producing in enormous quantities, and its product purity height, color and taste are just, kind is complete, the practical value height, and quality meets international standard, and equipment requirements is not high, and solvent loss is few, and is easy to operate, the extraction yield height.
Claims (11)
1, a kind of from tobacco the method for extraction nicotine, it is characterized in that, certain hour will be soaked in basic solution after the tobacco fragmentation, make nicotine enter immersion liquid, nicotine is extracted through breakdown of emulsion with extraction agent again, use contained nicotine in the acids solution absorption extraction agent then, obtain nicotine salt solution, remove acid group in the nicotine salt solution with hydrated barta, obtain the nicotine aqueous solution, reduce its pigment content and reject peculiar smell with gac again, carry out the extraction second time with extraction agent again, the saturated extraction agent of nicotine that has been purified carries out multi-effect distilling to this saturated extraction agent, can obtain stewing nicotine with molecular sieve dehydration again.
2, by the described method of claim 1, it is characterized in that used basic solution is the aqueous solution of sodium hydroxide or calcium hydroxide, the pH value is 12.
3, by the described method of claim 1, when it is characterized in that tobacco soaked in basic solution, solid-to-liquid ratio is 1: 7.
4, by the described method of claim 1, it is characterized in that soak time is 6～12 hours.
5, by the described method of claim 1, it is characterized in that extraction agent is a hydrochloric ether.
6, by the described method of claim 1, used acids solution when it is characterized in that using nicotine contained in the acids solution absorption extraction agent, concentration is the 0.5-1 equivalent.
7, by the described method of claim 1, when it is characterized in that using nicotine contained in the acids solution absorption extraction agent, the pH value that absorbs acid solution reaches till 4.
8, by the described method of claim 1, it is characterized in that reducing pigment with gac, when rejecting peculiar smell, the weight ratio of the used gac and the nicotine aqueous solution is 1: 25.
9,, it is characterized in that extracting used extraction agent for the second time is hydrochloric ether by the described method of claim 1.
10, by the described method of claim 1, it is characterized in that the condition of saturated extraction agent being carried out multi-effect distilling is: negative pressure 400～500mmHg, 60～70 ℃ of temperature.
11, by the described method of claim 1, it is characterized in that abolishing the emulsification that produces in the extraction process is to use mechanical process, distillation method, or the method for dosing is handled.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92101315 CN1064680A (en) | 1992-03-07 | 1992-03-07 | The production technique of nicotine salt and pure nicotine products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92101315 CN1064680A (en) | 1992-03-07 | 1992-03-07 | The production technique of nicotine salt and pure nicotine products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1064680A true CN1064680A (en) | 1992-09-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92101315 Pending CN1064680A (en) | 1992-03-07 | 1992-03-07 | The production technique of nicotine salt and pure nicotine products |
Country Status (1)
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|---|---|
| CN (1) | CN1064680A (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516227A (en) * | 2011-11-30 | 2012-06-27 | 刘岗 | Method for flocculating, decolorizing, separating and purifying nicotine |
| CN102516226A (en) * | 2011-11-30 | 2012-06-27 | 薛刚 | Method for distilling and refining nicotine circularly and nicotine distilling and absorbing device |
| CN103054159A (en) * | 2013-01-23 | 2013-04-24 | 云南瑞升烟草技术（集团）有限公司 | Method for lowering content of chloridion in tobacco stems and extracting nicotine simultaneously and application of method in preparation of reconstituted tobacco |
| CN103063489A (en) * | 2012-12-24 | 2013-04-24 | 四川农业大学 | Extraction method of nicotine with diffusion cell |
| CN105111184A (en) * | 2015-09-24 | 2015-12-02 | 恩施和诺生物工程有限责任公司 | Preparation method of high-purity nicotine |
| CN105433433A (en) * | 2015-10-31 | 2016-03-30 | 武汉纽威晨创科技发展股份有限公司 | Method for extracting tobacco aromatic components through water jet smashing and centrifugal membrane microwave distillation |
| CN105768202A (en) * | 2016-04-29 | 2016-07-20 | 华南理工大学 | Method for extracting nicotine from tobacco wastes |
| CN105985315A (en) * | 2015-02-06 | 2016-10-05 | 杨晓林 | Method for extracting nicotine from tobacco waste |
| CN106923373A (en) * | 2016-12-30 | 2017-07-07 | 中国烟草总公司广东省公司 | A kind of mint aroma smears cigarette and preparation method thereof |
| CN110613161A (en) * | 2019-09-05 | 2019-12-27 | 云南云烁科技有限公司 | Extraction process for extracting nicotine from tobacco waste |
| CN111528517A (en) * | 2020-04-30 | 2020-08-14 | 贵州黄果树金叶科技有限公司 | Extract for heating non-burning cigarette and preparation method thereof |
| CN111542234A (en) * | 2017-10-24 | 2020-08-14 | 莱战略控股公司 | Method of formulating aerosol precursors for aerosol delivery devices |
| CN113508919A (en) * | 2020-12-31 | 2021-10-19 | 上海零诺生物科技有限公司 | Tobacco extract and preparation method and application thereof |
-
1992
- 1992-03-07 CN CN 92101315 patent/CN1064680A/en active Pending
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516227A (en) * | 2011-11-30 | 2012-06-27 | 刘岗 | Method for flocculating, decolorizing, separating and purifying nicotine |
| CN102516226A (en) * | 2011-11-30 | 2012-06-27 | 薛刚 | Method for distilling and refining nicotine circularly and nicotine distilling and absorbing device |
| CN102516227B (en) * | 2011-11-30 | 2014-04-09 | 南阳理工学院 | Method for flocculating, decolorizing, separating and purifying nicotine |
| CN102516226B (en) * | 2011-11-30 | 2014-04-09 | 南阳理工学院 | Method for distilling and refining nicotine circularly and nicotine distilling and absorbing device |
| CN103063489A (en) * | 2012-12-24 | 2013-04-24 | 四川农业大学 | Extraction method of nicotine with diffusion cell |
| CN103063489B (en) * | 2012-12-24 | 2015-04-08 | 四川农业大学 | Extraction method of nicotine with diffusion cell |
| CN103054159A (en) * | 2013-01-23 | 2013-04-24 | 云南瑞升烟草技术（集团）有限公司 | Method for lowering content of chloridion in tobacco stems and extracting nicotine simultaneously and application of method in preparation of reconstituted tobacco |
| CN105985315A (en) * | 2015-02-06 | 2016-10-05 | 杨晓林 | Method for extracting nicotine from tobacco waste |
| CN105111184A (en) * | 2015-09-24 | 2015-12-02 | 恩施和诺生物工程有限责任公司 | Preparation method of high-purity nicotine |
| CN105433433A (en) * | 2015-10-31 | 2016-03-30 | 武汉纽威晨创科技发展股份有限公司 | Method for extracting tobacco aromatic components through water jet smashing and centrifugal membrane microwave distillation |
| CN105433433B (en) * | 2015-10-31 | 2017-03-22 | 武汉纽威晨创科技发展股份有限公司 | Method for extracting tobacco aromatic components through water jet smashing and centrifugal membrane microwave distillation |
| CN105768202A (en) * | 2016-04-29 | 2016-07-20 | 华南理工大学 | Method for extracting nicotine from tobacco wastes |
| CN105768202B (en) * | 2016-04-29 | 2017-06-23 | 华南理工大学 | A kind of method of nicotine in extraction tobacco waste |
| CN106923373A (en) * | 2016-12-30 | 2017-07-07 | 中国烟草总公司广东省公司 | A kind of mint aroma smears cigarette and preparation method thereof |
| CN111542234A (en) * | 2017-10-24 | 2020-08-14 | 莱战略控股公司 | Method of formulating aerosol precursors for aerosol delivery devices |
| CN110613161A (en) * | 2019-09-05 | 2019-12-27 | 云南云烁科技有限公司 | Extraction process for extracting nicotine from tobacco waste |
| CN111528517A (en) * | 2020-04-30 | 2020-08-14 | 贵州黄果树金叶科技有限公司 | Extract for heating non-burning cigarette and preparation method thereof |
| CN111528517B (en) * | 2020-04-30 | 2022-01-28 | 贵州黄果树金叶科技有限公司 | Extract for heating non-burning cigarette and preparation method thereof |
| CN111528517B8 (en) * | 2020-04-30 | 2022-03-29 | 贵州黄果树金叶科技有限公司 | Extract for heating non-burning cigarette and preparation method thereof |
| CN113508919A (en) * | 2020-12-31 | 2021-10-19 | 上海零诺生物科技有限公司 | Tobacco extract and preparation method and application thereof |
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