CN1268746C - 用于在真菌细胞中生产多肽的方法 - Google Patents
用于在真菌细胞中生产多肽的方法 Download PDFInfo
- Publication number
- CN1268746C CN1268746C CNB008045062A CN00804506A CN1268746C CN 1268746 C CN1268746 C CN 1268746C CN B008045062 A CNB008045062 A CN B008045062A CN 00804506 A CN00804506 A CN 00804506A CN 1268746 C CN1268746 C CN 1268746C
- Authority
- CN
- China
- Prior art keywords
- gene
- leu
- polypeptide
- cell
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24195599A | 1999-02-02 | 1999-02-02 | |
US09/241,955 | 1999-02-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1342204A CN1342204A (zh) | 2002-03-27 |
CN1268746C true CN1268746C (zh) | 2006-08-09 |
Family
ID=22912879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008045062A Expired - Fee Related CN1268746C (zh) | 1999-02-02 | 2000-02-02 | 用于在真菌细胞中生产多肽的方法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1151106A2 (de) |
JP (1) | JP2002535990A (de) |
CN (1) | CN1268746C (de) |
AU (1) | AU2755300A (de) |
WO (1) | WO2000046375A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2164574B1 (es) * | 1999-12-10 | 2003-05-16 | Consejo Superior Investigacion | Mejora de la produccion de penicilina mediante la utilizacion de cepas transgenicas merodiploides para un gen regulador. |
EP2505651A3 (de) * | 2006-12-10 | 2013-01-09 | Dyadic International, Inc. | Pilzisolate mit reduzierter Proteaseaktivität |
WO2013048661A1 (en) | 2011-09-30 | 2013-04-04 | Codexis, Inc. | Fungal proteases |
JP6245528B2 (ja) | 2012-01-05 | 2017-12-13 | グリコス・フィンランド・オーワイGlykos Finland Oy | プロテアーゼ欠損糸状菌細胞及びその使用方法 |
WO2013174927A1 (en) | 2012-05-23 | 2013-11-28 | Novartis International Pharmaceutical Limited | Production of fucosylated glycoproteins |
CN105980552A (zh) | 2013-07-10 | 2016-09-28 | 诺华股份有限公司 | 多种蛋白酶缺陷的丝状真菌细胞及其使用方法 |
KR101508353B1 (ko) * | 2013-08-30 | 2015-04-06 | 대상 주식회사 | 고활성 셀룰라아제를 생산하는 트리코데르마 레세이 변이주 및 그의 용도 |
FR3018522B1 (fr) * | 2014-03-17 | 2018-02-02 | IFP Energies Nouvelles | Souches mutantes de trichoderma reesei |
SG11201700446XA (en) | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
JP6473339B2 (ja) | 2015-02-05 | 2019-02-20 | 本田技研工業株式会社 | 麹菌変異株及び形質転換体 |
KR101751966B1 (ko) | 2015-06-23 | 2017-06-30 | 대상 주식회사 | 트리코데르마 속 균주의 혼합배양에 의한 고활성 셀룰라아제를 생산하는 방법 |
MX2022004361A (es) * | 2019-10-10 | 2022-05-03 | Carlsberg As | Metodos para preparar plantas mutantes. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958727A (en) * | 1996-09-13 | 1999-09-28 | Novo Nordisk Biotech, Inc | Methods for modifying the production of a polypeptide |
CN1307642A (zh) * | 1998-05-27 | 2001-08-08 | 诺沃诺尔迪斯克生物技术有限公司 | 通过改变基因拷贝数制备多肽的方法 |
-
2000
- 2000-02-02 WO PCT/US2000/002864 patent/WO2000046375A2/en not_active Application Discontinuation
- 2000-02-02 AU AU27553/00A patent/AU2755300A/en not_active Abandoned
- 2000-02-02 CN CNB008045062A patent/CN1268746C/zh not_active Expired - Fee Related
- 2000-02-02 EP EP00905971A patent/EP1151106A2/de not_active Withdrawn
- 2000-02-02 JP JP2000597435A patent/JP2002535990A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2755300A (en) | 2000-08-25 |
JP2002535990A (ja) | 2002-10-29 |
EP1151106A2 (de) | 2001-11-07 |
WO2000046375A3 (en) | 2000-11-23 |
WO2000046375A2 (en) | 2000-08-10 |
CN1342204A (zh) | 2002-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C56 | Change in the name or address of the patentee |
Owner name: NUOWOQIMEIZI CO.,LTD. Free format text: FORMER NAME OR ADDRESS: NOVO NORDISK BIOTECH INC. |
|
CP01 | Change in the name or title of a patent holder |
Address after: American California Patentee after: Novo Jymes A/S Address before: American California Patentee before: Novozymes Biotech Inc. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |