CN1244389A - 榄香烯注射液及其制备方法 - Google Patents
榄香烯注射液及其制备方法 Download PDFInfo
- Publication number
- CN1244389A CN1244389A CN98116563A CN98116563A CN1244389A CN 1244389 A CN1244389 A CN 1244389A CN 98116563 A CN98116563 A CN 98116563A CN 98116563 A CN98116563 A CN 98116563A CN 1244389 A CN1244389 A CN 1244389A
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- Prior art keywords
- elemene
- injection
- propylene glycol
- cremophor
- preparation
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims description 13
- 240000005209 Canarium indicum Species 0.000 title 1
- 239000004862 elemi Substances 0.000 title 1
- OPFTUNCRGUEPRZ-QLFBSQMISA-N (-)-beta-elemene Chemical compound CC(=C)[C@@H]1CC[C@@](C)(C=C)[C@H](C(C)=C)C1 OPFTUNCRGUEPRZ-QLFBSQMISA-N 0.000 claims abstract description 82
- OPFTUNCRGUEPRZ-UHFFFAOYSA-N (+)-beta-Elemen Natural products CC(=C)C1CCC(C)(C=C)C(C(C)=C)C1 OPFTUNCRGUEPRZ-UHFFFAOYSA-N 0.000 claims abstract description 81
- 239000008389 polyethoxylated castor oil Substances 0.000 claims abstract description 23
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims abstract description 19
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 claims abstract description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 63
- 238000002347 injection Methods 0.000 claims description 32
- 239000007924 injection Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000008215 water for injection Substances 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000012982 microporous membrane Substances 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- YZSJUQIFYHUSKU-UHFFFAOYSA-N ethanol;propane-1,2-diol Chemical compound CCO.CC(O)CO YZSJUQIFYHUSKU-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 230000001093 anti-cancer Effects 0.000 abstract description 4
- 239000000839 emulsion Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 206010006187 Breast cancer Diseases 0.000 abstract description 2
- 208000026310 Breast neoplasm Diseases 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 abstract 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 abstract 1
- 208000009956 adenocarcinoma Diseases 0.000 abstract 1
- 239000003005 anticarcinogenic agent Substances 0.000 abstract 1
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- 238000002844 melting Methods 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- QDUJKDRUFBJYSQ-UHFFFAOYSA-N alpha-elemene Natural products CC(C)C1=CC(=C(C)C)CCC1(C)C=C QDUJKDRUFBJYSQ-UHFFFAOYSA-N 0.000 description 6
- MXDMETWAEGIFOE-CABCVRRESA-N delta-elemene Chemical compound CC(C)C1=C[C@H](C(C)=C)[C@@](C)(C=C)CC1 MXDMETWAEGIFOE-CABCVRRESA-N 0.000 description 6
- RVOXATXFYDNXRE-UHFFFAOYSA-N gamma-elemene Natural products CC(=C1CCC(C)(C(C1)C(=C)C)C(=C)C)C RVOXATXFYDNXRE-UHFFFAOYSA-N 0.000 description 6
- BQSLMQNYHVFRDT-CABCVRRESA-N (-)-gamma-Elemene Natural products CC(C)=C1CC[C@](C)(C=C)[C@@H](C(C)=C)C1 BQSLMQNYHVFRDT-CABCVRRESA-N 0.000 description 3
- VMYXUZSZMNBRCN-AWEZNQCLSA-N Curcumene Natural products CC(C)=CCC[C@H](C)C1=CC=C(C)C=C1 VMYXUZSZMNBRCN-AWEZNQCLSA-N 0.000 description 3
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- 239000002552 dosage form Substances 0.000 description 3
- QDUJKDRUFBJYSQ-OAHLLOKOSA-N elemene Chemical compound CC(C)C1=CC(=C(C)C)CC[C@@]1(C)C=C QDUJKDRUFBJYSQ-OAHLLOKOSA-N 0.000 description 3
- BQSLMQNYHVFRDT-LSDHHAIUSA-N gamma-elemene Chemical compound CC(C)=C1CC[C@@](C)(C=C)[C@H](C(C)=C)C1 BQSLMQNYHVFRDT-LSDHHAIUSA-N 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 239000002547 new drug Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- MXDMETWAEGIFOE-UHFFFAOYSA-N rac-delta-elemene Natural products CC(C)C1=CC(C(C)=C)C(C)(C=C)CC1 MXDMETWAEGIFOE-UHFFFAOYSA-N 0.000 description 3
- VMYXUZSZMNBRCN-UHFFFAOYSA-N α-curcumene Chemical compound CC(C)=CCCC(C)C1=CC=C(C)C=C1 VMYXUZSZMNBRCN-UHFFFAOYSA-N 0.000 description 3
- -1 1-methyl isophthalic acid-vinyl-2,4-diisopropyl cyclohexane Chemical compound 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 208000032612 Glial tumor Diseases 0.000 description 2
- 206010018338 Glioma Diseases 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 239000006184 cosolvent Substances 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241001673954 Magnolia sieboldii Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 206010027191 meningioma Diseases 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN98116563A CN1080115C (zh) | 1998-08-12 | 1998-08-12 | 榄香烯注射液及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN98116563A CN1080115C (zh) | 1998-08-12 | 1998-08-12 | 榄香烯注射液及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1244389A true CN1244389A (zh) | 2000-02-16 |
CN1080115C CN1080115C (zh) | 2002-03-06 |
Family
ID=5225148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98116563A Expired - Lifetime CN1080115C (zh) | 1998-08-12 | 1998-08-12 | 榄香烯注射液及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1080115C (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100434066C (zh) * | 2002-04-17 | 2008-11-19 | 谢恬 | 姜黄提取物注射剂及其制备方法和用途 |
CN100457096C (zh) * | 2005-11-07 | 2009-02-04 | 刘玉辉 | 一种榄香烯制剂及其制备方法 |
CN101921164A (zh) * | 2004-07-07 | 2010-12-22 | 长途国际有限公司 | (-)-β-榄香烯、(-)-β-榄香醛、(-)-β-榄香醇、(-)-β-氟化榄香烯及其类似物、中间体和组合物的合成及应用 |
WO2011103806A1 (zh) * | 2010-02-25 | 2011-09-01 | Xie Tian | 榄香烯口服微乳 |
WO2011140872A1 (zh) | 2010-05-10 | 2011-11-17 | Xie Tian | 抗肿瘤植物药榄香烯缓释片 |
CN1981749B (zh) * | 2005-12-13 | 2012-12-05 | 石药集团远大(大连)制药有限公司 | β-榄香烯用于抑制脑血管内皮细胞的用途 |
CN111135143A (zh) * | 2020-01-19 | 2020-05-12 | 齐鲁工业大学 | 一种β-榄香烯自微乳及其制备方法 |
CN112315901A (zh) * | 2019-07-17 | 2021-02-05 | 成都康弘药业集团股份有限公司 | 一种注射用浓溶液及其制备方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102998409B (zh) * | 2012-12-19 | 2014-10-15 | 石药集团远大(大连)制药有限公司 | δ-榄香烯的含量测定方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1060038C (zh) * | 1993-02-15 | 2001-01-03 | 大连市医药科学研究所 | 榄香烯乳注射液及其制备方法 |
-
1998
- 1998-08-12 CN CN98116563A patent/CN1080115C/zh not_active Expired - Lifetime
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100434066C (zh) * | 2002-04-17 | 2008-11-19 | 谢恬 | 姜黄提取物注射剂及其制备方法和用途 |
CN101921164A (zh) * | 2004-07-07 | 2010-12-22 | 长途国际有限公司 | (-)-β-榄香烯、(-)-β-榄香醛、(-)-β-榄香醇、(-)-β-氟化榄香烯及其类似物、中间体和组合物的合成及应用 |
CN100457096C (zh) * | 2005-11-07 | 2009-02-04 | 刘玉辉 | 一种榄香烯制剂及其制备方法 |
CN1981749B (zh) * | 2005-12-13 | 2012-12-05 | 石药集团远大(大连)制药有限公司 | β-榄香烯用于抑制脑血管内皮细胞的用途 |
WO2011103806A1 (zh) * | 2010-02-25 | 2011-09-01 | Xie Tian | 榄香烯口服微乳 |
US20120322892A1 (en) * | 2010-02-25 | 2012-12-20 | Tian XIE | Oral microemulsion of elemene |
WO2011140872A1 (zh) | 2010-05-10 | 2011-11-17 | Xie Tian | 抗肿瘤植物药榄香烯缓释片 |
CN112315901A (zh) * | 2019-07-17 | 2021-02-05 | 成都康弘药业集团股份有限公司 | 一种注射用浓溶液及其制备方法 |
CN111135143A (zh) * | 2020-01-19 | 2020-05-12 | 齐鲁工业大学 | 一种β-榄香烯自微乳及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1080115C (zh) | 2002-03-06 |
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Owner name: DALIAN YUANDA PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: KEYU PHARMACEUTICAL SCIENCE + TECHNOLOGY DEVELOPMENT CO., LTD., DALIAN Effective date: 20040730 |
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Effective date of registration: 20040730 Address after: 2808, room 116001, Yuanda building, 19 independence street, Liaoning, Dalian Patentee after: YUANDA PHARMACEUTICAL Co.,Ltd. DALIAN Address before: 116001, Liu Yuxin, No. 5, building 30-8, people's lane, Xigang District, Liaoning, Dalian Patentee before: KEYU PHARMACEUTICAL SCIENCE & |
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Owner name: DALIAN YUANDA BUILDING CO., LTD. Free format text: FORMER OWNER: SHIJIAZHUANG PHARMACEUTICAL GROUP YUANDA (DALIAN) PHARMACEUTICAL CO., LTD. Effective date: 20130620 |
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Owner name: SHIJIAZHUANG PHARMACEUTICAL GROUP YUANDA (DALIAN) Free format text: FORMER NAME: YUANDA PHARMACEUTICAL CO., LTD., DALIAN |
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Address after: 116000 No. 19, independence street, Zhongshan District, Liaoning, Dalian Patentee after: CSPC YUANDA (DALIAN) PHARMACEUTICAL CO.,LTD. Address before: 2808, room 116001, Yuanda building, 19 independence street, Liaoning, Dalian Patentee before: YUANDA PHARMACEUTICAL Co.,Ltd. DALIAN |
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Effective date of registration: 20130620 Address after: 116000 No. 19, independence street, Zhongshan District, Liaoning, Dalian Patentee after: Dalian ambitious building Ltd. Address before: 116000 No. 19, independence street, Zhongshan District, Liaoning, Dalian Patentee before: CSPC YUANDA (DALIAN) PHARMACEUTICAL CO.,LTD. |
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Address after: 116000 No. 19, independence street, Zhongshan District, Liaoning, Dalian Patentee after: CSPC YUANDA (DALIAN) PHARMACEUTICAL CO.,LTD. Address before: 116000 No. 19, independence street, Zhongshan District, Liaoning, Dalian Patentee before: Dalian ambitious building Ltd. |
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