CN1088919A - The extraction process of lappaconitine - Google Patents
The extraction process of lappaconitine Download PDFInfo
- Publication number
- CN1088919A CN1088919A CN 93100499 CN93100499A CN1088919A CN 1088919 A CN1088919 A CN 1088919A CN 93100499 CN93100499 CN 93100499 CN 93100499 A CN93100499 A CN 93100499A CN 1088919 A CN1088919 A CN 1088919A
- Authority
- CN
- China
- Prior art keywords
- lappaconitine
- sinomontanum nakai
- aconitum sinomontanum
- drying
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Extraction Or Liquid Replacement (AREA)
Abstract
Extract the method for lappaconitine from the plant Aconitum sinomontanum Nakai, get the pulverizing medicinal material, behind alcohol heating reflux, filter, filtrate concentrates, and filters, and filter residue is drying to obtain by siccative.The present invention has the advantage that the extraction solvent is inexpensive, toxicity is little of use, the product yield height of extraction, purity height.
Description
The present invention relates to extract the production technique of lappaconitine (Lappaconitine) from plant Aconitum sinomontanum Nakai (Aconitum Sinomonatum) root.
Lappaconitine (Lappaconitine) is the compound (I) that Ranunculaceae aconitum plant Aconitum sinomontanum Nakai root is separated to, its extracting method of report is that the crude drug alkalization is after benzene extraction in the volumes such as Xu Rensheng " extraction of Chinese herbal medicine effective ingredients with separate ", counter carrying after the acidifying of benzene layer, add that ammoniacal liquor is counter again to be carried, utilize acetone solution at last, evaporation acetone is separated out crystallization, and this method is used organic solvent-benzene, chloroform harmful in a large number and that cost is high.
Purpose of the present invention is exactly in order to overcome the organic solvent extraction technology that present use toxicity is big, cost is high, the method for the extraction lappaconitine that a kind of cost is low, toxicity is little to be provided.
The present invention realizes like this.
Get the Aconitum sinomontanum Nakai root, crushed after being dried adds alcohol immersion, and reflux is filtered.Filtrate decompression concentrates, and reclaims ethanol, and being concentrated into has crystallization to occur on the vessel wall.Leave standstill, separate out throw out.Filter, filter residue promptly gets the lappaconitine crystallization by the siccative drying.
Return time is 2～24 hours, siccative can for Calcium Chloride Powder Anhydrous, the vitriol oil, sodium hydroxide, phosphorus trichloride, phosphorus pentachloride, Vanadium Pentoxide in FLAKES one of them, concentrating under reduced pressure pressure is 1 * 10
3～0.5～10
5Handkerchief.Extracting solvent can also be methyl alcohol, the acetone through processed, Virahol.
The present invention is further illustrated below in conjunction with embodiment.
Embodiment 1: get the Aconitum sinomontanum Nakai root, drying and crushing adds 8～20 times of (volume/weight) soaked in absolute ethyl alcohol, and reflux 2 hours is filtered.Filter residue is 0.5 * 10
5Handkerchief pressure concentrates down, reclaims ethanol, and being concentrated into has crystallization to occur on the vessel wall, leaves standstill 2 hours, filters.Filter residue promptly gets the lappaconitine crystallization by the Calcium Chloride Powder Anhydrous drying.
Embodiment 2: get the Aconitum sinomontanum Nakai root, drying and crushing adds 20～40 times of (volume/weight) soaked in absolute ethyl alcohol, and reflux 12 hours is filtered.Filter residue is 1 * 10
4Handkerchief pressure concentrates down, reclaims ethanol, and being concentrated into has crystallization to occur on the vessel wall, leaves standstill 3 hours.Filter, filter residue promptly gets the lappaconitine crystallization by the Vanadium Pentoxide in FLAKES drying.
Embodiment 3: get the Aconitum sinomontanum Nakai root of drying and crushing, add 40～60 times of (volume/weight) soaked in absolute ethyl alcohol, reflux 24 hours is filtered.Filter residue is 2 * 10
3Handkerchief pressure concentrates down, reclaims ethanol, and being concentrated into has crystallization to occur on the vessel wall, leaves standstill 4 hours.Filter, filter residue promptly gets the lappaconitine crystallization by vitriol oil drying.
It is inexpensive that the present invention has the extraction solvent of use, the advantage that toxicity is little, the lappaconitine crystallization yield height of extraction, embodiment 3 is 0.6%, and the purity of gained lappaconitine through stratographic analysis up to 99.97%.
Claims (4)
1, a kind of method from plant Aconitum sinomontanum Nakai root extraction lappaconitine has the following step:
-get the root of the Aconitum sinomontanum Nakai of drying and crushing, add alcohol immersion, reflux is filtered;
-filtrate decompression concentrates, and reclaims ethanol, and being concentrated into has crystallization to occur on the vessel wall;
-leave standstill, separate out throw out;
-filtering, filter residue is by the siccative drying.
2, the method from Aconitum sinomontanum Nakai root extraction lappaconitine according to claim 1 is characterized in that return time is 2～24 hours.
3, according to claim 1ly extract the method for lappaconitine from the Aconitum sinomontanum Nakai root, it is characterized in that siccative be Calcium Chloride Powder Anhydrous, the vitriol oil, sodium hydroxide, phosphorus trichloride, phosphorus pentachloride, Vanadium Pentoxide in FLAKES one of them.
4, the method from Aconitum sinomontanum Nakai root extraction lappaconitine according to claim 1 is characterized in that concentrating under reduced pressure pressure is 1 * 10
3～0.5 * 10
5Handkerchief.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93100499A CN1049429C (en) | 1993-01-01 | 1993-01-01 | Process for extraction of sinomontanine-A |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93100499A CN1049429C (en) | 1993-01-01 | 1993-01-01 | Process for extraction of sinomontanine-A |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1088919A true CN1088919A (en) | 1994-07-06 |
| CN1049429C CN1049429C (en) | 2000-02-16 |
Family
ID=4983057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93100499A Expired - Lifetime CN1049429C (en) | 1993-01-01 | 1993-01-01 | Process for extraction of sinomontanine-A |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1049429C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100417646C (en) * | 2006-10-20 | 2008-09-10 | 佘建文 | Lappaconitine hydrobromide preparation method |
| CN101731289A (en) * | 2009-12-17 | 2010-06-16 | 原春兰 | Aconitum sinomontanum water aqua pesticide and preparation method thereof |
| CN101851202A (en) * | 2010-05-07 | 2010-10-06 | 兰州大学 | Method for preparing Aconitum sungpanense Hand-mazz vitamin A |
| CN102078394A (en) * | 2010-12-24 | 2011-06-01 | 达吾列提别克·努尔沙汗 | Aconite extract-containing medicinal composition, preparation method and application thereof |
| CN102649776A (en) * | 2011-02-25 | 2012-08-29 | 苏州宝泽堂医药科技有限公司 | Method for preparing lappaconitine |
| CN104098510A (en) * | 2013-04-14 | 2014-10-15 | 长沙富能生物技术有限公司 | Method for extracting lappaconitine from aconitum sinomontanum plant roots |
| CN104876866A (en) * | 2015-05-04 | 2015-09-02 | 陕西科技大学 | Alpha-crystal-form lappaconitine and preparation method thereof |
| CN108409657A (en) * | 2017-11-24 | 2018-08-17 | 孙益民 | High-purity lappaconitine and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1196004A1 (en) * | 1984-04-11 | 1985-12-07 | Ордена Трудового Красного Знамени Институт Химии Растительных Веществ Ан Узсср | Method of obtaining hydrobromide lappaconitin |
-
1993
- 1993-01-01 CN CN93100499A patent/CN1049429C/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100417646C (en) * | 2006-10-20 | 2008-09-10 | 佘建文 | Lappaconitine hydrobromide preparation method |
| CN101731289A (en) * | 2009-12-17 | 2010-06-16 | 原春兰 | Aconitum sinomontanum water aqua pesticide and preparation method thereof |
| CN101731289B (en) * | 2009-12-17 | 2013-04-17 | 原春兰 | Aconitum sinomontanum water aqua pesticide and preparation method thereof |
| CN101851202A (en) * | 2010-05-07 | 2010-10-06 | 兰州大学 | Method for preparing Aconitum sungpanense Hand-mazz vitamin A |
| CN102078394A (en) * | 2010-12-24 | 2011-06-01 | 达吾列提别克·努尔沙汗 | Aconite extract-containing medicinal composition, preparation method and application thereof |
| CN102078394B (en) * | 2010-12-24 | 2013-03-13 | 达吾列提别克·努尔沙汗 | Aconite extract-containing medicinal composition, preparation method and application thereof |
| CN102649776A (en) * | 2011-02-25 | 2012-08-29 | 苏州宝泽堂医药科技有限公司 | Method for preparing lappaconitine |
| CN104098510A (en) * | 2013-04-14 | 2014-10-15 | 长沙富能生物技术有限公司 | Method for extracting lappaconitine from aconitum sinomontanum plant roots |
| CN104098510B (en) * | 2013-04-14 | 2016-09-28 | 长沙晋德生物制品有限责任公司 | Method for extracting lappaconitine from aconitum sinomontanum plant roots |
| CN104876866A (en) * | 2015-05-04 | 2015-09-02 | 陕西科技大学 | Alpha-crystal-form lappaconitine and preparation method thereof |
| CN108409657A (en) * | 2017-11-24 | 2018-08-17 | 孙益民 | High-purity lappaconitine and preparation method thereof |
| CN108409657B (en) * | 2017-11-24 | 2021-08-20 | 孙益民 | High-purity lappaconitine and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1049429C (en) | 2000-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109574810B (en) | Method for simultaneously extracting CBD and CBDV | |
| CN101830849B (en) | Method for preparing simplified high-purity bulleyaconitine A | |
| CN111978158A (en) | Method for extracting purified hypocannabidiol from industrial cannabis sativa | |
| CN1290850C (en) | Method for extracting bilobalide B and bilobalide from folium Ginkgo | |
| CN1049429C (en) | Process for extraction of sinomontanine-A | |
| CN101787060A (en) | Method for extracting and separating stilbene glucoside from polygonum multiflorum | |
| CN101982471B (en) | Technological process for extracting aucubin from fruits of eucommia ulmoides oliver | |
| CN103204776A (en) | Production method for extracting pyrethrin from pyrethrum flower | |
| CN1053435C (en) | Method for extracting tea polyphenol and by-products from tea leaves | |
| CN1064680A (en) | The production technique of nicotine salt and pure nicotine products | |
| CN103497170A (en) | Method for extracting procyanidine in receptaculum nelumbinis in full low temperature process | |
| CN1303078C (en) | Process for preparing effective constituent in tea | |
| CN106810619B (en) | A kind of gingko episperm pectin and polypentenol extracting method | |
| CN106811303B (en) | Method for simultaneously extracting essential oil and pectin from ginkgo biloba sarcotesta | |
| CN1038427C (en) | Method for extracting grease and tea saponin by one-step leaching cake meal | |
| CN1398868A (en) | Forsythigenol extracting process | |
| CN1106892C (en) | Process for extracting pure tobacco oil, melanoid and nicotine and preparing composite fertilizer | |
| CN1035333C (en) | Method for prodn. of salino mycin and its sodium salt | |
| CN1485324A (en) | Method of membrane separation technique for producing seabuckthorn flavone | |
| CN101974008B (en) | Process for extracting and purifying podophyllotoxin from Dysosma difformis | |
| CN104045624A (en) | Highly pure nicotine preparation method | |
| CN1026485C (en) | Process for preparing solanesol from mouldy tobacco or tobacco waste | |
| CN102408368A (en) | Method for preparing xanthophyll from calendula extract | |
| CN102697838A (en) | Method for extracting and separating flavone enrichment substance, saponin enrichment substance and polysaccharide from astragalus simultaneously | |
| CN1762398A (en) | A kind of extracting method of ferula feruloides medicinal composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CI01 | Correction of invention patent gazette |
Correction item: Right of patent application Correct: Resume the original approval procedure False: As withdrawn Number: 14 Page: 177 Volume: 12 |
|
| ERR | Gazette correction |
Free format text: CORRECT: RIGHT TO APPLY FOR A PATENT; FROM: DEEMED WITHDRAWAL TO: RECOVERY ORIGINAL EXAMINATION ANDAPPROVAL PROCEDURES |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130104 Granted publication date: 20000216 |