CN1261812A - 用于向组织中体内进行核酸载体最佳电转移的装置 - Google Patents

用于向组织中体内进行核酸载体最佳电转移的装置 Download PDF

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Publication number
CN1261812A
CN1261812A CN98806793A CN98806793A CN1261812A CN 1261812 A CN1261812 A CN 1261812A CN 98806793 A CN98806793 A CN 98806793A CN 98806793 A CN98806793 A CN 98806793A CN 1261812 A CN1261812 A CN 1261812A
Authority
CN
China
Prior art keywords
electrode
pulse
electrotransfer
nucleic acid
electric field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98806793A
Other languages
English (en)
Chinese (zh)
Inventor
M·布瑞奥
L·密尔
D·舍曼
B·施瓦茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Gustave Roussy (IGR)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Institut Gustave Roussy (IGR)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9708232A external-priority patent/FR2765241B1/fr
Priority claimed from FR9708233A external-priority patent/FR2765242B1/fr
Application filed by Rhone Poulenc Rorer SA, Institut Gustave Roussy (IGR) filed Critical Rhone Poulenc Rorer SA
Publication of CN1261812A publication Critical patent/CN1261812A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
CN98806793A 1997-06-30 1998-06-30 用于向组织中体内进行核酸载体最佳电转移的装置 Pending CN1261812A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
FR97/08233 1997-06-30
FR9708232A FR2765241B1 (fr) 1997-06-30 1997-06-30 Amelioration du transfert d'acide nucleique dans les cellules d'organismes eucaryotes pluricellulaires et combinaison permettant la mise en oeuvre du procede
FR97/08232 1997-06-30
FR9708233A FR2765242B1 (fr) 1997-06-30 1997-06-30 Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
US6748797P 1997-12-01 1997-12-01
US6748897P 1997-12-01 1997-12-01
US60/067,488 1997-12-01
US60/067,487 1997-12-01
US8385898P 1998-05-01 1998-05-01
US60/083,858 1998-05-01

Publications (1)

Publication Number Publication Date
CN1261812A true CN1261812A (zh) 2000-08-02

Family

ID=27515625

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98806793A Pending CN1261812A (zh) 1997-06-30 1998-06-30 用于向组织中体内进行核酸载体最佳电转移的装置

Country Status (11)

Country Link
EP (1) EP0993318A1 (ko)
JP (1) JP2002515816A (ko)
KR (1) KR20010014298A (ko)
CN (1) CN1261812A (ko)
AU (1) AU8730798A (ko)
BR (1) BR9810500A (ko)
CA (1) CA2295029A1 (ko)
IL (1) IL133709A0 (ko)
NO (1) NO996540L (ko)
PL (1) PL337617A1 (ko)
WO (1) WO1999001175A1 (ko)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101252953A (zh) * 2005-09-02 2008-08-27 生物联盟制药公司 核酸向组织细胞中的电转移
US8414133B2 (en) 2007-03-06 2013-04-09 Sanyo Electric Co., Ltd. Projection display device having an operation section for displacing a lens
CN112402798A (zh) * 2005-10-03 2021-02-26 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果

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FR2753379B1 (fr) 1996-09-13 1998-10-30 Rhone Poulenc Rorer Sa Methode de traitement de la sclerose laterale amyotrophique
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
AU2868200A (en) * 1999-02-08 2000-08-25 Chiron Corporation Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo
CA2402530C (en) 2000-03-13 2014-01-14 Cornell Research Foundation, Inc. Blocking leukocyte emigration and inflammation by interfering with cd99
AU5345901A (en) 2000-04-13 2001-10-30 Univ Rockefeller Enhancement of antibody-mediated immune responses
AU2001264759B2 (en) 2000-05-22 2006-06-01 Merck & Co., Inc. System and method for assessing the performance of a pharmaceutical agent delivery system
AU2002227450B2 (en) 2000-12-28 2008-02-28 Wyeth Recombinant protective protein from $I(streptococcus pneumoniae)
CA2441476A1 (en) 2001-03-02 2002-09-12 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
US20020198567A1 (en) * 2001-06-07 2002-12-26 Yona Keisari Electro-endocytotic therapy as a treatment modality of cancer
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
AU2003230601A1 (en) 2002-03-07 2003-09-22 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Clinical syringe with electrical stimulation aspects
NZ571508A (en) 2002-05-24 2010-05-28 Schering Corp Neutralizing human anti-IGFR antibody
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
JP4961137B2 (ja) * 2005-12-14 2012-06-27 久光製薬株式会社 イオントフォレーシス用デバイス
AU2007319604B2 (en) 2006-10-19 2011-03-24 Csl Limited High affinity antibody antagonists of interleukin-13 receptor alpha 1
WO2008060814A2 (en) 2006-10-19 2008-05-22 Merck & Co., Inc. ANTI-IL-13Rα1 ANTIBODIES AND THEIR USES THEREOF
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
US8093043B2 (en) 2008-06-04 2012-01-10 New York University β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
CN102124102B (zh) * 2008-07-18 2013-12-18 麦克赛特股份有限公司 优化电穿孔的方法
EP2356135B1 (en) 2008-11-05 2017-10-25 Wyeth LLC Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (bhs) disease
HUE052850T2 (hu) 2010-08-23 2021-05-28 Wyeth Llc Neisseria meningitidis RLP2086 antigéneket tartalmazó stabil készítmények
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
KR101763625B1 (ko) 2012-03-09 2017-08-01 화이자 인코포레이티드 수막염균 조성물 및 이의 사용 방법
WO2014107739A1 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Antibodies against pcsk9
ES2685894T3 (es) 2013-03-08 2018-10-15 Pfizer Inc. Polipéptidos de fusión inmunogénicos
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
EP3270959A1 (en) 2015-02-19 2018-01-24 Pfizer Inc Neisseria meningitidis compositions and methods thereof
SG11201906519RA (en) 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317380D0 (en) * 1993-08-20 1993-10-06 Therexsys Ltd Transfection process
US5641680A (en) * 1994-11-14 1997-06-24 Zhao; Xi Gene transfer apparatus and method for using the same
WO1997007826A1 (en) * 1995-08-29 1997-03-06 Cbr Laboratories, Inc. In vivo electroporation of cells

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101252953A (zh) * 2005-09-02 2008-08-27 生物联盟制药公司 核酸向组织细胞中的电转移
CN112402798A (zh) * 2005-10-03 2021-02-26 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
CN112402798B (zh) * 2005-10-03 2021-11-16 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US8414133B2 (en) 2007-03-06 2013-04-09 Sanyo Electric Co., Ltd. Projection display device having an operation section for displacing a lens

Also Published As

Publication number Publication date
IL133709A0 (en) 2001-04-30
EP0993318A1 (en) 2000-04-19
JP2002515816A (ja) 2002-05-28
NO996540L (no) 2000-02-03
BR9810500A (pt) 2000-09-05
PL337617A1 (en) 2000-08-28
KR20010014298A (ko) 2001-02-26
CA2295029A1 (en) 1999-01-14
WO1999001175A1 (en) 1999-01-14
NO996540D0 (no) 1999-12-29
AU8730798A (en) 1999-01-25

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