CN1257913C - 具有激素作用的17α－羟基－14β－甾族化合物 - Google Patents

具有激素作用的17α－羟基－14β－甾族化合物 Download PDF

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Publication number
CN1257913C
CN1257913C CNB02817853XA CN02817853A CN1257913C CN 1257913 C CN1257913 C CN 1257913C CN B02817853X A CNB02817853X A CN B02817853XA CN 02817853 A CN02817853 A CN 02817853A CN 1257913 C CN1257913 C CN 1257913C
Authority
CN
China
Prior art keywords
hydroxy
compounds
steroids
androgen
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB02817853XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1553917A (zh
Inventor
J·范德洛夫
D·莱森
M·E·德古伊杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8180920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1257913(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of CN1553917A publication Critical patent/CN1553917A/zh
Application granted granted Critical
Publication of CN1257913C publication Critical patent/CN1257913C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB02817853XA 2001-09-12 2002-09-06 具有激素作用的17α－羟基－14β－甾族化合物 Expired - Lifetime CN1257913C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203455 2001-09-12
EP01203455.9 2001-09-12

Publications (2)

Publication Number Publication Date
CN1553917A CN1553917A (zh) 2004-12-08
CN1257913C true CN1257913C (zh) 2006-05-31

Family

ID=8180920

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB02817853XA Expired - Lifetime CN1257913C (zh) 2001-09-12 2002-09-06 具有激素作用的17α－羟基－14β－甾族化合物

Country Status (28)

Country Link
US (1) US7169769B2 (enExample)
EP (1) EP1427748B1 (enExample)
JP (1) JP4471653B2 (enExample)
KR (1) KR100940054B1 (enExample)
CN (1) CN1257913C (enExample)
AR (1) AR036462A1 (enExample)
AT (1) ATE395352T1 (enExample)
AU (1) AU2002339536B2 (enExample)
BR (1) BR0212409A (enExample)
CA (1) CA2505575C (enExample)
CY (1) CY1108152T1 (enExample)
DE (1) DE60226623D1 (enExample)
DK (1) DK1427748T3 (enExample)
EC (1) ECSP045012A (enExample)
ES (1) ES2305306T3 (enExample)
HR (1) HRP20040193A2 (enExample)
HU (1) HUP0402139A3 (enExample)
IL (2) IL160451A0 (enExample)
IS (1) IS2555B (enExample)
MX (1) MXPA04002418A (enExample)
NO (1) NO326624B1 (enExample)
NZ (1) NZ531487A (enExample)
PL (1) PL207493B1 (enExample)
PT (1) PT1427748E (enExample)
RU (1) RU2294332C2 (enExample)
TW (1) TWI221154B (enExample)
WO (1) WO2003022864A1 (enExample)
ZA (1) ZA200401992B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI221154B (en) 2001-09-12 2004-09-21 Akzo Nobel Nv 17alpha-hydroxy-14beta-steroids with hormonal effect

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338925A (en) * 1965-10-25 1967-08-29 Syntex Corp 17-substituted 14beta-estr-4-enes
WO2000053619A1 (en) * 1999-03-08 2000-09-14 Akzo Nobel N.V. 14.beta., 17-alpha-hydroxymethylandrostane derivatives as androgens
AU4299301A (en) * 2000-02-29 2001-09-12 National University Of Singapore, The A method for modulating steroidogenic activity
US6391868B2 (en) * 2000-05-10 2002-05-21 Lpt Research, Inc. Use of 5-alpha-androst-1-en-3,17-dione to increase the level of the anabolic/androgenic hormone 17-beta-hydroxy-5-alpha-androst-1-en-3-one in humans
TWI221154B (en) 2001-09-12 2004-09-21 Akzo Nobel Nv 17alpha-hydroxy-14beta-steroids with hormonal effect

Also Published As

Publication number Publication date
RU2294332C2 (ru) 2007-02-27
WO2003022864A1 (en) 2003-03-20
ATE395352T1 (de) 2008-05-15
PL207493B1 (pl) 2010-12-31
CA2505575C (en) 2010-01-26
US20040259849A1 (en) 2004-12-23
ECSP045012A (es) 2004-09-27
AR036462A1 (es) 2004-09-08
NO326624B1 (no) 2009-01-19
AU2002339536B2 (en) 2008-04-24
CA2505575A1 (en) 2003-03-20
HUP0402139A2 (hu) 2005-02-28
CN1553917A (zh) 2004-12-08
IS7165A (is) 2004-02-26
HK1063637A1 (en) 2005-01-07
JP4471653B2 (ja) 2010-06-02
IS2555B (is) 2009-10-15
RU2004110934A (ru) 2005-08-20
PL368727A1 (en) 2005-04-04
JP2005505566A (ja) 2005-02-24
MXPA04002418A (es) 2004-07-30
ZA200401992B (en) 2005-04-21
NZ531487A (en) 2005-08-26
NO20041010L (no) 2004-03-10
EP1427748B1 (en) 2008-05-14
BR0212409A (pt) 2004-08-03
IL160451A0 (en) 2004-07-25
KR100940054B1 (ko) 2010-02-04
DK1427748T3 (da) 2008-09-08
KR20040039346A (ko) 2004-05-10
ES2305306T3 (es) 2008-11-01
EP1427748A1 (en) 2004-06-16
HUP0402139A3 (en) 2012-12-28
HRP20040193A2 (en) 2004-08-31
DE60226623D1 (de) 2008-06-26
PT1427748E (pt) 2008-08-27
IL160451A (en) 2009-11-18
US7169769B2 (en) 2007-01-30
CY1108152T1 (el) 2014-02-12
TWI221154B (en) 2004-09-21

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C06 Publication
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SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: ORGANON NV

Free format text: FORMER OWNER: AKZO NOVEL N.V. CORP.

Effective date: 20070105

C41 Transfer of patent application or patent right or utility model
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Effective date of registration: 20070105

Address after: Holland

Patentee after: N.V. ORGANON

Address before: Holland Arnhem

Patentee before: AKZO NOBEL N.V.

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Owner name: MSD OS CO., LTD.

Free format text: FORMER NAME: ORGANON NV

CP01 Change in the name or title of a patent holder

Address after: Dutch Oss

Patentee after: N.V. Organon

Address before: Dutch Oss

Patentee before: N.V. ORGANON

ASS Succession or assignment of patent right

Owner name: MERCK SHARP + DOHME CORP.

Free format text: FORMER OWNER: ORGANON BIOLOGICAL NETHERLANDS CO., LTD.

Effective date: 20131010

Owner name: ORGANON BIOLOGICAL NETHERLANDS CO., LTD.

Free format text: FORMER OWNER: MSD OUSI CO., LTD.

Effective date: 20131010

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20131010

Address after: Haarlem

Patentee after: MERCK SHARP & DOHME B.V.

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Patentee before: Organon biological science Holland Co.,Ltd.

Effective date of registration: 20131010

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Address before: Holland

Patentee before: N.V. Organon

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20060531