CN1246157A - 用脂酶进行苯并二氮杂䓬－乙酸酯的酶拆分 - Google Patents
用脂酶进行苯并二氮杂䓬－乙酸酯的酶拆分 Download PDFInfo
- Publication number
- CN1246157A CN1246157A CN97181853A CN97181853A CN1246157A CN 1246157 A CN1246157 A CN 1246157A CN 97181853 A CN97181853 A CN 97181853A CN 97181853 A CN97181853 A CN 97181853A CN 1246157 A CN1246157 A CN 1246157A
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- China
- Prior art keywords
- methyl
- benzodiazepine
- tetrahydrochysene
- oxo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- SPWVRYZQLGQKGK-UHFFFAOYSA-N dichloromethane;hexane Chemical compound ClCCl.CCCCCC SPWVRYZQLGQKGK-UHFFFAOYSA-N 0.000 description 1
- FRTGEIHSCHXMTI-UHFFFAOYSA-N dimethyl octanediimidate Chemical compound COC(=N)CCCCCCC(=N)OC FRTGEIHSCHXMTI-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000010931 ester hydrolysis Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000003791 organic solvent mixture Substances 0.000 description 1
- 125000005188 oxoalkyl group Chemical group 0.000 description 1
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
- 229940116369 pancreatic lipase Drugs 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 239000000088 plastic resin Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 description 1
- DNXIASIHZYFFRO-UHFFFAOYSA-N pyrazoline Chemical compound C1CN=NC1 DNXIASIHZYFFRO-UHFFFAOYSA-N 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 150000003233 pyrroles Chemical class 0.000 description 1
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- UJJDEOLXODWCGK-UHFFFAOYSA-N tert-butyl carbonochloridate Chemical compound CC(C)(C)OC(Cl)=O UJJDEOLXODWCGK-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 description 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical class C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3385396P | 1996-12-27 | 1996-12-27 | |
| US60/033,853 | 1996-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1246157A true CN1246157A (zh) | 2000-03-01 |
Family
ID=21872833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97181853A Pending CN1246157A (zh) | 1996-12-27 | 1997-12-23 | 用脂酶进行苯并二氮杂䓬－乙酸酯的酶拆分 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0964928A1 (xx) |
| JP (1) | JP2001507231A (xx) |
| KR (1) | KR20000069705A (xx) |
| CN (1) | CN1246157A (xx) |
| AR (1) | AR010860A1 (xx) |
| AU (1) | AU730064B2 (xx) |
| BR (1) | BR9714099A (xx) |
| CA (1) | CA2276134A1 (xx) |
| CO (1) | CO4930272A1 (xx) |
| HU (1) | HUP0002825A3 (xx) |
| IL (1) | IL130580A0 (xx) |
| NO (1) | NO993174D0 (xx) |
| NZ (1) | NZ336376A (xx) |
| PL (1) | PL334293A1 (xx) |
| TR (1) | TR199901487T2 (xx) |
| WO (1) | WO1998029561A1 (xx) |
| ZA (1) | ZA9711566B (xx) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100359019C (zh) * | 2001-01-04 | 2008-01-02 | 布里斯托尔-迈尔斯斯奎布公司 | 胺和氢氧化物的酶促去保护 |
| CN1768149B (zh) * | 2003-04-04 | 2012-10-31 | 索尔维公司 | 生产对映体纯β-氨基酸衍生物的方法和对映体纯β-氨基酸衍生物 |
| TWI467019B (zh) * | 2012-02-09 | 2015-01-01 | Servier Lab | （７ｓ）－３，４－二甲氧基雙環［４．２．０］辛－１，３，５－三烯－７－羧酸或其酯類之酵素合成方法及於依伐布雷定（ｉｖａｂｒａｄｉｎｅ）及其鹽類合成之應用 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1054996E (pt) | 1998-02-17 | 2004-05-31 | Searle & Co | Processo para resolucao enzimatica de lactamas |
| WO2001092553A1 (en) * | 2000-06-01 | 2001-12-06 | Sk Corporation | Method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid using enzyme |
| KR100378741B1 (ko) * | 2000-06-01 | 2003-04-07 | 에스케이 주식회사 | 효소를 이용하여 R-폼 또는 S-폼의 α-치환 헤테로싸이클릭 카르복실산 및 이와 상반되는 광학특성을 갖는 α-치환 헤테로싸이클릭 카르복실산 에스테르를 제조하는 방법 |
| KR100379756B1 (ko) * | 2000-10-02 | 2003-04-11 | 한국과학기술연구원 | 이성질체 분할방법 |
| KR100650798B1 (ko) * | 2004-07-19 | 2006-11-27 | (주)제이코통상 | 광학활성 카복실산의 제조방법 |
| FR2876102A1 (fr) * | 2004-10-04 | 2006-04-07 | Solvay | Compose heterocyclique enantiopur |
| KR100650797B1 (ko) * | 2005-12-12 | 2006-11-27 | (주)케미코월드 | 광학활성 사이클로프로판 카복사미드의 제조방법 |
| CN117363683A (zh) * | 2023-10-09 | 2024-01-09 | 江苏惠利生物科技有限公司 | 一种脂酶苯并二氮杂-乙酸酯的酶拆分方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2190428T3 (es) * | 1991-06-28 | 2003-08-01 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogeno. |
| CN1041921C (zh) * | 1992-12-21 | 1999-02-03 | 史密丝克莱恩比彻姆公司 | 双环血纤维蛋白原拮抗剂 |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US5529929A (en) * | 1995-06-07 | 1996-06-25 | Seprachem, Inc. | Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens |
-
1997
- 1997-12-23 EP EP97950309A patent/EP0964928A1/en not_active Withdrawn
- 1997-12-23 CN CN97181853A patent/CN1246157A/zh active Pending
- 1997-12-23 JP JP52974298A patent/JP2001507231A/ja active Pending
- 1997-12-23 HU HU0002825A patent/HUP0002825A3/hu unknown
- 1997-12-23 WO PCT/GB1997/003522 patent/WO1998029561A1/en not_active Application Discontinuation
- 1997-12-23 ZA ZA9711566A patent/ZA9711566B/xx unknown
- 1997-12-23 PL PL97334293A patent/PL334293A1/xx unknown
- 1997-12-23 IL IL13058097A patent/IL130580A0/xx unknown
- 1997-12-23 CA CA002276134A patent/CA2276134A1/en not_active Abandoned
- 1997-12-23 BR BR9714099A patent/BR9714099A/pt not_active IP Right Cessation
- 1997-12-23 AR ARP970106167A patent/AR010860A1/es not_active Application Discontinuation
- 1997-12-23 NZ NZ336376A patent/NZ336376A/xx unknown
- 1997-12-23 KR KR1019997005777A patent/KR20000069705A/ko not_active Application Discontinuation
- 1997-12-23 TR TR1999/01487T patent/TR199901487T2/xx unknown
- 1997-12-23 AU AU53314/98A patent/AU730064B2/en not_active Ceased
- 1997-12-26 CO CO97075096A patent/CO4930272A1/es unknown
-
1999
- 1999-06-25 NO NO993174A patent/NO993174D0/no not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100359019C (zh) * | 2001-01-04 | 2008-01-02 | 布里斯托尔-迈尔斯斯奎布公司 | 胺和氢氧化物的酶促去保护 |
| CN1768149B (zh) * | 2003-04-04 | 2012-10-31 | 索尔维公司 | 生产对映体纯β-氨基酸衍生物的方法和对映体纯β-氨基酸衍生物 |
| TWI467019B (zh) * | 2012-02-09 | 2015-01-01 | Servier Lab | （７ｓ）－３，４－二甲氧基雙環［４．２．０］辛－１，３，５－三烯－７－羧酸或其酯類之酵素合成方法及於依伐布雷定（ｉｖａｂｒａｄｉｎｅ）及其鹽類合成之應用 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000069705A (ko) | 2000-11-25 |
| EP0964928A1 (en) | 1999-12-22 |
| NO993174L (no) | 1999-06-25 |
| NO993174D0 (no) | 1999-06-25 |
| HUP0002825A3 (en) | 2002-09-30 |
| TR199901487T2 (xx) | 1999-11-22 |
| PL334293A1 (en) | 2000-02-14 |
| NZ336376A (en) | 2000-11-24 |
| HUP0002825A2 (hu) | 2000-12-28 |
| AU730064B2 (en) | 2001-02-22 |
| AU5331498A (en) | 1998-07-31 |
| ZA9711566B (en) | 1998-06-29 |
| CA2276134A1 (en) | 1998-07-09 |
| AR010860A1 (es) | 2000-07-12 |
| JP2001507231A (ja) | 2001-06-05 |
| WO1998029561A1 (en) | 1998-07-09 |
| CO4930272A1 (es) | 2000-06-27 |
| IL130580A0 (en) | 2000-06-01 |
| BR9714099A (pt) | 2000-03-21 |
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